{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:28:47Z","timestamp":1789972127085,"version":"4.0.1"},"reference-count":110,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T00:00:00Z","timestamp":1538092800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.02263","type":"journal-article","created":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T04:21:13Z","timestamp":1538108473000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":67,"title":["Bone Remodeling and the Role of TRAF3 in Osteoclastic Bone Resorption"],"prefix":"10.3389","volume":"9","author":[{"given":"Brendan F.","family":"Boyce","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinbo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianping","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenqiang","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,9,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"16041","DOI":"10.1038\/boneres.2016.41","article-title":"Vitamin D, calcium homeostasis and aging","volume":"4","author":"Veldurthy","year":"2016","journal-title":"Bone Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.3390\/ijms16011066","article-title":"Ca2+-dependent regulations and signaling in skeletal muscle: from electro-mechanical coupling to adaptation","volume":"16","author":"Gehlert","year":"2015","journal-title":"Int J Mol Sci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/B978-0-12-804182-6.00011-3","article-title":"Biology of bone and cartilage","volume":"23","author":"Boyce","year":"2018","journal-title":"Genet Bone Biol Skeletal Dis."},{"key":"B4","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s11154-014-9308-6","article-title":"RANKL\/OPG; critical role in bone physiology","volume":"16","author":"Martin","year":"2015","journal-title":"Rev Endocr Metab Disord."},{"key":"B5","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3389\/fendo.2015.00041","article-title":"Coupling signals between the osteoclast and osteoblast: how are messages transmitted between these temporary visitors to the bone surface?","volume":"6","author":"Sims","year":"2015","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B6","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1002\/jbmr.320","article-title":"The amazing osteocyte","volume":"26","author":"Bonewald","year":"2011","journal-title":"J Bone Miner Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1172\/JCI70050","article-title":"Bone marrow mesenchymal stem cells and TGF-beta signaling in bone remodeling","volume":"124","author":"Crane","year":"2014","journal-title":"J Clin Invest."},{"key":"B8","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/nrc.2016.44","article-title":"Bone metastasis: the importance of the neighbourhood","volume":"16","author":"Croucher","year":"2016","journal-title":"Nat Rev Cancer"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1038\/nm.3961","article-title":"Excess TGF-beta mediates muscle weakness associated with bone metastases in mice","volume":"21","author":"Waning","year":"2015","journal-title":"Nat Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1002\/jbmr.1885","article-title":"Advances in osteoclast biology reveal potential new drug targets and new roles for osteoclasts","volume":"28","author":"Boyce","year":"2013","journal-title":"J Bone Miner Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"336","DOI":"10.4248\/BR201304004","article-title":"Mice deficient in NF-kappaB p50 and p52 or RANK have defective growth plate formation and post-natal Dwarfism","volume":"1","author":"Xing","year":"2013","journal-title":"Bone Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"13667","DOI":"10.1038\/srep13667","article-title":"Chondrocytes-specific expression of osteoprotegerin modulates osteoclast formation in metaphyseal bone","volume":"5","author":"Wang","year":"2015","journal-title":"Sci Rep."},{"key":"B13","doi-asserted-by":"publisher","first-page":"125705","DOI":"10.1155\/2013\/125705","article-title":"The role of inflammatory cytokines, the RANKL\/OPG axis, and the immunoskeletal interface in physiological bone turnover and osteoporosis","volume":"2013","author":"Weitzmann","year":"2013","journal-title":"Scientifica"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1136\/annrheumdis-2014-207137","article-title":"RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation","volume":"75","author":"Danks","year":"2016","journal-title":"Ann Rheum Dis."},{"key":"B15","doi-asserted-by":"publisher","first-page":"a021857","DOI":"10.1101\/cshperspect.a021857","article-title":"CSF-1 receptor signaling in myeloid cells","volume":"6","author":"Stanley","year":"2014","journal-title":"Cold Spring Harb Perspect Biol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"706","DOI":"10.14348\/molcells.2017.0225","article-title":"Current understanding of RANK signaling in osteoclast differentiation and maturation","volume":"40","author":"Park","year":"2017","journal-title":"Mol Cells"},{"key":"B17","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1172\/JCI66947","article-title":"Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation","volume":"124","author":"Xiu","year":"2014","journal-title":"J Clin Invest."