{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:28:48Z","timestamp":1790634528320,"version":"4.1.0"},"reference-count":52,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T00:00:00Z","timestamp":1531094400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["141193\/2014-0, 11362\/2014-1, 448152\/2014-2"],"award-info":[{"award-number":["141193\/2014-0, 11362\/2014-1, 448152\/2014-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/010.002985\/2014, E-26\/203.027\/2015"],"award-info":[{"award-number":["E-26\/010.002985\/2014, E-26\/203.027\/2015"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.01531","type":"journal-article","created":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T04:50:28Z","timestamp":1531111828000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["Purinergic Cooperation Between P2Y2 and P2X7 Receptors Promote Cutaneous Leishmaniasis Control: Involvement of Pannexin-1 and Leukotrienes"],"prefix":"10.3389","volume":"9","author":[{"given":"Maria Luiza","family":"Thorstenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Vin\u00edcius","family":"Rangel Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia","family":"Amorim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Canetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda B.","family":"Morrone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Carlos","family":"Alves Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robson","family":"Coutinho-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,7,9]]},"reference":[{"key":"B1","article-title":"Control of the Leishmaniases","year":"2010","journal-title":"World Health Organ Tech Rep Ser"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e35671","DOI":"10.1371\/journal.pone.0035671","article-title":"Leishmaniasis worldwide and global estimates of its incidence","volume":"7","author":"Alvar","year":"2012","journal-title":"PLoS One"},{"key":"B3","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1038\/nri933","article-title":"The immunology of susceptibility and resistance to Leishmania major in mice","volume":"2","author":"Sacks","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/nri.2016.72","article-title":"Cutaneous leishmaniasis: immune responses in protection and pathogenesis","volume":"16","author":"Scott","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"4765","DOI":"10.4049\/jimmunol.1301058","article-title":"Leukotriene B4 modulates P2X7 receptor-mediated Leishmania amazonensis elimination in murine macrophages","volume":"192","author":"Chaves","year":"2014","journal-title":"J Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1159\/000453397","article-title":"Cellular innate immunity: an old game with new players","volume":"9","author":"Gasteiger","year":"2017","journal-title":"J Innate Immun"},{"key":"B7","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.it.2016.04.004","article-title":"Purinergic signaling during immune cell trafficking","volume":"37","author":"Ferrari","year":"2016","journal-title":"Trends Immunol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1038\/nature09413","article-title":"Pannexin 1 channels mediate \u2019find-me\u2019 signal release and membrane permeability during apoptosis","volume":"467","author":"Chekeni","year":"2010","journal-title":"Nature"},{"key":"B9","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0031-6997(24)01373-5","article-title":"Receptors for purines and pyrimidines","volume":"50","author":"Ralevic","year":"1998","journal-title":"Pharmacol Rev"},{"key":"B10","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1124\/pr.58.3.3","article-title":"International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy","volume":"58","author":"Abbracchio","year":"2006","journal-title":"Pharmacol Rev"},{"key":"B11","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/S1074-7613(03)00235-8","article-title":"Inhibition of chlamydial infectious activity due to P2X7R-dependent phospholipase D activation","volume":"19","author":"Coutinho-Silva","year":"2003","journal-title":"Immunity"},{"key":"B12","doi-asserted-by":"publisher","first-page":"C1139","DOI":"10.1152\/ajpcell.1999.276.5.C1139","article-title":"P2Z\/P2X7 receptor-dependent apoptosis of dendritic cells","volume":"276","author":"Coutinho-Silva","year":"1999","journal-title":"Am J Physiol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"8410","DOI":"10.4049\/jimmunol.180.12.8410","article-title":"A key role for redox signaling in rapid P2X7 receptor-induced IL-1 beta processing in human monocytes","volume":"180","author":"Hewinson","year":"2008","journal-title":"J Immunol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.jhep.2017.05.021","article-title":"CD39 limits P2X7 receptor inflammatory signaling and attenuates sepsis-induced liver injury","volume":"67","author":"Savio","year":"2017","journal-title":"J Hepatol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"e0133502","DOI":"10.1371\/journal.pone.0133502","article-title":"Pyrimidinergic receptor activation controls Toxoplasma gondii infection in macrophages","volume":"10","author":"Moreira-Souza","year":"2015","journal-title":"PLoS One"},{"key":"B16","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s11302-016-9544-1","article-title":"The role of the P2X7 receptor in murine