{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:03:18Z","timestamp":1791547398448,"version":"4.3.4"},"reference-count":96,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T00:00:00Z","timestamp":1539561600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.02271","type":"journal-article","created":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T04:34:22Z","timestamp":1539578062000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":52,"title":["Conjunctival Inflammatory Gene Expression Profiling in Dry Eye Disease: Correlations With HLA-DRA and HLA-DRB1"],"prefix":"10.3389","volume":"9","author":[{"given":"Karima","family":"Kessal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghislaine","family":"Rabut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Daull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-S\u00e9bastien","family":"Garrigue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mylene","family":"Docquier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Melik Parsadaniantz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Baudouin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Brignole-Baudouin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,10,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","article-title":"TFOS DEWS II definition and classification report","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul Surf."},{"key":"B2","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.preteyeres.2012.02.003","article-title":"Ocular surface immunity: homeostatic mechanisms and their disruption in dry eye disease","volume":"31","author":"Barabino","year":"2012","journal-title":"Prog Retin Eye Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3109\/08830185.2012.748052","article-title":"Dry eye as a mucosal autoimmune disease","volume":"32","author":"Stern","year":"2013","journal-title":"Int Rev Immunol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.jtos.2013.07.003","article-title":"Role of hyperosmolarity in the pathogenesis and management of dry eye disease: proceedings of the OCEAN group meeting","volume":"11","author":"Baudouin","year":"2013","journal-title":"Ocul Surf."},{"key":"B5","first-page":"240","article-title":"Dry eye: an inflammatory ocular disease","volume":"9","author":"Hessen","year":"2014","journal-title":"J Ophthalmic Vis Res"},{"key":"B6","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1001\/archophthalmol.2011.364","article-title":"Dry eye disease: an immune-mediated ocular surface disorder","volume":"130","author":"Stevenson","year":"2012","journal-title":"Arch Ophthalmol."},{"key":"B7","first-page":"1458","article-title":"Flow cytometry in impression cytology specimens","volume":"38","author":"Baudouin","year":"1997","journal-title":"a new method for evaluation of conjunctival inflammation Invest Ophthalmol Vis Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1007\/978-1-4615-0717-8_107","article-title":"Flow cytometric analysis of the inflammatory marker HLA-DR in dry eye syndrome: results from 12 months of randomized treatment with topical cyclosporin A","volume":"506","author":"Baudouin","year":"2002","journal-title":"Adv Exp Med Biol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1076\/ceyr.19.3.201.5309","article-title":"Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjogren's syndrome keratoconjunctivitis sicca","volume":"19","author":"Pflugfelder","year":"1999","journal-title":"Curr Eye Res."},{"key":"B10","first-page":"2283","article-title":"Pro- and anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye disease","volume":"42","author":"Solomon","year":"2001","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B11","first-page":"862","article-title":"Tear cytokine and chemokine analysis and clinical correlations in evaporative-type dry eye disease","volume":"16","author":"Enriquez-de-Salamanca","year":"2010","journal-title":"Mol Vis."},{"key":"B12","doi-asserted-by":"publisher","first-page":"S21","DOI":"10.1016\/S0092-8674(02)00696-7","article-title":"Genetic control of MHC class II expression","volume":"109","author":"Ting","year":"2002","journal-title":"Cell"},{"key":"B13","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1167\/iovs.15-16555","article-title":"Correlation between the inflammatory marker HLA-DR and signs and symptoms in moderate to severe dry eye disease","volume":"58","author":"Brignole-Baudouin","year":"2017","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1159\/000027387","article-title":"Conjunctival epithelium expression of HLA-DR in dry eye patients","volume":"213","author":"Tsubota","year":"1999","journal-title":"Ophthalmologica"},{"key":"B15","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.exer.2003.08.005","article-title":"Flow cytometry in conjunctival impression cytology: a new tool for exploring ocular surface pathologies","volume":"78","author":"Brignole-Baudouin","year":"2004","journal-title":"Exp Eye Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1097\/01.ico.0000157421.93522.00","article-title":"Distribution of conjunctival HLA-DR expression and the pathogenesis of damage in early dry eyes","volume":"24","author":"Rolando","year":"2005","journal-title":"Cornea"},{"key":"B17","doi-asserted-by":"publisher","first-page":"BIO1","DOI":"10.1167\/iovs.17-21709","article-title":"The growing need for validated biomarkers and