{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:12:06Z","timestamp":1790518326238,"version":"4.1.0"},"reference-count":48,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T00:00:00Z","timestamp":1535673600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["302 514\/2015-5"],"award-info":[{"award-number":["302 514\/2015-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014\/07125-6"],"award-info":[{"award-number":["2014\/07125-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["EMU 2015\/00658-1"],"award-info":[{"award-number":["EMU 2015\/00658-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.01970","type":"journal-article","created":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T04:24:58Z","timestamp":1535689498000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["CD18 Regulates Monocyte Hematopoiesis and Promotes Resistance to Experimental Schistosomiasis"],"prefix":"10.3389","volume":"9","author":[{"given":"Camila O. S.","family":"Souza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena S.","family":"Esp\u00edndola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Fontanari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgana K. B.","family":"Prado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiani G.","family":"Frantz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanderlei","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz G.","family":"Gardinassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00facia H.","family":"Faccioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,8,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1038\/sj.icb.7100014","article-title":"Immunopathology of schistosomiasis","volume":"85","author":"Wilson","year":"2007","journal-title":"Immunol Cell Biol."},{"key":"B2","unstructured":"2017"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1017\/S0031182009005708","article-title":"The saga of schistosome migration and attrition","volume":"136","author":"Wilson","year":"2009","journal-title":"Parasitology"},{"key":"B4","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1590\/S0101-81751994000400006","article-title":"Migration of Schistosoma mansoni sambon (Trematoda, Schistosomatidae) from skin to lungs in immunized NZ rabbits (Lagomorpha, Leporidae) by autoradiographic analysis","volume":"11","author":"Pinto","year":"1994","journal-title":"Rev Bras Zool."},{"key":"B5","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1164\/rccm.200903-0355OC","article-title":"Pulmonary vascular remodeling correlates with lung eggs and cytokines in murine schistosomiasis","volume":"181","author":"Crosby","year":"2010","journal-title":"Am J Respir Crit Care Med."},{"key":"B6","doi-asserted-by":"crossref","first-page":"6565","DOI":"10.1128\/IAI.67.12.6565-6571.1999","article-title":"Cytokine control of the granulomatous response in Schistosoma mansoni-infected baboons: role of exposure and treatment","volume":"67","author":"Mola","year":"1999","journal-title":"Infect Immun."},{"key":"B7","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nri843","article-title":"The immunobiology of schistosomiasis","volume":"2","author":"Pearce","year":"2002","journal-title":"Nat Rev Immunol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1128\/IAI.69.1.589\u2013592.2001","article-title":"Severe Schistosomiasis in the absence of interleukin-4 (IL-4) is IL-12 independent","volume":"69","author":"Patton","year":"2001","journal-title":"Infect Immun."},{"key":"B9","doi-asserted-by":"publisher","first-page":"3769","DOI":"10.4049\/jimmunol.1403240","article-title":"IL-4-producing dendritic cells induced during schistosoma japonica infection promote Th2 cells via IL-4-dependent pathway","volume":"195","author":"Ma","year":"2015","journal-title":"J Immunol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2535","DOI":"10.1002\/eji.201242480","article-title":"Role of inflammatory dendritic cells in innate and adaptive immunity","volume":"42","author":"Hespel","year":"2012","journal-title":"Eur J Immunol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2050-7771-2-1","article-title":"Monocyte and macrophage differentiation: circulation inflammatory monocyte as biomarker for inflammatory diseases","volume":"2","author":"Yang","year":"2014","journal-title":"Biomark Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1126\/science.1142883","article-title":"Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior","volume":"317","author":"Auffray","year":"2007","journal-title":"Science"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1161\/01.ATV.0000092941.77774.3C","article-title":"Mechanisms of leukotriene B4\u2013triggered monocyte adhesion","volume":"23","author":"Friedrich","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1016\/j.biocel.2004.01.020","article-title":"Myeloid cells","volume":"36","author":"Kawamoto","year":"2004","journal-title":"Int J Biochem Cell Biol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"e1004080","DOI":"10.1371\/journal.ppat.1004080","article-title":"Ly6Chigh monocytes become alternatively activated macrophages in Schistosome granulomas with help from CD4+ cells","volume":"10","author":"Girgis","year":"2014","journal-title":"PLOS Pathog."