cutaneous leishmaniasis: aspects of inflammation and parasite control","volume":"13","author":"Figliuolo","year":"2017","journal-title":"Purinergic Signal"},{"key":"B17","doi-asserted-by":"publisher","first-page":"4704","DOI":"10.4049\/jimmunol.165.8.4704","article-title":"Extracellular ATP and TNF-alpha synergize in the activation and maturation of human dendritic cells","volume":"165","author":"Schnurr","year":"2000","journal-title":"J Immunol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1159\/000336628","article-title":"Characterizing the presence and sensitivity of the P2X7 receptor in different compartments of the gut","volume":"4","author":"de Campos","year":"2012","journal-title":"J Innate Immun"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1111\/j.1462-5822.2011.01630.x","article-title":"Infection with Leishmania amazonensis upregulates purinergic receptor expression and induces host-cell susceptibility to UTP-mediated apoptosis","volume":"13","author":"Marques-da-Silva","year":"2011","journal-title":"Cell Microbiol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/j.micinf.2009.05.001","article-title":"Modulation of P2X(7) purinergic receptor in macrophages by Leishmania amazonensis and its role in parasite elimination","volume":"11","author":"Chaves","year":"2009","journal-title":"Microbes Infect"},{"key":"B21","doi-asserted-by":"publisher","first-page":"5076","DOI":"10.1128\/IAI.02546-14","article-title":"Toll-like receptor-triggered calcium mobilization protects mice against bacterial infection through extracellular ATP release","volume":"82","author":"Ren","year":"2014","journal-title":"Infect Immun"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1177\/0022034515593465","article-title":"A dual role for P2X7 receptor during Porphyromonas gingivalis infection","volume":"94","author":"Ramos-Junior","year":"2015","journal-title":"J Dent Res"},{"key":"B23","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0074-7696(04)40002-3","article-title":"Cellular distribution and functions of P2 receptor subtypes in different systems","volume":"240","author":"Burnstock","year":"2004","journal-title":"Int Rev Cytol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.micinf.2010.03.004","article-title":"Activation of the P2X(7) receptor triggers the elimination of Toxoplasma gondii tachyzoites from infected macrophages","volume":"12","author":"Correa","year":"2010","journal-title":"Microbes Infect"},{"key":"B25","doi-asserted-by":"publisher","first-page":"e1006595","DOI":"10.1371\/journal.ppat.1006595","article-title":"P2X7 receptor drives Th1\u2009cell differentiation and controls the follicular helper T cell population to protect against Plasmodium chabaudi malaria","volume":"13","author":"Salles","year":"2017","journal-title":"PLoS Pathog"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.3389\/fimmu.2017.01257","article-title":"The P2X7 receptor mediates Toxoplasma gondii control in macrophages through canonical NLRP3 inflammasome activation and reactive oxygen species production","volume":"8","author":"Moreira-Souza","year":"2017","journal-title":"Front Immunol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s11302-018-9606-7","article-title":"Intralesional uridine-5\u2019-triphosphate (UTP) treatment induced resistance to Leishmania amazonensis infection by boosting Th1 immune responses and reactive oxygen species production","volume":"14","author":"Marques-da-Silva","year":"2018","journal-title":"Purinergic Signal"},{"key":"B28","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1111\/j.1365-3024.1985.tb00098.x","article-title":"A limiting dilution assay for quantifying Leishmania major in tissues of infected mice","volume":"7","author":"Titus","year":"1985","journal-title":"Parasite Immunol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.autneu.2015.04.011","article-title":"Purinergic signaling in the immune system","volume":"191","author":"Di","year":"2015","journal-title":"Auton Neurosci"},{"key":"B30","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0014-2999(99)00350-7","article-title":"Pharmacological characterization of recombinant human and rat P2X receptor subtypes","volume":"376","author":"Bianchi","year":"1999","journal-title":"Eur J Pharmacol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1530\/JOE-17-0042","article-title":"Activation of the P2Y2 receptor regulates bone cell function by enhancing ATP release","volume":"233","author":"Orriss","year":"2017","journal-title":"J Endocrinol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1126\/science.1132559","article-title":"ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors","volume":"314","author":"Chen","year":"2006","journal-title":"Science"},{"key":"B33","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.bbamem.2017.07.009","article-title":"Mechanisms of pannexin1 channel gating and regulation","volume":"1860","author":"Whyte-Fagundes","year":"2018","journal-title":"Biochim Biophys Acta"},{"key":"B34","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1038\/nm.3221","article-title":"Inflammasome-derived IL-1beta production induces nitric oxide-mediated resistance to Leishmania","volume":"19","author":"Lima-Junior","year":"2013","journal-title":"Nat