{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T16:28:04Z","timestamp":1767889684330,"version":"3.49.0"},"reference-count":176,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T00:00:00Z","timestamp":1543363200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.02620","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T05:20:57Z","timestamp":1543382457000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Proteasomal Protein Degradation: Adaptation of Cellular Proteolysis With Impact on Virus\u2014and Cytokine-Mediated Damage of Heart Tissue During Myocarditis"],"prefix":"10.3389","volume":"9","author":[{"given":"Antje","family":"Beling","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meike","family":"Kespohl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,11,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1056\/NEJMra0800028","article-title":"Myocarditis","volume":"360","author":"Cooper","year":"2009","journal-title":"N Engl J Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/nri3800","article-title":"Role of innate and adaptive immune mechanisms in cardiac injury and repair","volume":"15","author":"Epelman","year":"2015","journal-title":"Nat Rev Immunol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/S0140-6736(11)60648-X","article-title":"Myocarditis","volume":"379","author":"Sagar","year":"2012","journal-title":"Lancet"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1093\/eurheartj\/eht210","article-title":"Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases","volume":"34","author":"Caforio","year":"2013","journal-title":"Eur Heart J."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1056\/NEJM200011093431908","article-title":"Myocarditis","volume":"343","author":"Feldman","year":"2000","journal-title":"N Engl J Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1073\/pnas.89.1.314","article-title":"Ongoing enterovirus-induced myocarditis is associated with persistent heart-muscle infection - quantitative-analysis of virus-replication, tissue-damage, and inflammation","volume":"89","author":"Klingel","year":"1992","journal-title":"Proc Natl Acad Sci USA."},{"key":"B7","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.molmed.2012.05.005","article-title":"Inflammation in viral myocarditis: friend or foe?","volume":"18","author":"Corsten","year":"2012","journal-title":"Trends Mol Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"510","DOI":"10.2353\/ajpath.2009.090033","article-title":"Differential interferon responses enhance viral epitope generation by myocardial immunoproteasomes in murine enterovirus myocarditis","volume":"175","author":"Jakel","year":"2009","journal-title":"Am J Pathol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1161\/CIRCULATIONAHA.108.769489","article-title":"Predictors of outcome in patients with suspected myocarditis","volume":"118","author":"Kindermann","year":"2008","journal-title":"Circulation"},{"key":"B10","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.virol.2017.09.017","article-title":"Immunological and pathological consequences of coxsackievirus RNA persistence in the heart","volume":"512","author":"Flynn","year":"2017","journal-title":"Virology"},{"key":"B11","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.clim.2012.07.003","article-title":"Coxsackievirus B3 infection leads to the generation of cardiac myosin heavy chain-alpha-reactive CD4 T cells in A\/J mice","volume":"144","author":"Gangaplara","year":"2012","journal-title":"Clin Immunol."},{"key":"B12","doi-asserted-by":"crossref","first-page":"343","DOI":"10.4049\/jimmunol.152.1.343","article-title":"Induction of multiple heart autoantibodies in mice with coxsackievirus B3- and cardiac myosin-induced autoimmune myocarditis","volume":"152","author":"Neumann","year":"1994","journal-title":"J Immunol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1007\/s10875-009-9339-z","article-title":"Myocarditis: infection versus autoimmunity","volume":"29","author":"Rose","year":"2009","journal-title":"J Clin Immunol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1161\/CIRCRESAHA.111.243360","article-title":"Autoantibodies in heart failure and cardiac dysfunction","volume":"110","author":"Kaya","year":"2012","journal-title":"Circ Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.2217\/fmb.10.101","article-title":"Type B coxsackieviruses and their interactions with the innate and adaptive immune systems","volume":"5","author":"Kemball","year":"2010","journal-title":"Fut Microbiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/nature02263","article-title":"Protein degradation and protection against misfolded or damaged proteins","volume":"426","author":"Goldberg","year":"2003","journal-title":"Nature"},{"key":"B17","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/386463a0","article-title":"Structure of 20S proteasome from yeast at 2","volume":"386","author":"Groll","year":"1997","journal-title":"Nature"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1038\/80992","article-title":"A gated channel into the proteasome core particle","volume":"7","author":"Groll","year":"2000","journal-title":"Nat Struct Biol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/nrm1336","article-title":"Proteasomes and their kin: proteases in the machine age","volume":"5","author":"Pickart","year":"2004","journal-title":"Nat Rev Mol Cell Biol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1093\/cvr\/cvp255","article-title":"Stressing the ubiquitin-proteasome system","volume":"85","author":"Dantuma","year":"2010","journal-title":"Cardiovasc Res."},{"key":"B21","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1146\/annurev-biochem-061516-044908","article-title":"Proteasomal and autophagic degradation systems","volume":"86","author":"Dikic","year":"2017","journal-title":"Annu Rev Biochem."},{"key":"B22","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/365264a0","article-title":"Gamma-interferon and expression of Mhc genes regulate peptide hydrolysis by proteasomes","volume":"365","author":"Gaczynska","year":"1993","journal-title":"Nature"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.ppat.1002233","article-title":"Impairment of immunoproteasome function by beta5i\/LMP7 subunit deficiency results in severe enterovirus myocarditis","volume":"7","author":"Opitz","year":"2011","journal-title":"PloS Pathog."