{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:14:30Z","timestamp":1787026470438,"version":"build-2736575974"},"reference-count":76,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T00:00:00Z","timestamp":1539820800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010571","name":"Bundesministerium f\u00fcr Bildung, Wissenschaft, Forschung und Technologie","doi-asserted-by":"publisher","award":["FKZ 03ZZ0816A"],"award-info":[{"award-number":["FKZ 03ZZ0816A"]}],"id":[{"id":"10.13039\/501100010571","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.02405","type":"journal-article","created":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T00:34:35Z","timestamp":1539822875000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":35,"title":["Intranasal Vaccination With Lipoproteins Confers Protection Against Pneumococcal Colonisation"],"prefix":"10.3389","volume":"9","author":[{"given":"Franziska","family":"Vo\u00df","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas P.","family":"Kohler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed R.","family":"Abdullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred J.","family":"van Opzeeland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malek","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Michalik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"van Selm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marien I.","family":"de Jonge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Hammerschmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,10,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3346\/jkms.2013.28.1.4","article-title":"Clinical implications of pneumococcal serotypes: invasive disease potential, clinical presentations, and antibiotic resistance","volume":"28","author":"Song","year":"2013","journal-title":"J Korean Med Sci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.vaccine.2012.04.093","article-title":"Pneumococcal vaccines WHO position paper\u22122012","volume":"87","year":"2012","journal-title":"Wkly Epidemiol Rec."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1056\/NEJMoa022823","article-title":"Decline in invasive pneumococcal disease after the introduction of protein-polysaccharide conjugate vaccine","volume":"348","author":"Whitney","year":"2003","journal-title":"N Engl J Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"5012","DOI":"10.1016\/j.vaccine.2010.05.021","article-title":"Efficacy of 7-valent pneumococcal conjugate vaccination in Germany: an analysis using the indirect cohort method","volume":"28","author":"Ruckinger","year":"2010","journal-title":"Vaccine"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e39150","DOI":"10.1371\/journal.pone.0039150","article-title":"Effect of serotype on focus and mortality of invasive pneumococcal disease: coverage of different vaccines and insight into non-vaccine serotypes","volume":"7","author":"van Hoek","year":"2012","journal-title":"PLoS ONE"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1962","DOI":"10.1016\/S0140-6736(10)62225-8","article-title":"Serotype replacement in disease after pneumococcal vaccination","volume":"378","author":"Weinberger","year":"2011","journal-title":"Lancet"},{"key":"B7","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.mimet.2015.03.006","article-title":"Current methods for capsular typing of Streptococcus pneumoniae","volume":"113","author":"Jauneikaite","year":"2015","journal-title":"J Microbiol Methods"},{"key":"B8","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1080\/21645515.2015.1052198","article-title":"Next generation protein based Streptococcus pneumoniae vaccines","volume":"12","author":"Pichichero","year":"2016","journal-title":"Hum Vaccines Immunotherapeut."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1111\/mmi.12729","article-title":"Structure of the pneumococcal l,d-carboxypeptidase DacB and pathophysiological effects of disabled cell wall hydrolases DacA and DacB","volume":"93","author":"Abdullah","year":"2014","journal-title":"Mol Microbiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.1002\/emmm.201202435","article-title":"Molecular architecture of Streptococcus pneumoniae surface thioredoxin-fold lipoproteins crucial for extracellular oxidative stress resistance and maintenance of virulence","volume":"5","author":"Saleh","year":"2013","journal-title":"EMBO Mol Med."},{"key":"B11","doi-asserted-by":"publisher","first-page":"e0118154","DOI":"10.1371\/journal.pone.0118154","article-title":"Conserved surface accessible nucleoside ABC transporter component SP0845 is essential for pneumococcal virulence and confers protection in vivo","volume":"10","author":"Saxena","year":"2015","journal-title":"PLoS ONE"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e49638","DOI":"10.1371\/journal.pone.0049638","article-title":"The effects of methionine acquisition and synthesis on Streptococcus pneumoniae growth and virulence","volume":"8","author":"Basavanna","year":"2013","journal-title":"PLoS ONE"},{"key":"B13","doi-asserted-by":"crossref","first-page":"5255","DOI":"10.1128\/IAI.64.12.5255-5262.1996","article-title":"Sequence heterogeneity of PsaA, a 37-kilodalton putative adhesin essential for virulence of Streptococcus pneumoniae","volume":"64","author":"Berry","year":"1996","journal-title":"Infect Immun."