{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:19:49Z","timestamp":1790716789059,"version":"4.1.0"},"reference-count":76,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T00:00:00Z","timestamp":1536710400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["104748MA"],"award-info":[{"award-number":["104748MA"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.01975","type":"journal-article","created":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T04:23:26Z","timestamp":1536726206000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":30,"title":["High-Frequency, Functional HIV-Specific T-Follicular Helper and Regulatory Cells Are Present Within Germinal Centers in Children but Not Adults"],"prefix":"10.3389","volume":"9","author":[{"given":"Julia","family":"Roider","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Maehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Ngoepe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duran","family":"Ramsuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Muenchhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Adland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toby","family":"Aicher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel W.","family":"Kazer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Jooste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farina","family":"Karim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren","family":"Kuhn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex K.","family":"Shalek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thumbi","family":"Ndung'u","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penny L.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiv","family":"Pillai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Kl\u00f8verpris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Goulder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alasdair","family":"Leslie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,9,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1111\/imr.12075","article-title":"HIV-1 neutralizing antibodies: understanding nature's pathways","volume":"254","author":"Mascola","year":"2013","journal-title":"Immunol Rev"},{"key":"B2","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/nm.3054","article-title":"Harnessing CD4(+) T cell responses in HIV vaccine development","volume":"19","author":"Streeck","year":"2013","journal-title":"Nat Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.cell.2014.01.052","article-title":"Structural insights on the role of antibodies in HIV-1 vaccine and therapy","volume":"156","author":"West","year":"2014","journal-title":"Cell"},{"key":"B4","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1111\/imr.12504","article-title":"Immunologic characteristics of HIV-infected individuals who make broadly neutralizing antibodies","volume":"275","author":"Borrow","year":"2017","journal-title":"Immunol Rev"},{"key":"B5","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/72309","article-title":"Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection","volume":"6","author":"Baba","year":"2000","journal-title":"Nat Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/72318","article-title":"Protection of macaques against vaginal transmission of a pathogenic HIV-1\/SIV chimeric virus by passive infusion of neutralizing antibodies","volume":"6","author":"Mascola","year":"2000","journal-title":"Nat Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"8340","DOI":"10.1128\/JVI.75.17.8340-8347.2001","article-title":"Antibody protects macaques against vaginal challenge with a pathogenic R5 simian\/human immunodeficiency virus at serum levels giving complete neutralization in vitro","volume":"75","author":"Parren","year":"2001","journal-title":"J Virol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"18921","DOI":"10.1073\/pnas.1214785109","article-title":"Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo","volume":"109","author":"Moldt","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"B9","doi-asserted-by":"publisher","first-page":"ra288","DOI":"10.1126\/scitranslmed.3008992","article-title":"Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor","volume":"6","author":"Pegu","year":"2014","journal-title":"Sci Transl Med"},{"key":"B10","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1056\/NEJMoa0908492","article-title":"Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand","volume":"361","author":"Rerks-Ngarm","year":"2009","journal-title":"N Engl J Med"},{"key":"B11","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1093\/infdis\/jis367","article-title":"Magnitude