endpoints for dry eye clinical research","volume":"58","author":"Roy","year":"2017","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S0014-4835(03)00087-3","article-title":"Up-regulated gene expression in the conjunctival epithelium of patients with Sjogren's syndrome","volume":"77","author":"Kawasaki","year":"2003","journal-title":"Exp Eye Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3109\/02713683.2013.823213","article-title":"Adaptation of impression cytology to enable conjunctival surface cell transcriptome analysis","volume":"39","author":"Bradley","year":"2014","journal-title":"Curr Eye Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/nbt1385","article-title":"Direct multiplexed measurement of gene expression with color-coded probe pairs","volume":"26","author":"Geiss","year":"2008","journal-title":"Nat Biotechnol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.1158\/0008-5472.CAN-15-0262","article-title":"Evaluating robustness and sensitivity of the nanostring technologies ncounter platform to enable multiplexed gene expression analysis of clinical samples","volume":"75","author":"Veldman-Jones","year":"2015","journal-title":"Cancer Res"},{"key":"B22","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1080\/14737159.2017.1268533","article-title":"NanoString, a novel digital color-coded barcode technology: current and future applications in molecular diagnostics","volume":"17","author":"Tsang","year":"2017","journal-title":"Expert Rev Mol Diagn."},{"key":"B23","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/368215a0","article-title":"Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide","volume":"368","author":"Stern","year":"1994","journal-title":"Nature"},{"key":"B24","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s00262-009-0804-6","article-title":"Regulation of immunity and oncogenesis by the IRF transcription factor family","volume":"59","author":"Savitsky","year":"2010","journal-title":"Cancer Immunol Immunother."},{"key":"B25","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1111\/j.1432-1033.1994.00877.x","article-title":"Induction of the human gene for p44, a hepatitis-C-associated microtubular aggregate protein, by interferon-alpha\/beta","volume":"224","author":"Kitamura","year":"1994","journal-title":"Eur J Biochem."},{"key":"B26","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.virol.2015.02.046","article-title":"IFI44 suppresses HIV-1 LTR promoter activity and facilitates its latency","volume":"481","author":"Power","year":"2015","journal-title":"Virology"},{"key":"B27","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1111\/j.1600-065X.2007.00562.x","article-title":"Recognition of viruses by innate immunity","volume":"220","author":"Takeuchi","year":"2007","journal-title":"Immunol Rev"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1006\/bbrc.2001.5890","article-title":"HSH2: a novel SH2 domain-containing adapter protein involved in tyrosine kinase signaling in hematopoietic cells","volume":"288","author":"Oda","year":"2001","journal-title":"Biochem Biophys Res Commun."},{"key":"B29","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/j.molcel.2006.06.001","article-title":"The human and mouse complement of SH2 domain proteins-establishing the boundaries of phosphotyrosine signaling","volume":"22","author":"Liu","year":"2006","journal-title":"Mol Cell."},{"key":"B30","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/nri2314","article-title":"Interferon-inducible antiviral effectors","volume":"8","author":"Sadler","year":"2008","journal-title":"Nat Rev Immunol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1016\/j.micinf.2007.09.010","article-title":"The Mx GTPase family of interferon-induced antiviral proteins","volume":"9","author":"Haller","year":"2007","journal-title":"Microbes Infect."},{"key":"B32","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1016\/j.biochi.2007.04.015","article-title":"Interferon-induced Mx proteins in antiviral host defense","volume":"89","author":"Haller","year":"2007","journal-title":"Biochimie"},{"key":"B33","doi-asserted-by":"publisher","first-page":"3929","DOI":"10.1038\/sj.emboj.7600420","article-title":"Structural basis for recognition of 2',5'-linked oligoadenylates by human ribonuclease L","volume":"23","author":"Tanaka","year":"2004","journal-title":"EMBO J."},{"key":"B34","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.cytogfr.2007.06.003","article-title":"On the discovery of interferon-inducible, double-stranded RNA activated enzymes: the 2'-5'oligoadenylate synthetases and the protein kinase PKR","volume":"18","author":"Hovanessian","year":"2007","journal-title":"Cytokine Growth Factor Rev."