{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T06:51:12Z","timestamp":1784616672456,"version":"3.55.0"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T00:00:00Z","timestamp":1530489600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001245","name":"Jeffrey Modell Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.01506","type":"journal-article","created":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T04:24:06Z","timestamp":1530505446000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["No Overt Clinical Immunodeficiency Despite Immune Biological Abnormalities in Patients With Constitutional Mismatch Repair Deficiency"],"prefix":"10.3389","volume":"9","author":[{"given":"Victoria K.","family":"Tesch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"IJspeert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Raicht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Rueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerea","family":"Dominguez-Pinilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis M.","family":"Allende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrystelle","family":"Colas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Rosenbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denisa","family":"Ilencikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagit N.","family":"Baris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela H. M.","family":"Nathrath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon","family":"Suerink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danuta","family":"Januszkiewicz-Lewandowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman","family":"Ragab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amedeo A.","family":"Azizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soeren S.","family":"Wenzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Zschocke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Schwinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Kloor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Blattmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Brugieres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam","family":"van der Burg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Wimmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus G.","family":"Seidel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,7,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1056\/NEJM199503303321302","article-title":"The molecular basis of Turcot\u2019s syndrome","volume":"332","author":"Hamilton","year":"1995","journal-title":"N Engl J Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/s00439-008-0542-4","article-title":"Constitutional mismatch repair-deficiency syndrome: have we so far seen only the tip of an iceberg?","volume":"124","author":"Wimmer","year":"2008","journal-title":"Hum Genet"},{"key":"B3","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1111\/cge.12904","article-title":"Connections between constitutional mismatch repair deficiency syndrome and neurofibromatosis type 1","volume":"91","author":"Wimmer","year":"2017","journal-title":"Clin Genet"},{"key":"B4","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1136\/jmedgenet-2013-102238","article-title":"Guidelines for surveillance of individuals with constitutional mismatch repair-deficiency proposed by the European consortium \"care for CMMR-D\" (C4CMMR-D)","volume":"51","author":"Vasen","year":"2014","journal-title":"J Med Genet"},{"key":"B5","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1136\/jmedgenet-2014-102284","article-title":"Diagnostic criteria for constitutional mismatch repair deficiency syndrome: suggestions of the European consortium \u2018care for CMMRD\u2019 (C4CMMRD)","volume":"51","author":"Wimmer","year":"2014","journal-title":"J Med Genet"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1053\/j.gastro.2017.02.011","article-title":"Recommendations on surveillance and management of biallelic mismatch repair deficiency (BMMRD) syndrome: a consensus statement by the US multi-society task force on colorectal cancer","volume":"152","author":"Durno","year":"2017","journal-title":"Gastroenterology"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e32","DOI":"10.1158\/1078-0432.CCR-17-0574","article-title":"Clinical management and tumor surveillance recommendations of inherited mismatch repair deficiency in childhood","volume":"23","author":"Tabori","year":"2017","journal-title":"Clin Cancer Res"},{"key":"B8","doi-asserted-by":"publisher","first-page":"a012633","DOI":"10.1101\/cshperspect.a012633","article-title":"Postreplicative mismatch repair","volume":"5","author":"Jiricny","year":"2013","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/ar3904","article-title":"Immunoglobulin class-switch recombination deficiencies","volume":"14","author":"Durandy","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"B10","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1111\/j.1365-2141.2010.08077.x","article-title":"Update on the hyper immunoglobulin M syndromes","volume":"149","author":"Davies","year":"2010","journal-title":"Br J