{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:38:57Z","timestamp":1792651137953,"version":"4.5.0"},"reference-count":76,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T00:00:00Z","timestamp":1538956800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.02282","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T04:32:59Z","timestamp":1538973179000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":81,"title":["Parasitic Nematodes Exert Antimicrobial Activity and Benefit From Microbiota-Driven Support for Host Immune Regulation"],"prefix":"10.3389","volume":"9","author":[{"given":"Sebastian","family":"Rausch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankur","family":"Midha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Kuhring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Affinass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandar","family":"Radonic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja A.","family":"K\u00fchl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Bleich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard Y.","family":"Renard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,10,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/j.immuni.2015.09.012","article-title":"The intestinal microbiota contributes to the ability of helminths to modulate allergic inflammation","volume":"43","author":"Zaiss","year":"2015","journal-title":"Immunity"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e74026","DOI":"10.1371\/journal.pone.0074026","article-title":"Small intestinal nematode infection of mice is associated with increased enterobacterial loads alongside the intestinal tract","volume":"8","author":"Rausch","year":"2013","journal-title":"PLoS ONE"},{"key":"B3","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s40168-015-0103-8","article-title":"Type 2 immunity-dependent reduction of segmented filamentous bacteria in mice infected with the helminthic parasite Nippostrongylus brasiliensis","volume":"3","author":"Fricke","year":"2015","journal-title":"Microbiome"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2150","DOI":"10.1128\/IAI.00141-12","article-title":"Alterations in the porcine colon microbiota induced by the gastrointestinal nematode Trichuris suis","volume":"80","author":"Li","year":"2012","journal-title":"Infect Immun."},{"key":"B5","doi-asserted-by":"publisher","first-page":"e1003000","DOI":"10.1371\/journal.ppat.1003000","article-title":"Therapeutic helminth infection of macaques with idiopathic chronic diarrhea alters the inflammatory signature and mucosal microbiota of the colon","volume":"8","author":"Broadhurst","year":"2012","journal-title":"PLoS Pathog."},{"key":"B6","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1006\/expr.2001.4643","article-title":"Trichuris suis: detection of antibacterial activity in excretory-secretory products from adults","volume":"99","author":"Abner","year":"2001","journal-title":"Exp Parasitol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"144","DOI":"10.3389\/fcimb.2017.00144","article-title":"Reciprocal interactions between nematodes and their microbial environments","volume":"7","author":"Midha","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3389\/fcimb.2018.00271.","article-title":"The intestinal roundworm ascaris suum releases antimicrobial factors which interfere with bacterial growth and biofilm formation","volume":"8","author":"Midha","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.exppara.2011.08.011","article-title":"Immune modulation and modulators in Heligmosomoides polygyrus infection","volume":"132","author":"Maizels","year":"2012","journal-title":"Exp Parasitol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.jaci.2016.07.007","article-title":"Regulation of the host immune system by helminth parasites","volume":"138","author":"Maizels","year":"2016","journal-title":"J Allergy Clin Immunol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.4049\/jimmunol.1401217","article-title":"A novel regulatory macrophage induced by a helminth molecule instructs IL-10 in CD4+ T cells and protects against mucosal inflammation","volume":"194","author":"Ziegler","year":"2015","journal-title":"J Immunol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e1003913","DOI":"10.1371\/journal.ppat.1003913","article-title":"Foxp3+ regulatory T cells delay expulsion of intestinal nematodes by suppression of IL-9-driven mast cell activation in BALB\/c but not in C57BL\/6 mice","volume":"10","author":"Blankenhaus","year":"2014","journal-title":"PLoS Pathog."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1002\/eji.200636751","article-title":"Expansion and activation of CD4+CD25+ regulatory T cells in Heligmosomoides polygyrus infection","volume":"37","author":"Finney","year":"2007","journal-title":"Eur J Immunol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1084\/jem.20101074","article-title":"Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-\u03b2 pathway","volume":"207","author":"Grainger","year":"2010","journal-title":"J Exp Med."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1908","DOI":"10.1128\/IAI.01233-07","article-title":"Functional analysis of effector and regulatory T cells in a parasitic nematode infection","volume":"76","author":"Rausch","year":"2008","journal-title":"Infect Immun."