},{"key":"B18","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.abb.2008.03.018","article-title":"Functions of RANKL\/RANK\/OPG in bone modeling and remodeling","volume":"473","author":"Boyce","year":"2008","journal-title":"Arch Biochem Biophys."},{"key":"B19","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1196\/annals.1365.035","article-title":"Bone remodeling","volume":"1092","author":"Hadjidakis","year":"2006","journal-title":"Ann N Y Acad Sci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1146\/annurev-pathol-011110-130203","article-title":"Disorders of bone remodeling","volume":"6","author":"Feng","year":"2011","journal-title":"Annu Rev Pathol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/microbiolspec.MCHD-0011-2015","article-title":"Osteoclasts-key players in skeletal health and disease","volume":"4","author":"Novack","year":"2016","journal-title":"Microbiol Spectr."},{"key":"B22","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.bone.2017.02.002","article-title":"Osteopetroses, emphasizing potential approaches to treatment","volume":"102","author":"Teti","year":"2017","journal-title":"Bone"},{"key":"B23","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.abb.2008.03.037","article-title":"Osteoclast lineage and function","volume":"473","author":"Vaananen","year":"2008","journal-title":"Arch Biochem Biophys."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1359\/jbmr.2001.16.9.1575","volume":"16","author":"Hauge","year":"2001","journal-title":"J Bone Miner Res."},{"key":"B25","article-title":"Apoptosis in bone cells","volume-title":"Novel Approaches to Treatment of Osteoporosis","author":"Boyce","year":"2001"},{"key":"B26","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1136\/mp.50.3.132","article-title":"Apoptosis in bone physiology and disease","volume":"50","author":"Hughes","year":"1997","journal-title":"Mol Pathol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1038\/nm1096-1132","article-title":"Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-beta","volume":"2","author":"Hughes","year":"1996","journal-title":"Nat Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1038\/nm.1979","article-title":"TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation","volume":"15","author":"Tang","year":"2009","journal-title":"Nat Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2140","DOI":"10.1002\/jbmr.2735","article-title":"Macrophages: their emerging roles in bone","volume":"30","author":"Sinder","year":"2015","journal-title":"J Bone Miner Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"E2556","DOI":"10.1073\/pnas.1713370115","article-title":"Bone degradation machinery of osteoclasts: An HIV-1 target that contributes to bone loss","volume":"115","author":"Raynaud-Messina","year":"2018","journal-title":"Proc Natl Acad Sci USA."},{"key":"B31","doi-asserted-by":"publisher","first-page":"S391","DOI":"10.1093\/infdis\/jis199","article-title":"Bone loss in the HIV-infected patient: evidence, clinical implications, and treatment strategies","volume":"205","author":"Walker Harris","year":"2012","journal-title":"J Infect Dis."},{"key":"B32","doi-asserted-by":"publisher","first-page":"832127","DOI":"10.1155\/2015\/832127","article-title":"Bone loss triggered by the cytokine network in inflammatory autoimmune diseases","volume":"2015","author":"Amarasekara","year":"2015","journal-title":"J Immunol Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/bonekey.2014.17","article-title":"Vitamin D endocrine system and osteoclasts","volume":"3","author":"Takahashi","year":"2014","journal-title":"Bonekey Rep."},{"key":"B34","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.jbo.2016.02.008","article-title":"The role of osteoclasts in breast cancer bone metastasis","volume":"5","author":"Le Pape","year":"2016","journal-title":"J Bone Oncol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.jbo.2016.03.007","article-title":"The role of osteoblasts in bone metastasis","volume":"5","author":"Ottewell","year":"2016","journal-title":"J Bone Oncol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1359\/jbmr.2000.15.7.1337","article-title":"Tartrate-resistant acid phosphatase 5b: a novel serum marker of bone resorption","volume":"15","author":"Halleen","year":"2000","journal-title":"J Bone Miner Res."