and breadth of the neutralizing antibody response in the RV144 and Vax003 HIV-1 vaccine efficacy trials","volume":"206","author":"Montefiori","year":"2012","journal-title":"J Infect Dis"},{"key":"B12","doi-asserted-by":"publisher","first-page":"2083","DOI":"10.1056\/NEJMoa1310566","article-title":"Efficacy trial of a DNA\/rAd5 HIV-1 preventive vaccine","volume":"369","author":"Hammer","year":"2013","journal-title":"N Engl J Med"},{"key":"B13","doi-asserted-by":"publisher","first-page":"11651","DOI":"10.1128\/JVI.01762-08","article-title":"Profiling the specificity of neutralizing antibodies in a large panel of plasmas from patients chronically infected with human immunodeficiency virus type 1 subtypes B and C","volume":"82","author":"Binley","year":"2008","journal-title":"J Virol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"2405","DOI":"10.1097\/QAD.0b013e32833243e7","article-title":"Prevalence of cross-reactive HIV-1-neutralizing activity in HIV-1-infected patients with rapid or slow disease progression","volume":"23","author":"van","year":"2009","journal-title":"AIDS"},{"key":"B15","doi-asserted-by":"publisher","first-page":"e1005369","DOI":"10.1371\/journal.ppat.1005369","article-title":"Broadly neutralizing antibody responses in a large longitudinal sub-saharan HIV primary infection cohort","volume":"12","author":"Landais","year":"2016","journal-title":"PLoS Pathog"},{"key":"B16","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1128\/JVI.02036-08","article-title":"Factors associated with the development of cross-reactive neutralizing antibodies during human immunodeficiency virus type 1 infection","volume":"83","author":"Sather","year":"2009","journal-title":"J Virol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"358ra125","DOI":"10.1126\/scitranslmed.aag1048","article-title":"Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection","volume":"8","author":"Muenchhoff","year":"2016","journal-title":"Sci Transl Med"},{"key":"B18","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1038\/nm.3565","article-title":"Early development of broadly neutralizing antibodies in HIV-1-infected infants","volume":"20","author":"Goo","year":"2014","journal-title":"Nat Med"},{"key":"B19","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1093\/infdis\/jiu444","article-title":"Infant HIV type 1 gp120 vaccination elicits robust and durable anti-V1V2 immunoglobulin G responses and only rare envelope-specific immunoglobulin A responses","volume":"211","author":"Fouda","year":"2015","journal-title":"J Infect Dis"},{"key":"B20","doi-asserted-by":"publisher","first-page":"e01070-17","DOI":"10.1128\/JVI.01070-17","article-title":"HIV-exposed infants vaccinated with an MF59\/recombinant gp120 vaccine have higher-magnitude anti-V1V2 IgG responses than adults immunized with the same vaccine","volume":"92","author":"McGuire","year":"2018","journal-title":"J Virol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1086\/651143","article-title":"HIV neutralizing antibodies: clinical correlates and implications for vaccines","volume":"201","author":"Doria-Rose","year":"2010","journal-title":"J Infect Dis"},{"key":"B22","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/nri3803","article-title":"A brief history of T cell help to B cells","volume":"15","author":"Crotty","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1146\/annurev-immunol-041015-055605","article-title":"Follicular helper T Cells","volume":"34","author":"Vinuesa","year":"2016","journal-title":"Annu Rev Immunol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.cell.2010.10.032","article-title":"Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter","volume":"143","author":"Victora","year":"2010","journal-title":"Cell"},{"key":"B25","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1038\/icb.2013.69","article-title":"Control of TFH cell numbers: why and how?","volume":"92","author":"Pratama","year":"2014","journal-title":"Immunol Cell Biol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1038\/nm.2426","article-title":"Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions","volume":"17","author":"Chung","year":"2011","journal-title":"Nat Med"},{"key":"B27","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1038\/nm.2425","article-title":"Foxp3+ follicular regulatory T cells control the germinal center response","volume":"17","author":"Linterman","year":"2011","journal-title":"Nat Med"},{"key":"B28","doi-asserted-by":"publisher","first-page":"4553","DOI":"10.4049\/jimmunol.1101328","article-title":"Regulation of the