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1182\/blood.V98.4.1108","article-title":"Tumor necrosis factor-alpha induces coordinated changes in major histocompatibility class I presentation pathway, resulting in increased stability of class I complexes at the cell surface","volume":"98","author":"Hallermalm","year":"2001","journal-title":"Blood"},{"key":"B25","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.tox.2016.04.010","article-title":"Inhibition of chymotryptic-like standard proteasome activity exacerbates doxorubicin-induced cytotoxicity in primary cardiomyocytes","volume":"354","author":"Spur","year":"2016","journal-title":"Toxicology"},{"key":"B26","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1042\/BJ20100878","article-title":"The immunoproteasome, the 20S proteasome and the PA28 alpha beta proteasome regulator are oxidative-stress-adaptive proteolytic complexes","volume":"432","author":"Pickering","year":"2010","journal-title":"Biochem J."},{"key":"B27","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1093\/oxfordjournals.jbchem.a124327","article-title":"Interferon-gamma induces different subunit organizations and functional diversity of proteasomes","volume":"115","author":"Aki","year":"1994","journal-title":"J Biochem."},{"key":"B28","doi-asserted-by":"publisher","first-page":"6238","DOI":"10.4049\/jimmunol.177.9.6238","article-title":"Immunoproteasomes are essential for clearance of Listeria monocytogenes in nonlymphoid tissues but not for induction of bacteria-specific CD8(+) T cells","volume":"177","author":"Strehl","year":"2006","journal-title":"J Immunol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.cell.2011.12.030","article-title":"Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity","volume":"148","author":"Huber","year":"2012","journal-title":"Cell"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.2353\/ajpath.2006.050865","article-title":"Ongoing coxsackievirus myocarditis is associated with increased formation and activity of myocardial immunoproteasomes","volume":"168","author":"Szalay","year":"","journal-title":"Am J Pathol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.virol.2016.08.009","article-title":"Interferon-dependent immunoproteasome activity during mouse adenovirus type 1 infection","volume":"498","author":"Mccarthy","year":"2016","journal-title":"Virology"},{"key":"B32","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.cell.2010.07.036","article-title":"Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress","volume":"142","author":"Seifert","year":"2010","journal-title":"Cell"},{"key":"B33","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/j.cell.2013.02.018","article-title":"Immunoproteasomes are important for proteostasis in immune responses","volume":"152","author":"Ebstein","year":"2013","journal-title":"Cell"},{"key":"B34","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/nrm2630","article-title":"Molecular mechanisms of proteasome assembly","volume":"10","author":"Murata","year":"2009","journal-title":"Nat Rev Mol Cell Biol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1126\/science.1141915","article-title":"Regulation of CD8+ T cell development by thymus-specific proteasomes","volume":"316","author":"Murata","year":"2007","journal-title":"Science"},{"key":"B36","doi-asserted-by":"publisher","first-page":"18599","DOI":"10.1073\/pnas.1009778107","article-title":"Two abundant proteasome subtypes that uniquely process some antigens presented by HLA class I molecules","volume":"107","author":"Guillaume","year":"2010","journal-title":"Proc Natl Acad Sci USA."},{"key":"B37","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.coi.2003.11.004","article-title":"Proteasome and peptidase function in MHC-class-I-mediated antigen presentation","volume":"16","author":"Kloetzel","year":"2004","journal-title":"Curr Opin Immunol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"9213","DOI":"10.1073\/pnas.91.20.9213","article-title":"Peptidase activities of proteasomes are differentially regulated by the major histocompatibility complex-encoded genes for LMP2 and LMP7","volume":"91","author":"Gaczynska","year":"1994","journal-title":"Proc Natl Acad Sci USA."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1007\/s00018-011-0657-y","article-title":"The role of the proteasome in the generation of MHC class I ligands and immune responses","volume":"68","author":"Sijts","year":"2011","journal-title":"Cell Mol Life Sci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"3508","DOI":"10.1002\/eji.201444902","article-title":"Proteasome isoforms exhibit only quantitative differences in cleavage and epitope generation","volume":"44","author":"Mishto","year":"2014","journal-title":"Eur J Immunol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"768","DOI":"10.4049\/jimmunol.165.2.768","article-title":"Overexpression of the proteasome subunits LMP2, LMP7, and MECL-1, but not PA28 alpha\/beta, enhances the presentation of an immunodominant lymphocytic choriomeningitis virus T cell epitope","volume":"165","author":"Schwarz","year":"2000","journal-title":"J Immunol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1084\/jem.193.11.1319","article-title":"Immunoproteasomes shape immunodominance hierarchies of antiviral CD8(+) T cells at the levels of T cell repertoire and presentation of viral antigens","volume":"193","author":"Chen","year":"2001","journal-title":"J Exp Med."},{"key":"B43","doi-asserted-by":"publisher","first-page":"7557","DOI":"10.4049\/jimmunol.178.12.7557","article-title":"Rates of processing determine the immunogenicity of immunoproteasome-generated epitopes","volume":"178","author":"Deol","year":"2007","journal-title":"J Immunol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"3385","DOI":"10.1002\/eji.200839117","article-title":"Critical role for the immunoproteasome subunit LMP7 in the resistance of mice to Toxoplasma gondii infection","volume":"39","author":"Tu","year":"2009","journal-title":"Eur J Immunol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/ni.2203","article-title":"Mice completely lacking immunoproteasomes show major changes in antigen presentation","volume":"13","author":"Kincaid","year":"2012","journal-title":"Nat Immunol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"e1005593","DOI":"10.1371\/journal.ppat.1005593","article-title":"The combined deficiency of immunoproteasome subunits affects both the magnitude and quality of pathogen- and genetic vaccination-induced CD8+ T cell responses to the human protozoan parasite Trypanosoma cruzi","volume":"12","author":"Ersching","year":"2016","journal-title":"PLoS Pathog."