{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T02:00:23Z","timestamp":1785376823617,"version":"3.55.0"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T00:00:00Z","timestamp":1536710400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.02035","type":"journal-article","created":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T04:22:40Z","timestamp":1536726160000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction"],"prefix":"10.3389","volume":"9","author":[{"given":"Hilde L.","family":"Orrem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per H.","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren E.","family":"Pischke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Kleveland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Yndestad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Ekholt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan K.","family":"Dam\u00e5s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terje","family":"Espevik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f8rn","family":"Bendz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bente","family":"Halvorsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida","family":"Gregersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rune","family":"Wiseth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geir \u00d8.","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thor","family":"Ueland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Gullestad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e5l","family":"Aukrust","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Barratt-Due","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom E.","family":"Mollnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,9,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1093\/eurheartj\/ehv320","article-title":"2015 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: task force for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC)","volume":"37","author":"Roffi","year":"2016","journal-title":"Eur Heart J."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1056\/NEJMra1606915","article-title":"Acute myocardial infarction","volume":"376","author":"Anderson","year":"2017","journal-title":"New Engl J Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1161\/CIRCRESAHA.114.302699","article-title":"Inflammation and its resolution as determinants of acute coronary syndromes","volume":"114","author":"Libby","year":"2014","journal-title":"Circ Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.cell.2010.03.006","article-title":"Inflammation 2010: new adventures of an old flame","volume":"140","author":"Medzhitov","year":"2010","journal-title":"Cell"},{"key":"B5","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.molimm.2014.06.036","article-title":"A vital role for complement in heart disease","volume":"61","author":"Lappegard","year":"2014","journal-title":"Mol Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2753","DOI":"10.1016\/j.molimm.2009.04.027","article-title":"The role of the anaphylatoxins in health and disease","volume":"46","author":"Klos","year":"2009","journal-title":"Mol Immunol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.atherosclerosis.2006.12.016","article-title":"Receptors for the anaphylatoxins C3a and C5a are expressed in human atherosclerotic coronary plaques","volume":"195","author":"Oksjoki","year":"2007","journal-title":"Atherosclerosis"},{"key":"B8","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1007\/s11427-014-4711-5","article-title":"Role of C5a-C5aR axis in the development of atherosclerosis","volume":"57","author":"An","year":"2014","journal-title":"Sci China Life Sci"},{"key":"B9","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1160\/TH14-12-1075","article-title":"Atheroprotective role of C5ar2 deficiency in apolipoprotein E-deficient mice","volume":"114","author":"Selle","year":"2015","journal-title":"Thromb Haemost"},{"key":"B10","doi-asserted-by":"publisher","first-page":"368","DOI":"10.3389\/fimmu.2012.00368","article-title":"New insights for C5a and C5a receptors in sepsis","volume":"3","author":"Yan","year":"2012","journal-title":"Front Immunol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.it.2007.02.006","article-title":"Complement and coagulation: strangers or partners in crime?","volume":"28","author":"Markiewski","year":"2007","journal-title":"Trends Immunol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1038\/ni.1923","article-title":"Complement: a key system for immune surveillance and homeostasis","volume":"11","author":"Ricklin","year":"2010","journal-title":"Nat Immunol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.1093\/eurheartj\/ehu203","article-title":"Anti-inflammatory therapies for cardiovascular disease","volume":"35","author":"Ridker","year":"2014","journal-title":"Eur Heart J"},{"key":"B14","doi-asserted-by":"publisher","first-page":"503","DOI":"10.4049\/jimmunol.170.1.503","article-title":"Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression","volume":"170","author":"Riedemann","year":"2003","journal-title":"J Immunol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"2406","DOI":"10.1093\/eurheartj\/ehw171","article-title":"Effect of a single dose of the interleukin-6 receptor antagonist tocilizumab on inflammation and troponin T release in patients with non-ST-elevation myocardial infarction: a double-blind, randomized, placebo-controlled phase 2 trial","volume":"37","author":"Kleveland","year":"2016","journal-title":"Eur Heart J"},{"key":"B16","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.atherosclerosis.2015.09.010","article-title":"Increased expression of NAMPT in PBMC from patients with acute coronary syndrome and in inflammatory M1 macrophages","volume":"243","author":"Halvorsen","year":"2015","journal-title":"Atherosclerosis"},{"key":"B17","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.molimm.2013.05.221","article-title":"An international serum standard for application in assays to detect human complement activation products","volume":"56","author":"Bergseth","year":"2013","journal-title":"Mol Immunol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/nrcardio.2014.28","article-title":"The inflammatory response in myocardial injury, repair, and remodelling","volume":"11","author":"Frangogiannis","year":"2014","journal-title":"Nat Rev Cardiol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"e003103","DOI":"10.1161\/JAHA.112.003103","article-title":"Inflammatory