{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T01:20:37Z","timestamp":1789780837939,"version":"4.0.1"},"reference-count":92,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T00:00:00Z","timestamp":1537833600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.02201","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T04:38:32Z","timestamp":1537850312000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":91,"title":["Inflammasome: A Double-Edged Sword in Liver Diseases"],"prefix":"10.3389","volume":"9","author":[{"given":"Jingyun","family":"Luan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianwen","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,9,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1038\/nri2873","article-title":"Sterile inflammation: sensing and reacting to damage","volume":"10","author":"Chen","year":"2010","journal-title":"Nat Rev Immunol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.it.2011.01.005","article-title":"Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation","volume":"32","author":"Krysko","year":"2011","journal-title":"Trends Immunol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1146\/annurev-cellbio-101011-155745","article-title":"Inflammasomes and their roles in health and disease","volume":"28","author":"Lamkanfi","year":"2012","journal-title":"Annu Rev Cell Dev Biol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1083\/jcb.201602089","article-title":"The cell biology of inflammasomes: mechanisms of inflammasome activation and regulation","volume":"213","author":"Sharma","year":"2016","journal-title":"J Cell Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/imr.12534","article-title":"Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases","volume":"277","author":"Man","year":"2017","journal-title":"Immunol Rev."},{"key":"B6","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"B7","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.immuni.2017.11.013","article-title":"The pore-forming protein gasdermin D regulates interleukin-1 secretion from living macrophages","volume":"48","author":"Evavold","year":"2018","journal-title":"Immunity"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1053\/j.gastro.2012.09.008","article-title":"Sterile inflammation in the liver","volume":"143","author":"Kubes","year":"2012","journal-title":"Gastroenterology"},{"key":"B9","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.chom.2013.10.013","article-title":"Inflammasome-microbiota interplay in host physiologies","volume":"14","author":"Ayres","year":"2013","journal-title":"Cell Host Microbe"},{"key":"B10","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.cmet.2017.06.018","article-title":"Inflammasomes on the crossroads of innate immune recognition and metabolic control","volume":"26","author":"Pr\u00f3chnicki","year":"2017","journal-title":"Cell Metab."},{"key":"B11","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.tim.2014.09.007","article-title":"Response of host inflammasomes to viral infection","volume":"23","author":"Chen","year":"2015","journal-title":"Trends Microbiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.cmet.2015.09.024","article-title":"IL-18 production from the NLRP1 inflammasome prevents obesity and metabolic syndrome","volume":"23","author":"Murphy","year":"2016","journal-title":"Cell Metab."},{"key":"B13","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.cmet.2015.12.014","article-title":"The NLRP1-IL18 connection: a stab in the back of obesity-induced inflammation","volume":"23","author":"Netea","year":"2016","journal-title":"Cell Metab."},{"key":"B14","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1053\/j.gastro.2014.03.046","article-title":"Monocytes activate natural killer cells via inflammasome induced interleukin 18 in response to hepatitis C virus replication","volume":"147","author":"Serti","year":"2014","journal-title":"Gastroenterology"},{"key":"B15","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nature10809","article-title":"Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity","volume":"482","author":"Henao-Mejia","year":"2012","journal-title":"Nature"},{"key":"B16","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.immuni.2015.08.013","article-title":"The Nlrp3 inflammasome suppresses colorectal cancer metastatic growth in the liver by promoting natural killer cell tumoricidal activity","volume":"43","author":"Dupaul-Chicoine","year":"2015","journal-title":"Immunity"},{"key":"B17","doi-asserted-by":"publisher","first-page":"e1129484","DOI":"10.1080\/2162402X.2015.1129484","article-title":"Linking cancer-induced Nlrp3 inflammasome activation to efficient NK cell-mediated immunosurveillance","volume":"5","author":"Dagenais","year":"2016","journal-title":"Oncoimmunology"},{"key":"B18","doi-asserted-by":"publisher","first-page":"3476","DOI":"10.1172\/JCI60777","article-title":"IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice","volume":"122","author":"Petrasek","year":"2012","journal-title":"J Clin Invest."