{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:41:41Z","timestamp":1792071701241,"version":"4.4.0"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T00:00:00Z","timestamp":1531094400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","award":["20130321"],"award-info":[{"award-number":["20130321"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["K2013-57X-14182-12-3"],"award-info":[{"award-number":["K2013-57X-14182-12-3"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","award":["3-1818\/2013"],"award-info":[{"award-number":["3-1818\/2013"]}],"id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.01516","type":"journal-article","created":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T04:18:01Z","timestamp":1531109881000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":77,"title":["In Situ Humoral Immunity to Vimentin in HLA-DRB1*03+ Patients With Pulmonary Sarcoidosis"],"prefix":"10.3389","volume":"9","author":[{"given":"Andrew J.","family":"Kinloch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ylva","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don","family":"Wolfgeher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junting","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Eklund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus R.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Grunewald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,7,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1056\/NEJMra071714","article-title":"Sarcoidosis","volume":"357","author":"Iannuzzi","year":"2007","journal-title":"N Engl J Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1164\/ajrccm.156.5.9704069","article-title":"HLA-DR predicts the prognosis in Scandinavian patients with pulmonary sarcoidosis","volume":"156","author":"Berlin","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1164\/ajrccm.161.3.9906001","article-title":"Lung T-helper cells expressing T-cell receptor AV2S3 associate with clinical features of pulmonary sarcoidosis","volume":"161","author":"Grunewald","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1164\/rccm.200807-1082OC","article-title":"Lofgren\u2019s syndrome: human leukocyte antigen strongly influences the disease course","volume":"179","author":"Grunewald","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1183\/09031936.03.00059103","article-title":"Markers of activity in clinically recovered human leukocyte antigen-DR17-positive sarcoidosis patients","volume":"21","author":"Planck","year":"2003","journal-title":"Eur Respir J"},{"key":"B6","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1172\/JCI110036","article-title":"Mechanisms of hypergammaglobulinemia in pulmonary sarcoidosis. Site of increased antibody production and role of T lymphocytes","volume":"67","author":"Hunninghake","year":"1981","journal-title":"J Clin Invest"},{"key":"B7","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1164\/rccm.201206-1024OC","article-title":"Perigranuloma localization and abnormal maturation of B cells: emerging key players in sarcoidosis?","volume":"187","author":"Kamphuis","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"B8","first-page":"493","article-title":"Evidence for circulating immune complexes in sarcoidosis","volume":"16","author":"Hedfors","year":"1974","journal-title":"Clin Exp Immunol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1111\/j.1749-6632.1976.tb47032.x","article-title":"Evidence for circulating immune complexes in erythema nodosum and early sarcoidosis","volume":"278","author":"Jones","year":"1976","journal-title":"Ann N Y Acad Sci"},{"key":"B10","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1164\/rccm.201407-1341OC","article-title":"Proteomic profiling reveals autoimmune targets in sarcoidosis","volume":"191","author":"Haggmark","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"B11","doi-asserted-by":"publisher","first-page":"3017","DOI":"10.1074\/mcp.M116.060764","article-title":"Approach for identifying human leukocyte antigen (HLA)-DR bound peptides from scarce clinical samples","volume":"15","author":"Heyder","year":"2016","journal-title":"Mol Cell Proteomics"},{"key":"B12","doi-asserted-by":"publisher","first-page":"3576","DOI":"10.1172\/JCI32401","article-title":"Identification of HLA-DR-bound peptides presented by human bronchoalveolar lavage cells in sarcoidosis","volume":"117","author":"Wahlstrom","year":"2007","journal-title":"J Clin Invest"},{"key":"B13","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.clim.2009.08.008","article-title":"Autoimmune T cell responses to antigenic peptides presented by bronchoalveolar lavage cell HLA-DR molecules in sarcoidosis","volume":"133","author":"Wahlstrom","year":"2009","journal-title":"Clin Immunol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1183\/13993003.01209-2015","article-title":"T-cell receptor-HLA-DRB1 associations suggest specific antigens in pulmonary sarcoidosis","volume":"47","author":"Grunewald","year":"2016","journal-title":"Eur Respir J"},{"key":"B15","first-page":"169","article-title":"En ny og spesifikk kutan-reaksjon ved Boecks sarcoid [A new and specific cutaneous reaction in Boeck\u2019s sarcoid]","volume":"9","author":"Kveim","year":"1941","journal-title":"Nord Med"},{"key":"B16","doi-asserted-by":"publisher","first-page":"e0170285","DOI":"10.1371\/journal.pone.0170285","article-title":"Proteomic analysis of kveim reagent identifies targets of