{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:59:49Z","timestamp":1790747989037,"version":"4.1.0"},"reference-count":85,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T00:00:00Z","timestamp":1539561600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI096879"],"award-info":[{"award-number":["R01 AI096879"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.02348","type":"journal-article","created":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T15:17:46Z","timestamp":1539616666000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":34,"title":["2D Kinetic Analysis of TCR and CD8 Coreceptor for LCMV GP33 Epitopes"],"prefix":"10.3389","volume":"9","author":[{"given":"Elizabeth M.","family":"Kolawole","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakieb","family":"Andargachew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesica R.","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian D.","family":"Evavold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,10,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1084\/jem.141.6.1427","article-title":"H-2 compatability requirement for T-cell-mediated lysis of targeT cells infected with lymphocytic choriomeningitis virus","volume":"141","author":"Zinkernagel","year":"1975","journal-title":"J Exp Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1136\/jcp.47.11.965","article-title":"Virus infections in primary immunodeficiency","volume":"47","author":"Webster","year":"1994","journal-title":"J Clin Pathol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1006\/viro.1997.8627","article-title":"The signal sequence of lymphocytic choriomeningitis virus contains an immunodominant cytotoxic T cell epitope that is restricted by both H-2Db and H-2Kb molecules","volume":"234","author":"Hudrisier","year":"1997","journal-title":"Virology"},{"key":"B4","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.immuni.2011.09.013","article-title":"T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex","volume":"35","author":"Adams","year":"2011","journal-title":"Immunity"},{"key":"B5","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/384577a0","article-title":"CD8 enhances formation of stable T-cell receptor\/MHC class I molecule complexes","volume":"384","author":"Garcia","year":"1996","journal-title":"Nature"},{"key":"B6","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1038\/nature08944","article-title":"The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness","volume":"464","author":"Huang","year":"2010","journal-title":"Nature"},{"key":"B7","doi-asserted-by":"publisher","first-page":"258","DOI":"10.4049\/jimmunol.1100267","article-title":"Mechanical Interactions between Dendritic Cells and T cells Correlate with T cell Responsiveness","volume":"187","author":"Lim","year":"2011","journal-title":"J Immunol."},{"key":"B8","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1128\/JVI.69.4.2297-2305.1995","article-title":"Optimal lymphocytic choriomeningitis virus sequences restricted by H-2Db major histocompatibility complex class I molecules and presented to cytotoxic T lymphocytes","volume":"69","author":"Gairin","year":"1995","journal-title":"J Virol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/j.cell.2018.06.017","article-title":"Isolation of a structural mechanism for uncoupling T cell receptor signaling from peptide-MHC binding","volume":"174","author":"Sibener","year":"2018","journal-title":"Cell"},{"key":"B10","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.cell.2014.02.053","article-title":"Accumulation of dynamic catch bonds between TCR and agonist peptide-MHC triggers T cell signaling","volume":"157","author":"Liu","year":"2014","journal-title":"Cell"},{"key":"B11","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1002\/eji.201445358","article-title":"The cellular environment regulates in situ kinetics of T-cell receptor interaction with peptide major histocompatibility complex","volume":"45","author":"Liu","year":"2015","journal-title":"Eur J Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1126\/science.aad9964","article-title":"Phase separation of signaling molecules promotes T cell receptor signal transduction","volume":"352","author":"Su","year":"2016","journal-title":"Science"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1529\/biophysj.105.080044","article-title":"Ligand detection and discrimination by spatial relocalization: A kinase-phosphatase segregation model of TCR activation","volume":"91","author":"Burroughs","year":"2006","journal-title":"Biophys J."},{"key":"B14","doi-asserted-by":"publisher","first-page":"E9338","DOI":"10.1073\/pnas.1710358114","article-title":"In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase","volume":"114","author":"Carbone","year":"2017","journal-title":"Proc Natl Acad Sci USA."