{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T12:36:27Z","timestamp":1772800587476,"version":"3.50.1"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T00:00:00Z","timestamp":1537833600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.02192","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T04:34:55Z","timestamp":1537850095000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["HFA-BDP Metered-Dose Inhaler Exhaled Through the Nose Improves Eosinophilic Chronic Rhinosinusitis With Bronchial Asthma: A Blinded, Placebo-Controlled Study"],"prefix":"10.3389","volume":"9","author":[{"given":"Yoshiki","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotaka","family":"Yasuba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikiya","family":"Asako","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahisa","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Takano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Tomoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Kanda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Iwai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,9,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"239","DOI":"10.2332\/allergolint.10-RAI-0231","article-title":"Eosinophilic chronic rhinosinusitis in Japan","volume":"59","author":"Ishidoya","year":"2010","journal-title":"Allergol Int."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1016\/j.jaci.2016.05.041","article-title":"Diversity of TH cytokine profiles in patients with chronic rhinosinusitis: a multicenter study in Europe, Asia, and Oceania","volume":"138","author":"Wang","year":"2016","journal-title":"J Allergy Clin Immunol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"27","DOI":"10.2332\/allergolint.13-OA-0579","article-title":"Lung functions of Japanese patients with chronic rhinosinusitis who underwent endoscopic sinus surgery","volume":"63","author":"Tanaka","year":"2014","journal-title":"Allergol Int."},{"key":"B4","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1111\/all.12644","article-title":"Novel scoring system and algorithm for classifying chronic rhinosinusitis: the JESREC Study","volume":"70","author":"Tokunaga","year":"2015","journal-title":"Allergy"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.3109\/02770903.2015.1054404","article-title":"Residual exhaled nitric oxide elevation in asthmatics is associated with eosinophilic chronic rhinosinusitis","volume":"52","author":"Kobayashi","year":"2015","journal-title":"J Asthma"},{"key":"B6","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.jaci.2013.04.052","article-title":"Severe adult-onset asthma: a distinct phenotype","volume":"132","author":"Amelink","year":"2013","journal-title":"J Allergy Clin Immunol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"914","DOI":"10.5414\/CP202100","article-title":"A novel therapeutic use of HFA-BDP metereddose inhaler for asthmatic patients with rhinosinusitis: case series","volume":"52","author":"Kobayashi","year":"2014","journal-title":"Int J Clin Pharmacol Ther."},{"key":"B8","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.jaip.2015.11.018","article-title":"Nasal exhalation of inhaled beclomethasone hydrofluoroalkane-134a to treat chronic rhinosinusitis","volume":"4","author":"Hamada","year":"2015","journal-title":"J Allergy Clin Immunol Pract."},{"key":"B9","doi-asserted-by":"publisher","first-page":"89","DOI":"10.5414\/CP202633","article-title":"Replacement of SFC-DPI with SFC-MDI exhaled through the nose improves eosinophilic chronic rhinosinusitis in patients with bronchial asthma","volume":"55","author":"Kobayashi","year":"2017","journal-title":"Int J Clin Pharmacol Ther."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.5414\/cp203272.","article-title":"Effect of nasally exhaling budesonide\/formoterol dry powder inhaled at \u201cfast\u201d inspiratory flow on eosinophilic chronic rhinosinusitis","author":"Hamada","year":"2018","journal-title":"Int J Clin Pharmacol Ther."},{"key":"B11","unstructured":"GlobalStrategy for Asthma Management and Prevention\n          Global Initiative for Asthma2017"},{"key":"B12","doi-asserted-by":"publisher","first-page":"S17","DOI":"10.1016\/j.jaci.2006.09.005","article-title":"Rhinosinusitis: developing guidance for clinical trials","volume":"118","author":"Meltzer","year":"2006","journal-title":"J Allergy Clin Immunol."},{"key":"B13","first-page":"183","article-title":"Staging in rhinosinusitus","volume":"31","author":"Lund","year":"1993","journal-title":"Rhinology"},{"key":"B14","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/1471-2377-11-157","article-title":"The odor stick identification test for Japanese differentiates Parkinson's disease from multiple system atrophy and progressive supra nuclear palsy","volume":"11","author":"Suzuki","year":"2011","journal-title":"BMC Neurol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1111\/j.1749-4486.2006.01275.x","article-title":"The national comparative audit of surgery for nasal polyposis and chronic rhinosinusitis","volume":"31","author":"Hopkins","year":"2006","journal-title":"Clin Otolaryngol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.jaci.2012.08.023","article-title":"The asthma control test and asthma control questionnaire for assessing asthma control: systematic review and meta-analysis","volume":"131","author":"Jia","year":"2013","journal-title":"J Allergy Clin Immunol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"e27627","DOI":"10.1371\/journal.pone.0027627","article-title":"Defects of protein phosphatase 2A causes corticosteroid insensitivity in severe asthma","volume":"6","author":"Kobayashi","year":"2011","journal-title":"PLoS ONE"},{"key":"B18","doi-asserted-by":"publisher","first-page":"e41582","DOI":"10.1371\/journal.pone.0041582","article-title":"Restoration of corticosteroid sensitivity by p38 mitogen activated protein kinase inhibition in peripheral blood mononuclear cells from severe asthma","volume":"7","author":"Mercado","year":"2012","journal-title":"PLoS ONE"},{"key":"B19","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.pharmthera.2006.04.011","article-title":"Mast cell function: regulation of degranulation by serine\/threonine phosphatases","volume":"112","author":"Sim","year":"2006","journal-title":"Pharmacol Ther."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.3109\/00016489.2015.1063784","article-title":"Post-operative steroid treatment for eosinophilic-type sinonasal polyposis","volume":"135","author":"Brescia","year":"2015","journal-title":"Acta Otolaryngol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"CD011996","DOI":"10.1002\/14651858.CD011996.pub2","article-title":"Intranasal steroids versus placebo or no intervention for chronic rhinosinusitis","volume":"4","author":"Chong","year":"2016","journal-title":"Cochrane Database Syst Rev."},{"key":"B22","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1002\/lary.23212","article-title":"Topical corticosteroids applied with a squirt system are more effective than a nasal spray for steroid-dependent olfactory impairment","volume":"122","author":"Shu","year":"2012","journal-title":"Laryngoscope"},{"key":"B23","doi-asserted-by":"crossref","DOI":"10.1007\/978-981-10-4220-1_11","article-title":"Flow visualization for nasal cavity flow in aerosol exhalation through nose treatment","volume-title":"The 17th International Conference on Biomedical Engineering","author":"Yamamoto","year":"2017"},{"key":"B24","first-page":"17","article-title":"Particle deposition efficiency of therapeutic aerosols in the human maxillary sinus","volume":"27","author":"Hyo","year":"1989","journal-title":"Rhinology"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1124\/mol.111.071993","article-title":"p38 mitogen-activated protein kinase-gamma inhibition by long-acting beta2 adrenergic agonists reversed steroid insensitivity in severe asthma","volume":"80","author":"Mercado","year":"2011","journal-title":"Mol Pharmacol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.pupt.2012.02.005","article-title":"Increased corticosteroid sensitivity by a long acting \u03b22 agonist formoterol via \u03b22 adrenoceptor independent protein phosphatase 2A activation","volume":"25","author":"Kobayashi","year":"2012","journal-title":"Pulm Pharmacol Ther"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.02192\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T04:35:44Z","timestamp":1537850144000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.02192\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,25]]},"references-count":26,"alternative-id":["10.3389\/fimmu.2018.02192"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.02192","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,25]]},"article-number":"2192"}}