{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T13:02:45Z","timestamp":1776171765636,"version":"3.50.1"},"reference-count":91,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T00:00:00Z","timestamp":1537315200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["UMO-2015\/17\/B\/NZ2\/00967"],"award-info":[{"award-number":["UMO-2015\/17\/B\/NZ2\/00967"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["UMO-2015\/16\/T\/NZ2\/00055"],"award-info":[{"award-number":["UMO-2015\/16\/T\/NZ2\/00055"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008648","name":"Krajowy Naukowy Osrodek Wiodacy","doi-asserted-by":"publisher","award":["01\/KNOW2\/2014"],"award-info":[{"award-number":["01\/KNOW2\/2014"]}],"id":[{"id":"10.13039\/501100008648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.02141","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T06:11:31Z","timestamp":1537337491000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Genome-Wide Inhibition of Pro-atherogenic Gene Expression by Multi-STAT Targeting Compounds as a Novel Treatment Strategy of CVDs"],"prefix":"10.3389","volume":"9","author":[{"given":"Martyna","family":"Plens-Galaska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malgorzata","family":"Szelag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida","family":"Collado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrice","family":"Marques","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Vallejo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariella","family":"Ramos-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Wesoly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jesus","family":"Sanz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concepci\u00f3n","family":"Peir\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans A. R.","family":"Bluyssen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,9,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/ni.2001","article-title":"The immune system in atherosclerosis","volume":"12","author":"Hansson","year":"2011","journal-title":"Nat Immunol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.immuni.2012.03.013","article-title":"The JAK-STAT pathway at twenty","volume":"36","author":"Stark","year":"2012","journal-title":"Immunity"},{"key":"B3","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.cytogfr.2008.08.004","article-title":"IFNgamma signaling-does it mean JAK-STAT?","volume":"19","author":"Gough","year":"2008","journal-title":"Cytokine Growth Factor Rev."},{"key":"B4","doi-asserted-by":"publisher","first-page":"C1337","DOI":"10.1152\/ajpcell.00276.2010","article-title":"STAT1-mediated signal integration between IFNgamma and LPS leads to increased EC and SMC activation and monocyte adhesion","volume":"300","author":"Sikorski","year":"2011","journal-title":"Am J Physiol Cell Physiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1189\/jlb.69.6.1036","article-title":"Different toll-like receptor agonists induce distinct macrophage responses","volume":"69","author":"Jones","year":"2001","journal-title":"J Leukoc Biol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat Immunol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"48788","DOI":"10.18632\/oncotarget.9195","article-title":"Targeted inhibition of STATs and IRFs as a potential treatment strategy in cardiovascular disease","volume":"7","author":"Szelag","year":"2016","journal-title":"Oncotarget"},{"key":"B8","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/nri1684","article-title":"The yin and yang of type I interferon activity in bacterial infection","volume":"5","author":"Decker","year":"2005","journal-title":"Nat Rev Immunol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/nri2079","article-title":"The family of five: TIR-domain-containing adaptors in toll-like receptor signalling","volume":"7","author":"O'Neill","year":"2007","journal-title":"Nat Rev Immunol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"e113318","DOI":"10.1371\/journal.pone.0113318","article-title":"STAT1-dependent signal integration between IFNgamma and TLR4 in vascular cells reflect pro-atherogenic responses in human atherosclerosis","volume":"9","author":"Chmielewski","year":"2014","journal-title":"PLoS ONE"},{"key":"B11","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/1756-8722-6-90","article-title":"STAT inhibitors for cancer therapy","volume":"6","author":"Furqan","year":"2013","journal-title":"J Hematol Oncol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1038\/nrd4088","article-title":"Therapeutic modulators of STAT signalling for human diseases","volume":"12","author":"Miklossy","year":"2013","journal-title":"Nat Rev Drug Discov."