{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T14:57:25Z","timestamp":1768316245854,"version":"3.49.0"},"reference-count":113,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T00:00:00Z","timestamp":1536624000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.02086","type":"journal-article","created":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T09:26:08Z","timestamp":1536657968000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["The Diversity of Mammalian Hemoproteins and Microbial Heme Scavengers Is Shaped by an Arms Race for Iron Piracy"],"prefix":"10.3389","volume":"9","author":[{"given":"Alessandra","family":"Mozzi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Forni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Clerici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachele","family":"Cagliani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Sironi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,9,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1002\/iub.1602","article-title":"Iron chemistry at the service of life","volume":"69","author":"Sanchez","year":"2017","journal-title":"IUBMB Life"},{"key":"B2","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.chom.2013.04.010","article-title":"Iron in infection and immunity","volume":"13","author":"Cassat","year":"2013","journal-title":"Cell Host Microbe"},{"key":"B3","doi-asserted-by":"publisher","first-page":"3503","DOI":"10.1128\/IAI.00602-13","article-title":"Sequestration and scavenging of iron in infection","volume":"81","author":"Parrow","year":"2013","journal-title":"Infect Immun."},{"key":"B4","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/nrmicro2836","article-title":"Nutritional immunity: transition metals at the pathogen-host interface","volume":"10","author":"Hood","year":"2012","journal-title":"Nat Rev Microbiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"e1000949","DOI":"10.1371\/journal.ppat.1000949","article-title":"The battle for iron between bacterial pathogens and their vertebrate hosts","volume":"6","author":"Skaar","year":"2010","journal-title":"PLoS Pathog"},{"key":"B6","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.tig.2015.09.001","article-title":"Buried treasure: evolutionary perspectives on microbial iron piracy","volume":"31","author":"Barber","year":"2015","journal-title":"Trends Genet."},{"key":"B7","doi-asserted-by":"publisher","first-page":"3408","DOI":"10.1016\/j.jmb.2016.03.018","article-title":"Heme synthesis and acquisition in bacterial pathogens","volume":"428","author":"Choby","year":"2016","journal-title":"J Mol Biol."},{"key":"B8","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/0092-8674(89)90798-8","article-title":"The genes and transcripts of an antigen gene expression site from T","volume":"57","author":"Pays","year":"1989","journal-title":"brucei. Cell"},{"key":"B9","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1002\/j.1460-2075.1991.tb08045.x","article-title":"A transferrin-binding protein of Trypanosoma brucei is encoded by one of the genes in the variant surface glycoprotein gene expression site","volume":"10","author":"Schell","year":"1991","journal-title":"EMBO J."},{"key":"B10","doi-asserted-by":"crossref","first-page":"6443","DOI":"10.1073\/pnas.91.14.6443","article-title":"Expression of a glycosylphosphatidylinositol-anchored Trypanosoma brucei transferrin-binding protein complex in insect cells","volume":"91","author":"Chaudhri","year":"1994","journal-title":"Proc Natl Acad Sci USA."},{"key":"B11","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1126\/science.1156296","article-title":"A haptoglobin-hemoglobin receptor conveys innate immunity to Trypanosoma brucei in humans","volume":"320","author":"Vanhollebeke","year":"2008","journal-title":"Science"},{"key":"B12","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1038\/nrg3905","article-title":"Evolutionary insights into host-pathogen interactions from mammalian sequence data","volume":"16","author":"Sironi","year":"2015","journal-title":"Nat Rev Genet."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1126\/science.1259329","article-title":"Nutritional immunity","volume":"346","author":"Barber","year":"2014","journal-title":"Science"},{"key":"B14","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1146\/annurev-genet-120215-035146","article-title":"Transition metals and virulence in bacteria","volume":"50","author":"Palmer","year":"2016","journal-title":"Annu Rev Genet."