},{"key":"B16","doi-asserted-by":"publisher","first-page":"e1004282","DOI":"10.1371\/journal.ppat.1004282","article-title":"Ly6Chi monocyte recruitment is responsible for Th2 associated host-protective macrophage accumulation in liver inflammation due to Schistosomiasis","volume":"10","author":"Nascimento","year":"2014","journal-title":"PLOS Pathog."},{"key":"B17","first-page":"105","article-title":"A lung model of schistosome immunity in mice","volume":"87","author":"von Lichtenberg","year":"1977","journal-title":"Am J Pathol."},{"key":"B18","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1002\/(SICI)1521-4141(199911)29:11<3691::AID-IMMU3691>3.0.CO;2-L","article-title":"Schistosoma mansoni schistosomula reduce E-selectin and VCAM-1 expression in TNF-alpha-stimulated lung microvascular endothelial cells by interfering with the NF-kappaB pathway","volume":"29","author":"Trottein","year":"1999","journal-title":"Eur J Immunol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.1084\/jem.20082401","article-title":"The lung vascular filter as a site of immune induction for T cell responses to large embolic antigen","volume":"206","author":"Willart","year":"2009","journal-title":"J Exp Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.3389\/fimmu.2017.01866","article-title":"\u03b22 integrins as regulators of dendritic cell, monocyte, and macrophage function","volume":"8","author":"Schittenhelm","year":"2017","journal-title":"Front Immunol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1111\/j.1476-5381.1994.tb14810.x","article-title":"Role of CD18 in the accumulation of eosinophils and neutrophils and local oedema formation in inflammatory reactions in guinea-pig skin","volume":"111","author":"Teixeira","year":"1994","journal-title":"Br J Pharmacol."},{"key":"B22","doi-asserted-by":"crossref","first-page":"804","DOI":"10.4049\/jimmunol.159.2.804","article-title":"Role of adhesion molecules of the selectin-carbohydrate families in antibody-dependent cell-mediated cytoxicity to schistosome targets","volume":"159","author":"Trottein","year":"1997","journal-title":"J Immunol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"943","DOI":"10.2353\/ajpath.2006.051319","article-title":"The Schistosoma mansoni Hepatic egg granuloma provides a favorable microenvironment for sustained growth of leishmania donovani","volume":"169","author":"Hassan","year":"2006","journal-title":"Am J Pathol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1186\/1471-2334-14-263","article-title":"Combined immunization using DNA-Sm14 and DNA-Hsp65 increases CD8+ memory T cells, reduces chronic pathology and decreases egg viability during Schistosoma mansoni infection","volume":"14","author":"Esp\u00edndola","year":"2014","journal-title":"BMC Infect Dis."},{"key":"B25","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.ijpara.2009.09.003","article-title":"Estimating the sensitivity and specificity of Kato-Katz stool examination technique for detection of hookworms, Ascaris lumbricoides and Trichuris trichiura infections in humans in the absence of a \u2018gold standard.\u2019","volume":"40","author":"Tarafder","year":"2010","journal-title":"Int J Parasitol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"949","DOI":"10.3389\/fimmu.2017.00949","article-title":"Th17-inducing cytokines IL-6 and IL-23 are crucial for granuloma formation during experimental Paracoccidioidomycosis","volume":"8","author":"Trist\u00e3o","year":"2017","journal-title":"Front Immunol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/nprot.2014.005","article-title":"Intravascular staining for discrimination of vascular and tissue leukocytes","volume":"9","author":"Anderson","year":"2014","journal-title":"Nat Protoc."},{"key":"B28","doi-asserted-by":"publisher","first-page":"10981","DOI":"10.1038\/s41598-017-11496-3","article-title":"Dormant 5-lipoxygenase in inflammatory macrophages is triggered by exogenous arachidonic acid","volume":"7","author":"Sorgi","year":"2017","journal-title":"Sci Rep."},{"key":"B29","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S1074-7613(03)00174-2","article-title":"Blood monocytes consist of two principal subsets with distinct migratory properties","volume":"19","author":"Geissmann","year":"2003","journal-title":"Immunity"},{"key":"B30","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1111\/j.1365-3024.1986.tb01038.x","article-title":"The role of pulmonary cellular reactions in the resistance of vaccinated mice to Schistosoma mansoni","volume":"8","author":"Crabtree","year":"1986","journal-title":"Parasite Immunol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.exppara.2016.06.001","article-title":"5-lipoxygenase pathway is essential for the control of granuloma extension induced by Schistosoma mansoni eggs in lung","volume":"167","author":"Toffoli da Silva","year":"2016","journal-title":"Exp Parasitol."