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1016\/j.jhep.2014.12.027","article-title":"Invariant NKT cells promote alcohol-induced steatohepatitis through interleukin-1\u03b2 in mice","volume":"62","author":"Cui","year":"2015","journal-title":"J Hepatol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1002\/hep.26592","article-title":"NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice","volume":"59","author":"Wree","year":"2014","journal-title":"Hepatology"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.jhep.2017.01.022","article-title":"NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice","volume":"66","author":"Mridha","year":"2017","journal-title":"J Hepatol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"3254","DOI":"10.1074\/jbc.M115.694059","article-title":"The hepatitis C virus-induced NLRP3 inflammasome activates the sterol regulatory element-binding protein (SREBP) and regulates lipid metabolism","volume":"291","author":"McRae","year":"2016","journal-title":"J Biol Chem."},{"key":"B23","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.biomaterials.2016.08.036","article-title":"Inhibition of lanthanide nanocrystal-induced inflammasome activation in macrophages by a surface coating peptide through abrogation of ROS production and TRPM2-mediated Ca(2+) influx","volume":"108","author":"Yao","year":"2016","journal-title":"Biomaterials"},{"key":"B24","doi-asserted-by":"publisher","first-page":"3836","DOI":"10.1021\/acsnano.8b01086","article-title":"Toxicological profiling of metal oxide nanoparticles in liver context reveals pyroptosis in kupffer cells and macrophages versus apoptosis in hepatocytes","volume":"12","author":"Mirshafiee","year":"2018","journal-title":"ACS Nano"},{"key":"B25","doi-asserted-by":"publisher","first-page":"9141","DOI":"10.1039\/c8nr00554k","article-title":"Mesoporous silica nanoparticles induced hepatotoxicity via NLRP3 inflammasome activation and caspase-1-dependent pyroptosis","volume":"10","author":"Zhang","year":"2018","journal-title":"Nanoscale"},{"key":"B26","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.biomaterials.2016.03.003","article-title":"CdSe\/ZnS quantum dots induce hepatocyte pyroptosis and liver inflammation via NLRP3 inflammasome activation","volume":"90","author":"Lu","year":"2016","journal-title":"Biomaterials"},{"key":"B27","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/j.immuni.2015.10.010","article-title":"Inflammasomes coordinate pyroptosis and natural killer cell cytotoxicity to clear infection by a ubiquitous environmental bacterium","volume":"43","author":"Maltez","year":"2015","journal-title":"Immunity"},{"key":"B28","doi-asserted-by":"publisher","first-page":"909827","DOI":"10.1155\/2015\/909827","article-title":"Constitutive activation of the Nlrc4 inflammasome prevents hepatic fibrosis and promotes hepatic regeneration after partial hepatectomy","volume":"2015","author":"DeSantis","year":"2015","journal-title":"Mediators Inflamm."},{"key":"B29","doi-asserted-by":"publisher","first-page":"751374","DOI":"10.1155\/2013\/751374","article-title":"Alcohol-induced liver injury is modulated by Nlrp3 and Nlrc4 inflammasomes in mice","volume":"2013","author":"DeSantis","year":"2013","journal-title":"Mediators Inflamm."},{"key":"B30","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/nature11250","article-title":"NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens","volume":"488","author":"Anand","year":"2012","journal-title":"Nature"},{"key":"B31","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1002\/lt.24770","article-title":"Extracellular vesicles from bone marrow-derived mesenchymal stem cells protect against murine hepatic ischemia\/reperfusion injury","volume":"23","author":"Haga","year":"2017","journal-title":"Liver Transpl."},{"key":"B32","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1073\/pnas.1317643111","article-title":"Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection","volume":"111","author":"Zaki","year":"2014","journal-title":"Proc Natl Acad Sci USA."},{"key":"B33","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/hep.28893","article-title":"Redox-dependent regulation of hepatocyte absent in melanoma 2 inflammasome activation in sterile liver injury in mice","volume":"65","author":"Sun","year":"2017","journal-title":"Hepatology"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1002\/1878-0261.12090","article-title":"HBx-mediated decrease of AIM2 contributes to hepatocellular carcinoma metastasis","volume":"11","author":"Chen","year":"2017","journal-title":"Mol Oncol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.jhep.2014.08.027","article-title":"Absent in melanoma 2 triggers a heightened inflammasome response in ascitic fluid macrophages of patients with cirrhosis","volume":"62","author":"Lozano-Ruiz","year":"2015","journal-title":"J Hepatol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1172\/JCI75254","article-title":"Evasion of inflammasome activation by microbial pathogens","volume":"125","author":"Ulland","year":"2015","journal-title":"J Clin Invest."