},{"key":"B15","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.bbapap.2017.01.006","article-title":"Diverse structural approaches to haem appropriation by pathogenic bacteria","volume":"1865","author":"Hare","year":"2017","journal-title":"Biochim Biophys Acta"},{"key":"B16","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1093\/molbev\/msn004","article-title":"Rapid rates of lineage-specific gene duplication and deletion in the alpha-globin gene family","volume":"25","author":"Hoffmann","year":"2008","journal-title":"Mol Biol Evol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1111\/j.1469-1809.2012.00716.x","article-title":"Molecular and population analysis of natural selection on the human haptoglobin duplication","volume":"76","author":"Rodriguez","year":"2012","journal-title":"Ann Hum Genet."},{"key":"B18","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s00439-013-1352-x","article-title":"Haptoglobin (HP) and Haptoglobin-related protein (HPR) copy number variation, natural selection, and trypanosomiasis","volume":"133","author":"Hardwick","year":"2014","journal-title":"Hum Genet."},{"key":"B19","doi-asserted-by":"publisher","first-page":"3537","DOI":"10.1093\/nar\/gkg609","article-title":"RevTrans: multiple alignment of coding DNA from aligned amino acid sequences","volume":"31","author":"Wernersson","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1093\/molbev\/mst064","article-title":"DAMBE5: a comprehensive software package for data analysis in molecular biology and evolution","volume":"30","author":"Xia","year":"2013","journal-title":"Mol Biol Evol."},{"key":"B21","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/PL00006320","article-title":"Synonymous and nonsynonymous rate variation in nuclear genes of mammals","volume":"46","author":"Yang","year":"1998","journal-title":"J Mol Evol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1093\/molbev\/msl051","article-title":"Automated phylogenetic detection of recombination using a genetic algorithm","volume":"23","author":"Kosakovsky","year":"2006","journal-title":"Mol Biol Evol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1093\/molbev\/msi105","article-title":"Not so different after all: a comparison of methods for detecting amino acid sites under selection","volume":"22","author":"Kosakovsky","year":"2005","journal-title":"Mol Biol Evol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1093\/bioinformatics\/bti079","article-title":"HyPhy: hypothesis testing using phylogenies","volume":"21","author":"Pond","year":"2005","journal-title":"Bioinformatics"},{"key":"B25","first-page":"555","article-title":"PAML: a program package for phylogenetic analysis by maximum likelihood","volume":"13","author":"Yang","year":"1997","journal-title":"Comput Appl Biosci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1093\/molbev\/msm088","article-title":"PAML 4: phylogenetic analysis by maximum likelihood","volume":"24","author":"Yang","year":"2007","journal-title":"Mol Biol Evol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/978-1-59745-251-9_6","article-title":"Estimating maximum likelihood phylogenies with PhyML","volume":"537","author":"Guindon","year":"2009","journal-title":"Methods Mol Biol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1093\/oxfordjournals.molbev.a004152","article-title":"Accuracy and power of bayes prediction of amino acid sites under positive selection","volume":"19","author":"Anisimova","year":"2002","journal-title":"Mol Biol Evol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1093\/molbev\/mst030","article-title":"FUBAR: a fast, unconstrained bayesian approximation for inferring selection","volume":"30","author":"Murrell","year":"2013","journal-title":"Mol Biol Evol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1093\/molbev\/msv022","article-title":"Less is more: an adaptive branch-site random effects model for efficient detection of episodic diversifying selection","volume":"32","author":"Smith","year":"2015","journal-title":"Mol Biol Evol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"e1002764","DOI":"10.1371\/journal.pgen.1002764","article-title":"Detecting individual sites subject to episodic diversifying selection","volume":"8","author":"Murrell","year":"2012","journal-title":"PLoS Genet."