},{"key":"B15","doi-asserted-by":"publisher","first-page":"4295","DOI":"10.1182\/blood-2012-07-442251","article-title":"The large ectodomains of CD45 and CD148 regulate their segregation from and inhibition of ligated T-cell receptor","volume":"121","author":"Cordoba","year":"2013","journal-title":"Blood"},{"key":"B16","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.it.2005.09.011","article-title":"Understanding specificity and sensitivity of T-cell recognition","volume":"26","author":"George","year":"2005","journal-title":"Trends Immunol."},{"key":"B17","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/ni1173","article-title":"How T cells \u2018see' antigen","volume":"6","author":"Krogsgaard","year":"2005","journal-title":"Nat Immunol."},{"key":"B18","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1146\/annurev.immunol.17.1.467","article-title":"The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation","volume":"17","author":"Germain","year":"1999","journal-title":"Annu Rev Immunol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/1074-7613(95)90074-8","article-title":"T cell receptor antagonists and partial agonists","volume":"2","author":"Jameson","year":"1995","journal-title":"Immunity"},{"key":"B20","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/380495a0","article-title":"Essential flexibility in the T cell recognition of antigen","volume":"380","author":"Kersh","year":"1996","journal-title":"Nature"},{"key":"B21","doi-asserted-by":"publisher","first-page":"86","DOI":"10.3389\/fimmu.2012.00086","article-title":"Insights into T cell recognition of antigen: significance of two-dimensional kinetic parameters","volume":"3","author":"Edwards","year":"2012","journal-title":"Front Immunol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1002\/eji.201343774","article-title":"2D TCR-pMHC-CD8 kinetics determines T-cell responses in a self-antigen-specific TCR system","volume":"44","author":"Liu","year":"2014","journal-title":"Eur J Immunol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"6973","DOI":"10.1073\/pnas.1221609110","article-title":"T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy","volume":"110","author":"Zhong","year":"","journal-title":"Proc Natl Acad Sci USA."},{"key":"B24","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/j.1600-065X.1997.tb01003.x","article-title":"What can we learn about human immunodeficiency virus infection from a study of lymphocytic choriomeningitis virus?","volume":"159","author":"Klenerman","year":"1997","journal-title":"Immunol Rev."},{"key":"B25","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1084\/jem.160.2.521","article-title":"Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice","volume":"60","author":"Ahmed","year":"1984","journal-title":"J Exp Med."},{"key":"B26","doi-asserted-by":"crossref","first-page":"912","DOI":"10.4049\/jimmunol.130.2.912","article-title":"Virus-induced immune complex disease: genetic control of C1q binding complexes in the circulation of mice persistently infected with lymphocytic choriomeningitis virus","volume":"130","author":"Oldstone","year":"1983","journal-title":"J Immunol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1038\/28860","article-title":"Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes","volume":"394","author":"Klenerman","year":"1998","journal-title":"Nature"},{"key":"B28","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1038\/nature04444","article-title":"Restoring function in exhausted CD8 T cells during chronic viral infection","volume":"439","author":"Barber","year":"2006","journal-title":"Nature"},{"key":"B29","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/S1074-7613(00)80470-7","article-title":"Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection","volume":"8","author":"Murali-Krishna","year":"1998","journal-title":"Immunity"},{"key":"B30","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1084\/jem.188.12.2205","article-title":"Viral immune evasion due to persistence of activated T cells without effector function","volume":"188","author":"Zajac","year":"1998","journal-title":"J Exp Med."},{"key":"B31","doi-asserted-by":"publisher","first-page":"4911","DOI":"10.1128\/JVI.77.8.4911-4927.2003","article-title":"Van Der, Ahmed R","volume":"77","author":"Wherry","year":"2003","journal-title":"J Virol."},{"key":"B32","doi-asserted-by":"crossref","first-page":"7423","DOI":"10.1128\/JVI.69.12.7423-7429.1995","article-title":"Discriminated selection among viral peptides with the appropriate anchor residues: implications for the size of the cytotoxic T-lymphocyte repertoire and control of viral infection","volume":"69","author":"Oldstone","year":"1995","journal-title":"J Virol."},{"key":"B33","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1084\/jem.187.10.1647-b","article-title":"Protective immunity does not correlate with the hierarchy of virus-specific cytotoxic T cell responses to naturally processed peptides","volume":"187","author":"Gallimore","year":"1998","journal-title":"J Exp Med."