{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:02:34Z","timestamp":1775001754908,"version":"3.50.1"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T00:00:00Z","timestamp":1535414400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.01965","type":"journal-article","created":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T04:38:54Z","timestamp":1535431134000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Host Restriction Factors APOBEC3G\/3F and Other Interferon-Related Gene Expressions Affect Early HIV-1 Infection in Northern Pig-Tailed Macaque (Macaca leonina)"],"prefix":"10.3389","volume":"9","author":[{"given":"Wei","family":"Pang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Hao","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Liang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Yi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Tang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,8,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/nrmicro2911","article-title":"Animal models for HIV\/AIDS research","volume":"10","author":"Hatziioannou","year":"2012","journal-title":"Nat Rev Microbiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1097\/COH.0b013e328361cee8","article-title":"Nonhuman primate models in AIDS research","volume":"8","author":"Evans","year":"2013","journal-title":"Curr Opin HIV AIDS"},{"key":"B3","doi-asserted-by":"publisher","first-page":"S19","DOI":"10.1097\/01.aids.0000304692.09143.1b","article-title":"A novel fusion gene, TRIM5-Cyclophilin A in the pig-tailed macaque determines its susceptibility to HIV-1 infection","volume":"21","author":"Liao","year":"2007","journal-title":"AIDS"},{"key":"B4","doi-asserted-by":"publisher","first-page":"3557","DOI":"10.1073\/pnas.0709003105","article-title":"Independent evolution of an antiviral TRIMCyp in rhesus macaques","volume":"105","author":"Wilson","year":"2008","journal-title":"Proc Natl Acad Sci USA."},{"key":"B5","doi-asserted-by":"publisher","first-page":"3563","DOI":"10.1073\/pnas.0709258105","article-title":"Independent genesis of chimeric TRIM5-cyclophilin proteins in two primate species","volume":"105","author":"Virgen","year":"2008","journal-title":"Proc Natl Acad Sci USA."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e1000003","DOI":"10.1371\/journal.ppat.1000003","article-title":"Evolution of a TRIM5-CypA splice isoform in old world monkeys","volume":"4","author":"Newman","year":"2008","journal-title":"PLoS Pathog."},{"key":"B7","doi-asserted-by":"publisher","first-page":"3569","DOI":"10.1073\/pnas.0709511105","article-title":"TRIMCyp expression in Old World primates Macaca nemestrina and Macaca fascicularis","volume":"105","author":"Brennan","year":"2008","journal-title":"Proc Natl Acad Sci USA."},{"key":"B8","doi-asserted-by":"publisher","first-page":"51","DOI":"10.4404\/hystrix-12.1-4171","article-title":"Notes on the taxonomy of Macaca nemestrina leonina blyth, 1863 (Primates: Cercopithecidae)","volume":"12","author":"Gippoliti","year":"2001","journal-title":"Hystrix It J Mamm."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1002\/ajp.22055","article-title":"Population genetics of the Washington National Primate Research Center's (WaNPRC) captive pigtailed macaque (Macaca nemestrina) population","volume":"74","author":"Kanthaswamy","year":"2012","journal-title":"Am J Primatol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1126\/science.1621083","article-title":"Infection of Macaca nemestrina by human immunodeficiency virus type-1","volume":"257","author":"Agy","year":"1992","journal-title":"Science"},{"key":"B11","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1600-0684.1993.tb00655.x","article-title":"Intra-amniotic inoculation of pigtailed macaque (Macaca nemestrina) fetuses with SIV and HIV-1","volume":"22","author":"Ochs","year":"1993","journal-title":"J Med Primatol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1006\/viro.1993.1392","article-title":"Acute infection of Macaca nemestrina by human immunodeficiency virus type 1","volume":"195","author":"Frumkin","year":"1993","journal-title":"Virology"},{"key":"B13","first-page":"S129","article-title":"HIV-1 infection in pigtailed macaques","volume":"10","author":"Gartner","year":"1994","journal-title":"AIDS Res Hum Retroviruses"},{"key":"B14","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1172\/JCI117647","article-title":"Cytotoxic and proliferative T cell responses in HIV-1-infected Macaca nemestrina","volume":"95","author":"Kent","year":"1995","journal-title":"J Clin Invest."