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1016\/j.chembiol.2006.09.018","article-title":"Stattic: a small-molecule inhibitor of STAT3 activation and dimerization","volume":"13","author":"Schust","year":"2006","journal-title":"Chem Biol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.3892\/ijo.2011.957","article-title":"Antitumor activity of a novel small molecule STAT3 inhibitor against a human lymphoma cell line with high STAT3 activation","volume":"38","author":"Ashizawa","year":"2011","journal-title":"Int J Oncol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.jocs.2015.03.001","article-title":"CAVS\u2014novel in silico selection strategy of specific STAT inhibitory compounds","volume":"10","author":"Czerwoniec","year":"2015","journal-title":"J Comput Sci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"e0116688","DOI":"10.1371\/journal.pone.0116688","article-title":"Identification of STAT1 and STAT3 specific inhibitors using comparative virtual screening and docking validation","volume":"10","author":"Szelag","year":"2015","journal-title":"PLoS ONE"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2013a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J Comput Chem."},{"key":"B18","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1002\/jmr.1047","article-title":"Characterization of molecular recognition of STAT3 SH2 domain inhibitors through molecular simulation","volume":"24","author":"Park","year":"2011","journal-title":"J Mol Recognit."},{"key":"B19","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1021\/jm020406h","article-title":"Surflex: fully automatic flexible molecular docking using a molecular similarity-based search engine","volume":"46","author":"Jain","year":"2003","journal-title":"J Med Chem."},{"key":"B20","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s10822-007-9114-2","article-title":"Surflex-Dock 2","volume":"21","author":"Jain","year":"2007","journal-title":"J Comput Aided Mol Des."},{"key":"B21","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1021\/ci049714+","article-title":"ZINC\u2013a free database of commercially available compounds for virtual screening","volume":"45","author":"Irwin","year":"2005","journal-title":"J Chem Inf Model."},{"key":"B22","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0169-409X(00)00129-0","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings","volume":"46","author":"Lipinski","year":"2001","journal-title":"Adv Drug Deliv Rev."},{"key":"B23","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.ddtec.2004.11.007","article-title":"Lead- and drug-like compounds: the rule-of-five revolution","volume":"1","author":"Lipinski","year":"2004","journal-title":"Drug Discov Today Technol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1016\/j.chembiol.2006.11.001","article-title":"A new small-molecule Stat3 inhibitor","volume":"13","author":"McMurray","year":"2006","journal-title":"Chem Biol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1021\/ml1000273","article-title":"Identification of a new series of STAT3 inhibitors by virtual screening","volume":"1","author":"Matsuno","year":"2010","journal-title":"ACS Med Chem Lett."},{"key":"B26","unstructured":"BonvinAM HADDOCK Small Molecule Binding Site Screening2007"},{"key":"B27","doi-asserted-by":"publisher","first-page":"e7","DOI":"10.1371\/journal.pbio.0050007","article-title":"Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors","volume":"5","author":"Sennhauser","year":"2007","journal-title":"PLoS Biol."},{"key":"B28","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/1523-1747.ep12613748","article-title":"HMEC-1: establishment of an immortalized human microvascular endothelial cell line","volume":"99","author":"Ades","year":"1992","journal-title":"J Invest Dermatol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1101\/gad.242685.114","article-title":"The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages","volume":"28","author":"Daniel","year":"2014","journal-title":"Genes Dev."},{"key":"B30","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.ab.2008.04.036","article-title":"Standardization of real-time PCR gene expression data from independent biological replicates","volume":"379","author":"Willems","year":"2008","journal-title":"Anal Biochem."