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1126\/science.8066463","article-title":"Mhc class-I expression in mice lacking the proteasome subunit Lmp-7","volume":"265","author":"Fehling","year":"1994","journal-title":"Science"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.4049\/jimmunol.175.2.1153","article-title":"Immunoproteasome-deficient mice mount largely normal CD8(+) T cell responses to lymphocytic choriomeningitis virus infection and DNA vaccination","volume":"175","author":"Nussbaum","year":"2005","journal-title":"J Immunol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/1074-7613(94)90043-4","article-title":"Altered peptidase and viral-specific T-cell response in Lmp2 mutant mice","volume":"1","author":"Vankaer","year":"1994","journal-title":"Immunity"},{"key":"B50","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1002\/emmm.201303543","article-title":"Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis","volume":"6","author":"Basler","year":"2014","journal-title":"EMBO Mol Med."},{"key":"B51","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.cbpa.2014.08.012","article-title":"Subunit specific inhibitors of proteasomes and their potential for immunomodulation","volume":"23","author":"Kisselev","year":"2014","journal-title":"Curr Opin Chem Biol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"2609","DOI":"10.1056\/NEJMoa030288","article-title":"A phase 2 study of bortezomib in relapsed, refractory myeloma","volume":"348","author":"Richardson","year":"2003","journal-title":"N Engl J Med."},{"key":"B53","doi-asserted-by":"publisher","first-page":"2487","DOI":"10.1056\/NEJMoa043445","article-title":"Bortezomib or high-dose dexamethasone for relapsed multiple myeloma","volume":"352","author":"Richardson","year":"2005","journal-title":"N Eng J Med."},{"key":"B54","doi-asserted-by":"publisher","first-page":"3439","DOI":"10.1182\/blood-2009-05-223677","article-title":"Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome","volume":"114","author":"Parlati","year":"2009","journal-title":"Blood"},{"key":"B55","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1056\/NEJMoa1411321","article-title":"Carfilzomib, lenalidomide, and dexamethasone for relapsed multiple myeloma","volume":"372","author":"Stewart","year":"2015","journal-title":"N Engl J Med."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1016\/S1470-2045(17)30578-8","article-title":"Carfilzomib or bortezomib in relapsed or refractory multiple myeloma (ENDEAVOR): an interim overall survival analysis of an open-label, randomised, phase 3 trial","volume":"18","author":"Dimopoulos","year":"2017","journal-title":"Lancet Oncol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1161\/01.RES.0000237386.98506.f7","article-title":"Mapping the murine cardiac 26S proteasome complexes","volume":"99","author":"Gomes","year":"2006","journal-title":"Circul Res."},{"key":"B58","doi-asserted-by":"publisher","first-page":"4199","DOI":"10.1002\/anie.201509092","article-title":"A set of activity-based probes to visualize human (Immuno)proteasome activities","volume":"55","author":"De Bruin","year":"2015","journal-title":"Angew Chem Int Ed Engl"},{"key":"B59","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1038\/nm.1978","article-title":"A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis","volume":"15","author":"Muchamuel","year":"2009","journal-title":"Nat Med."},{"key":"B60","doi-asserted-by":"publisher","first-page":"50873","DOI":"10.18632\/oncotarget.15141","article-title":"Inhibition and deficiency of the immunoproteasome subunit LMP7 suppress the development and progression of colorectal carcinoma in mice","volume":"8","author":"Koerner","year":"2017","journal-title":"Oncotarget"},{"key":"B61","doi-asserted-by":"publisher","first-page":"50447","DOI":"10.18632\/oncotarget.14579","article-title":"Prevention of colitis-associated cancer by selective targeting of immunoproteasome subunit LMP7","volume":"8","author":"Vachharajani","year":"2017","journal-title":"Oncotarget"},{"key":"B62","doi-asserted-by":"publisher","first-page":"634","DOI":"10.4049\/jimmunol.0903182","article-title":"Prevention of experimental colitis by a selective inhibitor of the immunoproteasome","volume":"185","author":"Basler","year":"2010","journal-title":"J Immunol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1002\/art.33333","article-title":"Beneficial effect of novel proteasome inhibitors in murine lupus via dual inhibition of type I interferon and autoantibody-secreting cells","volume":"64","author":"Ichikawa","year":"2012","journal-title":"Arthritis Rheum."},{"key":"B64","doi-asserted-by":"publisher","first-page":"e46512","DOI":"10.15252\/embr.201846512","article-title":"Co-inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity","volume":"19","author":"Basler","year":"2018","journal-title":"EMBO Rep."},{"key":"B65","doi-asserted-by":"publisher","first-page":"E8425","DOI":"10.1073\/pnas.1618548114","article-title":"Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice","volume":"113","author":"Sula Karreci","year":"2016","journal-title":"Proc Natl Acad Sci USA."},{"key":"B66","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/j.kint.2017.09.023","article-title":"Immunoproteasome inhibition prevents chronic antibody-mediated allograft rejection in renal transplantation","volume":"93","author":"Li","year":"2018","journal-title":"Kidney Int."},{"key":"B67","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/S0968-0004(03)00141-5","article-title":"Viruses and the 26S proteasome: hacking into destruction","volume":"28","author":"Banks","year":"2003","journal-title":"Trends Biochem Sci."