},{"key":"B15","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.1099\/0022-1317-76-10-2467","article-title":"Infection of Macaca nemestrina brain with human immunodeficiency virus type 1","volume":"76","author":"Frumkin","year":"1995","journal-title":"J Gen Virol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1086\/514112","article-title":"Human immunodeficiency virus type 1 (HIV-1)-specific T cell responses correlate with control of acute HIV-1 infection in macaques","volume":"176","author":"Kent","year":"1997","journal-title":"J Infect Dis."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1097\/00002030-199713000-00003","article-title":"Infection of Macaca nemestrina neonates with HIV-1 via different routes of inoculation","volume":"11","author":"Bosch","year":"1997","journal-title":"AIDS"},{"key":"B18","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1034\/j.1600-0684.2000.290303.x","article-title":"Enhanced replication of HIV-1 in vivo in pigtailed macaques (Macaca nemestrina)","volume":"29","author":"Bosch","year":"2000","journal-title":"J Med Primatol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s10329-012-0316-4","article-title":"Boundary zone between northern and southern pig-tailed macaques and their morphological differences","volume":"53","author":"Malaivijitnond","year":"2012","journal-title":"Primates"},{"key":"B20","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/1742-4690-6-58","article-title":"Genotyping of TRIM5 locus in northern pig-tailed macaques (Macaca leonina), a primate species susceptible to Human Immunodeficiency Virus type 1 infection","volume":"6","author":"Kuang","year":"2009","journal-title":"Retrovirology"},{"key":"B21","doi-asserted-by":"publisher","first-page":"186","DOI":"10.11813\/j.issn.0254-5853.2014.3.186","article-title":"Replication potentials of HIV-1\/HSIV in PBMCs from northern pig-tailed macaque (Macaca leonina)","volume":"35","author":"Lei","year":"2014","journal-title":"Zool Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1016\/j.scib.2017.09.020","article-title":"HIV-1 can infect northern pig-tailed macaques (Macaca leonina) and form viral reservoirs in vivo","volume":"62","author":"Pang","year":"2017","journal-title":"Sci Bull."},{"key":"B23","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1038\/nature00939","article-title":"Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein","volume":"418","author":"Sheehy","year":"2002","journal-title":"Nature"},{"key":"B24","doi-asserted-by":"publisher","first-page":"11220","DOI":"10.1128\/JVI.05238-11","article-title":"Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1","volume":"85","author":"Hultquist","year":"2011","journal-title":"J Virol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1146\/annurev-immunol-032713-120231","article-title":"Interferon-stimulated genes: a complex web of host defenses","volume":"32","author":"Schneider","year":"2014","journal-title":"Annu Rev Immunol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"2723","DOI":"10.1099\/0022-1317-76-11-2723","article-title":"Early replication block of human immunodeficiency virus type 1 in monkey cells","volume":"76","author":"Shibata","year":"1995","journal-title":"J Gen Virol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"11549","DOI":"10.1128\/JVI.00960-07","article-title":"Human immunodeficiency virus type 1 derivative with 7% simian immunodeficiency virus genetic content is able to establish infections in pig-tailed macaques","volume":"81","author":"Igarashi","year":"2007","journal-title":"J Virol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"4425","DOI":"10.1073\/pnas.0812587106","article-title":"A macaque model of HIV-1 infection","volume":"106","author":"Hatziioannou","year":"2009","journal-title":"Proc Natl Acad Sci USA."