germinal center reaction by Foxp3+ follicular regulatory T cells","volume":"187","author":"Wollenberg","year":"2011","journal-title":"J Immunol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"2601","DOI":"10.1002\/art.38735","article-title":"Interleukin-21 promotes germinal center reaction by skewing the follicular regulatory T cell to follicular helper T cell balance in autoimmune BXD2 mice","volume":"66","author":"Ding","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"5191","DOI":"10.1172\/JCI76861","article-title":"Circulating T follicular regulatory and helper cells have memory-like properties","volume":"124","author":"Sage","year":"2014","journal-title":"J Clin Invest"},{"key":"B31","doi-asserted-by":"publisher","first-page":"3059","DOI":"10.1172\/JCI65175","article-title":"HIV and T follicular helper cells: a dangerous relationship","volume":"122","author":"Vinuesa","year":"2012","journal-title":"J Clin Invest"},{"key":"B32","doi-asserted-by":"publisher","first-page":"3237","DOI":"10.4049\/jimmunol.1402701","article-title":"Decreased T follicular regulatory cell\/T follicular helper cell (TFH) in simian immunodeficiency virus-infected rhesus macaques may contribute to accumulation of TFH in chronic infection","volume":"195","author":"Chowdhury","year":"2015","journal-title":"J Immunol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.immuni.2014.05.016","article-title":"Foxp3+ T cells regulate immunoglobulin a selection and facilitate diversification of bacterial species responsible for immune homeostasis","volume":"41","author":"Kawamoto","year":"2014","journal-title":"Immunity"},{"key":"B34","doi-asserted-by":"publisher","first-page":"3495","DOI":"10.1038\/ncomms4495","article-title":"FoxP3+ regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availability","volume":"5","author":"Leon","year":"2014","journal-title":"Nat Commun"},{"key":"B35","doi-asserted-by":"publisher","first-page":"3352","DOI":"10.1002\/eji.200636746","article-title":"CXCR5+ CCR7-CD8 T cells are early effector memory cells that infiltrate tonsil B cell follicles","volume":"37","author":"Quigley","year":"2007","journal-title":"Eur J Immunol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1038\/nature19317","article-title":"Follicular CXCR5- expressing CD8+ T cells curtail chronic viral infection","volume":"537","author":"He","year":"2016","journal-title":"Nature"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.1073\/pnas.1621418114","article-title":"Dynamics of SIV-specific CXCR5+ CD8 T cells during chronic SIV infection","volume":"114","author":"Mylvaganam","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"B38","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1038\/nature09370","article-title":"Inhibition of follicular T-helper cells by CD8+ regulatory T cells is essential for self tolerance","volume":"467","author":"Kim","year":"2010","journal-title":"Nature"},{"key":"B39","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1073\/pnas.1018974108","article-title":"CD8+ T regulatory cells express the Ly49 Class I MHC receptor and are defective in autoimmune prone B6-Yaa mice","volume":"108","author":"Kim","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1172\/JCI66938","article-title":"Amelioration of arthritis through mobilization of peptide-specific CD8+ regulatory T cells","volume":"123","author":"Leavenworth","year":"2013","journal-title":"J Clin Invest"},{"key":"B41","doi-asserted-by":"publisher","first-page":"4828","DOI":"10.1128\/JVI.00198-11","article-title":"The neutralization breadth of HIV-1 develops incrementally over four years and is associated with CD4+ T cell decline and high viral load during acute infection","volume":"85","author":"Gray","year":"2011","journal-title":"J Virol"},{"key":"B42","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4939-7346-0_9","article-title":"Multiparameter intracellular cytokine staining","volume-title":"Flow Cytometry Protocols. Methods in Molecular Biology.","author":"Lovelace","year":"2018"},{"key":"B43","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1002\/cyto.a.21015","article-title":"SPICE: exploration and analysis of post-cytometric complex multivariate datasets","volume":"79","author":"Roederer","year":"2011","journal-title":"Cytometry A"},{"key":"B44","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1016\/j.immuni.2013.08.031","article-title":"Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses","volume":"39","author":"Locci","year":"2013","journal-title":"Immunity"},{"key":"B45","doi-asserted-by":"publisher","first-page":"13310","DOI":"10.1128\/JVI.02186-14","article-title":"Early