},{"key":"B32","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.1093\/bioinformatics\/btq429","article-title":"Datamonkey 2010: a suite of phylogenetic analysis tools for evolutionary biology","volume":"26","author":"Delport","year":"2010","journal-title":"Bioinformatics"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1099\/mic.0.046946-0","article-title":"Influence of the combination and phase variation status of the haemoglobin receptors HmbR and HpuAB on meningococcal virulence","volume":"157","author":"Tauseef","year":"2011","journal-title":"Microbiology"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1534\/genetics.105.044917","article-title":"Estimating diversifying selection and functional constraint in the presence of recombination","volume":"172","author":"Wilson","year":"2006","journal-title":"Genetics"},{"key":"B35","doi-asserted-by":"publisher","first-page":"W252","DOI":"10.1093\/nar\/gku340","article-title":"SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information","volume":"42","author":"Biasini","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1093\/bioinformatics\/btq662","article-title":"Toward the estimation of the absolute quality of individual protein structure models","volume":"27","author":"Benkert","year":"2011","journal-title":"Bioinformatics"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1038\/nprot.2012.085","article-title":"Template-based protein structure modeling using the RaptorX web server","volume":"7","author":"Kallberg","year":"2012","journal-title":"Nat Protoc"},{"key":"B38","doi-asserted-by":"publisher","first-page":"W233","DOI":"10.1093\/nar\/gkn216","article-title":"The RosettaDock server for local protein-protein docking","volume":"36","author":"Lyskov","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"B39","doi-asserted-by":"publisher","first-page":"e63906","DOI":"10.1371\/journal.pone.0063906","article-title":"Serverification of molecular modeling applications: the Rosetta Online Server that Includes Everyone (ROSIE)","volume":"8","author":"Lyskov","year":"2013","journal-title":"PLoS ONE"},{"key":"B40","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s12185-008-0120-5","article-title":"Body iron metabolism and pathophysiology of iron overload","volume":"88","author":"Kohgo","year":"2008","journal-title":"Int J Hematol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"5705","DOI":"10.1021\/bi300752r","article-title":"Mechanisms of mammalian iron homeostasis","volume":"51","author":"Pantopoulos","year":"2012","journal-title":"Biochemistry"},{"key":"B42","doi-asserted-by":"publisher","first-page":"E130","DOI":"10.3390\/ijms17010130","article-title":"Iron homeostasis in health and disease","volume":"17","author":"Gozzelino","year":"2016","journal-title":"Int J Mol Sci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.ympev.2012.07.013","article-title":"Gene duplication, genome duplication, and the functional diversification of vertebrate globins","volume":"66","author":"Storz","year":"2013","journal-title":"Mol Phylogenet Evol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1093\/gbe\/evu097","article-title":"Repeated evolution of chimeric fusion genes in the beta-globin gene family of laurasiatherian mammals","volume":"6","author":"Gaudry","year":"2014","journal-title":"Genome Biol Evol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1093\/oxfordjournals.molbev.a003928","article-title":"A novel approach to detecting and measuring recombination: new insights into evolution in viruses, bacteria, and mitochondria","volume":"18","author":"Worobey","year":"2001","journal-title":"Mol Biol Evol."},{"key":"B46","unstructured":"Consequences of recombination on traditional phylogenetic analysis87991 SchierupMH HeinJ 11014833Genetics1562000"},{"key":"B47","doi-asserted-by":"publisher","first-page":"2472","DOI":"10.1093\/molbev\/msi237","article-title":"Evaluation of an improved branch-site likelihood method for detecting positive selection at the molecular level","volume":"22","author":"Zhang","year":"2005","journal-title":"Mol Biol Evol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1111\/bjh.14886","article-title":"The role of the red blood cell in host defence against falciparum malaria: an expanding repertoire of evolutionary alterations","volume":"179","author":"Goheen","year":"2017","journal-title":"Br J Haematol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"e1002535","DOI":"10.1371\/journal.ppat.1002535","article-title":"Taste for blood: hemoglobin as a nutrient source for pathogens","volume":"8","author":"Pishchany","year":"2012","journal-title":"PLoS Pathog"},{"key":"B50","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0092-8674(00)81706-7","article-title":"A VSG expression site-associated gene confers resistance to human serum in Trypanosoma rhodesiense","volume":"95","author":"Xong","year":"1998","journal-title":"Cell"},{"key":"B51","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0166-6851(01)00208-0","article-title":"A receptor-like flagellar pocket glycoprotein specific to Trypanosoma