biomarkers, death, and recurrent nonfatal coronary events after an acute coronary syndrome in the MIRACL study","volume":"2","author":"Zamani","year":"2013","journal-title":"J Am Heart Assoc"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1161\/01.CIR.101.15.1767","article-title":"Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men","volume":"101","author":"Ridker","year":"2000","journal-title":"Circulation"},{"key":"B21","doi-asserted-by":"publisher","first-page":"2294","DOI":"10.1093\/eurheartj\/ehi339","article-title":"Complement component C5a predicts future cardiovascular events in patients with advanced atherosclerosis","volume":"26","author":"Speidl","year":"2005","journal-title":"Eur Heart J"},{"key":"B22","doi-asserted-by":"publisher","first-page":"e003014","DOI":"10.1161\/JAHA.115.003014","article-title":"Circulating levels of IL-6 receptor and gp130 and long-term clinical outcomes in ST-elevation myocardial infarction","volume":"5","author":"Ritschel","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"B23","doi-asserted-by":"publisher","first-page":"2414","DOI":"10.1093\/eurheartj\/ehw207","article-title":"Anti-inflammatory treatment of acute coronary syndromes: the need for precision medicine","volume":"37","author":"Crea","year":"2016","journal-title":"Eur Heart J"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1093\/eurheartj\/ehp597","article-title":"Influence of functional deficiency of complement mannose-binding lectin on outcome of patients with acute ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention","volume":"31","author":"Trendelenburg","year":"2010","journal-title":"Eur Heart J"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1016\/S0140-6736(11)61931-4","article-title":"Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies","volume":"379","author":"Sarwar","year":"2012","journal-title":"Lancet"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1016\/S0140-6736(12)60110-X","article-title":"The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis","volume":"379","author":"Swerdlow","year":"2012","journal-title":"Lancet"},{"key":"B27","doi-asserted-by":"publisher","first-page":"H448","DOI":"10.1152\/ajpheart.1995.268.1.H448","article-title":"Limitation of reperfusion injury by a monoclonal antibody to C5a during myocardial infarction in pigs","volume":"268","author":"Amsterdam","year":"1995","journal-title":"Am J Physiol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.1161\/01.CIR.97.22.2259","article-title":"Myocardial infarction and apoptosis after myocardial ischemia and reperfusion: role of the terminal complement components and inhibition by anti-C5 therapy","volume":"97","author":"Vakeva","year":"1998","journal-title":"Circulation"},{"key":"B29","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1186\/1471-2261-10-45","article-title":"Inhibition of c5a related neutrophil activation by adc-1004 reduces myocardial infarct in a porcine ischemia-reperfusion model","volume":"31","author":"Van Der Pals","year":"2010","journal-title":"Eur Heart J."},{"key":"B30","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1007\/s00395-017-0610-9","article-title":"Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function","volume":"112","author":"Pischke","year":"2017","journal-title":"Basic Res Cardiol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1093\/cvr\/cvu153","article-title":"Leucocyte expression of complement C5a receptors exacerbates infarct size after myocardial reperfusion injury","volume":"103","author":"De Hoog","year":"2014","journal-title":"Cardiovasc Res"},{"key":"B32","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1096\/fj.12-220509","article-title":"C5L2: a controversial receptor of complement anaphylatoxin, C5a","volume":"27","author":"Li","year":"2013","journal-title":"Faseb j"},{"key":"B33","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1124\/pr.111.005223","article-title":"International union of basic and clinical pharmacology","volume":"65","author":"Klos","year":"2013","journal-title":"Pharmacol Rev."},{"key":"B34","doi-asserted-by":"publisher","first-page":"3542","DOI":"10.4049\/jimmunol.1403068","article-title":"Is the complement activation product C3a a proinflammatory molecule? Re-evaluating the evidence and the myth","volume":"194","author":"Coulthard","year":"2015","journal-title":"J Immunol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"9439","DOI":"10.1073\/pnas.1218815110","article-title":"The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization","volume":"110","author":"Wu","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"B36","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.4049\/jimmunol.162.7.4018","article-title":"Human T cells express the C5a receptor and are chemoattracted to C5a","volume":"162","author":"Nataf","year":"1999","journal-title":"J Immunol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1189\/jlb.1005582","article-title":"Mycobacteria-primed macrophages and dendritic cells induce an up-regulation of complement C5a anaphylatoxin receptor (CD88) in CD3+ murine T cells","volume":"81","author":"Connelly","year":"2007","journal-title":"J Leukoc Biol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1182\/blood-2008-04-151068","article-title":"Locally produced C5a binds to T cell-expressed C5aR to enhance effector T-cell expansion by limiting antigen-induced apoptosis","volume":"112","author":"Lalli","year":"2008","journal-title":"Blood"},{"key":"B39","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.immuni.2008.02.001","article-title":"Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells","volume":"28","author":"Strainic","year":"2008","journal-title":"Immunity"},{"key":"B40","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/nrneph.2016.70","article-title":"Complement in disease: a defence system turning offensive","volume":"12","author":"Ricklin","year":"2016","journal-title":"Nat Rev Nephrol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.02035\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T01:21:13Z","timestamp":1693876873000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.02035\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,12]]},"references-count":40,"alternative-id":["10.3389\/fimmu.2018.02035"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.02035","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,12]]},"article-number":"2035"}}