Haematol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/j.jaip.2016.09.013","article-title":"Clinical phenotypes of hyper-IgM syndromes","volume":"4","author":"de la Morena","year":"2016","journal-title":"J Allergy Clin Immunol Pract"},{"key":"B12","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1111\/j.1749-6632.2011.06322.x","article-title":"DNA repair: the link between primary immunodeficiency and cancer","volume":"1246","author":"de Miranda","year":"2011","journal-title":"Ann N Y Acad Sci"},{"key":"B13","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1111\/j.1399-0004.2007.00803.x","article-title":"A homozygous germ-line mutation in the human MSH2 gene predisposes to hematological malignancy and multiple cafe-au-lait spots","volume":"62","author":"Whiteside","year":"2002","journal-title":"Cancer Res"},{"key":"B14","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1002\/ajmg.a.30998","article-title":"Neurofibromatosis von Recklinghausen type I phenotype and early onset of cancers in siblings compound heterozygous for mutations in MSH6","author":"Ostergaard","year":"2005","journal-title":"Am J Med Genet A"},{"key":"B15","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1038\/ncponc0719","article-title":"Medulloblastoma, acute myelocytic leukemia and colonic carcinomas in a child with biallelic MSH6 mutations","volume":"4","author":"Scott","year":"2007","journal-title":"Nat Clin Pract Oncol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1084\/jem.20080789","article-title":"Human PMS2 deficiency is associated with impaired immunoglobulin class switch recombination","volume":"205","author":"Peron","year":"2008","journal-title":"J Exp Med"},{"key":"B17","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.4049\/jimmunol.1102984","article-title":"Human MSH6 deficiency is associated with impaired antibody maturation","volume":"188","author":"Gardes","year":"2012","journal-title":"J Immunol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"7193","DOI":"10.1073\/pnas.0700815104","article-title":"Role for Msh5 in the regulation of Ig class switch recombination","volume":"104","author":"Sekine","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B19","doi-asserted-by":"publisher","first-page":"e12260","DOI":"10.1371\/journal.pone.0012260","article-title":"Unique DNA repair gene variations and potential associations with the primary antibody deficiency syndromes IgAD and CVID","volume":"5","author":"Offer","year":"2010","journal-title":"PLoS One"},{"key":"B20","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.jaci.2017.06.009","article-title":"Intrinsic and extrinsic causes of malignancies in patients with primary immunodeficiency disorders","volume":"141","author":"Hauck","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1136\/jmedgenet-2015-103299","article-title":"Constitutional mismatch repair deficiency syndrome: clinical description in a French cohort","volume":"52","author":"Lavoine","year":"2015","journal-title":"J Med Genet"},{"key":"B22","first-page":"S34","article-title":"Constitutional mismatch repair-deficiency syndrome (CMMR-D) - a case report of a family with biallelic MSH6 mutation","volume":"25","author":"Ilen\u010d\u00edkov\u00e1","year":"2012","journal-title":"Klin Onkol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1002\/pbc.25818","article-title":"Constitutional Mismatch Repair Deficiency in Israel: High Proportion of Founder Mutations in MMR Genes and Consanguinity","volume":"63","author":"Baris","year":"2016","journal-title":"Pediatr Blood Cancer"},{"key":"B24","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1111\/cge.13053","article-title":"Constitutional mismatch repair deficiency in a healthy child: on the spot diagnosis?","volume":"93","author":"Suerink","year":"2018","journal-title":"Clin Genet"},{"key":"B25","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the association for molecular pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"B26","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1002\/humu.22311","article-title":"Simple detection of germline microsatellite instability for diagnosis of constitutional mismatch repair cancer syndrome","volume":"34","author":"Ingham","year":"2013","journal-title":"Hum Mutat"},{"key":"B27","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.jpeds.2006.01.009","article-title":"Mutations in the DNA mismatch repair gene MLH1 associated with early-onset colon cancer","volume":"148","author":"Marcos","year":"2006","journal-title":"J Pediatr"},{"key":"B28","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1002\/cyto.b.20432","article-title":"Flowcytometric phenotyping of common variable immunodeficiency","volume":"74","author":"Warnatz","year":"2008","journal-title":"Cytometry B Clin Cytom"},{"key":"B29","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.clim.2008.11.008","article-title":"Memory B-cells in healthy and antibody-deficient children","volume":"131","author":"Huck","year":"2009","journal-title":"Clin Immunol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1172\/JCI18161","article-title":"Hyper-IgM syndrome type 4 with a B lymphocyte-intrinsic selective deficiency in Ig class-switch