brucei gambiense","volume":"113","author":"Berberof","year":"2001","journal-title":"Mol Biochem Parasitol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"e1003686","DOI":"10.1371\/journal.ppat.1003686","article-title":"The TgsGP gene is essential for resistance to human serum in Trypanosoma brucei gambiense","volume":"9","author":"Capewell","year":"2013","journal-title":"PLoS Pathog"},{"key":"B53","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/nature12516","article-title":"Mechanism of Trypanosoma brucei gambiense resistance to human serum","volume":"501","author":"Uzureau","year":"2013","journal-title":"Nature"},{"key":"B54","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1111\/j.1365-2958.2010.07156.x","article-title":"The trypanolytic factor of human serum: many ways to enter the parasite, a single way to kill","volume":"76","author":"Vanhollebeke","year":"2010","journal-title":"Mol Microbiol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"16137","DOI":"10.1073\/pnas.1007074107","article-title":"Mechanism of Trypanosoma brucei gambiense (group 1) resistance to human trypanosome lytic factor","volume":"107","author":"Kieft","year":"2010","journal-title":"Proc Natl Acad Sci USA."},{"key":"B56","doi-asserted-by":"publisher","first-page":"e1003317","DOI":"10.1371\/journal.ppat.1003317","article-title":"A single amino acid substitution in the group 1 Trypanosoma brucei gambiense haptoglobin-hemoglobin receptor abolishes TLF-1 binding","volume":"9","author":"DeJesus","year":"2013","journal-title":"PLoS Pathog"},{"key":"B57","doi-asserted-by":"publisher","first-page":"e1728","DOI":"10.1371\/journal.pntd.0001728","article-title":"Trypanosoma brucei gambiense group 1 is distinguished by a unique amino acid substitution in the HpHb receptor implicated in human serum resistance","volume":"6","author":"Symula","year":"2012","journal-title":"PLoS Negl Trop Dis."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1073\/pnas.1214943110","article-title":"Structure of the trypanosome haptoglobin-hemoglobin receptor and implications for nutrient uptake and innate immunity","volume":"110","author":"Higgins","year":"2013","journal-title":"Proc Natl Acad Sci USA."},{"key":"B59","doi-asserted-by":"publisher","first-page":"e05553","DOI":"10.7554\/eLife.05553","article-title":"Structural basis for ligand and innate immunity factor uptake by the trypanosome haptoglobin-haemoglobin receptor","volume":"3","author":"Lane-Serff","year":"2014","journal-title":"Elife"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.13044","article-title":"Evolutionary diversification of the trypanosome haptoglobin-haemoglobin receptor from an ancestral haemoglobin receptor","volume":"5","author":"Lane-Serff","year":"2016","journal-title":"Elife"},{"key":"B61","doi-asserted-by":"publisher","first-page":"e1006055","DOI":"10.1371\/journal.ppat.1006055","article-title":"A Receptor's tale: an eon in the life of a Trypanosome receptor","volume":"13","author":"Higgins","year":"2017","journal-title":"PLoS Pathog"},{"key":"B62","doi-asserted-by":"publisher","first-page":"5487","DOI":"10.1038\/ncomms6487","article-title":"Structural basis for trypanosomal haem acquisition and susceptibility to the host innate immune system","volume":"5","author":"Stodkilde","year":"2014","journal-title":"Nat Commun."},{"key":"B63","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1196\/annals.1373.040","article-title":"Trypanosomosis in goats: current status","volume":"1081","author":"Gutierrez","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"B64","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1126\/science.1193032","article-title":"Association of trypanolytic ApoL1 variants with kidney disease in African Americans","volume":"329","author":"Genovese","year":"2010","journal-title":"Science"},{"key":"B65","doi-asserted-by":"publisher","first-page":"RESEARCH0047","DOI":"10.1186\/gb-2002-3-9-research0047","article-title":"NEAT: a domain duplicated in genes near the components of a putative Fe3+ siderophore transporter from Gram-positive pathogenic bacteria","volume":"3","author":"Andrade","year":"2002","journal-title":"Genome Biol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1126\/science.1081147","article-title":"Passage of heme-iron across the envelope of Staphylococcus aureus","volume":"299","author":"Mazmanian","year":"2003","journal-title":"Science"},{"key":"B67","doi-asserted-by":"publisher","first-page":"28125","DOI":"10.1074\/jbc.M802171200","article-title":"Demonstration of the iron-regulated surface determinant (Isd) heme transfer pathway in Staphylococcus aureus","volume":"283","author":"Muryoi","year":"2008","journal-title":"J Biol Chem."