preservation of CXCR5+ PD-1+ helper T cells and B cell activation predict the breadth of neutralizing antibody responses in chronic HIV-1 infection","volume":"88","author":"Cohen","year":"2014","journal-title":"J Virol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/j.immuni.2013.09.007","article-title":"Circulating precursor CCR7(lo)PD-1(hi) CXCR5+ CD4+ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure","volume":"39","author":"He","year":"2013","journal-title":"Immunity"},{"key":"B47","doi-asserted-by":"publisher","first-page":"5099","DOI":"10.4049\/jimmunol.179.8.5099","article-title":"Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation","volume":"179","author":"Haynes","year":"2007","journal-title":"J Immunol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"3271","DOI":"10.1172\/JCI64314","article-title":"Expansion of HIV-specific T follicular helper cells in chronic HIV infection","volume":"122","author":"Lindqvist","year":"2012","journal-title":"J Clin Invest"},{"key":"B49","doi-asserted-by":"publisher","first-page":"5154","DOI":"10.4049\/jimmunol.172.9.5154","article-title":"Cutting edge: IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells","volume":"172","author":"Pene","year":"2004","journal-title":"J Immunol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"5236","DOI":"10.4049\/jimmunol.177.8.5236","article-title":"Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21","volume":"177","author":"Good","year":"2006","journal-title":"J Immunol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"8180","DOI":"10.4049\/jimmunol.179.12.8180","article-title":"Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells","volume":"179","author":"Bryant","year":"2007","journal-title":"J Immunol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.immuni.2012.11.020","article-title":"Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype","volume":"38","author":"Baumjohann","year":"2013","journal-title":"Immunity"},{"key":"B53","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1038\/ni.2496","article-title":"The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood","volume":"14","author":"Sage","year":"2013","journal-title":"Nat Immunol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"e1005924","DOI":"10.1371\/journal.ppat.1005924","article-title":"Follicular Regulatory CD8 T Cells Impair the Germinal Center Response in SIV and Ex Vivo HIV Infection","volume":"12","author":"Miles","year":"2016","journal-title":"PLoS Pathog"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1038\/ni.3561","article-title":"Dances with cytokines, featuring TFH cells, IL-21, IL-4 and B cells","volume":"17","author":"Belanger","year":"2016","journal-title":"Nat Immunol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"4213","DOI":"10.1128\/JVI.06000-11","article-title":"Antiretroviral therapy reduces the magnitude and T cell receptor repertoire diversity of HIV-specific T cell responses without changing T cell clonotype dominance","volume":"86","author":"Conrad","year":"2012","journal-title":"J Virol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1146\/annurev-immunol-031210-101400","article-title":"Follicular helper CD4 T cells (TFH)","volume":"29","author":"Crotty","year":"2011","journal-title":"Annu Rev Immunol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.immuni.2015.12.011","article-title":"Circulating HIV-specific interleukin-21+CD4+ T cells represent peripheral Tfh cells with antigen-dependent helper functions","volume":"44","author":"Schultz","year":"2016","journal-title":"Immunity"},{"key":"B59","doi-asserted-by":"publisher","first-page":"298ra120","DOI":"10.1126\/scitranslmed.aab3964","article-title":"Quality and quantity of TFH cells are critical for broad antibody development in SHIVAD8 infection","volume":"7","author":"Yamamoto","year":"2015","journal-title":"Sci Transl Med"},{"key":"B60","doi-asserted-by":"publisher","first-page":"5625","DOI":"10.4049\/jimmunol.1501524","article-title":"Reversible reprogramming of circulating memory T follicular helper cell function during chronic HIV infection","volume":"195","author":"Cubas","year":"2015","journal-title":"J Immunol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.4049\/jimmunol.1600143","article-title":"Induction of Th1-biased T follicular helper (Tfh) cells in lymphoid tissues during chronic simian immunodeficiency virus infection defines functionally distinct germinal center Tfh cells","volume":"197","author":"Velu","year":"2016","journal-title":"J