},{"key":"B31","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/1471-2105-12-35","article-title":"VennDiagram: a package for the generation of highly-customizable Venn and Euler diagrams in R","volume":"12","author":"Chen","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"B32","doi-asserted-by":"publisher","first-page":"e39","DOI":"10.1371\/journal.pcbi.0030039","article-title":"Discovering motifs in ranked lists of DNA sequences","volume":"3","author":"Eden","year":"2007","journal-title":"PLoS Comput Biol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/1471-2105-10-48","article-title":"GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists","volume":"10","author":"Eden","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"B34","doi-asserted-by":"publisher","first-page":"e21800","DOI":"10.1371\/journal.pone.0021800","article-title":"REVIGO summarizes and visualizes long lists of gene ontology terms","volume":"6","author":"Supek","year":"2011","journal-title":"PLoS ONE"},{"key":"B35","doi-asserted-by":"publisher","first-page":"W247","DOI":"10.1093\/nar\/gkp464","article-title":"Pscan: finding over-represented transcription factor binding site motifs in sequences from co-regulated or co-expressed genes","volume":"37","author":"Zambelli","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"B36","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"B37","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/nprot.2007.30","article-title":"In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro","volume":"2","author":"Liang","year":"2007","journal-title":"Nat Protoc."},{"key":"B38","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1161\/ATVBAHA.112.254870","article-title":"Arterial and venous endothelia display differential functional fractalkine (CX3CL1) expression by angiotensin-II","volume":"33","author":"Rius","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.3389\/fimmu.2017.01766","article-title":"Cigarette smoke increases endothelial CXCL16-leukocyte CXCR6 adhesion in vitro and in vivo. Potential consequences in chronic obstructive pulmonary disease","volume":"8","author":"Marques","year":"2017","journal-title":"Front Immunol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1182\/blood-2007-01-070607","article-title":"A critical role for TNFalpha in the selective attachment of mononuclear leukocytes to angiotensin-II-stimulated arterioles","volume":"110","author":"Mateo","year":"2007","journal-title":"Blood"},{"key":"B41","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1136\/thoraxjnl-2012-202212","article-title":"Critical role of fractalkine (CX3CL1) in cigarette smoke-induced mononuclear cell adhesion to the arterial endothelium","volume":"68","author":"Rius","year":"2013","journal-title":"Thorax"},{"key":"B42","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.bcp.2017.01.012","article-title":"Mas receptor is involved in the estrogen-receptor induced nitric oxide-dependent vasorelaxation","volume":"129","author":"Sobrino","year":"2017","journal-title":"Biochem Pharmacol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1002\/jcc.21720","article-title":"Web servers and services for electrostatics calculations with APBS and PDB2PQR","volume":"32","author":"Unni","year":"2011","journal-title":"J Comput Chem."},{"key":"B44","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.jmgm.2009.08.013","article-title":"Molecular dynamics simulations of the conformational changes in signal transducers and activators of transcription, Stat1 and Stat3","volume":"28","author":"Lin","year":"2009","journal-title":"J Mol Graph Model."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1093\/emboj\/21.7.1754","article-title":"Regulated nuclear import of the STAT1 transcription factor by direct binding of importin-alpha","volume":"21","author":"McBride","year":"2002","journal-title":"EMBO J."},{"key":"B46","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1002\/j.1460-2075.1996.tb00445.x","article-title":"The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signals","volume":"15","author":"Gupta","year":"1996","journal-title":"EMBO J."},{"key":"B47","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1042\/BJ20030708","article-title":"Analysis of Stat3 (signal transducer and activator of transcription 3) dimerization by fluorescence resonance energy transfer in living cells","volume":"377","author":"Kretzschmar","year":"2004","journal-title":"Biochem J."