},{"key":"B68","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1099\/ijs.0.062752-0","article-title":"Novel staphylococcal species that form part of a Staphylococcus aureus-related complex: the non-pigmented Staphylococcus argenteus sp. nov. and the non-human primate-associated Staphylococcus schweitzeri sp. nov","volume":"65","author":"Tong","year":"2015","journal-title":"Int J Syst Evol Microbiol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.3389\/fmicb.2017.01512","article-title":"Whole Genome sequencing of danish Staphylococcus argenteus reveals a genetically diverse collection with clear separation from Staphylococcus aureus","volume":"8","author":"Hansen","year":"2017","journal-title":"Front Microbiol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"6728","DOI":"10.1074\/jbc.M113.545566","article-title":"Structure of the hemoglobin-IsdH complex reveals the molecular basis of iron capture by Staphylococcus aureus","volume":"289","author":"Dickson","year":"2014","journal-title":"J Biol Chem."},{"key":"B71","doi-asserted-by":"publisher","first-page":"3922","DOI":"10.1021\/bi5005188","article-title":"Solution structure and molecular determinants of hemoglobin binding of the first NEAT domain of IsdB in Staphylococcus aureus","volume":"53","author":"Fonner","year":"2014","journal-title":"Biochemistry"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1093\/infdis\/jit817","article-title":"IsdB-dependent hemoglobin binding is required for acquisition of heme by Staphylococcus aureus","volume":"209","author":"Pishchany","year":"2014","journal-title":"J Infect Dis."},{"key":"B73","doi-asserted-by":"publisher","first-page":"e100744","DOI":"10.1371\/journal.pone.0100744","article-title":"Non-heme-binding domains and segments of the Staphylococcus aureus IsdB protein critically contribute to the kinetics and equilibrium of heme acquisition from methemoglobin","volume":"9","author":"Zhu","year":"2014","journal-title":"PLoS ONE"},{"key":"B74","doi-asserted-by":"publisher","first-page":"23989","DOI":"10.1074\/jbc.M116.755934","article-title":"The Staphylococcus aureus Protein IsdH inhibits host hemoglobin scavenging to promote heme acquisition by the pathogen","volume":"291","author":"Saederup","year":"2016","journal-title":"J Biol Chem."},{"key":"B75","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1074\/jbc.M117.806562","article-title":"Structure-function analyses reveal key features in Staphylococcus aureus IsdB-associated unfolding of the heme-binding pocket of human hemoglobin","volume":"293","author":"Bowden","year":"2018","journal-title":"J Biol Chem."},{"key":"B76","doi-asserted-by":"publisher","first-page":"8421","DOI":"10.1128\/JB.01335-06","article-title":"Staphylococcus aureus IsdB is a hemoglobin receptor required for heme iron utilization","volume":"188","author":"Torres","year":"2006","journal-title":"J Bacteriol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/nrmicro.2017.27","article-title":"Leukocidins: staphylococcal bi-component pore-forming toxins find their receptors","volume":"15","author":"Spaan","year":"2017","journal-title":"Nat Rev Microbiol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1126\/science.1099930","article-title":"Iron-source preference of Staphylococcus aureus infections","volume":"305","author":"Skaar","year":"2004","journal-title":"Science"},{"key":"B79","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/82_2016_497","article-title":"Epidemiology of Staphylococcus aureus nasal carriage patterns in the community","volume":"398","author":"Mehraj","year":"2016","journal-title":"Curr Top Microbiol Immunol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/S1473-3099(05)70295-4","article-title":"The role of nasal carriage in Staphylococcus aureus infections","volume":"5","author":"Wertheim","year":"2005","journal-title":"Lancet Infect Dis."},{"key":"B81","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1056\/NEJM199808203390806","article-title":"Staphylococcus aureus infections","volume":"339","author":"Lowy","year":"1998","journal-title":"N Engl J Med."