},{"key":"B37","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/nature07713","article-title":"Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis","volume":"458","author":"Ishii","year":"2009","journal-title":"Nature"},{"key":"B38","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/j.0105-2896.2005.00336.x","article-title":"Osteoclast precursors, RANKL\/RANK, and immunology","volume":"208","author":"Xing","year":"2005","journal-title":"Immunol Rev."},{"key":"B39","doi-asserted-by":"publisher","first-page":"3505","DOI":"10.1096\/fj.12-225763","article-title":"CXCL12\/CXCR4 signaling in the osteoblast regulates the mesenchymal stem cell and osteoclast lineage populations","volume":"27","author":"Shahnazari","year":"2013","journal-title":"FASEB J."},{"key":"B40","doi-asserted-by":"publisher","first-page":"20764","DOI":"10.1073\/pnas.0805133106","article-title":"Regulation of bone formation by osteoclasts involves Wnt\/BMP signaling and the chemokine sphingosine-1-phosphate","volume":"105","author":"Pederson","year":"2008","journal-title":"Proc Natl Acad Sci USA."},{"key":"B41","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1302\/0301-620X.94B7.28927","article-title":"The management of diffuse-type giant cell tumour (pigmented villonodular synovitis) and giant cell tumour of tendon sheath (nodular tenosynovitis)","volume":"94","author":"van der Heijden","year":"2012","journal-title":"J Bone Joint Surg Br."},{"key":"B42","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.autrev.2010.07.001","article-title":"Molecular pathways involved in synovial cell inflammation and tumoral proliferation in diffuse pigmented villonodular synovitis","volume":"9","author":"Fiocco","year":"2010","journal-title":"Autoimmun Rev."},{"key":"B43","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1038\/s41379-018-0012-z","article-title":"An expanded immunohistochemical profile of osteoclast-rich undifferentiated carcinoma of the urinary tract","volume":"31","author":"Priore","year":"2018","journal-title":"Mod Pathol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1186\/s12957-016-0982-6","article-title":"Invasive ductal carcinoma of the breast with osteoclast-like giant cells and clear cell features: a case report of a novel finding and review of the literature","volume":"14","author":"Zagelbaum","year":"2016","journal-title":"World J Surg Oncol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s13058-015-0621-0","article-title":"Human breast cancer cells educate macrophages toward the M2 activation status","volume":"17","author":"Sousa","year":"2015","journal-title":"Breast Cancer Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.3390\/cancers6031670","article-title":"Tumor-associated macrophages as major players in the tumor microenvironment","volume":"6","author":"Chanmee","year":"2014","journal-title":"Cancers (Basel)"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cellimm.2017.04.005","article-title":"Tumor promoting role of anti-tumor macrophages in tumor microenvironment","volume":"316","author":"Goswami","year":"2017","journal-title":"Cell Immunol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/978-94-007-0763-4_7","article-title":"Macrophage fusion and multinucleated giant cells of inflammation","volume":"713","author":"McNally","year":"2011","journal-title":"Adv Exp Med Biol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1002\/art.39489","article-title":"Production of RANKL by memory B cells: a link between B cells and bone erosion in rheumatoid arthritis","volume":"68","author":"Meednu","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1002\/jbmr.3059","article-title":"BMI-1 mediates estrogen-deficiency-induced bone loss by inhibiting reactive oxygen species accumulation and T cell activation","volume":"32","author":"Li","year":"2017","journal-title":"J Bone Miner Res."},{"key":"B51","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1038\/35046102","article-title":"T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma","volume":"408","author":"Takayanagi","year":"2000","journal-title":"Nature"},{"key":"B52","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1002\/jbmr.1547","article-title":"Osteocyte RANKL: new insights into the control of bone remodeling","volume":"27","author":"Xiong","year":"2012","journal-title":"J Bone Miner Res."},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138189","article-title":"Osteocytes, not osteoblasts or lining cells, are the main source of the RANKL required for osteoclast formation in remodeling bone","author":"Xiong","year":"2015","journal-title":"PLoS ONE"},{"key":"B54","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1210\/er.2012-1026","article-title":"The osteocyte: an endocrine cell. and more","volume":"34","author":"Dallas","year":"2013","journal-title":"Endocr Rev."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1038\/nm.2452","article-title":"Evidence for osteocyte regulation of bone homeostasis through RANKL expression","volume":"17","author":"Nakashima","year":"2011","journal-title":"Nat Med."