},{"key":"B34","doi-asserted-by":"crossref","first-page":"5764","DOI":"10.1128\/JVI.71.8.5764-5768.1997","article-title":"Functional management of an antiviral cytotoxic T-cell response","volume":"71","author":"Bachmann","year":"1997","journal-title":"J Virol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1006\/jmbi.2000.4501","article-title":"Viral escape at the molecular level explained by quantitative T-cell receptor\/peptide\/MHC interactions and the crystal structure of a peptide\/MHC complex","volume":"302","author":"Tissot","year":"2000","journal-title":"J Mol Biol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/ni1559","article-title":"T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation","volume":"9","author":"Henrickson","year":"2008","journal-title":"Nat. Immunol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1006\/viro.1997.8934","article-title":"Identification of Db- and Kb-restricted subdominant cytotoxic T-cell responses in lymphocytic choriomeningitis virus-infected mice","volume":"240","author":"van","year":"1998","journal-title":"Virology"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.6.2439","article-title":"Participation in TCR \u2013 ligand binding","author":"Renard","year":"1996","journal-title":"J Exp Med."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1084\/jem.194.10.1485","article-title":"CD8beta endows CD8 with efficient coreceptor function by coupling T cell receptor\/CD3 to raft-associated CD8\/p56(lck) complexes","volume":"194","author":"Arcaro","year":"2001","journal-title":"J Exp Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"23799","DOI":"10.1074\/jbc.M700976200","article-title":"Different T cell receptor affinity thresholds and CD8 coreceptor dependence govern cytotoxic T lymphocyte activation and tetramer binding properties","volume":"282","author":"Laugel","year":"2007","journal-title":"J Biol Chem."},{"key":"B41","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.immuni.2010.12.017","article-title":"Two-stage cooperative T cell receptor-peptide major histocompatibility complex-CD8 trimolecular interactions amplify antigen discrimination","volume":"34","author":"Jiang","year":"2011","journal-title":"Immunity"},{"key":"B42","doi-asserted-by":"publisher","first-page":"2348","DOI":"10.4049\/jimmunol.1200244","article-title":"Stability and function of secondary Th1 memory cells are dependent on the nature of the secondary stimulus","volume":"189","author":"Kim","year":"2012","journal-title":"J Immunol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1084\/jem.20101574","article-title":"High prevalence of low affinity peptide\u2013MHC II tetramer\u2013negative effectors during polyclonal CD4 + T cell responses","volume":"208","author":"Sabatino","year":"2011","journal-title":"J Exp Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"19","DOI":"10.4049\/jimmunol.1800295","article-title":"CD4 T cell affinity diversity is equally maintained during acute and chronic infection","volume":"201","author":"Andargachew","year":"2018","journal-title":"J Immunol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"13848","DOI":"10.1038\/ncomms13848.","article-title":"Low-affinity CD4+ T cells are major responders in the primary immune response","volume":"7","author":"Martinez","year":"2016","journal-title":"Nat Commun."},{"key":"B46","doi-asserted-by":"publisher","first-page":"7653","DOI":"10.4049\/jimmunol.179.11.7653","article-title":"Kinetics of MHC-CD8 interaction at the T cell membrane","volume":"179","author":"Huang","year":"2007","journal-title":"J Immunol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"11281","DOI":"10.1073\/pnas.0401870101","article-title":"Mechanical switching and coupling between two dissociation pathways in a P-selectin adhesion bond","volume":"101","author":"Evans","year":"2004","journal-title":"Proc Natl Acad Sci USA."},{"key":"B48","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3791\/52975","article-title":"Fluorescence biomembrane force probe: concurrent quantitation of receptor-ligand kinetics and binding-induced intracellular signaling on a single cell","volume":"102","author":"Chen","year":"2015","journal-title":"J Vis Exp."},{"key":"B49","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1529\/biophysj.107.117895","article-title":"Monitoring receptor-ligand interactions between surfaces by thermal fluctuations","volume":"94","author":"Chen","year":"2008","journal-title":"Biophys J."