},{"key":"B16","doi-asserted-by":"publisher","first-page":"3066","DOI":"10.1002\/eji.200939644","article-title":"Establishment of nematode infection despite increased Th2 responses and immunopathology after selective depletion of Foxp3+ cells","volume":"39","author":"Rausch","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"522","DOI":"10.4161\/gmic.32155","article-title":"Commensal-pathogen interactions in the intestinal tract","volume":"5","author":"Reynolds","year":"2014","journal-title":"Gut Microb."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1084\/jem.20042572","article-title":"Suppression of allergic airway inflammation by helminth-induced regulatory T cells","volume":"202","author":"Wilson","year":"2005","journal-title":"J Exp Med."},{"key":"B19","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1128\/AAC.40.10.2280","article-title":"Evaluation of susceptibility of gram-positive and -negative bacteria to human defensins by using radial diffusion assay","volume":"40","author":"Takemura","year":"1996","journal-title":"Antimicrob Agents Chemother."},{"key":"B20","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3390\/bios7010012","article-title":"High bacterial agglutination activity in a single-CRD C-type lectin from Spodoptera exigua (Lepidoptera: Noctuidae)","volume":"7","author":"Gasmi","year":"2017","journal-title":"Biosensors"},{"key":"B21","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"B22","doi-asserted-by":"publisher","first-page":"R46","DOI":"10.1186\/gb-2014-15-3-r46","article-title":"Kraken: ultrafast metagenomic sequence classification using exact alignments","volume":"15","author":"Wood","year":"2014","journal-title":"Genome Biol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"R36","DOI":"10.1186\/gb-2013-14-4-r36","article-title":"TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions","volume":"14","author":"Kim","year":"2013","journal-title":"Genome Biol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/nbt.2450","article-title":"Differential analysis of gene regulation at transcript resolution with RNA-seq","volume":"31","author":"Trapnell","year":"2013","journal-title":"Nat Biotechnol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.molbiopara.2016.11.005","article-title":"WormBase ParaSite \u2013 a comprehensive resource for helminth genomics","volume":"215","author":"Howe","year":"2017","journal-title":"Mol Biochem Parasitol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"B27","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/S0168-9525(00)02024-2","article-title":"EMBOSS: the European molecular biology open software suite","volume":"16","author":"Rice","year":"2000","journal-title":"Trends Genet."},{"key":"B30","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"B31","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1186\/1471-2105-10-421","article-title":"BLAST+: architecture and applications","volume":"10","author":"Camacho","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"B32","doi-asserted-by":"publisher","first-page":"3674","DOI":"10.1093\/bioinformatics\/bti610","article-title":"Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research","volume":"21","author":"Conesa","year":"2005","journal-title":"Bioinformatics"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1093\/bioinformatics\/btu031","article-title":"InterProScan 5: genome-scale protein function classification","volume":"30","author":"Jones","year":"2014","journal-title":"Bioinformatics"},{"key":"B34","doi-asserted-by":"crossref","first-page":"D158","DOI":"10.1093\/nar\/gkw1099","article-title":"UniProt: the universal protein knowledgebase","volume":"45","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1093\/nar\/gkh131","article-title":"Eosinophils are required to suppress Th2 responses in Peyer's patches during intestinal infection by nematodes","volume":"10","author":"Strandmark","year":"2017","journal-title":"Mucosal Immunol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1002\/ibd.21299","article-title":"Alteration of the murine gut microbiota during infection with the parasitic helminth Heligmosomoides polygyrus","volume":"16","author":"Walk","year":"2010","journal-title":"Inflamm Bowel Dis."},{"key":"B37","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.dci.2014.02.002","article-title":"The C-type lectin-like domain containing proteins Clec-39 and Clec-49 are crucial for Caenorhabditis elegans immunity against Serratia marcescens infection","volume":"45","author":"Miltsch","year":"2014","journal-title":"Dev Comp Immunol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.parint.2009.08.011","article-title":"C-type lectins from the nematode parasites Heligmosomoides polygyrus and Nippostrongylus brasiliensis","volume":"58","author":"Harcus","year":"2009","journal-title":"Parasitol Int."