},{"key":"B56","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1038\/bonekey.2013.183","article-title":"Mechanisms of osteoclast-dependent bone formation","volume":"2","author":"Teti","year":"2013","journal-title":"Bonekey Rep."},{"key":"B57","doi-asserted-by":"publisher","first-page":"3505","DOI":"10.1172\/JCI45913","article-title":"OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice","volume":"121","author":"Barrow","year":"2011","journal-title":"J Clin Invest."},{"key":"B58","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1159\/000371845","article-title":"The RANKL-RANK Story","volume":"61","author":"Nagy","year":"2015","journal-title":"Gerontology"},{"key":"B59","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1038\/nm.4076","article-title":"LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption","volume":"22","author":"Luo","year":"2016","journal-title":"Nat Med."},{"key":"B60","doi-asserted-by":"publisher","first-page":"2910","DOI":"10.1242\/jcs.099986","article-title":"Fos plays an essential role in the upregulation of RANK expression in osteoclast precursors within the bone microenvironment","volume":"125","author":"Arai","year":"2012","journal-title":"J Cell Sci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1002\/jcb.21886","article-title":"Lipopolysaccharide suppresses RANK gene expression in macrophages by down-regulating PU","volume":"105","author":"Ishii","year":"2008","journal-title":"J Cell Biochem."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1091\/mbc.e09-07-0584","article-title":"Mitf induction by RANKL is critical for osteoclastogenesis","volume":"21","author":"Lu","year":"2010","journal-title":"Mol Biol Cell."},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018689","article-title":"The critical role of IL-34 in osteoclastogenesis","author":"Chen","year":"2011","journal-title":"PLoS ONE"},{"key":"B64","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/nm.2653","article-title":"Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis","volume":"18","author":"Maeda","year":"2012","journal-title":"Nat Med."},{"key":"B65","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1074\/jbc.M008198200","article-title":"Tumor necrosis factor-alpha (TNF) stimulates RANKL-induced osteoclastogenesis via coupling of TNF type 1 receptor and RANK signaling pathways","volume":"276","author":"Zhang","year":"2001","journal-title":"J Biol Chem."},{"key":"B66","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1097\/BOR.0000000000000509","article-title":"Long-term treatment strategies for postmenopausal osteoporosis","volume":"30","author":"Cosman","year":"2018","journal-title":"Curr Opin Rheumatol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.jpainsymman.2018.05.021","article-title":"Denosumab: AHFS 92:24","volume":"56","author":"Wilcock","year":"2018","journal-title":"J Pain Symptom Manage."},{"key":"B68","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1038\/nrendo.2013.137","article-title":"Osteopetrosis: genetics, treatment and new insights into osteoclast function","volume":"9","author":"Sobacchi","year":"2013","journal-title":"Nat Rev Endocrinol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"372156","DOI":"10.1155\/2015\/372156","article-title":"Osteopetrosis and its relevance for the discovery of new functions associated with the skeleton","volume":"2015","author":"Coudert","year":"2015","journal-title":"Int J Endocrinol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00198-010-1272-8","article-title":"New knowledge on critical osteoclast formation and activation pathways from study of rare genetic diseases of osteoclasts: focus on the RANK\/RANKL axis","volume":"22","author":"Crockett","year":"2011","journal-title":"Osteoporos Int."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1161\/ATVBAHA.109.199661","article-title":"Biomarkers of the osteoprotegerin pathway: clinical correlates, subclinical disease, incident cardiovascular disease, and mortality","volume":"30","author":"Lieb","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1056\/NEJMoa013096","article-title":"Osteoprotegerin deficiency and juvenile Paget's disease","volume":"347","author":"Whyte","year":"2002","journal-title":"N Engl J Med."},{"key":"B73","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1093\/hmg\/11.18.2119","article-title":"A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotype","volume":"11","author":"Cundy","year":"2002","journal-title":"Hum Mol Genet."