},{"key":"B50","doi-asserted-by":"publisher","first-page":"4493","DOI":"10.4049\/jimmunol.171.9.4493","article-title":"Interplay between TCR affinity and necessity of coreceptor ligation: high-affinity peptide-MHC\/TCR interaction overcomes lack of CD8 engagement","volume":"171","author":"Kerry","year":"2003","journal-title":"J. Immunol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"2952","DOI":"10.4049\/jimmunol.179.5.2952","article-title":"CD8+ T cell Activation is governed by TCR-peptide\/MHC affinity, not dissociation rate","volume":"179","author":"Tian","year":"2007","journal-title":"J Immunol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1002\/eji.200636743","article-title":"Potent T cell agonism mediated by a very rapid TCR\/pMHC interaction","volume":"37","author":"Boulter","year":"2007","journal-title":"Eur J Immunol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1038\/nature08746","article-title":"TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity","volume":"463","author":"Huppa","year":"2010","journal-title":"Nature"},{"key":"B54","doi-asserted-by":"publisher","first-page":"e32562","DOI":"10.1371\/journal.pone.0032562","article-title":"Low 2-dimensional CD4 T cell receptor affinity for myelin sets in motion delayed response kinetics","volume":"7","author":"Rosenthal","year":"2012","journal-title":"PLoS ONE"},{"key":"B55","doi-asserted-by":"publisher","first-page":"2838","DOI":"10.4049\/jimmunol.1500639","article-title":"Low-affinity memory CD8+ T cells mediate robust heterologous immunity","volume":"196","author":"Krummey","year":"2016","journal-title":"J Immunol."},{"key":"B56","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1084\/jem.166.4.956","article-title":"A single amino acid substitution on the alpha3 domain of the H-2 class-I molecule abrogates reactivity with CTL","volume":"166","author":"Potter","year":"1987","journal-title":"J Exp Med."},{"key":"B57","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/337073a0","article-title":"Substitution at the 227 of H-2 class-I molecules abrogates recognition by Cd8- dependent, but not CD8- independent, cytotoxic T lymphocytes","volume":"337","author":"Potter","year":"1989","journal-title":"Nature"},{"key":"B58","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/345041a0","article-title":"A binding site for the T-cell co-receptor CD8 on the alpha 3 domain of HLA-A2","volume":"345","author":"Salter","year":"1990","journal-title":"Nature"},{"key":"B59","doi-asserted-by":"publisher","first-page":"32786","DOI":"10.1074\/jbc.M102498200","article-title":"The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor \u03b7 chain","volume":"276","author":"Purbhoo","year":"2001","journal-title":"J Biol Chem."},{"key":"B60","doi-asserted-by":"publisher","first-page":"31028","DOI":"10.1074\/jbc.M109.052712","article-title":"The \u03b1\u03b2 T cell receptor is an anisotropic mechanosensor","volume":"284","author":"Kim","year":"2009","journal-title":"J Biol Chem."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1073\/pnas.1424829112","article-title":"Force-dependent transition in the T-cell receptor \u03b2-subunit allosterically regulates peptide discrimination and pMHC bond lifetime","volume":"112","author":"Das","year":"2015","journal-title":"Proc Natl Acad Sci USA."},{"key":"B62","doi-asserted-by":"publisher","first-page":"5610","DOI":"10.1073\/pnas.1600163113","article-title":"DNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity","volume":"113","author":"Liu","year":"2016","journal-title":"Proc Natl Acad Sci USA."},{"key":"B63","doi-asserted-by":"publisher","first-page":"3557","DOI":"10.4049\/jimmunol.1501407","article-title":"Force-regulated in situ TCR\u2013peptide-bound MHC class II kinetics determine functions of CD4 + T cells","volume":"195","author":"Hong","year":"2015","journal-title":"J Immunol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"E8204","DOI":"10.1073\/pnas.1703559114","article-title":"Mechanosensing drives acuity of \u03b1\u03b2 T-cell recognition","volume":"114","author":"Feng","year":"2017","journal-title":"Proc Natl Acad Sci USA."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1084\/jem.20110308","article-title":"T cell receptor signal strength in T reg and iNKT cell development demonstrated by a novel fluorescent reporter mouse","volume":"208","author":"Moran","year":"2011","journal-title":"J Exp Med."},{"key":"B66","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.immuni.2013.10.007","article-title":"Interferon regulatory factor 4 sustains CD8+ T cell expansion and effector differentiation","volume":"39","author":"Yao","year":"2013","journal-title":"Immunity"},{"key":"B67","doi-asserted-by":"publisher","first-page":"15019","DOI":"10.1073\/pnas.1309378110","article-title":"The transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8+ T cells","volume":"110","author":"Raczkowski","year":"2013","journal-title":"Proc Natl Acad Sci USA."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1038\/ni.2710","article-title":"The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells","volume":"14","author":"Man","year":"2013","journal-title":"Nat Immunol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.celrep.2013.07.008","article-title":"Low-affinity T cells are programmed to maintain normal primary responses but are impaired in their recall to low-affinity ligands","volume":"4","author":"Knudson","year":"2013","journal-title":"Cell Rep."