},{"key":"B39","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/0014-4894(72)90060-4","article-title":"Infectivity, fecundity, and survival of Nematospiroides dubius in gnotobiotic mice","volume":"32","author":"Chang","year":"1972","journal-title":"Exp Parasitol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/0014-4894(68)90099-4","article-title":"Experimental Nematospiroides dubius infection in germfree and conventional mice","volume":"22","author":"Wescott","year":"1968","journal-title":"Exp Parasitol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"138","DOI":"10.2307\/3276048","article-title":"A Comparison of the development of Nippostrongylus brasiliensis in germ-free and conventional mice","volume":"50","author":"Wescott","year":"1964","journal-title":"J Parasitol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"24","DOI":"10.2307\/3283340","article-title":"The food resource of adult Heligmosomoides polygyrus in the small intestine","volume":"80","author":"Bansemir","year":"1994","journal-title":"J Parasitol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1126\/science.aac4263","article-title":"The microbiota regulates type 2 immunity through ROR\u03b3t+ T cells","volume":"349","author":"Ohnmacht","year":"2015","journal-title":"Science"},{"key":"B44","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1126\/science.1241165","article-title":"The microbial metabolites, short-chain fatty acids, regulate colonic treg cell homeostasis","volume":"341","author":"Smith","year":"2013","journal-title":"Science"},{"key":"B45","doi-asserted-by":"publisher","first-page":"12204","DOI":"10.1073\/pnas.0909122107","article-title":"Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota","volume":"107","author":"Round","year":"2010","journal-title":"Proc Natl Acad Sci USA."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1016\/j.celrep.2014.11.006","article-title":"Regulatory T cells occupy an isolated niche in the intestine that is antigen independent","volume":"9","author":"Korn","year":"2014","journal-title":"Cell Rep."},{"key":"B47","doi-asserted-by":"publisher","first-page":"e156","DOI":"10.1038\/cti.2017.39","article-title":"Functional heterogeneity of gut-resident regulatory T cells","volume":"6","author":"Luu","year":"2017","journal-title":"Clin Transl Immunol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.immuni.2011.08.012","article-title":"An essential role of the transcription factor GATA-3 for the function of regulatory t cells","volume":"35","author":"Wang","year":"2011","journal-title":"Immunity"},{"key":"B49","doi-asserted-by":"publisher","first-page":"4503","DOI":"10.1172\/JCI57456","article-title":"GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice","volume":"121","author":"Wohlfert","year":"2011","journal-title":"J Clin Invest."},{"key":"B50","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1038\/mi.2015.74","article-title":"Foxp3+ T cells expressing ROR\u03b3t represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation","volume":"9","author":"Yang","year":"2016","journal-title":"Mucosal Immunol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3389\/fcimb.2017.00261","article-title":"Th2\/1 hybrid cells occurring in murine and human strongyloidiasis share effector functions of Th1 cells","volume":"7","author":"Bock","year":"2017","journal-title":"Front. Cell. Infect. Microbiol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"e1001633","DOI":"10.1371\/journal.pbio.1001633","article-title":"Stable T-bet(+)GATA-3(+) Th1\/Th2 hybrid cells arise in vivo, can develop directly from naive precursors, and limit immunopathologic inflammation","volume":"11","author":"Peine","year":"2013","journal-title":"PLoS Biol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.cell.2015.08.058","article-title":"Th17 cell induction by adhesion of microbes to intestinal epithelial cells","volume":"163","author":"Atarashi","year":"2015","journal-title":"Cell"},{"key":"B54","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.cell.2009.09.033","article-title":"Induction of intestinal Th17 cells by segmented filamentous bacteria","volume":"139","author":"Ivanov","year":"2009","journal-title":"Cell"},{"key":"B55","doi-asserted-by":"publisher","first-page":"e00101","DOI":"10.1128\/IAI.00101-17","article-title":"Parasitic protozoa and interactions with the host intestinal microbiota","volume":"85","author":"Burgess","year":"2017","journal-title":"Infect Immun."},{"key":"B56","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/pim.12274","article-title":"Interactions between the intestinal microbiome and helminth parasites","volume":"38","author":"Zaiss","year":"2016","journal-title":"Parasite Immunol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"e0125495","DOI":"10.1371\/journal.pone.0125495","article-title":"Chronic trichuris muris infection decreases diversity of the intestinal microbiota and concomitantly increases the abundance of Lactobacilli","volume":"10","author":"Holm","year":"2015","journal-title":"PLOS ONE"},{"key":"B58","doi-asserted-by":"publisher","first-page":"e00948","DOI":"10.1128\/IAI.00948-16","article-title":"Giardia alters commensal microbial diversity throughout the murine gut","volume":"85","author":"Barash","year":"2017","journal-title":"Infect Immun."