},{"key":"B14","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1111\/j.1365-2958.2004.04164.x","article-title":"Molecular analysis of the psa permease complex of Streptococcus pneumoniae","volume":"53","author":"McAllister","year":"2004","journal-title":"Mol Microbiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1016\/S0969-2126(98)00153-1","article-title":"The crystal structure of pneumococcal surface antigen PsaA reveals a metal-binding site and a novel structure for a putative ABC-type binding protein","volume":"6","author":"Lawrence","year":"1998","journal-title":"Structure"},{"key":"B16","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1046\/j.1365-2958.1997.5111879.x","article-title":"Competence and virulence of Streptococcus pneumoniae: Adc and PsaA mutants exhibit a requirement for Zn and Mn resulting from inactivation of putative ABC metal permeases","volume":"25","author":"Dintilhac","year":"1997","journal-title":"Mol Microbiol."},{"key":"B17","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1128\/IAI.65.5.1967-1971.1997","article-title":"Limited diversity of Streptococcus pneumoniae psaA among pneumococcal vaccine serotypes","volume":"65","author":"Sampson","year":"1997","journal-title":"Infect Immun."},{"key":"B18","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.micpath.2007.02.003","article-title":"E-cadherin is a receptor for the common protein pneumococcal surface adhesin A (PsaA) of Streptococcus pneumoniae","volume":"42","author":"Anderton","year":"2007","journal-title":"Microbial Pathogen."},{"key":"B19","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1128\/JCM.38.1.434-437.2000","article-title":"Confirmation of psaA in all 90 serotypes of Streptococcus pneumoniae by PCR and potential of this assay for identification and diagnosis","volume":"38","author":"Morrison","year":"2000","journal-title":"J Clin Microbiol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1086\/315822","article-title":"Natural development of antibodies to pneumococcal surface protein A, pneumococcal surface adhesin A, and pneumolysin in relation to pneumococcal carriage and acute otitis media","volume":"182","author":"Rapola","year":"2000","journal-title":"J Infect Dis."},{"key":"B21","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1086\/319246","article-title":"Pneumococcal carriage and otitis media induce salivary antibodies to pneumococcal surface adhesin a, pneumolysin, and pneumococcal surface protein a in children","volume":"183","author":"Simell","year":"2001","journal-title":"J Infect Dis."},{"key":"B22","doi-asserted-by":"publisher","first-page":"3331","DOI":"10.1128\/IAI.72.6.3331-3335.2004","article-title":"Age-specific immunoglobulin g (IgG) and IgA to pneumococcal protein antigens in a population in coastal kenya","volume":"72","author":"Laine","year":"2004","journal-title":"Infect. Immun."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1016\/S0264-410X(99)00511-3","article-title":"The potential to use PspA and other pneumococcal proteins to elicit protection against pneumococcal infection","volume":"18","author":"Briles","year":"2000","journal-title":"Vaccine"},{"key":"B24","doi-asserted-by":"publisher","first-page":"3303","DOI":"10.1007\/s00018-012-1234-8","article-title":"Serotype-independent pneumococcal vaccines","volume":"70","author":"Miyaji","year":"2013","journal-title":"Cell Mol Life Sci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"3982","DOI":"10.1016\/j.vaccine.2011.03.081","article-title":"Th17\/Th1 biased immunity to the pneumococcal proteins PcsB, StkP and PsaA in adults of different age","volume":"29","author":"Schmid","year":"2011","journal-title":"Vaccine"},{"key":"B26","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.1128\/IAI.01632-13","article-title":"Toll-like receptor 2-dependent protection against pneumococcal carriage by immunization with lipidated pneumococcal proteins","volume":"82","author":"Moffitt","year":"2014","journal-title":"Infect Immun."},{"key":"B27","article-title":"Pneumococcal protein vaccine GEN-004 reduces experimental human pneumococcal carriage in healthy adults","volume-title":"International Symposium on Pneumococci and Pneumococcal Diseases","author":"Skoberne","year":"2016"},{"key":"B28","doi-asserted-by":"publisher","first-page":"e51174","DOI":"10.3791\/51174","article-title":"Following in real time the impact of pneumococcal virulence factors in an acute mouse pneumonia model using bioluminescent bacteria","volume":"84","author":"Saleh","year":"2014","journal-title":"J Visual Exp."