},{"key":"B37","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/ni.2231","article-title":"Sensing and reacting to microbes through the inflammasomes","volume":"13","author":"Franchi","year":"2012","journal-title":"Nat Immunol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.4049\/jimmunol.1501223","article-title":"Caspase-1 but not caspase-11 is required for NLRC4-mediated pyroptosis and restriction of infection by flagellated legionella species in mouse macrophages and in vivo","volume":"195","author":"Cerqueira","year":"2015","journal-title":"J Immunol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.chom.2014.07.001","article-title":"Epithelium-intrinsic NAIP\/NLRC4 inflammasome drives infected enterocyte expulsion to restrict Salmonella replication in the intestinal mucosa","volume":"16","author":"Sellin","year":"2014","journal-title":"Cell Host Microbe"},{"key":"B40","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1038\/nature10510","article-title":"The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus","volume":"477","author":"Zhao","year":"2011","journal-title":"Nature"},{"key":"B41","doi-asserted-by":"publisher","first-page":"14408","DOI":"10.1073\/pnas.1306376110","article-title":"Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation","volume":"110","author":"Yang","year":"2013","journal-title":"Proc Natl Acad Sci USA."},{"key":"B42","doi-asserted-by":"publisher","first-page":"2213","DOI":"10.3389\/fmicb.2017.02213","article-title":"Chromobacterium violaceum pathogenicity: updates and insights from genome sequencing of novel chromobacterium species","volume":"8","author":"Batista","year":"2017","journal-title":"Front Microbiol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/j.cell.2014.04.007","article-title":"Mechanisms and functions of inflammasomes","volume":"157","author":"Lamkanfi","year":"2014","journal-title":"Cell"},{"key":"B44","doi-asserted-by":"publisher","first-page":"36926","DOI":"10.18632\/oncotarget.6142","article-title":"A single cut to pyroptosis","volume":"6","author":"Yoon","year":"2015","journal-title":"Oncotarget"},{"key":"B45","doi-asserted-by":"publisher","first-page":"e2469","DOI":"10.1371\/journal.pntd.0002469","article-title":"NLRP3 controls Trypanosoma cruzi infection through a caspase-1-dependent IL-1R-independent NO production","volume":"7","author":"Goncalves","year":"2013","journal-title":"PLoS Negl Trop Dis."},{"key":"B46","doi-asserted-by":"publisher","first-page":"913","DOI":"10.3389\/fimmu.2018.00913","article-title":"NLRP3 Inflammasome and caspase-1\/11 pathway orchestrate different outcomes in the host protection against Trypanosoma cruzi acute infection","volume":"9","author":"Paroli","year":"2018","journal-title":"Front Immunol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1101\/sqb.2013.78.021246","article-title":"IL-1beta strikingly enhances antigen-driven CD4 and CD8 T-cell responses","volume":"78","author":"Ben-Sasson","year":"2013","journal-title":"Cold Spring Harb Symp Quant Biol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/nri3707","article-title":"The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing","volume":"14","author":"Gaffen","year":"2014","journal-title":"Nat Rev Immunol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"758","DOI":"10.3389\/fimmu.2018.00758","article-title":"NOD-Like receptor protein 3 inflammasome-dependent IL-1\u03b2 accelerated ConA-induced hepatitis","volume":"9","author":"Luan","year":"2018","journal-title":"Front Immunol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"31715","DOI":"10.1074\/jbc.M113.501122","article-title":"Interleukin-1 and tumor necrosis factor-\u03b1 trigger restriction of hepatitis B virus infection via a cytidine deaminase activation-induced cytidine deaminase (AID)","volume":"288","author":"Watashi","year":"2013","journal-title":"J Biol Chem."},{"key":"B51","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1007\/s13365-017-0574-4","article-title":"Role of the inflammasome-related cytokines IL-1 and IL-18 during infection with murine coronavirus","volume":"23","author":"Zalinger","year":"2017","journal-title":"J Neurovirol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"e1003330","DOI":"10.1371\/journal.ppat.1003330","article-title":"IL-1\u03b2 production through the NLRP3 inflammasome by hepatic macrophages links hepatitis C virus infection with liver inflammation and disease","volume":"9","author":"Negash","year":"2013","journal-title":"PLoS Pathog."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1016\/j.freeradbiomed","article-title":"Linking oxidative stress to inflammation: Toll-like receptors","volume":"48","author":"Gill","year":"2010","journal-title":"Free Radic Biol Med."