},{"key":"B29","doi-asserted-by":"publisher","first-page":"3767","DOI":"10.1128\/JVI.02438-10","article-title":"Vif substitution enables persistent infection of pig-tailed macaques by human immunodeficiency virus type 1","volume":"85","author":"Thippeshappa","year":"2011","journal-title":"J Virol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1126\/science.1250761","article-title":"HIV-1-induced AIDS in monkeys","volume":"344","author":"Hatziioannou","year":"2014","journal-title":"Science"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1128\/JVI.06033-11","article-title":"Dynamics of simian immunodeficiency virus SIVmac239 infection in pigtail macaques","volume":"86","author":"Klatt","year":"2012","journal-title":"J Virol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1111\/imm.12794","article-title":"Predict disease progression from T-cell phenotypes in northern pig-tailed macaques (Macaca leonina) during SIVmac239 infection","volume":"152","author":"Zhang","year":"2017","journal-title":"Immunology"},{"key":"B33","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1002\/eji.201747284","article-title":"Northern Pig-tailed Macaques (Macaca leonina) maintain superior CD4+ T cell homeostasis during SIVmac239 infection","volume":"48","author":"Zhang","year":"2018","journal-title":"Eur J Immunol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/1742-4690-10-41","article-title":"Cell-associated HIV RNA: a dynamic biomarker of viral persistence","volume":"10","author":"Pasternak","year":"2013","journal-title":"Retrovirology"},{"key":"B35","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/nature12542","article-title":"Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection","volume":"502","author":"Goujon","year":"2013","journal-title":"Nature"},{"key":"B36","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.chom.2008.03.001","article-title":"The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein","volume":"3","author":"Van","year":"2008","journal-title":"Cell Host Microbe."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1016\/j.cub.2004.06.050","article-title":"APOBEC3F properties and hypermutation preferences indicate activity against HIV-1 in vivo","volume":"14","author":"Liddament","year":"2004","journal-title":"Curr Biol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"e4","DOI":"10.1017\/S1462399409001343","article-title":"Interactions of host APOBEC3 restriction factors with HIV-1 in vivo: implications for therapeutics","volume":"12","author":"Albin","year":"2010","journal-title":"Expert Rev Mol Med."},{"key":"B39","doi-asserted-by":"publisher","first-page":"246","DOI":"10.13918\/j.issn.2095-8137.2016.4.246","article-title":"Molecular cloning and anti-HIV-1 activities of APOBEC3s from northern pig-tailed macaques (Macaca leonina)","volume":"37","author":"Zhang","year":"2016","journal-title":"Zool Res."},{"key":"B40","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1084\/jem.20091933","article-title":"The antiviral factor APOBEC3G improves CTL recognition of cultured HIV-infected T cells","volume":"207","author":"Casartelli","year":"2010","journal-title":"J Exp Med."},{"key":"B41","doi-asserted-by":"publisher","first-page":"3549","DOI":"10.1128\/JVI.03219-12","article-title":"Adaptation to the interferon-induced antiviral state by human and simian immunodeficiency viruses","volume":"87","author":"Bitzegeio","year":"2013","journal-title":"J Virol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"6678","DOI":"10.1128\/JVI.00338-13","article-title":"A variant macaque-tropic human immunodeficiency virus type 1 is resistant to alpha interferon-induced restriction in pig-tailed macaque CD4+ T cells","volume":"87","author":"Thippeshappa","year":"2013","journal-title":"J Virol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"e1004241","DOI":"10.1371\/journal.ppat.1004241","article-title":"Innate immune responses and rapid control of inflammation in African green monkeys treated or not with interferon-alpha during primary SIVagm infection","volume":"10","author":"Jacquelin","year":"2014","journal-title":"PLoS Pathog."},{"key":"B44","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1038\/nature13554","article-title":"Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression","volume":"511","author":"Sandler","year":"2014","journal-title":"Nature"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01965\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,8]],"date-time":"2020-11-08T09:26:11Z","timestamp":1604827571000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01965\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,28]]},"references-count":44,"alternative-id":["10.3389\/fimmu.2018.01965"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.01965","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,28]]},"article-number":"1965"}}