recombination","volume":"112","author":"Imai","year":"2003","journal-title":"J Clin Invest"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1084\/jem.20070087","article-title":"A primary immunodeficiency characterized by defective immunoglobulin class switch recombination and impaired DNA repair","volume":"204","author":"Peron","year":"2007","journal-title":"J Exp Med"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1373\/clinchem.2003.022350","article-title":"IgG subclass concentrations in certified reference material 470 and reference values for children and adults determined with the binding site reagents","volume":"49","author":"Schauer","year":"2003","journal-title":"Clin Chem"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1016\/j.jaci.2013.01.053","article-title":"Antibody deficiency in patients with ataxia telangiectasia is caused by disturbed B- and T-cell homeostasis and reduced immune repertoire diversity","volume":"131","author":"Driessen","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2150","DOI":"10.1182\/blood-2011-04-345579","article-title":"Human memory B cells originate from three distinct germinal center-dependent and -independent maturation pathways","volume":"118","author":"Berkowska","year":"2011","journal-title":"Blood"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1126\/science.1086907","article-title":"Predominant autoantibody production by early human B cell precursors","volume":"301","author":"Wardemann","year":"2003","journal-title":"Science"},{"key":"B36","doi-asserted-by":"publisher","first-page":"410","DOI":"10.3389\/fimmu.2016.00410","article-title":"Evaluation of the antigen-experienced B-cell receptor repertoire in healthy children and adults","volume":"7","author":"IJspeert","year":"2016","journal-title":"Front Immunol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"3484","DOI":"10.1093\/emboj\/18.12.3484","article-title":"Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation","volume":"18","author":"Ehrenstein","year":"1999","journal-title":"EMBO J"},{"key":"B38","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1084\/jem.190.3.323","article-title":"Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes","volume":"190","author":"Schrader","year":"1999","journal-title":"J Exp Med"},{"key":"B39","doi-asserted-by":"publisher","first-page":"14553","DOI":"10.1073\/pnas.241525998","article-title":"Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination","volume":"98","author":"Ehrenstein","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B40","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1084\/jem.20011877","article-title":"Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions","volume":"195","author":"Schrader","year":"2002","journal-title":"J Exp Med"},{"key":"B41","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1084\/jem.20040691","article-title":"A role for Msh6 but not Msh3 in somatic hypermutation and class switch recombination","volume":"200","author":"Martomo","year":"2004","journal-title":"J Exp Med"},{"key":"B42","doi-asserted-by":"publisher","first-page":"5386","DOI":"10.4049\/jimmunol.177.8.5386","article-title":"Somatic hypermutation and class switch recombination in Msh6(-\/-)Ung(-\/-) double-knockout mice","volume":"177","author":"Shen","year":"2006","journal-title":"J Immunol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"5593","DOI":"10.1073\/pnas.0901726106","article-title":"Interference of mismatch and base excision repair during the processing of adjacent U\/G mispairs may play a key role in somatic hypermutation","volume":"106","author":"Schanz","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B44","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.biopha.2011.09.001","article-title":"Mismatch-mediated error prone repair at the immunoglobulin genes","volume":"65","author":"Chahwan","year":"2011","journal-title":"Biomed Pharmacother"},{"key":"B45","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/j.1749-6632.2011.06206.x","article-title":"Ten warning signs of primary immunodeficiency: a new paradigm is needed for the 21st century","volume":"1238","author":"Arkwright","year":"2011","journal-title":"Ann N Y Acad Sci"},{"key":"B46","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1055\/s-0031-1287835","article-title":"[Interdisciplinary AWMF guideline for the diagnostics of primary immunodeficiency]","volume":"223","author":"Farmand","year":"2011","journal-title":"Klin Padiatr"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1007\/s00431-011-1400-2","article-title":"Study of patients with hyper-IgM type IV phenotype who recovered spontaneously during late childhood and review of the literature","volume":"170","author":"Karaca","year":"2011","journal-title":"Eur J Pediatr"},{"key":"B48","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.ajhg.2015.01.013","article-title":"Mutations in the NHEJ component XRCC4 cause primordial dwarfism","volume":"96","author":"Murray","year":"2015","journal-title":"Am J Hum Genet"},{"key":"B49","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1007\/s10875-015-0201-1","article-title":"Primary immunodeficiency diseases: an update on the classification from