},{"key":"B48","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.virol.2013.06.019","article-title":"The measles virus phosphoprotein interacts with the linker domain of STAT1","volume":"444","author":"Devaux","year":"2013","journal-title":"Virology"},{"key":"B49","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.vph.2005.08.021","article-title":"JANUS under stress\u2013role of JAK\/STAT signaling pathway in vascular diseases","volume":"43","author":"Grote","year":"2005","journal-title":"Vascul Pharmacol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1161\/HYPERTENSIONAHA.113.02795","article-title":"Interferon regulatory factors in heart: stress response beyond inflammation","volume":"63","author":"Sun","year":"2014","journal-title":"Hypertension"},{"key":"B51","doi-asserted-by":"publisher","first-page":"77998","DOI":"10.18632\/oncotarget.12868","article-title":"Evaluation of quantitative assays for the identification of direct signal transducer and activator of transcription 3 (STAT3) inhibitors","volume":"7","author":"Furtek","year":"2016","journal-title":"Oncotarget"},{"key":"B52","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1158\/1535-7163.MCT-15-0003","article-title":"Applying small molecule Signal Transducer and Activator of Transcription-3 (STAT3) protein inhibitors as pancreatic cancer therapeutics","volume":"15","author":"Arpin","year":"2016","journal-title":"Mol Cancer Ther."},{"key":"B53","doi-asserted-by":"publisher","first-page":"e40724","DOI":"10.1371\/journal.pone.0040724","article-title":"Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines","volume":"7","author":"Bill","year":"2012","journal-title":"PLoS ONE"},{"key":"B54","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1158\/0008-5472.CAN-08-2575","article-title":"Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells","volume":"69","author":"Shin","year":"2009","journal-title":"Cancer Res."},{"key":"B55","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1111\/j.1471-4159.2011.07594.x","article-title":"Resveratrol mitigates lipopolysaccharide- and Abeta-mediated microglial inflammation by inhibiting the TLR4\/NF-kappaB\/STAT signaling cascade","volume":"120","author":"Capiralla","year":"2012","journal-title":"J Neurochem."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1016\/j.chembiol.2012.08.021","article-title":"Revisiting the specificity of small molecule inhibitors: the example of stattic in dendritic cells","volume":"19","author":"Sanseverino","year":"2012","journal-title":"Chem Biol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"6645","DOI":"10.1021\/jm300207s","article-title":"Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein","volume":"55","author":"Debnath","year":"2012","journal-title":"J Med Chem."},{"key":"B58","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/1476-4598-9-165","article-title":"The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity","volume":"9","author":"Bill","year":"2010","journal-title":"Mol Cancer"},{"key":"B59","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/cvr\/cvv103","article-title":"Emerging translational approaches to target STAT3 signalling and its impact on vascular disease","volume":"106","author":"Dutzmann","year":"2015","journal-title":"Cardiovasc Res."},{"key":"B60","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.4049\/jimmunol.147.8.2777","article-title":"Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5'-regulatory region. Induction by cytokines and phorbol ester","volume":"147","author":"Voraberger","year":"1991","journal-title":"J Immunol."},{"key":"B61","doi-asserted-by":"crossref","first-page":"9730","DOI":"10.1073\/pnas.90.20.9730","article-title":"Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide","volume":"90","author":"Lowenstein","year":"1993","journal-title":"Proc Natl Acad Sci USA."},{"key":"B62","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/0014-5793(94)01130-3","article-title":"Synergistic activation of intercellular adhesion molecule 1 (ICAM-1) by TNF-alpha and IFN-gamma is mediated by p65\/p50 and p65\/c-Rel and interferon-responsive factor Stat1 alpha (p91) that can be activated by both IFN-gamma and IFN-alpha","volume":"354","author":"Jahnke","year":"1994","journal-title":"FEBS Lett."},{"key":"B63","doi-asserted-by":"crossref","first-page":"5235","DOI":"10.4049\/jimmunol.154.10.5235","article-title":"The interferon-stimulated response element and a kappa B site mediate synergistic induction of murine IP-10 gene transcription by IFN-gamma and TNF-alpha","volume":"154","author":"Ohmori","year":"1995","journal-title":"J Immunol."