},{"key":"B35","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.exer.2010.12.005","article-title":"Toll-like receptor activation modulates antimicrobial peptide expression by ocular surface cells","volume":"92","author":"Redfern","year":"2011","journal-title":"Exp Eye Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/S1081-1206(10)61120-9","article-title":"Toll-like receptor 2 expression on human conjunctival epithelial cells: a pathway for Staphylococcus aureus involvement in chronic ocular proinflammatory responses","volume":"94","author":"Cook","year":"2005","journal-title":"Ann Allergy Asthma Immunol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1016\/j.ophtha.2005.04.009","article-title":"Expression of Toll-like receptors in healthy and allergic conjunctiva","volume":"112","author":"Bonini","year":"2005","journal-title":"Ophthalmology"},{"key":"B38","doi-asserted-by":"publisher","first-page":"461","DOI":"10.3389\/fimmu.2014.00461","article-title":"Toll-like receptor signaling pathways","volume":"5","author":"Kawasaki","year":"2014","journal-title":"Front Immunol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"3154","DOI":"10.4049\/jimmunol.171.6.3154","article-title":"Subcellular localization of Toll-like receptor 3 in human dendritic cells","volume":"171","author":"Matsumoto","year":"2003","journal-title":"J Immunol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.smim.2014.02.009","article-title":"TNF and MAP kinase signalling pathways","volume":"26","author":"Sabio","year":"2014","journal-title":"Semin Immunol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1002\/jlb.67.1.2","article-title":"CD40-CD40 ligand","volume":"67","author":"van","year":"2000","journal-title":"J Leukoc Biol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"11836","DOI":"10.1021\/bi981067q","article-title":"CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization","volume":"37","author":"Pullen","year":"1998","journal-title":"Biochemistry"},{"key":"B43","doi-asserted-by":"publisher","first-page":"10168","DOI":"10.1021\/bi9909905","article-title":"High-affinity interactions of tumor necrosis factor receptor-associated factors (TRAFs) and CD40 require TRAF trimerization and CD40 multimerization","volume":"38","author":"Pullen","year":"1999","journal-title":"Biochemistry"},{"key":"B44","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S0092-8674(03)00521-X","article-title":"Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes","volume":"114","author":"Micheau","year":"2003","journal-title":"Cell"},{"key":"B45","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1038\/ni.2563","article-title":"Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection","volume":"14","author":"Lupfer","year":"2013","journal-title":"Nat Immunol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/S1074-7613(00)80252-6","article-title":"TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex","volume":"4","author":"Hsu","year":"1996","journal-title":"Immunity"},{"key":"B47","doi-asserted-by":"publisher","first-page":"7420","DOI":"10.1074\/jbc.270.13.7420","article-title":"Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine","volume":"270","author":"Raingeaud","year":"1995","journal-title":"J Biol Chem."},{"key":"B48","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1042\/BJ20130755","article-title":"Endoplasmic reticulum-associated ubiquitin-conjugating enzyme Ube2j1 is a novel substrate of MK2 (MAPKAP kinase-2) involved in MK2-mediated TNFalpha production","volume":"456","author":"Menon","year":"2013","journal-title":"Biochem J"},{"key":"B49","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1006\/bbrc.1998.9434","article-title":"Interleukin-1 beta and reactive oxygen species mediate activation of c-Jun NH2-terminal kinases, in human epithelial cells, by two independent pathways","volume":"251","author":"Roberts","year":"1998","journal-title":"Biochem Biophys Res Commun."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1101\/gad.14.14.1693","article-title":"Lineage commitment in the immune system: the T helper lymphocyte grows up","volume":"14","author":"Glimcher","year":"2000","journal-title":"Genes Dev."},{"key":"B51","doi-asserted-by":"publisher","first-page":"4191","DOI":"10.1182\/blood-2004-12-4726","article-title":"Leukocyte migration and graft-versus-host disease","volume":"105","author":"Wysocki","year":"2005","journal-title":"Blood"},{"key":"B52","doi-asserted-by":"publisher","first-page":"2578","DOI":"10.1172\/JCI118321","article-title":"Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-gamma by natural killer cells in vitro","volume":"96","author":"Carson","year":"1995","journal-title":"J Clin Invest."},{"key":"B53","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/0167-5699(91)90009-I","article-title":"The role of complement in inflammation and phagocytosis","volume":"12","author":"Frank","year":"1991","journal-title":"Immunol Today."},{"key":"B54","first-page":"27","article-title":"Activation and control of the complement system","volume":"22","author":"Reid","year":"1986","journal-title":"Essays Biochem."},{"key":"B55","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1111\/aos.13436","article-title":"Clinical impact of inflammation in dry eye disease: proceedings of the ODISSEY group meeting","volume":"96","author":"Baudouin","year":"2018","journal-title":"Acta Ophthalmol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/S1542-0124(12)70148-9","article-title":"Inflammation in dry eye","volume":"2","author":"Stern","year":"2004","journal-title":"Ocul Surf"},{"key":"B57","first-page":"28","article-title":"Regulation of human leukocyte antigen expression in human conjunctival epithelium","volume":"40","author":"Tsubota","year":"1999","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B58","doi-asserted-by":"publisher","first-page":"S145","DOI":"10.1016\/S1542-0124(12)70241-0","article-title":"Variation in the expression of inflammatory markers and neuroreceptors in human conjunctival epithelial cells","volume":"3","author":"Calonge","year":"2005","journal-title":"Ocul Surf."