},{"key":"B70","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1038\/nature05269","article-title":"Thymic selection threshold defined by compartmentalization of Ras\/MAPK signalling","volume":"444","author":"Daniels","year":"2006","journal-title":"Nature"},{"key":"B71","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/nature07657","article-title":"Complete but curtailed T-cell response to very low-affinity antigen","volume":"458","author":"Zehn","year":"2009","journal-title":"Nature"},{"key":"B72","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/j.1600-065X.1998.tb01205.x","article-title":"Hierarchies of antigen-specific cytotoxic T-cell responses","volume":"164","author":"Gallimore","year":"1998","journal-title":"Immunol Rev."},{"key":"B73","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1146\/annurev.immunol.17.1.51","article-title":"Immunodominance in major histocompatibility complex class I\u2013restricted T lymphocyte responses 1","volume":"17","author":"Yewdell","year":"1999","journal-title":"Annu. Rev. Immunol."},{"key":"B74","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1074-7613(00)80161-2","article-title":"Dissecting the multifactorial causes of immunodominance in class I\u2013restricted T cell responses to viruses","volume":"12","author":"Chen","year":"2000","journal-title":"Immunity"},{"key":"B75","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.1128\/MCB.00136-08","article-title":"How antigen quantity and quality determine T-cell decisions in lymphoid tissue","volume":"28","author":"Zheng","year":"2008","journal-title":"Mol Cell Biol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3389\/fimmu.2018.00025","article-title":"Integrins modulate T cell receptor signaling by constraining actin flow at the immunological synapse","volume":"9","author":"Jankowska","year":"2018","journal-title":"Front Immunol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"10281","DOI":"10.1038\/ncomms10281","article-title":"Stepwise B-cell-dependent expansion of T helper clonotypes diversifies the T-cell response","volume":"7","author":"Merkenschlager","year":"2016","journal-title":"Nat Commun."},{"key":"B78","doi-asserted-by":"publisher","first-page":"4162","DOI":"10.4049\/jimmunol.1501464","article-title":"Regulatory and T effector cells have overlapping low to high ranges in TCR affinities for self during demyelinating Disease","volume":"195","author":"Hood","year":"2015","journal-title":"J Immunol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.3389\/fimmu.2018.01290","article-title":"T cell receptor\u2013major histocompatibility complex interaction strength defines trafficking and CD103+ memory status of CD8 T cells in the Brain","volume":"9","author":"Sanecka","year":"2018","journal-title":"Front Immunol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"E3679","DOI":"10.1073\/pnas.1413726111","article-title":"A sharp T-cell antigen receptor signaling threshold for T-cell proliferation","volume":"111","author":"Au-Yeung","year":"2014","journal-title":"Proc Natl Acad Sci USA."},{"key":"B81","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1038\/nature16141","article-title":"A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance","volume":"528","author":"Feng","year":"2015","journal-title":"Nature"},{"key":"B82","doi-asserted-by":"publisher","first-page":"170","DOI":"10.3389\/fimmu.2013.00170","article-title":"Monitoring the dynamics of T cell clonal diversity using recombinant peptide:MHC technology","volume":"4","author":"Blanchfield","year":"2013","journal-title":"Front Immunol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"468","DOI":"10.3389\/fimmu.2015.00468","article-title":"Lower affinity T cells are critical components and active participants of the immune response","volume":"6","author":"Martinez","year":"2015","journal-title":"Front Immunol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"e0149582","DOI":"10.1371\/journal.pone.0149582","article-title":"Viral escape mutant epitope maintains TCR affinity for antigen yet curtails CD8 T cell responses","volume":"11","author":"Shorter","year":"2016","journal-title":"PLoS ONE"},{"key":"B85","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/S1074-7613(00)80178-8","article-title":"A functional hot spot for antigen recognition in a superagonist TCR\/MHC complex","volume":"12","author":"Degano","year":"2000","journal-title":"Immunity"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.02348\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T00:36:02Z","timestamp":1693960562000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.02348\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,15]]},"references-count":85,"alternative-id":["10.3389\/fimmu.2018.02348"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.02348","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,15]]},"article-number":"2348"}}