{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:46:12Z","timestamp":1790693172048,"version":"4.1.0"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T00:00:00Z","timestamp":1539734400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["W1253-B24"],"award-info":[{"award-number":["W1253-B24"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.02177","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T04:21:29Z","timestamp":1539750089000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":45,"title":["Active Human Complement Reduces the Zika Virus Load via Formation of the Membrane-Attack Complex"],"prefix":"10.3389","volume":"9","author":[{"given":"Britta","family":"Schiela","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Bernklau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Malekshahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Deutschmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Koske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoltan","family":"Banki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole M.","family":"Thielens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"W\u00fcrzner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Speth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guenter","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Stiasny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eike","family":"Steinmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heribert","family":"Stoiber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,10,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S0065-3527(03)59002-9","article-title":"Molecular biology of flaviviruses","volume":"59","author":"Lindenbach","year":"2003","journal-title":"Adv Virus Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1128\/CMR.18.4.608-637.2005","article-title":"Biological transmission of arboviruses: reexamination of and new insights into components, mechanisms, and unique traits as well as their evolutionary trends","volume":"18","author":"Kuno","year":"2005","journal-title":"Clin Microbiol Rev."},{"key":"B3","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/s41594-017-0010-8","article-title":"Structural biology of Zika virus and other flaviviruses","volume":"25","author":"Hasan","year":"2018","journal-title":"Nat Struct Mol Biol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"I100","DOI":"10.1016\/j.vaccine.2008.11.061","article-title":"Complement and its role in protection and pathogenesis of flavivirus infections","volume":"26","author":"Avirutnan","year":"2008","journal-title":"Vaccine"},{"key":"B5","doi-asserted-by":"publisher","first-page":"213","DOI":"10.3389\/fmicb.2017.00213","article-title":"The Complement system in flavivirus infections","volume":"8","author":"Conde","year":"2017","journal-title":"Front Microbiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1146\/annurev-immunol-032713-120154","article-title":"Complement and its receptors: new insights into human disease","volume":"32","author":"Holers","year":"2014","journal-title":"Annu Rev Immunol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1078\/0171-2985-00155","article-title":"Interaction of C1q and mannan-binding lectin with viruses","volume":"205","author":"Thielens","year":"2002","journal-title":"Immunobiology"},{"key":"B8","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1097\/COH.0b013e3283495a26","article-title":"Emerging role for complement in HIV infection","volume":"6","author":"Huber","year":"2011","journal-title":"Curr Opin HIV AIDS"},{"key":"B9","doi-asserted-by":"publisher","first-page":"E510","DOI":"10.1016\/S2214-109X(16)30098-5","article-title":"WHO interim guidance on pregnancy management in the context of Zika virus infection","volume":"4","author":"Oladapo","year":"2016","journal-title":"Lancet Global Health"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1056\/NEJMp1605367","article-title":"Zika and the Risk of Microcephaly","volume":"375","author":"Johansson","year":"2016","journal-title":"N Engl J Med."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1016\/S0140-6736(16)00562-6","article-title":"Guillain-Barre Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study","volume":"387","author":"Cao-Lormeau","year":"2016","journal-title":"Lancet"},{"key":"B12","doi-asserted-by":"publisher","first-page":"4169","DOI":"10.4049\/jimmunol.1001819","article-title":"Selective inhibition of the lectin pathway of complement with phage display selected peptides against mannose-binding lectin-associated serine protease (MASP)-1 and\u22122: significant contribution of MASP-1 to lectin pathway activation","volume":"185","author":"Kocsis","year":"2010","journal-title":"J Immunol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.3201\/eid1408.080287","article-title":"Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia","volume":"14","author":"Lanciotti","year":"2008","journal-title":"Emerg Infect Dis."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1016\/j.immuni.2016.06.002","article-title":"Host inflammatory response to mosquito bites enhances the severity of arbovirus infection","volume":"44","author":"Pingen","year":"2016","journal-title":"Immunity"},{"key":"B15","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1128\/IAI.11.6.1235-1243.1975","article-title":"Function of the classical and alternate pathways of human complement in serum treated with ethylene glycol tetraacetic acid and MgCl2-ethylene glycol tetraacetic acid","volume":"11","author":"Des","year":"1975","journal-title":"Infect Immun."},{"key":"B16","doi-asserted-by":"publisher","first-page":"3487","DOI":"10.1128\/JVI.02128-06","article-title":"Natural antibody and complement mediate neutralization of influenza virus in the absence of prior immunity","volume":"81","author":"Jayasekera","year":"2007","journal-title":"J Virol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.molimm.2013.01.009","article-title":"The control of the complement lectin pathway activation revisited: both C1-inhibitor and antithrombin are likely physiological inhibitors, while alpha2-macroglobulin is not","volume":"54","author":"Parej","year":"2013","journal-title":"Mol Immunol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.1099\/vir.0.012120-0","article-title":"N-linked glycans on dengue viruses grown in mammalian and insect cells","volume":"90","author":"Hacker","year":"2009","journal-title":"J Gen Virol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.chom.2010.07.007","article-title":"Direct complement restriction of flavivirus infection requires glycan recognition by mannose-binding lectin","volume":"8","author":"Fuchs","year":"2010","journal-title":"Cell Host Microbe."