},{"key":"B59","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1038\/nri1708","article-title":"Regulation of MHC class II gene expression by the class II transactivator","volume":"5","author":"Reith","year":"2005","journal-title":"Nat Rev Immunol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"7510","DOI":"10.1167\/iovs.13-12453","article-title":"Interferon regulatory factor-1 in flagellin-induced reprogramming: potential protective role of CXCL10 in cornea innate defense against Pseudomonas aeruginosa infection","volume":"54","author":"Yoon","year":"2013","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"4187","DOI":"10.4049\/jimmunol.171.8.4187","article-title":"IFN-gamma-induced MHC class II expression: transactivation of class II transactivator promoter IV by IFN regulatory factor-1 is regulated by protein kinase C-alpha","volume":"171","author":"Giroux","year":"2003","journal-title":"J Immunol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"15208","DOI":"10.1074\/jbc.M611907200","article-title":"Minocycline down-regulates MHC II expression in microglia and macrophages through inhibition of IRF-1 and protein kinase C (PKC)alpha\/betaII","volume":"282","author":"Nikodemova","year":"2007","journal-title":"J Biol Chem."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1002\/art.21006","article-title":"Gene expression profiling of minor salivary glands clearly distinguishes primary Sjogren's syndrome patients from healthy control subjects","volume":"52","author":"Hjelmervik","year":"2005","journal-title":"Arthritis Rheum."},{"key":"B64","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/gene.2009.20","article-title":"Peripheral blood gene expression profiling in Sjogren's syndrome","volume":"10","author":"Emamian","year":"2009","journal-title":"Genes Immun."},{"key":"B65","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1089\/jir.2007.0021","article-title":"Antiproliferative activity of the human IFN-alpha-inducible protein IFI44","volume":"27","author":"Hallen","year":"2007","journal-title":"J Interferon Cytokine Res."},{"key":"B66","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s10067-014-2799-4","article-title":"Identification of interferon-inducible genes as diagnostic biomarker for systemic lupus erythematosus","volume":"34","author":"Feng","year":"2015","journal-title":"Clin Rheumatol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"45128","DOI":"10.1074\/jbc.M306283200","article-title":"Cloning and characterization of ALX, an adaptor downstream of CD28","volume":"278","author":"Greene","year":"2003","journal-title":"J Biol Chem."},{"key":"B68","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1038\/gene.2015.23","article-title":"Transcriptome analysis reveals a classical interferon signature induced by IFNlambda4 in human primary cells","volume":"16","author":"Lauber","year":"2015","journal-title":"Genes Immun."},{"key":"B69","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.exer.2010.03.012","article-title":"Toll-like receptors in ocular surface disease","volume":"90","author":"Redfern","year":"2010","journal-title":"Exp Eye Res."},{"key":"B70","first-page":"813","article-title":"Expression of toll-like receptors in human limbal and conjunctival epithelial cells","volume":"13","author":"Li","year":"2007","journal-title":"Mol Vis."},{"key":"B71","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/j.1365-2567.2005.02258.x","article-title":"Toll-like receptor 3 agonist poly (I:C)-induced antiviral response in human corneal epithelial cells","volume":"117","author":"Kumar","year":"2006","journal-title":"Immunology"},{"key":"B72","doi-asserted-by":"publisher","first-page":"2821","DOI":"10.1101\/gad.12.18.2821","article-title":"Tumor necrosis factor receptor-associated factors (TRAFs)\u2013a family of adapter proteins that regulates life and death","volume":"12","author":"Arch","year":"1998","journal-title":"Genes Dev"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1126\/science.7544915","article-title":"TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40","volume":"269","author":"Rothe","year":"1995","journal-title":"Science"},{"key":"B74","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.immuni.2004.08.017","article-title":"Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles","volume":"21","author":"Schneider-Brachert","year":"2004","journal-title":"Immunity"},{"key":"B75","first-page":"1356","article-title":"Flow cytometric analysis of inflammatory markers in conjunctival epithelial cells of patients with dry eyes","volume":"41","author":"Brignole","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B76","first-page":"90","article-title":"Flow cytometric analysis of inflammatory markers in KCS: 6-month treatment with topical cyclosporin A","volume":"42","author":"Brignole","year":"2001","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B77","first-page":"2531","article-title":"Fas- and interferon gamma-induced apoptosis in Chang conjunctival cells: further investigations","volume":"41","author":"De","year":"2000","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B78","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1097\/01.ico.0000133994.22392.47","article-title":"Topical cyclosporine inhibits conjunctival epithelial apoptosis in experimental murine keratoconjunctivitis sicca","volume":"24","author":"Strong","year":"2005","journal-title":"Cornea"},{"key":"B79","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0079-6468(08)70091-2","article-title":"p38 MAP kinase: molecular target for the inhibition of pro-inflammatory cytokines","volume":"38","author":"Adams","year":"2001","journal-title":"Prog Med Chem."