the international union of immunological societies expert committee for primary immunodeficiency 2015","volume":"35","author":"Picard","year":"2015","journal-title":"J Clin Immunol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1038\/sj.ejhg.5201568","article-title":"Compound heterozygosity for two MSH6 mutations in a patient with early onset of HNPCC-associated cancers, but without hematological malignancy and brain tumor","volume":"14","author":"Plaschke","year":"2006","journal-title":"Eur J Hum Genet"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1002\/ajmg.a.32210","article-title":"Compound heterozygosity for two MSH6 mutations in a patient with early onset colorectal cancer, vitiligo and systemic lupus erythematosus","author":"Rahner","year":"2008","journal-title":"Am J Med Genet A"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.3899\/jrheum.130948","article-title":"Prevalence of antinuclear antibodies in schoolchildren during puberty and possible relationship with musculoskeletal pain: a longitudinal study","volume":"41","author":"Sperotto","year":"2014","journal-title":"J Rheumatol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.1002\/eji.200324133","article-title":"Activation-induced cytidine deaminase: a dual role in class-switch recombination and somatic hypermutation","volume":"33","author":"Durandy","year":"2003","journal-title":"Eur J Immunol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1002\/humu.23237","article-title":"panelcn.MOPS: copy-number detection in targeted NGS panel data for clinical diagnostics","volume":"38","author":"Povysil","year":"2017","journal-title":"Hum Mutat"},{"key":"B55","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1002\/humu.20657","article-title":"RNA-based mutation analysis identifies an unusual MSH6 splicing defect and circumvents PMS2 pseudogene interference","volume":"29","author":"Etzler","year":"2008","journal-title":"Hum Mutat"},{"key":"B56","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1002\/gcc.21966","article-title":"Improved multiplex ligation-dependent probe amplification analysis identifies a deleterious PMS2 allele generated by recombination with crossover between PMS2 and PMS2CL","volume":"51","author":"Wernstedt","year":"2012","journal-title":"Genes Chromosomes Cancer"},{"key":"B57","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/(SICI)1098-1004(200001)15:1<7::AID-HUMU4>3.0.CO;2-N","article-title":"Mutation nomenclature extensions and suggestions to describe complex mutations: a discussion","volume":"15","author":"den Dunnen","year":"2000","journal-title":"Hum Mutat"},{"key":"B58","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1007\/BF03401602","article-title":"Oligoclonality in the human CD8+ T cell repertoire in normal subjects and monozygotic twins: implications for studies of infectious and autoimmune diseases","volume":"1","author":"Monteiro","year":"1995","journal-title":"Mol Med"},{"key":"B59","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.1038\/sj.leu.2403202","article-title":"Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 concerted action BMH4-CT98-3936","volume":"17","author":"van Dongen","year":"2003","journal-title":"Leukemia"},{"key":"B60","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.jim.2007.09.017","article-title":"Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning","volume":"329","author":"Tiller","year":"2008","journal-title":"J Immunol Methods"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.4049\/jimmunol.1402708","article-title":"Circulating human CD27-IgA+ memory B cells recognize bacteria with polyreactive Igs","volume":"195","author":"Berkowska","year":"2015","journal-title":"J Immunol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"4156","DOI":"10.4049\/jimmunol.1601921","article-title":"Antigen receptor galaxy: a user-friendly, web-based tool for analysis and visualization of T and B cell receptor repertoire data","volume":"198","author":"IJspeert","year":"2017","journal-title":"J Immunol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1007\/978-1-61779-842-9_32","article-title":"IMGT((R)) tools for the nucleotide analysis of immunoglobulin (IG) and T cell receptor (TR) V-(D)-J repertoires, polymorphisms, and IG mutations: IMGT\/V-QUEST and IMGT\/HighV-QUEST for NGS","volume":"882","author":"Alamyar","year":"2012","journal-title":"Methods Mol Biol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"3356","DOI":"10.1093\/bioinformatics\/btv359","article-title":"Change-O: a toolkit for analyzing large-scale B cell immunoglobulin repertoire sequencing data","volume":"31","author":"Gupta","year":"2015","journal-title":"Bioinformatics"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01506\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,20]],"date-time":"2019-10-20T06:37:38Z","timestamp":1571553458000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01506\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,2]]},"references-count":64,"alternative-id":["10.3389\/fimmu.2018.01506"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.01506","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,2]]},"article-number":"1506"}}