{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:36:09Z","timestamp":1790922969183,"version":"4.1.0"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T00:00:00Z","timestamp":1531958400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR000142"],"award-info":[{"award-number":["UL1 TR000142"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30KD034989"],"award-info":[{"award-number":["P30KD034989"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.01612","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T06:39:01Z","timestamp":1531982341000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["Inflammasome Priming Mediated via Toll-Like Receptors 2 and 4, Induces Th1-Like Regulatory T Cells in De Novo Autoimmune Hepatitis"],"prefix":"10.3389","volume":"9","author":[{"given":"Adam S.","family":"Arterbery","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaron","family":"Avitzur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Lobritto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gan","family":"Geliang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameet","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Knight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udeme D.","family":"Ekong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,7,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"4040","DOI":"10.4049\/jimmunol.1502276","article-title":"Production of proinflammatory cytokines by monocytes in liver-transplanted recipients with de novo autoimmune hepatitis is enhanced and induces TH1-like regulatory T cells","volume":"196","author":"Arterbery","year":"2016","journal-title":"J Immunol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1007\/s00018-010-0567-4","article-title":"Inflammasomes: current understanding and open questions","volume":"68","author":"Bauernfeind","year":"2011","journal-title":"Cell Mol Life Sci"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1053\/j.gastro.2012.09.008","article-title":"Sterile inflammation in the liver","volume":"143","author":"Kubes","year":"2012","journal-title":"Gastroenterology"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/petr.12945","article-title":"Long-term outcomes of de novo autoimmune hepatitis in pediatric liver transplant recipients","volume":"21","author":"Ekong","year":"2017","journal-title":"Pediatr Transplant"},{"key":"B5","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1002\/hep.22322","article-title":"Simplified criteria for the diagnosis of autoimmune hepatitis","volume":"48","author":"Hennes","year":"2008","journal-title":"Hepatology"},{"key":"B6","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1097\/MPG.0b013e3181a1c265","article-title":"Autoimmune hepatitis","volume":"49","author":"Mieli-Vergani","year":"2009","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"B7","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1107\/S0907444913001558","article-title":"The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized","volume":"69","author":"Chen","year":"2013","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"B8","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.immuni.2013.08.037","article-title":"Mechanisms of NOD-like receptor-associated inflammasome activation","volume":"39","author":"Wen","year":"2013","journal-title":"Immunity"},{"key":"B9","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/nature13322","article-title":"Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis","volume":"512","author":"Vande Walle","year":"2014","journal-title":"Nature"},{"key":"B10","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/nbt.3192","article-title":"Spatial reconstruction of single-cell gene expression data","volume":"33","author":"Satija","year":"2015","journal-title":"Nat Biotechnol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/nm.2389","article-title":"Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease","volume":"17","author":"Dominguez-Villar","year":"2011","journal-title":"Nat Med"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.15252\/embr.201541905","article-title":"AKT isoforms modulate Th1-like Treg generation and function in human autoimmune disease","volume":"17","author":"Kitz","year":"2016","journal-title":"EMBO Rep"},{"key":"B13","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1097\/TP.0000000000001872","article-title":"New answers to old conundrums: what antibodies, exosomes and inflammasomes bring to the conversation. Canadian National Transplant Research Program international summit report","volume":"102","author":"Dieude","year":"2018","journal-title":"Transplantation"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1016\/j.cmet.2017.04.005","article-title":"Cholesterol accumulation in dendritic cells links the inflammasome to acquired immunity","volume":"25","author":"Westerterp","year":"2017","journal-title":"Cell Metab"},{"key":"B15","doi-asserted-by":"publisher","first-page":"11942","DOI":"10.1073\/pnas.1003893107","article-title":"A critical cysteine is required for HMGB1 binding to toll-like receptor 4 and activation of macrophage cytokine release","volume":"107","author":"Yang","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B16","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1369\/jhc.6A7101.2006","article-title":"Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response","volume":"55","author":"Kummer","year":"2007","journal-title":"J Histochem Cytochem"},{"key":"B17","doi-asserted-by":"publisher","first-page":"e18907","DOI":"10.1371\/journal.pone.0018907","article-title":"Th17\u2009cells and activated dendritic cells are increased in vitiligo lesions","volume":"6","author":"Wang","year":"2011","journal-title":"PLoS One"},{"key":"B18","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1007\/s10875-013-9881-6","article-title":"AIM2 facilitates the apoptotic DNA-induced systemic lupus erythematosus via arbitrating macrophage functional maturation","volume":"33","author":"Zhang","year":"2013","journal-title":"J Clin Immunol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1093\/rheumatology\/keu318","article-title":"Sex-dependent differential activation of NLRP3 and AIM2 inflammasomes in SLE macrophages","volume":"54","author":"Yang","year":"2015","journal-title":"Rheumatology (Oxford)"},{"key":"B20","doi-asserted-by":"publisher","first-page":"859145","DOI":"10.1155\/2013\/859145","article-title":"NLRP3 inflammasome and MS\/EAE","volume":"2013","author":"Inoue","year":"2013","journal-title":"Autoimmune Dis"},{"key":"B21","doi-asserted-by":"publisher","first-page":"10480","DOI":"10.1073\/pnas.1201836109","article-title":"NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis","volume":"109","author":"Inoue","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B22","doi-asserted-by":"publisher","first-page":"6143","DOI":"10.4049\/jimmunol.1101284","article-title":"Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus","volume":"187","author":"Kahlenberg","year":"2011","journal-title":"J Immunol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/S0165-5728(02)00018-8","article-title":"IL-18 is linked to raised IFN-gamma in multiple sclerosis and is induced by activated CD4(+) T cells via CD40-CD40 ligand interactions","volume":"125","author":"Karni","year":"2002","journal-title":"J Neuroimmunol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1089\/jir.2011.0050","article-title":"Interleukin-18: a mediator of inflammation and angiogenesis in rheumatoid arthritis","volume":"31","author":"Volin","year":"2011","journal-title":"J Interferon Cytokine Res"},{"key":"B25","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1002\/hep.28847","article-title":"CD14(+) monocyte-derived galectin-9 induces natural killer cell cytotoxicity in chronic hepatitis C","volume":"65","author":"Nishio","year":"2017","journal-title":"Hepatology"},{"key":"B26","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1002\/hep.26016","article-title":"Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics","volume":"57","author":"Liaskou","year":"2013","journal-title":"Hepatology"},{"key":"B27","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.imbio.2006.05.025","article-title":"Migratory fate and differentiation of blood monocyte subsets","volume":"211","author":"Tacke","year":"2006","journal-title":"Immunobiology"},{"key":"B28","doi-asserted-by":"publisher","first-page":"2816","DOI":"10.1111\/ajt.13909","article-title":"Comprehensive update of the Banff Working Group on liver allograft pathology: introduction of antibody-mediated rejection","volume":"16","author":"Demetris","year":"2016","journal-title":"Am J Transplant"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01612\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T06:39:07Z","timestamp":1531982347000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01612\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,19]]},"references-count":28,"alternative-id":["10.3389\/fimmu.2018.01612"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.01612","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,19]]},"article-number":"1612"}}