},{"key":"B20","doi-asserted-by":"publisher","first-page":"e00276","DOI":"10.1128\/mBio.00276-11","article-title":"Complement-mediated neutralization of dengue virus requires mannose-binding lectin","volume":"2","author":"Avirutnan","year":"2011","journal-title":"MBio"},{"key":"B21","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.virusres.2013.11.007","article-title":"C1q binding to dengue virus decreases levels of infection and inflammatory molecules transcription in THP-1 cells","volume":"179","author":"Douradinha","year":"2014","journal-title":"Virus Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1186\/s12879-015-1271-7","article-title":"Differential proteomic analysis of virus-enriched fractions obtained from plasma pools of patients with dengue fever or severe dengue","volume":"15","author":"Fragnoud","year":"2015","journal-title":"BMC Infect Dis."},{"key":"B23","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.jprot.2015.11.003","article-title":"Novel interactions of domain III from the envelope glycoprotein of dengue 2 virus with human plasma proteins","volume":"131","author":"Huerta","year":"2016","journal-title":"J Proteomics"},{"key":"B24","doi-asserted-by":"publisher","first-page":"e57514","DOI":"10.1371\/journal.pone.0057514","article-title":"Mapping the interactions of dengue virus NS1 protein with human liver proteins using a yeast two-hybrid system: identification of C1q as an interacting partner","volume":"8","author":"Silva","year":"2013","journal-title":"PLoS ONE"},{"key":"B25","doi-asserted-by":"publisher","first-page":"2156","DOI":"10.1126\/science.286.5447.2156","article-title":"Control of early viral and bacterial distribution and disease by natural antibodies","volume":"286","author":"Ochsenbein","year":"1999","journal-title":"Science"},{"key":"B26","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1038\/nri2849","article-title":"The importance of natural IgM: scavenger, protector and regulator","volume":"10","author":"Ehrenstein","year":"2010","journal-title":"Nat Rev Immunol."},{"key":"B27","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.4049\/jimmunol.126.4.1562","article-title":"Neutralization of vesicular stomatitis virus (VSV) by human complement requires a natural IgM antibody present in human serum","volume":"126","author":"Beebe","year":"1981","journal-title":"J Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"6148","DOI":"10.1128\/JVI.00074-14","article-title":"Vesiculovirus neutralization by natural IgM and complement","volume":"88","author":"Tesfay","year":"2014","journal-title":"J Virol."},{"key":"B29","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1128\/JVI.72.3.2253-2258.1998","article-title":"Enhanced virus clearance by early inducible lymphocytic choriomeningitis virus-neutralizing antibodies in immunoglobulin-transgenic mice","volume":"72","author":"Seiler","year":"1998","journal-title":"J Virol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"2250","DOI":"10.1073\/pnas.96.5.2250","article-title":"Innate and acquired humoral immunities to influenza virus are mediated by distinct arms of the immune system","volume":"96","author":"Baumgarth","year":"1999","journal-title":"Proc Natl Acad Sci USA."},{"key":"B31","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1084\/jem.192.2.271","article-title":"B-1 and B-2 cell-derived immunoglobulin M antibodies are nonredundant components of the protective response to influenza virus infection","volume":"192","author":"Baumgarth","year":"2000","journal-title":"J Exp Med."},{"key":"B32","doi-asserted-by":"publisher","first-page":"3053","DOI":"10.1084\/jem.20080979","article-title":"Dual role for B-1a cells in immunity to influenza virus infection","volume":"205","author":"Choi","year":"2008","journal-title":"J Exp Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1084\/jem.20031223","article-title":"A critical role for induced IgM in the protection against West Nile virus infection","volume":"198","author":"Diamond","year":"2003","journal-title":"J Exp Med."},{"key":"B34","doi-asserted-by":"publisher","first-page":"7466","DOI":"10.1128\/JVI.79.12.7466-7477.2005","article-title":"Complement activation is required for induction of a protective antibody response against West Nile virus infection","volume":"79","author":"Mehlhop","year":"2005","journal-title":"J Virol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1084\/jem.20052388","article-title":"Protective immune responses against West Nile virus are primed by distinct complement activation pathways","volume":"203","author":"Mehlhop","year":"2006","journal-title":"J Exp Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.virol.2011.01.003","article-title":"The lectin pathway of complement activation contributes to protection from West Nile virus infection","volume":"412","author":"Fuchs","year":"2011","journal-title":"Virology"},{"key":"B37","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.virol.2009.08.019","article-title":"Complement modulates pathogenesis and antibody-dependent neutralization of West Nile virus infection through a C5-independent mechanism","volume":"393","author":"Mehlhop","year":"2009","journal-title":"Virology"},{"key":"B38","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/0042-6822(88)90105-5","article-title":"Interactions of a nonneutralizing IgM antibody and complement in parainfluenza virus neutralization","volume":"167","author":"Vasantha","year":"1988","journal-title":"Virology"},{"key":"B39","doi-asserted-by":"crossref","first-page":"5869","DOI":"10.1128\/JVI.64.12.5869-5873.1990","article-title":"Neutralization of human immunodeficiency virus type 1 by complement occurs by viral lysis","volume":"64","author":"Spear","year":"1990","journal-title":"J Virol."},{"key":"B40","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1128\/JVI.67.1.53-59.1993","article-title":"Complement activation by human monoclonal antibodies to human immunodeficiency virus","volume":"67","author":"Spear","year":"1993","journal-title":"J Virol."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.02177\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T02:16:10Z","timestamp":1693966570000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.02177\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,17]]},"references-count":40,"alternative-id":["10.3389\/fimmu.2018.02177"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.02177","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,17]]},"article-number":"2177"}}