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.coviro.2015.09.005","article-title":"Interplay between the virus and the ubiquitin-proteasome system: molecular mechanism of viral pathogenesis","volume":"17","author":"Luo","year":"2016","journal-title":"Curr Opin Virol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/S0042-6822(03)00527-0","article-title":"Adenovirus E4-34kDa requires active proteasomes to promote late gene expression","volume":"315","author":"Corbin-Lickfett","year":"2003","journal-title":"Virology"},{"key":"B70","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/S0002-9440(10)63667-X","article-title":"Proteasome inhibition reduces coxsackievirus B3 replication in murine cardiomyocytes","volume":"163","author":"Luo","year":"2003","journal-title":"Am J Pathol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"H401","DOI":"10.1152\/ajpheart.00292.2008","article-title":"Proteasome inhibition attenuates coxsackievirus-induced myocardial damage in mice","volume":"295","author":"Gao","year":"2008","journal-title":"Am J Physiol Heart Circul Physiol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"200","DOI":"10.15252\/emmm.201708089","article-title":"The immunoproteasome-specific inhibitor ONX 0914 reverses susceptibility to acute viral myocarditis","volume":"10","author":"Althof","year":"2018","journal-title":"EMBO Mol Med."},{"key":"B73","doi-asserted-by":"publisher","first-page":"e0173259","DOI":"10.1371\/journal.pone.0173259","article-title":"PA28 modulates antigen processing and viral replication during coxsackievirus B3 infection","volume":"12","author":"Respondek","year":"2017","journal-title":"PLoS ONE"},{"key":"B74","doi-asserted-by":"publisher","first-page":"3381","DOI":"10.1128\/JVI.02296-07","article-title":"Cellular proteasome activity facilitates herpes simplex virus entry at a postpenetration step","volume":"82","author":"Delboy","year":"2008","journal-title":"J Virol."},{"key":"B75","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1177\/135965350601100805","article-title":"Antiviral activity of proteasome inhibitors in herpes simplex virus-1 infection: role of nuclear factor-kappaB","volume":"11","author":"La Frazia","year":"2006","journal-title":"Antivir Ther."},{"key":"B76","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.febslet.2008.01.040","article-title":"Proteasome inhibitor MG132 blocks viral DNA replication and assembly of human cytomegalovirus","volume":"582","author":"Kaspari","year":"2008","journal-title":"FEBS Lett."},{"key":"B77","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1177\/135965350300800608","article-title":"Proteasome inhibitors: a novel tool to suppress human cytomegalovirus replication and virus-induced immune modulation","volume":"8","author":"Pr\u00f6sch","year":"2003","journal-title":"Antivir Ther."},{"key":"B78","doi-asserted-by":"publisher","first-page":"13057","DOI":"10.1073\/pnas.97.24.13057","article-title":"Proteasome inhibition interferes with gag polyprotein processing, release, and maturation of HIV-1 and HIV-2","volume":"97","author":"Schubert","year":"2000","journal-title":"Proc Natl Acad Sci USA."},{"key":"B79","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/1742-4690-10-120","article-title":"Proteasome inhibitors act as bifunctional antagonists of human immunodeficiency virus type 1 latency and replication","volume":"10","author":"Miller","year":"2013","journal-title":"Retrovirology"},{"key":"B80","doi-asserted-by":"publisher","first-page":"9625","DOI":"10.1128\/JVI.01048-10","article-title":"Inhibition of the ubiquitin-proteasome system affects influenza A virus infection at a postfusion step","volume":"84","author":"Widjaja","year":"2010","journal-title":"J Virol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"12634","DOI":"10.1128\/JVI.76.24.12634-12645.2002","article-title":"Cytoplasmic trafficking of minute virus of mice: low-pH requirement, routing to late endosomes, and proteasome interaction","volume":"76","author":"Ros","year":"2002","journal-title":"J Virol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"e1887","DOI":"10.1371\/journal.pone.0001887","article-title":"Different effect of proteasome inhibition on vesicular stomatitis virus and poliovirus replication","volume":"3","author":"Neznanov","year":"2008","journal-title":"PLoS ONE"},{"key":"B83","doi-asserted-by":"publisher","first-page":"2469","DOI":"10.1128\/JVI.01986-08","article-title":"Inhibition of the ubiquitin-proteasome system prevents vaccinia virus DNA replication and expression of intermediate and late genes","volume":"83","author":"Satheshkumar","year":"2009","journal-title":"J Virol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1016\/j.celrep.2012.09.003","article-title":"RNAi screening reveals proteasome- and Cullin3-dependent stages in vaccinia virus infection","volume":"2","author":"Mercer","year":"2012","journal-title":"Cell Rep."},{"key":"B85","doi-asserted-by":"publisher","first-page":"5898","DOI":"10.1093\/emboj\/20.21.5898","article-title":"Immunoproteasome assembly and antigen presentation in mice lacking both PA28 alpha and PA28 beta","volume":"20","author":"Murata","year":"2001","journal-title":"Embo J."},{"key":"B86","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1099\/vir.0.19626-0","article-title":"Productive human herpesvirus 6 infection causes aberrant accumulation of p53 and prevents apoptosis","volume":"85","author":"Takemoto","year":"2004","journal-title":"J Gen Virol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1016\/0092-8674(90)90409-8","article-title":"The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53","volume":"63","author":"Scheffner","year":"1990","journal-title":"Cell"},{"key":"B88","doi-asserted-by":"publisher","first-page":"3263","DOI":"10.1073\/pnas.0538058100","article-title":"Proteasome-dependent, ubiquitin-independent degradation of the Rb family of tumor suppressors by the human cytomegalovirus pp71 protein","volume":"100","author":"Kalejta","year":"2003","journal-title":"Proc Natl Acad Sci USA."},{"key":"B89","doi-asserted-by":"publisher","first-page":"4759","DOI":"10.1093\/emboj\/19.17.4759","article-title":"Regulation of the 26S proteasome by adenovirus E1A","volume":"19","author":"Turnell","year":"2000","journal-title":"Embo J."