},{"key":"B29","doi-asserted-by":"publisher","first-page":"3412","DOI":"10.1128\/IAI.01543-08","article-title":"Screening of Streptococcus pneumoniae ABC transporter mutants demonstrates that LivJHMGF, a branched-chain amino acid ABC transporter, is necessary for disease pathogenesis","volume":"77","author":"Basavanna","year":"2009","journal-title":"Infect Immun."},{"key":"B30","doi-asserted-by":"publisher","first-page":"3118","DOI":"10.1096\/fj.06-7992com","article-title":"Thrombospondin-1 promotes cellular adherence of gram-positive pathogens via recognition of peptidoglycan","volume":"21","author":"Rennemeier","year":"2007","journal-title":"FASEB J."},{"key":"B31","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/S0923-2508(02)01312-8","article-title":"Construction of new unencapsulated (rough) strains of Streptococcus pneumoniae","volume":"153","author":"Pearce","year":"2002","journal-title":"Res Microbiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1074\/jbc.M510014200","article-title":"The streptococcal lipoprotein rotamase A (SlrA) is a functional peptidyl-prolyl isomerase involved in pneumococcal colonization","volume":"281","author":"Hermans","year":"2006","journal-title":"J Biol Chem."},{"key":"B33","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1128\/IAI.67.4.1683-1687.1999","article-title":"Identification of pneumococcal surface protein A as a lactoferrin-binding protein of Streptococcus pneumoniae","volume":"67","author":"Hammerschmidt","year":"1999","journal-title":"Infect Immun."},{"key":"B34","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1046\/j.1365-2958.2000.01897.x","article-title":"Species-specific binding of human secretory component to SpsA protein of Streptococcus pneumoniae via a hexapeptide motif","volume":"36","author":"Hammerschmidt","year":"2000","journal-title":"Mol Microbiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1046\/j.1365-2958.1997.5391899.x","article-title":"SpsA, a novel pneumococcal surface protein with specific binding to secretory immunoglobulin A and secretory component","volume":"25","author":"Hammerschmidt","year":"1997","journal-title":"Mol Microbiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/j.1365-2958.2010.07189.x","article-title":"PavB is a surface-exposed adhesin of Streptococcus pneumoniae contributing to nasopharyngeal colonization and airways infections","volume":"77","author":"Jensch","year":"2010","journal-title":"Mol Microbiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/S0022-1759(98)00015-5","article-title":"The need for IgG2c specific antiserum when isotyping antibodies from C57BL\/6 and NOD mice","volume":"212","author":"Martin","year":"1998","journal-title":"J Immunol Methods"},{"key":"B38","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.jprot.2017.01.008","article-title":"Characterization of human and Staphylococcus aureus proteins in respiratory mucosa by in vivo- and immunoproteomics","volume":"155","author":"Schmidt","year":"2017","journal-title":"J Proteomics"},{"key":"B39","doi-asserted-by":"publisher","first-page":"3740","DOI":"10.1128\/IAI.68.6.3740-3743.2000","article-title":"Detection of 23 immunogenic pneumococcal proteins using convalescent-phase serum","volume":"68","author":"Zysk","year":"2000","journal-title":"Infect Immun."},{"key":"B40","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1021\/pr400768v","article-title":"Influence of impaired lipoprotein biogenesis on surface and exoproteome of Streptococcus pneumoniae","volume":"13","author":"Pribyl","year":"2014","journal-title":"J Proteome Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1111\/mmi.12504","article-title":"AdcA and AdcAII employ distinct zinc acquisition mechanisms and contribute additively to zinc homeostasis in Streptococcus pneumoniae","volume":"91","author":"Plumptre","year":"2014","journal-title":"Mol Microbiol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1099\/mic.0.026765-0","article-title":"Surface-associated lipoprotein PpmA of Streptococcus pneumoniae is involved in colonization in a strain-specific manner","volume":"155","author":"Cron","year":"2009","journal-title":"Microbiology"},{"key":"B43","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.micpath.2006.01.007","article-title":"Capsule does not block antibody binding to PspA, a surface virulence protein of Streptococcus pneumoniae","volume":"40","author":"Daniels","year":"2006","journal-title":"Microbial Pathogen."},{"key":"B44","doi-asserted-by":"publisher","first-page":"4848","DOI":"10.1073\/pnas.0501254102","article-title":"CD4+ T cells mediate antibody-independent acquired immunity to pneumococcal colonization","volume":"102","author":"Malley","year":"2005","journal-title":"Proc Natl Acad Sci USA."},{"key":"B45","doi-asserted-by":"publisher","first-page":"5460","DOI":"10.1128\/IAI.00773-07","article-title":"Antibody-independent, CD4+ T-cell-dependent protection against pneumococcal colonization elicited by intranasal immunization with purified pneumococcal proteins","volume":"75","author":"Basset","year":"2007","journal-title":"Infect Immun."