Immunol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"8608","DOI":"10.1038\/ncomms9608","article-title":"Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection","volume":"6","author":"Miles","year":"2015","journal-title":"Nat Commun"},{"key":"B63","doi-asserted-by":"publisher","first-page":"3186","DOI":"10.4049\/jimmunol.1301285","article-title":"Immune tolerance negatively regulates B cells in knock-in mice expressing broadly neutralizing HIV antibody 4E10","volume":"191","author":"Doyle-Cooper","year":"2013","journal-title":"J Immunol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/nature12053","article-title":"Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus","volume":"496","author":"Liao","year":"2013","journal-title":"Nature"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1172\/JCI73441","article-title":"An autoreactive antibody from an SLE\/HIV-1 individual broadly neutralizes HIV-1","volume":"124","author":"Bonsignori","year":"2014","journal-title":"J Clin Invest"},{"key":"B66","doi-asserted-by":"publisher","first-page":"aag0851","DOI":"10.1126\/sciimmunol.aag0851","article-title":"Immune perturbations in HIV-1-infected individuals who make broadly neutralizing antibodies","volume":"1","author":"Moody","year":"2016","journal-title":"Sci Immunol"},{"key":"B67","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1172\/JCI117677","article-title":"Diminished expression of CD40 ligand by activated neonatal T cells","volume":"95","author":"Nonoyama","year":"1995","journal-title":"J Clin Invest"},{"key":"B68","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1136\/mp.56.5.256","article-title":"Immunological and genetic analysis of 65 patients with a clinical suspicion of X linked hyper-IgM","volume":"56","author":"Gilmour","year":"2003","journal-title":"Mol Pathol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1128\/CDLI.11.1.186-194.2004","article-title":"Prevalence of neutralizing antibodies against different rotavirus serotypes in children with severe rotavirus-induced diarrhea and their mothers","volume":"11","author":"Ray","year":"2004","journal-title":"Clin Diagn Lab Immunol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1038\/s41467-017-00736-9","article-title":"Epitope-associated and specificity-focused features of EV71-neutralizing antibody repertoires from plasmablasts of infected children","volume":"8","author":"Arthur","year":"2017","journal-title":"Nat Commun"},{"key":"B71","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.jcv.2015.05.025","article-title":"Absence of neutralizing antibodies against influenza A\/H5N1 virus among children in Kamphaeng Phet, Thailand","volume":"69","author":"Khuntirat","year":"2015","journal-title":"J Clin Virol"},{"key":"B72","doi-asserted-by":"publisher","first-page":"e85371","DOI":"10.1371\/journal.pone.0085371","article-title":"HIV-1 specific antibody titers and neutralization among chronically infected patients on long-term suppressive antiretroviral therapy (ART): a cross-sectional study","volume":"9","author":"Gach","year":"2014","journal-title":"PLoS ONE"},{"key":"B73","doi-asserted-by":"publisher","first-page":"522","DOI":"10.3389\/fimmu.2016.00522","article-title":"The dynamics of T and B cells in lymph node during chronic HIV infection: TFH and HIV, unhappy dance partners?","volume":"7","author":"Hong","year":"2016","journal-title":"Front Immunol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"35","DOI":"10.4161\/chim.2.2.16329","article-title":"At the crossroads between tolerance and aggression: revisiting the \u201clayered immune system\u201d hypothesis","volume":"2","author":"Mold","year":"2011","journal-title":"Chimerism"},{"key":"B75","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.immuni.2012.10.014","article-title":"Innate immune function by Toll-like receptors: distinct responses in newborns and the elderly","volume":"37","author":"Kollmann","year":"2012","journal-title":"Immunity"},{"key":"B76","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.immuni.2017.03.009","article-title":"Protecting the newborn and young infant from infectious diseases: lessons from immune ontogeny","volume":"46","author":"Kollmann","year":"2017","journal-title":"Immunity"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01975\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T04:23:30Z","timestamp":1536726210000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.01975\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,12]]},"references-count":76,"alternative-id":["10.3389\/fimmu.2018.01975"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.01975","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,12]]},"article-number":"1975"}}