},{"key":"B54","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/nature08780","article-title":"Circulating mitochondrial DAMPs cause inflammatory responses to injury","volume":"464","author":"Zhang","year":"2010","journal-title":"Nature"},{"key":"B55","doi-asserted-by":"publisher","first-page":"15947","DOI":"10.1074\/jbc.M112.426791","article-title":"Caspase 1 activation is protective against hepatocyte cell death by up-regulating beclin 1 protein and mitochondrial autophagy in the setting of redox stress","volume":"288","author":"Sun","year":"2013","journal-title":"J Biol Chem."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.2119\/molmed.2011.00015","article-title":"Caspase-1 is hepatoprotective during trauma and hemorrhagic shock by reducing liver injury and inflammation","volume":"17","author":"Menzel","year":"2011","journal-title":"Mol Med."},{"key":"B57","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1159\/000329801","article-title":"Mechanisms balancing tolerance and immunity in the liver","volume":"29","author":"B\u00f6ttcher","year":"2011","journal-title":"Dig Dis."},{"key":"B58","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.tem.2014.02.004","article-title":"Role of interleukins in obesity: implications for metabolic disease","volume":"25","author":"Febbraio","year":"2014","journal-title":"Trends Endocrinol Metab."},{"key":"B59","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1038\/nm1415","article-title":"Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance","volume":"12","author":"Netea","year":"2006","journal-title":"Nat Med."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1136\/gut.2010.215665","article-title":"Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models","volume":"59","author":"Murphy","year":"2010","journal-title":"Gut"},{"key":"B61","doi-asserted-by":"publisher","first-page":"G589","DOI":"10.1152\/ajpgi.00488.2011","article-title":"Saturated fat stimulates obesity and hepatic steatosis and affects gut microbiota composition by an enhanced overflow of dietary fat to the distal intestine","volume":"303","author":"de","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.jcmgh.2015.12.008","article-title":"Intestinal dysbiosis contributes to the delayed gastrointestinal transit in high-fat diet fed mice","volume":"2","author":"Anitha","year":"2016","journal-title":"Cell Mol Gastroenterol Hepatol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1016\/j.cell.2015.10.048.","article-title":"Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling","volume":"163","author":"Levy","year":"2015","journal-title":"Cell"},{"key":"B64","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/nature11535","article-title":"IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine","volume":"491","author":"Huber","year":"2012","journal-title":"Nature"},{"key":"B65","doi-asserted-by":"publisher","first-page":"50766","DOI":"10.18632\/oncotarget.9391","article-title":"The inflammasome: an emerging therapeutic oncotarget for cancer prevention","volume":"7","author":"Zhiyu","year":"2016","journal-title":"Oncotarget"},{"key":"B66","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/labinvest.2013.126","article-title":"Deregulation of the NLRP3 inflammasome in hepatic parenchymal cells during liver cancer progression","volume":"94","author":"Wei","year":"2014","journal-title":"Lab Invest."},{"key":"B67","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1038\/labinvest.2015.63","article-title":"Estrogen suppresses hepatocellular carcinoma cells through ER\u03b2-mediated upregulation of the NLRP3 inflammasome","volume":"95","author":"Wei","year":"2015","journal-title":"Lab Invest."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1053\/j.gastro.2011.09.002","article-title":"Alcoholic liver disease: pathogenesis and new therapeutic targets","volume":"141","author":"Gao","year":"2011","journal-title":"Gastroenterology"},{"key":"B69","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1002\/hep.29645","article-title":"Pyroptosis by caspase11\/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients","volume":"67","author":"Khanova","year":"2018","journal-title":"Hepatology"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-315123","article-title":"Alcohol dysregulates miR-148a in hepatocytes through FoxO1, facilitating pyroptosis via TXNIP overexpression","author":"Heo","year":"2018","journal-title":"Gut"},{"key":"B71","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1146\/annurev-med-051215-031109","article-title":"Nonalcoholic Steatohepatitis","volume":"68","author":"Suzuki","year":"2017","journal-title":"Annu Rev Med."},{"key":"B72","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.jhep.2017.11.014","article-title":"Lipotoxicity and the gut-liver axis in NASH pathogenesis","volume":"68","author":"Marra","year":"2018","journal-title":"J Hepatol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nm.2279","article-title":"The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance","volume":"17","author":"Vandanmagsar","year":"2011","journal-title":"Nat Med."},{"key":"B74","doi-asserted-by":"publisher","first-page":"29402","DOI":"10.1074\/jbc.M115.680199","article-title":"Macrophage-specific de novo synthesis of ceramide is dispensable for inflammasome-driven inflammation and insulin resistance in obesity","volume":"290","author":"Camell","year":"2015","journal-title":"J Biol Chem."