},{"key":"B74","doi-asserted-by":"publisher","first-page":"2630","DOI":"10.1210\/en.2006-1372","article-title":"In vivo analysis of Wnt signaling in bone","volume":"148","author":"Glass","year":"2007","journal-title":"Endocrinology"},{"key":"B75","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.devcel.2005.02.017","article-title":"Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation","volume":"8","author":"Glass","year":"2005","journal-title":"Dev Cell"},{"key":"B76","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1002\/jbmr.2599","article-title":"Wnt signaling inhibits osteoclast differentiation by activating canonical and noncanonical cAMP\/PKA pathways","volume":"31","author":"Weivoda","year":"2016","journal-title":"J Bone Miner Res."},{"key":"B77","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1038\/nm.3654","article-title":"Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures","volume":"20","author":"Moverare-Skrtic","year":"2014","journal-title":"Nat Med."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1038\/nm.3586","article-title":"Wnt4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor-kappaB","volume":"20","author":"Yu","year":"2014","journal-title":"Nat Med."},{"key":"B79","doi-asserted-by":"publisher","first-page":"4706","DOI":"10.1128\/MCB.05980-11","article-title":"Biphasic and dosage-dependent regulation of osteoclastogenesis by beta-catenin","volume":"31","author":"Wei","year":"2011","journal-title":"Mol Cell Biol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"3482","DOI":"10.1101\/gad.11.24.3482","article-title":"Requirement for NF-kappaB in osteoclast and B-cell development","volume":"11","author":"Franzoso","year":"1997","journal-title":"Genes Dev."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1038\/nm1197-1285","article-title":"Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2","volume":"3","author":"Iotsova","year":"1997","journal-title":"Nat Med."},{"key":"B82","doi-asserted-by":"publisher","first-page":"18245","DOI":"10.1074\/jbc.M610701200","article-title":"NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1","volume":"282","author":"Yamashita","year":"2007","journal-title":"J Biol Chem."},{"key":"B83","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/S1074-7613(00)80390-8","article-title":"TRAF2 is essential for JNK but not NF-kappaB activation and regulates lymphocyte proliferation and survival","volume":"7","author":"Lee","year":"1997","journal-title":"Immunity"},{"key":"B84","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/S1074-7613(00)80391-X","article-title":"Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice","volume":"7","author":"Yeh","year":"1997","journal-title":"Immunity"},{"key":"B85","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/S1074-7613(00)80497-5","article-title":"Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses","volume":"5","author":"Xu","year":"1996","journal-title":"Immunity"},{"key":"B86","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1359\/JBMR.041225","article-title":"TRAF2 is essential for TNF-alpha-induced osteoclastogenesis","volume":"20","author":"Kanazawa","year":"2005","journal-title":"J Bone Miner Res."},{"key":"B87","doi-asserted-by":"publisher","first-page":"9803","DOI":"10.1073\/pnas.96.17.9803","article-title":"Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation","volume":"96","author":"Nakano","year":"1999","journal-title":"Proc Natl Acad Sci USA."},{"key":"B88","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/S0002-9440(10)64578-6","article-title":"TRAF4 deficiency leads to tracheal malformation with resulting alterations in air flow to the lungs","volume":"157","author":"Shiels","year":"2000","journal-title":"Am J Pathol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"3024","DOI":"10.1172\/JCI38716","article-title":"NF-kappaB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism","volume":"119","author":"Yao","year":"2009","journal-title":"J Clin Invest."},{"key":"B90","doi-asserted-by":"publisher","first-page":"12971","DOI":"10.1074\/jbc.M109.076091","article-title":"TRAF3 controls activation of the canonical and alternative NFkappaB by the lymphotoxin beta receptor","volume":"285","author":"Bista","year":"2010","journal-title":"J Biol Chem."},{"key":"B91","doi-asserted-by":"publisher","first-page":"3503","DOI":"10.1073\/pnas.0707959105","article-title":"Control of canonical NF-kappaB activation through the NIK-IKK complex pathway","volume":"105","author":"Zarnegar","year":"2008","journal-title":"Proc Natl Acad Sci USA."},{"key":"B92","doi-asserted-by":"publisher","first-page":"e15383","DOI":"10.1371\/journal.pone.0015383","article-title":"NIK stabilization in osteoclasts results in osteoporosis and enhanced inflammatory osteolysis","volume":"5","author":"Yang","year":"2010","journal-title":"PLoS ONE"},{"key":"B93","doi-asserted-by":"publisher","first-page":"334","DOI":"10.4049\/jimmunol.1401548","article-title":"Myeloid cell TRAF3 regulates immune responses and inhibits inflammation and tumor development in mice","volume":"194","author":"Lalani","year":"2015","journal-title":"J Immunol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"eaan2392","DOI":"10.1126\/scisignal.aan2392","article-title":"Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes","volume":"10","author":"Molony","year":"2017","journal-title":"Sci Signal."