},{"key":"B64","doi-asserted-by":"crossref","first-page":"14899","DOI":"10.1074\/jbc.272.23.14899","article-title":"Synergy between interferon-gamma and tumor necrosis factor-alpha in transcriptional activation is mediated by cooperation between signal transducer and activator of transcription 1 and nuclear factor kappaB","volume":"272","author":"Ohmori","year":"1997","journal-title":"J Biol Chem."},{"key":"B65","doi-asserted-by":"crossref","first-page":"4346","DOI":"10.1093\/nar\/25.21.4346","article-title":"Convergence of TNFalpha and IFNgamma signalling pathways through synergistic induction of IRF-1\/ISGF-2 is mediated by a composite GAS\/kappaB promoter element","volume":"25","author":"Pine","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"B66","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1189\/jlb.69.4.598","article-title":"Requirement for STAT1 in LPS-induced gene expression in macrophages","volume":"69","author":"Ohmori","year":"2001","journal-title":"J Leukoc Biol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1042\/BJ20031873","article-title":"Nuclear factor-kappaB motif and interferon-alpha-stimulated response element co-operate in the activation of guanylate-binding protein-1 expression by inflammatory cytokines in endothelial cells","volume":"379","author":"Naschberger","year":"2004","journal-title":"Biochem J."},{"key":"B68","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.celrep.2015.06.021","article-title":"Cooperative transcriptional activation of antimicrobial genes by STAT and NF-kappaB pathways by concerted recruitment of the mediator complex","volume":"12","author":"Wienerroither","year":"2015","journal-title":"Cell Rep."},{"key":"B69","doi-asserted-by":"publisher","first-page":"241","DOI":"10.4161\/jkst.22469","article-title":"STAT1 as a central mediator of IFNgamma and TLR4 signal integration in vascular dysfunction","volume":"1","author":"Sikorski","year":"2012","journal-title":"JAKSTAT"},{"key":"B70","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/nri702","article-title":"Cytokines and autoimmunity","volume":"2","author":"O'Shea","year":"2002","journal-title":"Nat Rev Immunol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"14313","DOI":"10.3390\/ijms150814313","article-title":"Data mining of atherosclerotic plaque transcriptomes predicts STAT1-dependent inflammatory signal integration in vascular disease","volume":"15","author":"Sikorski","year":"2014","journal-title":"Int J Mol Sci."},{"key":"B72","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1093\/cvr\/cvv194","article-title":"Platelets and thromboxane receptors: pivotal players in arteriogenesis","volume":"107","author":"Van","year":"2015","journal-title":"Cardiovasc Res."},{"key":"B73","doi-asserted-by":"publisher","first-page":"20059","DOI":"10.1074\/jbc.R700016200","article-title":"JAK-STAT signaling: from interferons to cytokines","volume":"282","author":"Schindler","year":"2007","journal-title":"J Biol Chem."},{"key":"B74","doi-asserted-by":"crossref","first-page":"27","DOI":"10.18388\/abp.2007_3266","article-title":"STAT activation and differential complex formation dictate selectivity of interferon responses","volume":"54","author":"Wesoly","year":"2007","journal-title":"Acta Biochim Pol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"17432","DOI":"10.1073\/pnas.1418399111","article-title":"Protein kinase IKKbeta-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells","volume":"111","author":"Lopez-Pelaez","year":"2014","journal-title":"Proc Natl Acad Sci USA."},{"key":"B76","doi-asserted-by":"crossref","first-page":"21146","DOI":"10.1016\/S0021-9258(17)31942-7","article-title":"Stimulation of the human intercellular adhesion molecule-1 promoter by interleukin-6 and interferon-gamma involves binding of distinct factors to a palindromic response element","volume":"269","author":"Caldenhoven","year":"1994","journal-title":"J Biol Chem."