},{"key":"B46","doi-asserted-by":"publisher","first-page":"e1000159","DOI":"10.1371\/journal.ppat.1000159","article-title":"Interleukin-17A mediates acquired immunity to pneumococcal colonization","volume":"4","author":"Lu","year":"2008","journal-title":"PLoS Pathog."},{"key":"B47","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/S1473-3099(04)00938-7","article-title":"Streptococcus pneumoniae colonisation: the key to pneumococcal disease","volume":"4","author":"Bogaert","year":"2004","journal-title":"Lancet Infect Dis."},{"key":"B48","doi-asserted-by":"publisher","first-page":"2714","DOI":"10.1128\/IAI.00416-16","article-title":"Infant Mouse Model for the Study of Shedding and Transmission during Streptococcus pneumoniae Monoinfection","volume":"84","author":"Zafar","year":"2016","journal-title":"Infect Immun."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1128\/IAI.73.3.1304-1312.2005","article-title":"Relationship between surface accessibility for PpmA, PsaA, and PspA and antibody-mediated immunity to systemic infection by Streptococcus pneumoniae","volume":"73","author":"Gor","year":"2005","journal-title":"Infect Immun."},{"key":"B50","doi-asserted-by":"publisher","first-page":"6852","DOI":"10.1128\/IAI.73.10.6852-6859.2005","article-title":"Antibodies to the iron uptake ABC transporter lipoproteins PiaA and PiuA promote opsonophagocytosis of Streptococcus pneumoniae","volume":"73","author":"Jomaa","year":"2005","journal-title":"Infect Immun."},{"key":"B51","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1128\/IAI.01161-07","article-title":"Pneumococcal virulence gene expression and host cytokine profiles during pathogenesis of invasive disease","volume":"76","author":"Mahdi","year":"2008","journal-title":"Infect Immun."},{"key":"B52","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1099\/00221287-148-7-2045","article-title":"The genes encoding virulence-associated proteins and the capsule of Streptococcus pneumoniae are upregulated and differentially expressed in vivo","volume":"148","author":"Ogunniyi","year":"2002","journal-title":"Microbiology"},{"key":"B53","doi-asserted-by":"publisher","first-page":"5582","DOI":"10.1128\/IAI.72.10.5582-5596.2004","article-title":"Microarray analysis of pneumococcal gene expression during invasive disease","volume":"72","author":"Orihuela","year":"2004","journal-title":"Infect Immun."},{"key":"B54","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.1172\/JCI45850","article-title":"Identification of a novel pneumococcal vaccine antigen preferentially expressed during meningitis in mice","volume":"122","author":"Mahdi","year":"2012","journal-title":"J Clin Invest."},{"key":"B55","doi-asserted-by":"publisher","first-page":"e0141816","DOI":"10.1371\/journal.pone.0141816","article-title":"Characterization of pneumococcal genes involved in bloodstream invasion in a mouse model","volume":"10","author":"Mahdi","year":"2015","journal-title":"PLoS ONE"},{"key":"B56","doi-asserted-by":"publisher","first-page":"E357","DOI":"10.1073\/pnas.1613937114","article-title":"Diverse evolutionary patterns of pneumococcal antigens identified by pangenome-wide immunological screening","volume":"114","author":"Croucher","year":"2017","journal-title":"Proc Natl Acad Sci USA."},{"key":"B57","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.jprot.2015.06.011","article-title":"Proteomics-driven design of a multiplex bead-based platform to assess natural IgG antibodies to pneumococcal protein antigens in children","volume":"126","author":"Jimenez-Munguia","year":"2015","journal-title":"J Proteomics"},{"key":"B58","doi-asserted-by":"publisher","first-page":"6702","DOI":"10.1128\/IAI.69.11.6702-6706.2001","article-title":"Immunization with components of two iron uptake ABC transporters protects mice against systemic Streptococcus pneumoniae infection","volume":"69","author":"Brown","year":"2001","journal-title":"Infect Immun."},{"key":"B59","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.imbio.2011.10.012","article-title":"Protection against Streptococcus pneumoniae serotype 1 acute infection shows a signature of Th17- and IFN-gamma-mediated immunity","volume":"217","author":"Marques","year":"2012","journal-title":"Immunobiology"},{"key":"B60","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.chom.2011.01.007","article-title":"T(H)17-based vaccine design for prevention of Streptococcus pneumoniae colonization","volume":"9","author":"Moffitt","year":"2011","journal-title":"Cell Host Microbe"},{"key":"B61","doi-asserted-by":"publisher","first-page":"e00281","DOI":"10.1128\/IAI.00281-17","article-title":"Th17-mediated cross protection against pneumococcal carriage by vaccination with a variable antigen","volume":"85","author":"Kuipers","year":"2017","journal-title":"Infect Immun."