},{"key":"B90","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1128\/JVI.02077-14","article-title":"Proinflammatory effects of interferon gamma in mouse adenovirus 1 myocarditis","volume":"89","author":"Mccarthy","year":"2015","journal-title":"J Virol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"566","DOI":"10.3390\/biom4020566","article-title":"PA28alphabeta: the enigmatic magic ring of the proteasome?","volume":"4","author":"Cascio","year":"2014","journal-title":"Biomolecules"},{"key":"B92","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/nri3787","article-title":"Type I interferons in infectious disease","volume":"15","author":"Mcnab","year":"2015","journal-title":"Nat Rev Immunol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1161\/01.CIR.103.5.756","article-title":"Cardioselective infection with coxsackievirus B3 requires intact type I interferon signaling - implications for mortality and early viral replication","volume":"103","author":"Wessely","year":"2001","journal-title":"Circulation"},{"key":"B94","doi-asserted-by":"publisher","first-page":"3540","DOI":"10.1161\/01.CIR.0000136824.73458.20","article-title":"Protective role for interferon-beta in coxsackievirus B3 infection","volume":"110","author":"Deonarain","year":"2004","journal-title":"Circulation"},{"key":"B95","doi-asserted-by":"publisher","first-page":"5087","DOI":"10.1128\/JVI.00184-14","article-title":"In vivo ablation of type I interferon receptor from cardiomyocytes delays coxsackieviral clearance and accelerates myocardial disease","volume":"88","author":"Althof","year":"2014","journal-title":"J Virol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"2793","DOI":"10.1161\/01.CIR.0000072766.67150.51","article-title":"Interferon-beta treatment eliminates cardiotropic viruses and improves left ventricular function in patients with myocardial persistence of viral genomes and left ventricular dysfunction","volume":"107","author":"Kuhl","year":"2003","journal-title":"Circulation"},{"key":"B97","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1016\/j.jacc.2012.06.026","article-title":"Interferon-Beta improves survival in enterovirus-associated cardiomyopathy","volume":"60","author":"Kuhl","year":"2012","journal-title":"J Am Coll Cardiol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"11794","DOI":"10.1073\/pnas.1116584109","article-title":"Cardiomyocyte-specific IkappaB kinase (IKK)\/NF-kappaB activation induces reversible inflammatory cardiomyopathy and heart failure","volume":"109","author":"Maier","year":"2012","journal-title":"Proc Natl Acad Sci USA."},{"key":"B99","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1161\/CIRCULATIONAHA.114.009847","article-title":"Ubiquitin-like protein ISG15 (interferon-stimulated gene of 15 kDa) in host defense against heart failure in a mouse model of virus-induced cardiomyopathy","volume":"130","author":"Rahnefeld","year":"2014","journal-title":"Circulation"},{"key":"B100","doi-asserted-by":"publisher","first-page":"8149","DOI":"10.1128\/JVI.00047-08","article-title":"Effective chemokine secretion by dendritic cells and expansion of cross-presenting CD4(-)\/CD8(+) dendritic cells define a protective phenotype in the mouse model of coxsackievirus myocarditis","volume":"82","author":"Weinzierl","year":"2008","journal-title":"J Virol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.immuni.2010.03.012","article-title":"Intracellular toll-like receptors","volume":"32","author":"Blasius","year":"2010","journal-title":"Immunity"},{"key":"B102","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1084\/jem.20151531","article-title":"Ubiquitin in the activation and attenuation of innate antiviral immunity","volume":"213","author":"Heaton","year":"2016","journal-title":"J Exp Med."},{"key":"B103","doi-asserted-by":"publisher","first-page":"2774","DOI":"10.1002\/eji.201041039","article-title":"Antigen-presentation capacity of dendritic cells is impaired in ongoing enterovirus myocarditis","volume":"41","author":"Rahnefeld","year":"2011","journal-title":"Eur J Immunol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1182\/blood-2005-08-3494","article-title":"Proteasome inhibitor bortezomib modulates TLR4-induced dendritic cell activation","volume":"108","author":"Nencioni","year":"2006","journal-title":"Blood"},{"key":"B105","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.4049\/jimmunol.1400871","article-title":"Immunoproteasomes shape the transcriptome and regulate the function of dendritic cells","volume":"193","author":"De Verteuil","year":"2014","journal-title":"J Immunol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"3864","DOI":"10.1038\/ncomms4864","article-title":"Pathogenic potential of interferon alphabeta in acute influenza infection","volume":"5","author":"Davidson","year":"2014","journal-title":"Nat Commun."},{"key":"B107","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.cell.2008.06.032","article-title":"Trex1 prevents cell-intrinsic initiation of autoimmunity","volume":"134","author":"Stetson","year":"2008","journal-title":"Cell"},{"key":"B108","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.4049\/jimmunol.1500969","article-title":"Cutting edge: cGAS is required for lethal autoimmune disease in the Trex1-deficient mouse model of aicardi-goutieres syndrome","volume":"195","author":"Gray","year":"2015","journal-title":"J Immunol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1016\/j.ajhg.2010.10.031","article-title":"PSMB8 encoding the beta 5i proteasome subunit is mutated in joint contractures, muscle atrophy, microcytic anemia, and panniculitis-induced lipodystrophy syndrome","volume":"87","author":"Agarwal","year":"2010","journal-title":"Am J Hum Genet."},{"key":"B110","doi-asserted-by":"publisher","first-page":"4150","DOI":"10.1172\/JCI58414","article-title":"A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans","volume":"121","author":"Kitamura","year":"2011","journal-title":"J Clin Invest."},{"key":"B111","doi-asserted-by":"publisher","first-page":"4196","DOI":"10.1172\/JCI81260","article-title":"Additive loss-of-function proteasome subunit mutations in CANDLE\/PRAAS patients promote type I IFN production","volume":"125","author":"Brehm","year":"2015","journal-title":"J Clin Invest."