},{"key":"B77","doi-asserted-by":"publisher","first-page":"3099","DOI":"10.1161\/circ.103.25.3099","article-title":"Genetic deficiency of inducible nitric oxide synthase reduces atherosclerosis and lowers plasma lipid peroxides in apolipoprotein E-knockout mice","volume":"103","author":"Kuhlencordt","year":"2001","journal-title":"Circulation"},{"key":"B78","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1161\/circ.103.8.1115","article-title":"Inducible nitric oxide synthase deficiency does not affect the susceptibility of mice to atherosclerosis but increases collagen content in lesions","volume":"103","author":"Niu","year":"2001","journal-title":"Circulation"},{"key":"B79","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.immuni.2010.07.001","article-title":"Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression","volume":"33","author":"Farlik","year":"2010","journal-title":"Immunity"},{"key":"B80","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1126\/science.8197455","article-title":"Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins","volume":"264","author":"Darnell","year":"1994","journal-title":"Science"},{"key":"B81","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1161\/HYPERTENSIONAHA.111.00299","article-title":"Small-molecule inhibitors of signal transducer and activator of transcription 3 protect against angiotensin II-induced vascular dysfunction and hypertension","volume":"61","author":"Johnson","year":"2013","journal-title":"Hypertension"},{"key":"B82","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1161\/01.CIR.0000043244.13596.20","article-title":"Fluvastatin enhances the inhibitory effects of a selective angiotensin II type 1 receptor blocker, valsartan, on vascular neointimal formation","volume":"107","author":"Horiuchi","year":"2003","journal-title":"Circulation"},{"key":"B83","doi-asserted-by":"publisher","first-page":"H1291","DOI":"10.1152\/ajpheart.00181.2007","article-title":"Angiotensin II and endothelin-1 augment the vascular complications of diabetes via JAK2 activation","volume":"293","author":"Banes-Berceli","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.ejim.2006.12.007","article-title":"STAT1 and STAT3 as intracellular regulators of vascular remodeling","volume":"18","author":"Wincewicz","year":"2007","journal-title":"Eur J Int Med."},{"key":"B85","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1139\/y11-105","article-title":"Losartan inhibits STAT1 activation and protects human glomerular mesangial cells from angiotensin II induced premature senescence","volume":"90","author":"Jiao","year":"2012","journal-title":"Can J Physiol Pharmacol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1593\/neo.11612","article-title":"Glioma cell migration on three-dimensional nanofiber scaffolds is regulated by substrate topography and abolished by inhibition of STAT3 signaling","volume":"13","author":"Agudelo-Garcia","year":"2011","journal-title":"Neoplasia"},{"key":"B87","doi-asserted-by":"publisher","first-page":"7226","DOI":"10.1158\/0008-5472.CAN-10-4660","article-title":"STAT3 is necessary for proliferation and survival in colon cancer-initiating cells","volume":"71","author":"Lin","year":"2011","journal-title":"Cancer Res."},{"key":"B88","doi-asserted-by":"publisher","first-page":"608","DOI":"10.18632\/oncotarget.520","article-title":"Targeting of Rac GTPases blocks the spread of intact human breast cancer","volume":"3","author":"Katz","year":"2012","journal-title":"Oncotarget"},{"key":"B89","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1016\/j.oraloncology.2012.06.00","article-title":"Targeting STAT3 inhibits growth and enhances radiosensitivity in head and neck squamous cell carcinoma","volume":"48","author":"Adachi","year":"2012","journal-title":"Oral Oncol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"2986","DOI":"10.1074\/jbc.M112.386573","article-title":"Cytokine response is determined by duration of receptor and signal transducers and activators of transcription 3 (STAT3) activation","volume":"288","author":"Braun","year":"2013","journal-title":"J Biol Chem."},{"key":"B91","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1160\/TH14-06-0509","article-title":"Interleukin-10 protects against atherosclerosis by modulating multiple atherogenic macrophage function","volume":"113","author":"Han","year":"2015","journal-title":"Thromb Haemost."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.02141\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T06:34:13Z","timestamp":1693895653000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.02141\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,19]]},"references-count":91,"alternative-id":["10.3389\/fimmu.2018.02141"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.02141","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,19]]},"article-number":"2141"}}