},{"key":"B59","doi-asserted-by":"publisher","first-page":"8785","DOI":"10.4049\/jimmunol.177.12.8785","article-title":"Gram-negative bacteria aggravate murine small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii","volume":"177","author":"Heimesaat","year":"2006","journal-title":"J Immunol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"948","DOI":"10.4049\/jimmunol.171.2.948","article-title":"Dependence of IL-4, IL-13, and nematode-induced alterations in murine small intestinal smooth muscle contractility on Stat6 and enteric nerves","volume":"171","author":"Zhao","year":"2003","journal-title":"J Immunol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1471-2172-9-11","article-title":"IL-4\/IL-13 independent goblet cell hyperplasia in experimental helminth infections","volume":"9","author":"Marillier","year":"2008","journal-title":"BMC Immunol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"e1283385","DOI":"10.1080\/21688370.2017.1283385","article-title":"Helminths and intestinal barrier function","volume":"5","author":"McKay","year":"2017","journal-title":"Tissue Barr."},{"key":"B63","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/j.0105-2896.2004.00192.x","article-title":"Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites","volume":"201","author":"Finkelman","year":"2004","journal-title":"Immunol. Rev."},{"key":"B64","doi-asserted-by":"publisher","first-page":"e0178647","DOI":"10.1371\/journal.pone.0178647","article-title":"Giardia co-infection promotes the secretion of antimicrobial peptides beta-defensin 2 and trefoil factor 3 and attenuates attaching and effacing bacteria-induced intestinal disease","volume":"12","author":"Manko","year":"2017","journal-title":"PLOS ONE"},{"key":"B65","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1042\/bj20021948","article-title":"Induction of ASABF (Ascaris suum antibacterial factor)-type antimicrobial peptides by bacterial injection: novel members of ASABF in the nematode Ascaris suum","volume":"371","author":"Pillai","year":"2003","journal-title":"Biochem J."},{"key":"B66","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1042\/BJ20050218","article-title":"Cecropin P1 and novel nematode cecropins: a bacteria-inducible antimicrobial peptide family in the nematode Ascaris suum","volume":"390","author":"Pillai","year":"2005","journal-title":"Biochem J."},{"key":"B67","doi-asserted-by":"publisher","first-page":"E3941","DOI":"10.1073\/pnas.1607183113","article-title":"Caenorhabditis elegans responses to bacteria from its natural habitats","volume":"113","author":"Samuel","year":"2016","journal-title":"Proc Natl Acad Sci USA."},{"key":"B68","doi-asserted-by":"publisher","first-page":"e44255","DOI":"10.1371\/journal.pone.0044255","article-title":"System wide analysis of the evolution of innate immunity in the nematode model species Caenorhabditis elegans and Pristionchus pacificus","volume":"7","author":"Sinha","year":"2012","journal-title":"PLoS ONE"},{"key":"B69","doi-asserted-by":"publisher","first-page":"e93119","DOI":"10.1371\/journal.pone.0093119","article-title":"Chitinases are negative regulators of Francisella novicida biofilms","volume":"9","author":"Chung","year":"2014","journal-title":"PLoS ONE"},{"key":"B70","doi-asserted-by":"publisher","first-page":"20150299","DOI":"10.1098\/rstb.2015.0299","article-title":"Antimicrobial effectors in the nematode Caenorhabditis elegans: an outgroup to the Arthropoda","volume":"371","author":"Dierking","year":"2016","journal-title":"Philos Trans R Soc B Biol Sci."},{"key":"B71","doi-asserted-by":"publisher","first-page":"e1005795","DOI":"10.1371\/journal.ppat.1005795","article-title":"Surveillance immunity: an emerging paradigm of innate defense activation in Caenorhabditis elegans","volume":"12","author":"Pukkila-Worley","year":"2016","journal-title":"PLOS Pathog."},{"key":"B72","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1186\/1471-2148-8-114","article-title":"Diversification and adaptive sequence evolution of Caenorhabditislysozymes (Nematoda: Rhabditidae)","volume":"8","author":"Schulenburg","year":"2008","journal-title":"BMC Evol Biol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/icb.2013.109","article-title":"Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection","volume":"92","author":"Filbey","year":"2014","journal-title":"Immunol Cell Biol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/mi.2015.73","article-title":"Low-level regulatory T-cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths","volume":"9","author":"Smith","year":"2016","journal-title":"Mucosal Immunol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1016\/j.immuni.2011.03.021","article-title":"Intestinal bacterial colonization induces mutualistic regulatory T cell responses","volume":"34","author":"Geuking","year":"2011","journal-title":"Immunity"},{"key":"B76","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.immuni.2008.02.017","article-title":"Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces","volume":"28","author":"Rubtsov","year":"2008","journal-title":"Immunity"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.02282\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T18:53:03Z","timestamp":1572029583000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.02282\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,8]]},"references-count":76,"alternative-id":["10.3389\/fimmu.2018.02282"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.02282","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,8]]},"article-number":"2282"}}