},{"key":"B80","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/10061","article-title":"MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis","volume":"1","author":"Kotlyarov","year":"1999","journal-title":"Nat Cell Biol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1746-1596-9-5","article-title":"Dry eye management in a Sjogren's syndrome mouse model by inhibition of p38-MAPK pathway","volume":"9","author":"Ma","year":"2014","journal-title":"Diagn Pathol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"4293","DOI":"10.1167\/iovs.03-1145","article-title":"Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface","volume":"45","author":"Luo","year":"2004","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B83","doi-asserted-by":"publisher","first-page":"e43","DOI":"10.1016\/j.ophtha.2012.03.017","article-title":"Immunomodulatory effect of the topical ophthalmic Janus kinase inhibitor tofacitinib (CP-690,550) in patients with dry eye disease","volume":"119","author":"Huang","year":"2012","journal-title":"Ophthalmology"},{"key":"B84","first-page":"363","article-title":"Transforming growth factor-beta: a general review","volume":"7","author":"Lawrence","year":"1996","journal-title":"Eur Cytokine Netw"},{"key":"B85","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1097\/ICO.0b013e3181cf98ff","article-title":"Evaluation of the transforming growth factor-beta activity in normal and dry eye human tears by CCL-185 cell bioassay","volume":"29","author":"Zheng","year":"2010","journal-title":"Cornea"},{"key":"B86","doi-asserted-by":"publisher","first-page":"3203","DOI":"10.1167\/iovs.08-2476","article-title":"Production and activity of matrix metalloproteinase-9 on the ocular surface increase in dysfunctional tear syndrome","volume":"50","author":"Chotikavanich","year":"2009","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B87","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3109\/02713683.2011.622852","article-title":"Expression of CCR5 and its ligands CCL3,\u22124, and\u22125 in the tear film and ocular surface of patients with dry eye disease","volume":"37","author":"Choi","year":"2012","journal-title":"Curr Eye Res."},{"key":"B88","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/j.jaci.2005.05.033","article-title":"CCR 4 and CCR 5 expression in conjunctival specimens as differential markers of T(H)1\/ T(H)2 in ocular surface disorders","volume":"116","author":"Baudouin","year":"2005","journal-title":"J Allergy Clin Immunol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1093\/rheumatology\/keq121","article-title":"Salivary chemokine levels in patients with primary Sjogren's syndrome","volume":"49","author":"Lee","year":"2010","journal-title":"Rheumatology"},{"key":"B90","doi-asserted-by":"publisher","first-page":"9917","DOI":"10.1093\/nar\/gkx579","article-title":"HMGN1 and 2 remodel core and linker histone tail domains within chromatin","volume":"45","author":"Murphy","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"B91","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1084\/jem.20101354","article-title":"High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses","volume":"209","author":"Yang","year":"2012","journal-title":"J Exp Med."},{"key":"B92","doi-asserted-by":"publisher","first-page":"367","DOI":"10.3324\/haematol.2009.006890","article-title":"Rho GTPase Cdc42 is essential for human T-cell development","volume":"95","author":"Smits","year":"2010","journal-title":"Haematologica"},{"key":"B93","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.2147\/OPTH.S35685","article-title":"Managing Sjogren's syndrome and non-Sjogren syndrome dry eye with anti-inflammatory therapy","volume":"8","author":"Coursey","year":"2014","journal-title":"Clin Ophthalmol"},{"key":"B94","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.2147\/OPTH.S89700","article-title":"Associations between signs and symptoms of dry eye disease: a systematic review","volume":"9","author":"Bartlett","year":"2015","journal-title":"Clin Ophthalmol."},{"key":"B95","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1016\/S1470-2045(13)70449-2","article-title":"Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis","volume":"14","author":"Ramaswamy","year":"2013","journal-title":"Lancet Oncol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s40425-017-0215-8","article-title":"Gene expression markers of tumor infiltrating leukocytes","volume":"5","author":"Danaher","year":"2017","journal-title":"J Immunother Cancer"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.02271\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T04:34:27Z","timestamp":1539578067000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.02271\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,15]]},"references-count":96,"alternative-id":["10.3389\/fimmu.2018.02271"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.02271","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,15]]},"article-number":"2271"}}