},{"key":"B112","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.molmed.2016.04.007","article-title":"The dual complexity of PTX3 in health and disease: a balancing act?","volume":"22","author":"Magrini","year":"2016","journal-title":"Trends Mol Med."},{"key":"B113","doi-asserted-by":"publisher","first-page":"e27","DOI":"10.1016\/j.carpath.2010.02.005","article-title":"PTX3 expression in the heart tissues of patients with myocardial infarction and infectious myocarditis","volume":"20","author":"Nebuloni","year":"2011","journal-title":"Cardiovasc Pathol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1002\/eji.201545892","article-title":"The immunoproteasome controls the availability of the cardioprotective pattern recognition molecule Pentraxin3","volume":"46","author":"Paeschke","year":"2016","journal-title":"Eur J Immunol."},{"key":"B115","doi-asserted-by":"crossref","first-page":"4300","DOI":"10.1182\/blood.V96.13.4300","article-title":"The long pentraxin PTX3 binds to apoptotic cells and regulates their clearance by antigen-presenting dendritic cells","volume":"96","author":"Rovere","year":"2000","journal-title":"Blood"},{"key":"B116","doi-asserted-by":"publisher","first-page":"e0153847","DOI":"10.1371\/journal.pone.0153847","article-title":"Proteasome beta5i subunit deficiency affects opsonin synthesis and aggravates pneumococcal pneumonia","volume":"11","author":"Kirschner","year":"2016","journal-title":"PLoS ONE"},{"key":"B117","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/j.molcel.2016.01.013","article-title":"mTORC1 coordinates protein synthesis and immunoproteasome formation via PRAS40 to prevent accumulation of protein stress","volume":"61","author":"Yun","year":"2016","journal-title":"Mol Cell"},{"key":"B118","first-page":"55","article-title":"Differential effects of myocarditic variants of Coxsackievirus B3 in inbred mice","volume":"64","author":"Chow","year":"1991","journal-title":"Lab Invest."},{"key":"B119","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1172\/JCI0213971","article-title":"Enhanced ERK-1\/2 activation in mice susceptible to coxsackievirus-induced myocarditis","volume":"109","author":"Opavsky","year":"2002","journal-title":"J Clin Invest."},{"key":"B120","doi-asserted-by":"publisher","first-page":"e1004546","DOI":"10.1371\/journal.ppat.1004546","article-title":"Virus-induced NETs\u2013critical component of host defense or pathogenic mediator?","volume":"11","author":"Jenne","year":"2015","journal-title":"PLoS Pathog."},{"key":"B121","doi-asserted-by":"publisher","first-page":"19434","DOI":"10.1038\/srep19434","article-title":"Inhibiting the immunoproteasome exacerbates the pathogenesis of systemic Candida albicans infection in mice","volume":"6","author":"Mundt","year":"","journal-title":"Sci Rep."},{"key":"B122","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1016\/0002-8703(95)90152-3","article-title":"Colony-stimulating factors and coxackievirus B3 myocarditis in mice: macrophage colony-stimulating factor suppresses acute myocarditis with increasing interferon-alpha","volume":"130","author":"Hiraoka","year":"1995","journal-title":"Am Heart J."},{"key":"B123","doi-asserted-by":"publisher","first-page":"157","DOI":"10.3389\/fcimb.2018.00157","article-title":"Gr-1+ cells other than Ly6G+ neutrophils limit virus replication and promote myocardial inflammation and fibrosis following coxsackievirus B3 infection of mice","volume":"8","author":"Xu","year":"2018","journal-title":"Front Cell Infect Microbiol"},{"key":"B124","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/nri.2017.28","article-title":"Monocyte differentiation and antigen-presenting functions","volume":"17","author":"Jakubzick","year":"2017","journal-title":"Nat Rev Immunol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"3400","DOI":"10.1161\/CIRCULATIONAHA.105.572396","article-title":"Critical role for monocyte chemoattractant protein-1 and macrophage inflammatory protein-1alpha in induction of experimental autoimmune myocarditis and effective anti-monocyte chemoattractant protein-1 gene therapy","volume":"112","author":"Goser","year":"2005","journal-title":"Circulation"},{"key":"B126","doi-asserted-by":"publisher","first-page":"e003293","DOI":"10.1161\/JAHA.112.003293","article-title":"Successful use of mRNA-nucleofection for overexpression of interleukin-10 in murine monocytes\/macrophages for anti-inflammatory therapy in a murine model of autoimmune myocarditis","volume":"1","author":"Zimmermann","year":"2012","journal-title":"J Am Heart Assoc."},{"key":"B127","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.yjmcc.2015.05.010","article-title":"Macrophages and galectin 3 play critical roles in CVB3-induced murine acute myocarditis and chronic fibrosis","volume":"85","author":"Jaquenod De Giusti","year":"2015","journal-title":"J Mol Cell Cardiol."},{"key":"B128","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1093\/eurheartj\/ehu225","article-title":"Silencing of CCR2 in myocarditis","volume":"36","author":"Leuschner","year":"2015","journal-title":"Eur Heart J."},{"key":"B129","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/nri3671","article-title":"Monocytes and macrophages: developmental pathways and tissue homeostasis","volume":"14","author":"Ginhoux","year":"2014","journal-title":"Nat Rev Immunol."},{"key":"B130","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.smim.2003.10.003","article-title":"TLR signaling pathways","volume":"16","author":"Takeda","year":"2004","journal-title":"Semin Immunol."},{"key":"B131","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat Immunol."},{"key":"B132","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/S0092-8674(00)00126-4","article-title":"Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain","volume":"103","author":"Deng","year":"2000","journal-title":"Cell"},{"key":"B133","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.it.2013.03.007","article-title":"Cell type-specific function of TAK1 in innate immune signaling","volume":"34","author":"Ajibade","year":"2013","journal-title":"Trends Immunol."