},{"key":"B95","article-title":"Deletion of TRAF3 specifically in mesenchymal progenitor cells results in age-related osteoporosis through effects on both osteoblasts and osteoclasts","volume-title":"ASBMR 2014 Annual Meeting (No. FR0362)","author":"Li","year":"2014"},{"key":"B96","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1002\/jcp.26028","article-title":"Hydroxychloroquine affects bone resorption both in vitro and in vivo.","volume":"233","author":"Both","year":"2018","journal-title":"J Cell Physiol."},{"key":"B97","article-title":"Bone-targeted chloroquine inhibits osteoclastogenesis and bone resorption more effectively than chloroquine","volume-title":"ASBMR 2016 Annual Meeting (No. SU0161)","author":"Yao","year":"2016"},{"key":"B98","doi-asserted-by":"publisher","first-page":"10169","DOI":"10.1074\/jbc.M116.771816","article-title":"RANKL cytokine enhances TNF-induced osteoclastogenesis independently of TNF receptor associated factor (TRAF) 6 by degrading TRAF3 in osteoclast precursors","volume":"292","author":"Yao","year":"2017","journal-title":"J Biol Chem."},{"key":"B99","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1128\/MCB.22.4.992-1000.2002","article-title":"Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6","volume":"22","author":"Mizukami","year":"2002","journal-title":"Mol Cell Biol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.cyto.2008.10.010","article-title":"TRAF6 negatively regulates TNFalpha-induced NF-kappaB activation","volume":"45","author":"Funakoshi-Tago","year":"2009","journal-title":"Cytokine"},{"key":"B101","doi-asserted-by":"publisher","first-page":"2889","DOI":"10.1002\/art.39837","article-title":"RANK-independent osteoclast formation and bone erosion in inflammatory arthritis","volume":"68","author":"O'Brien","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1172\/JCI11176","article-title":"TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand","volume":"106","author":"Lam","year":"2000","journal-title":"J Clin Invest."},{"key":"B103","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1186\/ar3379","article-title":"Negative regulation of osteoclastogenesis and bone resorption by cytokines and transcriptional repressors","volume":"13","author":"Zhao","year":"2011","journal-title":"Arthritis Res Ther."},{"key":"B104","doi-asserted-by":"publisher","first-page":"5725","DOI":"10.1016\/j.bmc.2013.07.020","article-title":"Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists","volume":"21","author":"Asano","year":"2013","journal-title":"Bioorg Med Chem."},{"key":"B105","first-page":"508","article-title":"Ocular complications of chloroquine therapy","volume":"92","author":"Lloyd","year":"1965","journal-title":"Can Med Assoc J."},{"key":"B106","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1080\/08820530802049962","article-title":"Ocular toxicity of hydroxychloroquine","volume":"23","author":"Tehrani","year":"2008","journal-title":"Semin Ophthalmol."},{"key":"B107","first-page":"5775","article-title":"A Phase II trial of chloroquine in combination with bortezomib and cyclophosphamide in patients with relapsed and refractory multiple myeloma","volume-title":"ASH Annual Meeting.","author":"Montanari","year":"2014"},{"key":"B108","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.4161\/auto.29264","article-title":"Combined autophagy and proteasome inhibition: a phase 1 trial of hydroxychloroquine and bortezomib in patients with relapsed\/refractory myeloma","volume":"10","author":"Vogl","year":"2014","journal-title":"Autophagy"},{"key":"B109","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.canlet.2016.08.019","article-title":"Inhibition of autophagy with chloroquine potentiates carfilzomib-induced apoptosis in myeloma cells in vitro and in vivo.","volume":"382","author":"Jarauta","year":"2016","journal-title":"Cancer Lett."},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10066","article-title":"Manipulation of the alternative NF-\u03baB pathway in mice has sexually dimorphic effects on bone","author":"Zarei","year":"2018","journal-title":"JBMR Plus"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.02263\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T04:21:18Z","timestamp":1538108478000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.02263\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,28]]},"references-count":110,"alternative-id":["10.3389\/fimmu.2018.02263"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.02263","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,28]]},"article-number":"2263"}}