Med"},{"key":"B35","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.immuni.2009.02.007","article-title":"Critical regulation of early Th17\u2009cell differentiation by interleukin-1 signaling","volume":"30","author":"Chung","year":"2009","journal-title":"Immunity"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1093\/infdis\/jiu531","article-title":"Interleukin 17A acts synergistically with interferon gamma to promote protection against Leishmania infantum infection","volume":"211","author":"Nascimento","year":"2015","journal-title":"J Infect Dis"},{"key":"B37","doi-asserted-by":"publisher","first-page":"830374","DOI":"10.1155\/2014\/830374","article-title":"P2Y receptor modulation of ATP release in the urothelium","volume":"2014","author":"Mansfield","year":"2014","journal-title":"Biomed Res Int"},{"key":"B38","doi-asserted-by":"publisher","first-page":"eaah7107","DOI":"10.1126\/scisignal.aah7107","article-title":"ATP promotes the fast migration of dendritic cells through the activity of pannexin 1 channels and P2X7 receptors","volume":"10","author":"Saez","year":"2017","journal-title":"Sci Signal"},{"key":"B39","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s11302-013-9404-1","article-title":"UTP-induced ATP release is a fine-tuned signalling pathway in osteocytes","volume":"10","author":"Kringelbach","year":"2014","journal-title":"Purinergic Signal"},{"key":"B40","doi-asserted-by":"publisher","first-page":"786","DOI":"10.3389\/fimmu.2017.00786","article-title":"NOD-Like receptor P3 inflammasome controls protective Th1\/Th17 immunity against pulmonary paracoccidioidomycosis","volume":"8","author":"Feriotti","year":"2017","journal-title":"Front Immunol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1111\/j.2042-7158.1981.tb13884.x","article-title":"The stimulation of lysosomal enzyme secretion from human polymorphonuclear leucocytes by leukotriene B4","volume":"33","author":"Rae","year":"1981","journal-title":"J Pharm Pharmacol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3389\/fphar.2018.00052","article-title":"The P2X7 receptor in inflammatory diseases: Angel or Demon?","volume":"9","author":"Savio","year":"2018","journal-title":"Front Pharmacol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/0005-2736(95)00200-6","article-title":"A cation non-selective channel induced by extracellular ATP in macrophages and phagocytic cells of the thymic reticulum","volume":"1278","author":"Coutinho-Silva","year":"1996","journal-title":"Biochim Biophys Acta"},{"key":"B44","doi-asserted-by":"publisher","first-page":"C1793","DOI":"10.1152\/ajpcell.1997.273.6.C1793","article-title":"P2Z purinoceptor-associated pores induced by extracellular ATP in macrophages and J774 cells","volume":"273","author":"Coutinho-Silva","year":"1997","journal-title":"Am J Physiol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"5071","DOI":"10.1038\/sj.emboj.7601378","article-title":"Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor","volume":"25","author":"Pelegrin","year":"2006","journal-title":"EMBO J"},{"key":"B46","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/nature13085","article-title":"Nucleotide signalling during inflammation","volume":"509","author":"Idzko","year":"2014","journal-title":"Nature"},{"key":"B47","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1111\/j.1600-065X.2008.00628.x","article-title":"Th17\u2009cells in human disease","volume":"223","author":"Tesmer","year":"2008","journal-title":"Immunol Rev"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1111\/j.1476-5381.1988.tb11632.x","article-title":"Evidence that neutrophil accumulation induced by interleukin-1 requires both local protein biosynthesis and neutrophil CD18 antigen expression in vivo","volume":"94","author":"Rampart","year":"1988","journal-title":"Br J Pharmacol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"264270","DOI":"10.1155\/2014\/264270","article-title":"Protective role of 5-lipoxigenase during Leishmania infantum infection is associated with Th17 subset","volume":"2014","author":"Sacramento","year":"2014","journal-title":"Biomed Res Int"},{"key":"B50","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/j.bbrc.2009.05.011","article-title":"Blockade of murine T cell activation by antagonists of P2Y6 and P2X7 receptors","volume":"384","author":"Tsukimoto","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1601549","DOI":"10.4049\/jimmunol.1601549","article-title":"Critical role of P2Y12 receptor in regulation of th17 differentiation and experimental autoimmune encephalomyelitis pathogenesis","volume":"199","author":"Qin","year":"2017","journal-title":"J Immunol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"661","DOI":"10.3389\/fphar.2017.00661","article-title":"Purinergic signalling: therapeutic developments","volume":"8","author":"Burnstock","year":"2017","journal-title":"Front Pharmacol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01531\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T17:07:22Z","timestamp":1751735242000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01531\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,9]]},"references-count":52,"alternative-id":["10.3389\/fimmu.2018.01531"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.01531","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,9]]},"article-number":"1531"}}