cellular immunity in sarcoidosis","volume":"12","author":"Eberhardt","year":"2017","journal-title":"PLoS One"},{"key":"B17","doi-asserted-by":"publisher","first-page":"3359","DOI":"10.1002\/art.38888","article-title":"Vimentin is a dominant target of in situ humoral immunity in human lupus tubulointerstitial nephritis","volume":"66","author":"Kinloch","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"2088","DOI":"10.1111\/j.1600-6143.2012.04053.x","article-title":"Expansion of polyreactive B cells cross-reactive to HLA and self in the blood of a patient with kidney graft rejection","volume":"12","author":"Porcheray","year":"2012","journal-title":"Am J Transplant"},{"key":"B19","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1038\/sj.ejhg.5201827","article-title":"Specific combinations of HLA-DR2 and DR3 class II haplotypes contribute graded risk for disease susceptibility and autoantibodies in human SLE","volume":"15","author":"Graham","year":"2007","journal-title":"Eur J Hum Genet"},{"key":"B20","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/1465-9921-11-25","article-title":"Different HLA-DRB1 allele distributions in distinct clinical subgroups of sarcoidosis patients","volume":"11","author":"Grunewald","year":"2010","journal-title":"Respir Res"},{"key":"B21","doi-asserted-by":"publisher","first-page":"e43644","DOI":"10.1371\/journal.pone.0043644","article-title":"Bronchoalveolar lavage results are independent of season, age, gender and collection site","volume":"7","author":"Olsen","year":"2012","journal-title":"PLoS One"},{"key":"B22","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1034\/j.1399-3003.1999.14d02.x","article-title":"ATS\/ERS\/WASOG statement on sarcoidosis. Sarcoidosis Statement Committee. American Thoracic Society. European Respiratory Society. World Association for Sarcoidosis and Other Granulomatous Disorders","volume":"14","author":"Costabel","year":"1999","journal-title":"Eur Respir J"},{"key":"B23","doi-asserted-by":"publisher","first-page":"652","DOI":"10.4049\/jimmunol.176.1.652","article-title":"SC5 mAb represents a unique tool for the detection of extracellular vimentin as a specific marker of Sezary cells","volume":"176","author":"Huet","year":"2006","journal-title":"J Immunol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/ncb898","article-title":"Vimentin is secreted by activated macrophages","volume":"5","author":"Mor-Vaknin","year":"2003","journal-title":"Nat Cell Biol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"4887","DOI":"10.4049\/jimmunol.1300179","article-title":"Nonstereotyped lymphoma B cell receptors recognize vimentin as a shared autoantigen","volume":"190","author":"Cha","year":"2013","journal-title":"J Immunol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.4049\/jimmunol.1700473","article-title":"Autoimmunity to vimentin is associated with outcomes of patients with idiopathic pulmonary fibrosis","volume":"199","author":"Li","year":"2017","journal-title":"J Immunol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/gene.2013.68","article-title":"The influence of polygenic risk scores on heritability of anti-CCP level in RA","volume":"15","author":"Cui","year":"2014","journal-title":"Genes Immun"},{"key":"B28","doi-asserted-by":"publisher","first-page":"3813","DOI":"10.1002\/art.21419","article-title":"Regulation of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: contrasting effects of HLA-DR3 and the shared epitope alleles","volume":"52","author":"Irigoyen","year":"2005","journal-title":"Arthritis Rheum"},{"key":"B29","doi-asserted-by":"publisher","first-page":"3058","DOI":"10.1002\/art.21302","article-title":"Association of HLA-DR3 with anti-cyclic citrullinated peptide antibody-negative rheumatoid arthritis","volume":"52","author":"Verpoort","year":"2005","journal-title":"Arthritis Rheum"},{"key":"B30","doi-asserted-by":"publisher","first-page":"2279","DOI":"10.4049\/jimmunol.1700570","article-title":"Shared alphabeta TCR usage in lungs of sarcoidosis patients with Lofgren\u2019s syndrome","volume":"199","author":"Mitchell","year":"2017","journal-title":"J Immunol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"21607","DOI":"10.1038\/srep21607","article-title":"High-throughput proteomics reveal alarmins as amplifiers of tissue pathology and inflammation after spinal cord injury","volume":"6","author":"Didangelos","year":"2016","journal-title":"Sci Rep"},{"key":"B32","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.immuni.2012.03.008","article-title":"F-actin is an evolutionarily conserved damage-associated molecular pattern recognized by DNGR-1, a receptor for dead cells","volume":"36","author":"Ahrens","year":"2012","journal-title":"Immunity"},{"key":"B33","doi-asserted-by":"publisher","first-page":"76","DOI":"10.3109\/08916930903374618","article-title":"Regulation of autoreactive B cell responses to endogenous TLR ligands","volume":"43","author":"Avalos","year":"2010","journal-title":"Autoimmunity"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01516\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T04:18:09Z","timestamp":1531109889000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01516\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,9]]},"references-count":33,"alternative-id":["10.3389\/fimmu.2018.01516"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.01516","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,9]]},"article-number":"1516"}}