},{"key":"B134","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/nri3495","article-title":"Mitogen-activated protein kinases in innate immunity","volume":"13","author":"Arthur","year":"2013","journal-title":"Nat Rev Immunol."},{"key":"B135","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"key":"B136","doi-asserted-by":"publisher","first-page":"3271","DOI":"10.1002\/1521-4141(200111)31:113.0.CO;2-2","article-title":"Pronounced up-regulation of the PA28 alpha\/beta proteasome regulator but little increase in the steady-state content of immunoproteasome during dendritic cell maturation","volume":"31","author":"Macagno","year":"2001","journal-title":"Eur J Immunol."},{"key":"B137","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.molimm.2017.01.019","article-title":"Immunoproteasome subunit deficiency has no influence on the canonical pathway of NF-kappaB activation","volume":"83","author":"Bitzer","year":"2017","journal-title":"Mol Immunol."},{"key":"B138","doi-asserted-by":"publisher","first-page":"5548","DOI":"10.4049\/jimmunol.1101064","article-title":"The antiviral immune response in mice devoid of immunoproteasome activity","volume":"187","author":"Basler","year":"2011","journal-title":"J Immunol."},{"key":"B139","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1111\/j.1462-5822.2005.00537.x","article-title":"Human cardiac inflammatory responses triggered by Coxsackie B viruses are mainly Toll-like receptor (TLR) 8-dependent","volume":"7","author":"Triantafilou","year":"2005","journal-title":"Cell Microbiol."},{"key":"B140","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/ni0602-499","article-title":"Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848","volume":"3","author":"Jurk","year":"2002","journal-title":"Nat Immunol."},{"key":"B141","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1128\/JVI.02702-13","article-title":"Adenovirus detection by the cGAS\/STING\/TBK1 DNA sensing cascade","volume":"88","author":"Lam","year":"2014","journal-title":"J Virol."},{"key":"B142","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1038\/nri3921","article-title":"STING: infection, inflammation and cancer","volume":"15","author":"Barber","year":"2015","journal-title":"Nat Rev Immunol."},{"key":"B143","doi-asserted-by":"publisher","first-page":"8646","DOI":"10.1128\/MCB.19.12.8646","article-title":"NOD mice are defective in proteasome production and activation of NF-kappa B","volume":"19","author":"Hayashi","year":"1999","journal-title":"Mol Cell Biol."},{"key":"B144","doi-asserted-by":"publisher","first-page":"3195","DOI":"10.1172\/JCI28804","article-title":"Proteasome-mediated degradation of I kappa B alpha and processing of p105 in Crohn disease and ulcerative colitis","volume":"116","author":"Visekruna","year":"2006","journal-title":"J Clin Invest."},{"key":"B145","doi-asserted-by":"publisher","first-page":"5238","DOI":"10.1074\/jbc.275.7.5238","article-title":"Essential role of human leukocyte antigen-encoded proteasome subunits in NF-kappa B activation and prevention of tumor necrosis factor-alpha-induced apoptosis","volume":"275","author":"Hayashi","year":"2000","journal-title":"J Biol Chem."},{"key":"B146","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1038\/80349","article-title":"LMP2 expression and proteasome activity in NOD mice","volume":"6","author":"Runnels","year":"2000","journal-title":"Nat Med."},{"key":"B147","doi-asserted-by":"publisher","first-page":"4115","DOI":"10.4049\/jimmunol.0903003","article-title":"Unexpected role for the immunoproteasome subunit LMP2 in antiviral humoral and innate immune responses","volume":"184","author":"Hensley","year":"2010","journal-title":"J Immunol."},{"key":"B148","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.1039\/c2mb25125f","article-title":"Revisiting the role of the immunoproteasome in the activation of the canonical NF-kappaB pathway","volume":"8","author":"Jang","year":"2012","journal-title":"Mol Biosyst."},{"key":"B149","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1136\/gut.2009.203554","article-title":"Targeting the proteasome: partial inhibition of the proteasome by bortezomib or deletion of the immunosubunit LMP7 attenuates experimental colitis","volume":"59","author":"Schmidt","year":"2010","journal-title":"Gut"},{"key":"B150","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1038\/80346","article-title":"LMP2 expression and proteasome activity in NOD mice","volume":"6","author":"Kessler","year":"2000","journal-title":"Nat Med."},{"key":"B151","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1128\/MCB.01456-06","article-title":"The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK","volume":"27","author":"Ronkina","year":"2007","journal-title":"Mol Cell Biol."},{"key":"B152","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.4049\/jimmunol.137.5.1695","article-title":"Involvement of natural killer cells in coxsackievirus B3-induced murine myocarditis","volume":"137","author":"Godeny","year":"1986","journal-title":"J Immunol."},{"key":"B153","doi-asserted-by":"crossref","first-page":"913","DOI":"10.4049\/jimmunol.139.3.913","article-title":"Murine natural killer cells limit coxsackievirus B3 replication","volume":"139","author":"Godeny","year":"1987","journal-title":"J Immunol."},{"key":"B154","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1002\/path.4369","article-title":"The activating receptor NKG2D of natural killer cells promotes resistance against enterovirus-mediated inflammatory cardiomyopathy","volume":"234","author":"Klingel","year":"2014","journal-title":"J Pathol."},{"key":"B155","doi-asserted-by":"publisher","first-page":"163","DOI":"10.4049\/jimmunol.180.1.163","article-title":"Sensitization of tumor cells to NK cell-mediated killing by proteasome inhibition","volume":"180","author":"Hallett","year":"2008","journal-title":"J Immunol."},{"key":"B156","first-page":"24","article-title":"Enteroviral infection of mice with severe combined immunodeficiency","volume":"66","author":"Chow","year":"1992","journal-title":"Lab Invest."},{"key":"B157","first-page":"102","article-title":"Coxsackievirus B3-induced myocarditis in MHC class II-deficient mice","volume":"2","author":"Leipner","year":"1999","journal-title":"J Hum Virol."