},{"key":"B82","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.chom.2010.11.002","article-title":"Specificity for human hemoglobin enhances Staphylococcus aureus infection","volume":"8","author":"Pishchany","year":"2010","journal-title":"Cell Host Microbe"},{"key":"B83","doi-asserted-by":"publisher","first-page":"6382","DOI":"10.1016\/j.vaccine.2010.02.097","article-title":"IsdA and IsdB antibodies protect mice against Staphylococcus aureus abscess formation and lethal challenge","volume":"28","author":"Kim","year":"2010","journal-title":"Vaccine"},{"key":"B84","doi-asserted-by":"publisher","first-page":"e1001769","DOI":"10.1371\/journal.pbio.1001769","article-title":"Limiting damage during infection: lessons from infection tolerance for novel therapeutics","volume":"12","author":"Vale","year":"2014","journal-title":"PLoS Biol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"3423","DOI":"10.1099\/mic.0.26448-0","article-title":"Identification of functionally important regions of a haemoglobin receptor from Neisseria meningitidis","volume":"149","author":"Perkins-Balding","year":"2003","journal-title":"Microbiology"},{"key":"B86","doi-asserted-by":"crossref","first-page":"6043","DOI":"10.1128\/JB.180.22.6043-6047.1998","article-title":"Transport of intact porphyrin by HpuAB, the hemoglobin-haptoglobin utilization system of Neisseria meningitidis","volume":"180","author":"Lewis","year":"1998","journal-title":"J Bacteriol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1099\/mic.0.036475-0","article-title":"Variation and molecular evolution of HmbR, the Neisseria meningitidis haemoglobin receptor","volume":"156","author":"Evans","year":"2010","journal-title":"Microbiology"},{"key":"B88","doi-asserted-by":"publisher","first-page":"3058","DOI":"10.1016\/j.bbagen.2014.06.009","article-title":"Spectroscopic evidence for a 5-coordinate oxygenic ligated high spin ferric heme moiety in the Neisseria meningitidis hemoglobin binding receptor","volume":"1840","author":"Mokry","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"B89","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1046\/j.1365-2958.1997.2501619.x","article-title":"Molecular characterization of hpuAB, the haemoglobin-haptoglobin-utilization operon of Neisseria meningitidis","volume":"23","author":"Lewis","year":"1997","journal-title":"Mol Microbiol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"2494","DOI":"10.1128\/IAI.72.5.2494-2506.2004","article-title":"Analysis of haptoglobin and hemoglobin-haptoglobin interactions with the Neisseria meningitidis TonB-dependent receptor HpuAB by flow cytometry","volume":"72","author":"Rohde","year":"2004","journal-title":"Infect Immun."},{"key":"B91","doi-asserted-by":"publisher","first-page":"10172","DOI":"10.1038\/ncomms10172","article-title":"Structural analysis of haemoglobin binding by HpuA from the Neisseriaceae family","volume":"6","author":"Wong","year":"2015","journal-title":"Nat Commun."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1099\/mic.0.068874-0","article-title":"Distribution and diversity of the haemoglobin-haptoglobin iron-acquisition systems in pathogenic and non-pathogenic Neisseria","volume":"159","author":"Harrison","year":"2013","journal-title":"Microbiology"},{"key":"B93","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.mib.2008.09.002","article-title":"Population genomics: diversity and virulence in the Neisseria","volume":"11","author":"Maiden","year":"2008","journal-title":"Curr Opin Microbiol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1086\/324564","article-title":"Selection for expression of the gonococcal hemoglobin receptor during menses","volume":"184","author":"Anderson","year":"2001","journal-title":"J Infect Dis."},{"key":"B95","doi-asserted-by":"publisher","first-page":"ftx112","DOI":"10.1093\/femspd\/ftx112","article-title":"Subversion of nutritional immunity by the pathogenic Neisseriae","volume":"76","author":"Cornelissen","year":"2017","journal-title":"Pathog Dis."},{"key":"B96","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1089\/104454902753759717","article-title":"Hemopexin: structure, function, and regulation","volume":"21","author":"Tolosano","year":"2002","journal-title":"DNA Cell Biol."},{"key":"B97","doi-asserted-by":"crossref","first-page":"4511","DOI":"10.1128\/IAI.66.9.4511-4516.1998","article-title":"Binding of heme-hemopexin complexes by soluble HxuA protein allows utilization of this complexed heme by Haemophilus influenzae","volume":"66","author":"Cope","year":"1998","journal-title":"Infect Immun."},{"key":"B98","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1111\/j.1365-2958.2011.07562.x","article-title":"Haem release from haemopexin by HxuA allows Haemophilus influenzae to escape host nutritional immunity","volume":"80","author":"Fournier","year":"2011","journal-title":"Mol Microbiol."