},{"key":"B75","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1038\/ni.2343","article-title":"Immunological complications of obesity","volume":"13","author":"Kanneganti","year":"2012","journal-title":"Nat Immunol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1002\/hep.24341","article-title":"Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells","volume":"54","author":"Csak","year":"2011","journal-title":"Hepatology"},{"key":"B77","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.jhep.2017.11.040","article-title":"Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice","volume":"68","author":"Xu","year":"2018","journal-title":"J Hepatol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1007\/s00109-014-1170-1","article-title":"NLRP3 inflammasome activation is required for fibrosis development in NAFLD","volume":"92","author":"Wree","year":"2014","journal-title":"J Mol Med."},{"key":"B79","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1111\/imr.12288","article-title":"The cooperation between the autophagy machinery and the inflammasome to implement an appropriate innate immune response: do they regulate each other?","volume":"265","author":"Abdelaziz","year":"2015","journal-title":"Immunol Rev."},{"key":"B80","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1038\/ni.2022","article-title":"Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling","volume":"12","author":"Wen","year":"2011","journal-title":"Nat Immunol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/ni.2228","article-title":"A role for the NLRP3 inflammasome in metabolic diseases\u2014did Warburg miss inflammation?","volume":"13","author":"Wen","year":"2012","journal-title":"Nat Immunol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1080\/15548627.2017.1356977","article-title":"Ezetimibe ameliorates steatohepatitis via AMP activated protein kinase-TFEB-mediated activation of autophagy and NLRP3 inflammasome inhibition","volume":"13","author":"Kim","year":"2017","journal-title":"Autophagy"},{"key":"B83","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1002\/hep.26695","article-title":"Dysbiosis contributes to fibrogenesis in the course of chronic liver injury in mice","volume":"59","author":"De Minicis","year":"2014","journal-title":"Hepatology"},{"key":"B84","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.immuni.2010.03.003","article-title":"The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis","volume":"32","author":"Zaki","year":"2010","journal-title":"Immunity"},{"key":"B85","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/S0140-6736(15)60692-4","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"386","author":"Global","year":"2015","journal-title":"Lancet"},{"key":"B86","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.cyto.2018.04.032","article-title":"The role of the NLRP3 inflammasome and the activation of IL-1\u03b2 in the pathogenesis of chronic viral hepatic inflammation","volume":"110","author":"Molyvdas","year":"2018","journal-title":"Cytokine"},{"key":"B87","doi-asserted-by":"publisher","first-page":"e1004082","DOI":"10.1371\/journal.ppat.1004082","article-title":"HIV and HCV activate the inflammasome in monocytes and macrophages via endosomal Toll-like receptors without induction of type 1 interferon","volume":"10","author":"Chattergoon","year":"2014","journal-title":"Plos Pathog."},{"key":"B88","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.toxlet.2006.12.001","article-title":"Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration","volume":"168","author":"Wang","year":"2007","journal-title":"Toxicol Lett."},{"key":"B89","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J Clin Invest."},{"key":"B90","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.1038\/ncomms3823","article-title":"Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology","volume":"4","author":"Mederacke","year":"2013","journal-title":"Nat Commun."},{"key":"B91","doi-asserted-by":"publisher","first-page":"G1248","DOI":"10.1152\/ajpgi.90223.2008","article-title":"Inflammasome-mediated regulation of hepatic stellate cells","volume":"296","author":"Watanabe","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1002\/hep.29523","article-title":"NLRP3 inflammasome driven liver injury and fibrosis: Roles of IL-17 and TNF in mice","volume":"67","author":"Wree","year":"2017","journal-title":"Hepatology"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.02201\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T04:38:36Z","timestamp":1537850316000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.02201\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,25]]},"references-count":92,"alternative-id":["10.3389\/fimmu.2018.02201"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.02201","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,25]]},"article-number":"2201"}}