},{"key":"B32","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.4049\/jimmunol.151.3.1430","article-title":"Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schistosoma mansoni","volume":"151","author":"Wynn","year":"1993","journal-title":"J Immunol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s13071-018-2656-4","article-title":"Current epidemiological evidence for predisposition to high or low intensity human helminth infection: a systematic review","volume":"11","author":"Wright","year":"2018","journal-title":"Parasit Vectors"},{"key":"B34","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1086\/324668","article-title":"Clinical and immunologic evaluation of 31 patients with acute Schistosomiasis mansoni","volume":"185","author":"de Jesus","year":"2002","journal-title":"J Infect Dis."},{"key":"B35","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.cell.2015.08.030","article-title":"Microbiota-Dependent sequelae of acute infection compromise tissue-specific immunity","volume":"163","author":"Fonseca","year":"2015","journal-title":"Cell"},{"key":"B36","doi-asserted-by":"publisher","first-page":"e2817","DOI":"10.1371\/journal.pntd.0002817","article-title":"Circulating CD14brightCD16+ \u2018Intermediate\u2019 monocytes exhibit enhanced parasite pattern recognition in human helminth infection","volume":"8","author":"Turner","year":"2014","journal-title":"PLoS Negl Trop Dis."},{"key":"B37","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/S1074-7613(04)00107-4","article-title":"Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology","volume":"20","author":"Herbert","year":"2004","journal-title":"Immunity"},{"key":"B38","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1016\/j.immuni.2018.04.022","article-title":"Dietary fiber confers protection against Flu by shaping Ly6c- patrolling monocyte hematopoiesis and CD8+ T cell metabolism","volume":"48","author":"Trompette","year":"2018","journal-title":"Immunity"},{"key":"B39","doi-asserted-by":"publisher","first-page":"2794","DOI":"10.1002\/stem.1762","article-title":"Brief report: reduced expression of CD18 leads to the in vivo expansion of hematopoietic stem cells in mouse bone marrow","volume":"32","author":"Leon-Rico","year":"2014","journal-title":"Stem Cells Dayt Ohio."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1172\/JCI119293","article-title":"LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient mice","volume":"99","author":"Lu","year":"1997","journal-title":"J Clin Invest."},{"key":"B41","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.4049\/jimmunol.156.7.2558","article-title":"Cytokine-regulated expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in human microvascular endothelial cells","volume":"156","author":"Haraldsen","year":"1996","journal-title":"J Immunol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.2353\/ajpath.2006.060271","article-title":"Intercellular adhesion molecule-1 is required for the early formation of granulomas and participates in the resistance of mice to the infection with the fungus Paracoccidioides brasiliensis","volume":"169","author":"Moreira","year":"2006","journal-title":"Am J Pathol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"238","DOI":"10.4269\/ajtmh.1992.47.238","article-title":"Evidence that both normal and immune elimination of Schistosoma mansoni take place at the lung stage of migration prior to parasite death","volume":"47","author":"Dean","year":"1992","journal-title":"Am J Trop Med Hyg."},{"key":"B44","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1017\/S0031182006001648","article-title":"Biology of the Schistosome lung-stage Schistosomulum","volume":"134","author":"Gobert","year":"2007","journal-title":"Parasitology"},{"key":"B45","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1590\/S0074-02761987000800042","article-title":"Schistosoma mansoni: migration patterns in normal and immunized swiss webster mice, by means of autoradiographic analysis","volume":"82","author":"Pinto","year":"1987","journal-title":"Mem Inst Oswaldo Cruz."},{"key":"B46","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1590\/S1519-69842005000400020","article-title":"Reappraisal of experimental infections with cercariae and schistosomula of a Brazilian strain of Schistosoma mansoni in mice","volume":"65","author":"Vilar","year":"2005","journal-title":"Braz J Biol Rev Brasleira Biol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1590\/S1516-31802012000400011","article-title":"Leukocyte adhesion deficiency syndrome: report on the first case in Chile and South America","volume":"130","author":"V\u00e1squez-De Kartzow","year":"2012","journal-title":"Sao Paulo Med J."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1056\/NEJM199212173272505","article-title":"Recurrent severe infections caused by a novel Leukocyte adhesion deficiency","volume":"327","author":"Etzioni","year":"1992","journal-title":"N Engl J Med."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01970\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T18:52:29Z","timestamp":1693853549000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01970\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,31]]},"references-count":48,"alternative-id":["10.3389\/fimmu.2018.01970"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.01970","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,31]]},"article-number":"1970"}}