},{"key":"B99","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1128\/IAI.62.1.48-59.1994","article-title":"Identification and characterization of an iron-regulated hemopexin receptor in Haemophilus influenzae type b","volume":"62","author":"Wong","year":"1994","journal-title":"Infect Immun"},{"key":"B100","doi-asserted-by":"publisher","first-page":"11590","DOI":"10.1038\/ncomms11590","article-title":"Structural basis for haem piracy from host haemopexin by Haemophilus influenzae","volume":"7","author":"Zambolin","year":"2016","journal-title":"Nat Commun."},{"key":"B101","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1099\/mic.0.2006\/000190-0","article-title":"The haem-haemopexin utilization gene cluster (hxuCBA) as a virulence factor of Haemophilus influenzae","volume":"153","author":"Morton","year":"2007","journal-title":"Microbiology"},{"key":"B102","doi-asserted-by":"publisher","first-page":"7257","DOI":"10.1128\/JB.00675-06","article-title":"The genome sequence of Mannheimia haemolytica A1: insights into virulence, natural competence, and Pasteurellaceae phylogeny","volume":"188","author":"Gioia","year":"2006","journal-title":"J Bacteriol."},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019631","article-title":"Genomic characterization of Haemophilus parasuis SH0165, a highly virulent strain of serovar 5 prevalent in China","author":"Xu","year":"2011","journal-title":"PLoS ONE"},{"key":"B104","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1021\/bi801860g","article-title":"Structural characterization of the hemophore HasAp from Pseudomonas aeruginosa: NMR spectroscopy reveals protein-protein interactions between Holo-HasAp and hemoglobin","volume":"48","author":"Alontaga","year":"2009","journal-title":"Biochemistry"},{"key":"B105","doi-asserted-by":"publisher","first-page":"9857","DOI":"10.1021\/ja103498z","article-title":"Structural, NMR spectroscopic, and computational investigation of hemin loading in the hemophore HasAp from Pseudomonas aeruginosa","volume":"132","author":"Jepkorir","year":"2010","journal-title":"J Am Chem Soc."},{"key":"B106","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s10534-006-0003-2","article-title":"Feo\u2013transport of ferrous iron into bacteria","volume":"19","author":"Cartron","year":"2006","journal-title":"Biometals"},{"key":"B107","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1099\/mic.0.023531-0","article-title":"Citrate-mediated iron uptake in Pseudomonas aeruginosa: involvement of the citrate-inducible FecA receptor and the FeoB ferrous iron transporter","volume":"155","author":"Marshall","year":"2009","journal-title":"Microbiology"},{"key":"B108","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.femsle.2005.04.010","article-title":"The Pseudomonas aeruginosa pirA gene encodes a second receptor for ferrienterobactin and synthetic catecholate analogues","volume":"246","author":"Ghysels","year":"2005","journal-title":"FEMS Microbiol Lett"},{"key":"B109","unstructured":"Regulation of heme biosynthesis in non-phototrophic bacteria28794 SchobertM JahnD 11931560J Mol Microbiol Biotechnol.42002"},{"key":"B110","doi-asserted-by":"publisher","first-page":"e1003582","DOI":"10.1371\/journal.ppat.1003582","article-title":"A comprehensive analysis of in vitro and in vivo genetic fitness of Pseudomonas aeruginosa using high-throughput sequencing of transposon libraries","volume":"9","author":"Skurnik","year":"2013","journal-title":"PLoS Pathog"},{"key":"B111","doi-asserted-by":"publisher","first-page":"e00966","DOI":"10.1128\/mBio.00966-14","article-title":"Within-host evolution of Pseudomonas aeruginosa reveals adaptation toward iron acquisition from hemoglobin","volume":"5","author":"Marvig","year":"2014","journal-title":"MBio"},{"key":"B112","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1046\/j.1462-2920.2002.00369.x","article-title":"Diversity of siderophore-mediated iron uptake systems in fluorescent pseudomonads: not only pyoverdines","volume":"4","author":"Cornelis","year":"2002","journal-title":"Environ Microbiol."},{"key":"B113","doi-asserted-by":"publisher","first-page":"e1006063","DOI":"10.1371\/journal.pgen.1006063","article-title":"Antimicrobial functions of lactoferrin promote genetic conflicts in ancient primates and modern humans","volume":"12","author":"Barber","year":"2016","journal-title":"PLoS Genet."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.02086\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T11:47:09Z","timestamp":1604922429000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.02086\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,11]]},"references-count":113,"alternative-id":["10.3389\/fimmu.2018.02086"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.02086","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,11]]},"article-number":"2086"}}