{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T08:32:34Z","timestamp":1789029154794,"version":"build-2803163510"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T00:00:00Z","timestamp":1542067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.02609","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T16:17:10Z","timestamp":1542125830000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["PRL2 Controls Phagocyte Bactericidal Activity by Sensing and Regulating ROS"],"prefix":"10.3389","volume":"9","author":[{"given":"Cennan","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juebiao","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqiang","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaokui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaojun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,11,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1042\/EBC20160017","article-title":"The immune system","volume":"60","author":"Nicholson","year":"2016","journal-title":"Essays Biochem."},{"key":"B2","doi-asserted-by":"publisher","first-page":"aaf1098","DOI":"10.1126\/science.aaf1098","article-title":"Trained immunity: a program of innate immune memory in health and disease","volume":"352","author":"Netea","year":"2016","journal-title":"Science"},{"key":"B3","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1111\/j.1600-065X.2012.01135.x","article-title":"The innate immune system in demyelinating disease","volume":"248","author":"Mayo","year":"2012","journal-title":"Immunol Rev."},{"key":"B4","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/nri3423","article-title":"Beyond oxidative stress:an immunologist's guide to reactive oxygen species","volume":"13","author":"Nathan","year":"2013","journal-title":"Nat Rev Immunol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/j.cell.2010.03.008","article-title":"Snapshot:reactive oxygen intermediates (ROI)","volume":"140","author":"Nathan","year":"2010","journal-title":"Cell"},{"key":"B6","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1042\/BST20140060","article-title":"ROS signalling, NADPH oxidases and cancer","volume":"42","author":"Landry","year":"2014","journal-title":"Biochem Soc Trans."},{"key":"B7","doi-asserted-by":"publisher","first-page":"R453","DOI":"10.1016\/j.cub.2014.03.034","article-title":"ROS function in redox signaling and oxidative stress","volume":"24","author":"Schieber","year":"2014","journal-title":"Curr Biol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1111\/febs.12077","article-title":"Protein tyrosine phosphatases\u2013from housekeeping enzymes to master regulators of signal transduction","volume":"280","author":"Tonks","year":"2013","journal-title":"FEBS J."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1158\/1535-7163.MCT-05-0248","article-title":"PRL phosphatases as potential molecular targets in cancer","volume":"4","author":"Stephens","year":"2005","journal-title":"Mol Cancer Therap."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1002\/jcb.22913","article-title":"PRL-3 phosphatase and cancer metastasis","volume":"111","author":"Al-Aidaroos","year":"2010","journal-title":"J Cell Biochem."},{"key":"B11","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1111\/j.1742-4658.2012.08565.x","article-title":"Molecular mechanisms of the PRL phosphatases","volume":"280","author":"Rios","year":"2013","journal-title":"FEBS J."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.2147\/OTT.S85899","article-title":"The prognostic significance of protein tyrosine phosphatase 4A2 in breast cancer","volume":"8","author":"Zhao","year":"2015","journal-title":"Oncot Thera."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1369\/jhc.6A7019.2006","article-title":"Cellular localization of PRL-1 and PRL-2 gene expression in normal adult human tissues","volume":"54","author":"Dumaual","year":"2006","journal-title":"J. Histochem. Cytochem."},{"key":"B14","doi-asserted-by":"publisher","first-page":"10923","DOI":"10.1128\/MCB.24.24.10923-10932.2004","article-title":"PRAM-1 is required for optimal integrin-dependent neutrophil function","volume":"24","author":"Clemens","year":"2004","journal-title":"Mol Cell Biol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"15413","DOI":"10.1073\/pnas.1204525109","article-title":"TIPE2 protein serves as a negative regulator of phagocytosis and oxidative burst during infection","volume":"109","author":"Wang","year":"2012","journal-title":"Proc Nat Acad Sci USA."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1089\/ars.2012.5149","article-title":"Reactive oxygen species in inflammation and tissue injury","volume":"20","author":"Mittal","year":"2014","journal-title":"Antioxid Redox Signal."},{"key":"B17","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.ymeth.2013.06.032","article-title":"Reversible oxidation of PRL family protein-tyrosine phosphatases","volume":"65","author":"Funato","year":"2014","journal-title":"Methods"},{"key":"B18","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1093\/eurheartj\/ehr304","article-title":"Nitric oxide synthases:regulation and function","volume":"33","author":"Forstermann","year":"2012","journal-title":"Eur Heart J."},{"key":"B19","doi-asserted-by":"publisher","first-page":"3029","DOI":"10.1073\/pnas.1216141110","article-title":"Transforming mutations of RAC guanosine triphosphatases in human cancers","volume":"110","author":"Kawazu","year":"2013","journal-title":"Proc Nat Acad Sci USA."},{"key":"B20","doi-asserted-by":"publisher","first-page":"456352","DOI":"10.1155\/2013\/456352","article-title":"Parasitic infections:a role for C-type lectins receptors","volume":"2013","author":"Vazquez-Mendoza","year":"2013","journal-title":"BioMed Res Int."},{"key":"B21","doi-asserted-by":"publisher","first-page":"32172","DOI":"10.1074\/jbc.M112.393462","article-title":"Phosphatase of regenerating liver 2 (PRL2) is essential for placental development by down-regulating PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) and activating Akt protein","volume":"287","author":"Dong","year":"2012","journal-title":"J Biol Chem."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1956","DOI":"10.1002\/stem.1672","article-title":"PRL2\/PTP4A2 phosphatase is important for hematopoietic stem cell self-renewal","volume":"32","author":"Kobayashi","year":"2014","journal-title":"Stem Cells"},{"key":"B23","doi-asserted-by":"publisher","first-page":"3799","DOI":"10.1074\/jbc.M113.512079","article-title":"Phosphatase of regenerating liver 2 (PRL2) deficiency impairs Kit signaling and spermatogenesis","volume":"289","author":"Dong","year":"2014","journal-title":"J Biol Chem."},{"key":"B24","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1189\/jlb.1012544","article-title":"ROS production in phagocytes:why, when, and where?","volume":"94","author":"Dupre-Crochet","year":"2013","journal-title":"J Leukocyte Biol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1517\/14728222.2014.892926","article-title":"Phosphatase of regenerating liver:a novel target for cancer therapy","volume":"18","author":"Campbell","year":"2014","journal-title":"Exp Opin Therap Targets"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1016\/j.bbamcr.2007.06.005","article-title":"Oxidative stress-induced expression and modulation of Phosphatase of Regenerating Liver-1 (PRL-1) in mammalian retina","volume":"1773","author":"Yu","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"B27","doi-asserted-by":"publisher","first-page":"7263","DOI":"10.1074\/jbc.M112.418004","article-title":"Thioredoxin-related protein 32 (TRP32) specifically reduces oxidized phosphatase of regenerating liver (PRL)","volume":"288","author":"Ishii","year":"2013","journal-title":"J Biol Chem."},{"key":"B28","doi-asserted-by":"publisher","first-page":"4262","DOI":"10.1021\/bi900241k","article-title":"Enzyme activity of phosphatase of regenerating liver is controlled by the redox environment and its C-terminal residues","volume":"48","author":"Skinner","year":"2009","journal-title":"Biochemistry"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.02609\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T16:17:12Z","timestamp":1542125832000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.02609\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,13]]},"references-count":28,"alternative-id":["10.3389\/fimmu.2018.02609"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.02609","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,13]]},"article-number":"2609"}}