},{"key":"B158","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1016\/S0002-9440(10)65223-6","article-title":"The role of B lymphocytes in coxsackievirus B3 infection","volume":"155","author":"Mena","year":"1999","journal-title":"Am J Pathol."},{"key":"B159","doi-asserted-by":"crossref","first-page":"6720","DOI":"10.1128\/JVI.69.11.6720-6728.1995","article-title":"The Role of Cd8(+) T-Lymphocytes in Coxsackievirus B3-Induced Myocarditis","volume":"69","author":"Henke","year":"1995","journal-title":"J Virol."},{"key":"B160","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1016\/S0002-9440(10)64305-2","article-title":"beta 2-microglobulin-associated regulation of interferon-gamma and virus-specific immunoglobulin G confer resistance against the development of chronic coxsackievirus myocarditis","volume":"162","author":"Klingel","year":"2003","journal-title":"Am J Pathol."},{"key":"B161","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/S0002-9440(10)65585-X","article-title":"Coxsackievirus B3-induced myocarditis: perforin exacerbates disease, but plays no detectable role in virus clearance","volume":"153","author":"Gebhard","year":"1998","journal-title":"Am J Pathol."},{"key":"B162","doi-asserted-by":"publisher","first-page":"4331","DOI":"10.1128\/JVI.02639-07","article-title":"Enumeration and functional evaluation of virus-specific CD4(+) and CD8(+) T cells in lymphoid and peripheral sites of coxsackievirus B3 infection","volume":"82","author":"Kemball","year":"2008","journal-title":"J Virol."},{"key":"B163","doi-asserted-by":"publisher","first-page":"e1000618","DOI":"10.1371\/journal.ppat.1000618","article-title":"Coxsackievirus B3 inhibits antigen presentation in vivo, exerting a profound and selective effect on the MHC class I pathway","volume":"5","author":"Kemball","year":"2009","journal-title":"PLoS Pathog."},{"key":"B164","doi-asserted-by":"publisher","first-page":"6637","DOI":"10.1128\/JVI.02572-05","article-title":"Inhibition of protein trafficking by coxsackievirus B3: multiple viral proteins target a single organelle","volume":"80","author":"Cornell","year":"2006","journal-title":"J Virol."},{"key":"B165","doi-asserted-by":"publisher","first-page":"6785","DOI":"10.1128\/JVI.00198-07","article-title":"Coxsackievirus B3 proteins directionally complement each other to downregulate surface major histocompatibility complex class I","volume":"81","author":"Cornell","year":"2007","journal-title":"J Virol."},{"key":"B166","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s00726-009-0434-5","article-title":"Generation of in silico predicted coxsackievirus B3-derived MHC class I epitopes by proteasomes","volume":"39","author":"Voigt","year":"2010","journal-title":"Amino Acids"},{"key":"B167","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.2353\/ajpath.2006.060350","article-title":"Sustained nitric oxide synthesis contributes to immunopathology in ongoing myocarditis attributable to interleukin-10 disorders","volume":"169","author":"Szalay","year":"","journal-title":"Am J Pathol."},{"key":"B168","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1038\/ni1171","article-title":"A cytosolic pathway for MHC class II-restricted antigen processing that is proteasome and TAP dependent","volume":"6","author":"Tewari","year":"2005","journal-title":"Nat Immunol."},{"key":"B169","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1158\/2326-6066.CIR-13-0138","article-title":"Nonclassical antigen-processing pathways are required for MHC class II-restricted direct tumor recognition by NY-ESO-1-specific CD4(+) T cells","volume":"2","author":"Matsuzaki","year":"2014","journal-title":"Cancer Immunol Res."},{"key":"B170","doi-asserted-by":"publisher","first-page":"3439","DOI":"10.1002\/eji.201040620","article-title":"Immunoproteasomes are essential for survival and expansion of T cells in virus-infected mice","volume":"40","author":"Moebius","year":"2010","journal-title":"Eur J Immunol."},{"key":"B171","doi-asserted-by":"publisher","first-page":"4182","DOI":"10.4049\/jimmunol.1201183","article-title":"Immunoproteasome subunit LMP7 deficiency and inhibition suppresses Th1 and Th17 but enhances regulatory T cell differentiation","volume":"189","author":"Kalim","year":"2012","journal-title":"J Immunol."},{"key":"B172","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1161\/CIRCRESAHA.112.270983","article-title":"Genetically induced moderate inhibition of the proteasome in cardiomyocytes exacerbates myocardial ischemia-reperfusion injury in mice","volume":"111","author":"Tian","year":"2012","journal-title":"Circ Res."},{"key":"B173","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1002\/eji.201545578","article-title":"Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis","volume":"46","author":"Mundt","year":"","journal-title":"Eur J Immunol."},{"key":"B174","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/76277","article-title":"Pancreatic expression of interferon-gamma protects mice from lethal coxsackievirus B3 infection and subsequent myocarditis","volume":"6","author":"Horwitz","year":"2000","journal-title":"Nat Med."},{"key":"B175","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1006\/viro.2000.0332","article-title":"Coxsackievirus infection of the pancreas: evaluation of receptor expression, pathogenesis, and immunopathology","volume":"271","author":"Mena","year":"2000","journal-title":"Virology"},{"key":"B176","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1146\/annurev.pathmechdis.3.121806.151534","article-title":"Molecular biology and pathogenesis of viral myocarditis","volume":"3","author":"Esfandiarei","year":"2008","journal-title":"Annu Rev Pathol."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.02620\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T16:22:29Z","timestamp":1694103749000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.02620\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,28]]},"references-count":176,"alternative-id":["10.3389\/fimmu.2018.02620"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.02620","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,28]]},"article-number":"2620"}}