},{"key":"B62","doi-asserted-by":"publisher","first-page":"579","DOI":"10.3390\/vaccines3030579","article-title":"Cholera toxin subunit B as adjuvant\u2014An accelerator in protective immunity and a break in autoimmunity","volume":"3","author":"Stratmann","year":"2015","journal-title":"Vaccines"},{"key":"B63","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1177\/2051013617691041","article-title":"Utilization of cholera toxin B as a mucosal adjuvant elicits antibody-mediated protection against S","volume":"5","author":"Wiedinger","year":"2017","journal-title":"Therapeut Adv Vaccines"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.4161\/hv.28407","article-title":"Intranasal immunization with influenza antigens conjugated with cholera toxin subunit B stimulates broad spectrum immunity against influenza viruses","volume":"10","author":"Li","year":"2014","journal-title":"Hum Vaccines Immunotherapeut."},{"key":"B65","doi-asserted-by":"publisher","first-page":"5968","DOI":"10.1016\/j.vaccine.2016.09.057","article-title":"Role of antibodies and IL17-mediated immunity in protection against pneumococcal otitis media","volume":"34","author":"Habets","year":"2016","journal-title":"Vaccine"},{"key":"B66","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1183\/09031936.01.00228801","article-title":"Lung mucosal immunity: immunoglobulin-A revisited","volume":"18","author":"Pilette","year":"2001","journal-title":"Eur Resp J."},{"key":"B67","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1128\/IAI.22.3.790-797.1978","article-title":"Secretory immunoglobulin A and G antibodies prevent adhesion of Escherichia coli to human urinary tract epithelial cells","volume":"22","author":"Svanborg-Eden","year":"1978","journal-title":"Infect Immun."},{"key":"B68","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1128\/IAI.63.8.3166-3173.1995","article-title":"Selective neutralization of a bacterial enterotoxin by serum immunoglobulin A in response to mucosal disease","volume":"63","author":"Johnson","year":"1995","journal-title":"Infect Immun."},{"key":"B69","doi-asserted-by":"publisher","first-page":"6901","DOI":"10.1073\/pnas.89.15.6901","article-title":"Intracellular neutralization of virus by immunoglobulin A antibodies","volume":"89","author":"Mazanec","year":"1992","journal-title":"Proc Natl Acad Sci USA."},{"key":"B70","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1146\/annurev.iy.04.040186.002133","article-title":"Immunoglobulin A: strategic defense initiative at the mucosal surface","volume":"4","author":"Underdown","year":"1986","journal-title":"Ann Rev Immunol."},{"key":"B71","doi-asserted-by":"crossref","first-page":"6448","DOI":"10.4049\/jimmunol.163.12.6448","article-title":"Aluminium hydroxide adjuvant initiates strong antigen-specific Th2 responses in the absence of IL-4- or IL-13-mediated signaling","volume":"163","author":"Brewer","year":"1999","journal-title":"J Immunol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/S0169-409X(98)00008-8","article-title":"Aluminum compounds as vaccine adjuvants","volume":"32","author":"Gupta","year":"1998","journal-title":"Adv Drug Deliv Rev."},{"key":"B73","doi-asserted-by":"publisher","first-page":"4257","DOI":"10.1016\/j.vaccine.2005.03.039","article-title":"Antibodies to the pneumococcal surface protein A, PspA, can be produced in splenectomized and can protect splenectomized mice from infection with Streptococcus pneumoniae","volume":"23","author":"Coats","year":"2005","journal-title":"Vaccine"},{"key":"B74","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/1743-422X-4-118","article-title":"Roles of adjuvant and route of vaccination in antibody response and protection engendered by a synthetic matrix protein 2-based influenza A virus vaccine in the mouse","volume":"4","author":"Mozdzanowska","year":"2007","journal-title":"Virol J."},{"key":"B75","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1017\/S0031182009991259","article-title":"Intraperitoneal and intra-nasal vaccination of mice with three distinct recombinant Neospora caninum antigens results in differential effects with regard to protection against experimental challenge with Neospora caninum tachyzoites","volume":"137","author":"Debache","year":"2010","journal-title":"Parasitology"},{"key":"B76","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/j.1365-3083.1992.tb03126.x","article-title":"Effect of mucosal and systemic immunization with pneumococcal polysaccharide type 3, 4 and 14 in the rat","volume":"36","author":"van den Dobbelsteen","year":"1992","journal-title":"Scandinavian J Immunol."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.02405\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T23:34:41Z","timestamp":1693956881000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.02405\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,18]]},"references-count":76,"alternative-id":["10.3389\/fimmu.2018.02405"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.02405","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,18]]},"article-number":"2405"}}