{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:57:47Z","timestamp":1790301467466,"version":"4.1.0"},"reference-count":58,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T00:00:00Z","timestamp":1542672000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2015-1921"],"award-info":[{"award-number":["PICT 2015-1921"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010253","name":"Secretar\u00eda de Ciencia y T\u00e9cnica, Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["20020110100034"],"award-info":[{"award-number":["20020110100034"]}],"id":[{"id":"10.13039\/501100010253","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIP-11220110101089"],"award-info":[{"award-number":["PIP-11220110101089"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01EK1603A-Neuro2D3"],"award-info":[{"award-number":["01EK1603A-Neuro2D3"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.02633","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T05:34:05Z","timestamp":1542692045000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":50,"title":["Cell Death Is Counteracted by Mitophagy in HIV-Productively Infected Astrocytes but Is Promoted by Inflammasome Activation Among Non-productively Infected Cells"],"prefix":"10.3389","volume":"9","author":[{"given":"Diego S.","family":"Ojeda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Grasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Urquiza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Till","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda In\u00e9s","family":"Vaccaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Quarleri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,11,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1097\/COH.0b013e32835fc601","article-title":"Where does HIV hide? A focus on the central nervous system","volume":"8","author":"Churchill","year":"2013","journal-title":"Curr Opin HIV AIDS"},{"key":"B2","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/ana.21697","article-title":"Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia","volume":"66","author":"Churchill","year":"2009","journal-title":"Ann Neurol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1111\/jnc.12443","article-title":"Cytochrome C dysregulation induced by HIV infection of astrocytes results in bystander apoptosis of uninfected astrocytes by an IP3 and calcium-dependent mechanism","volume":"127","author":"Eugenin","year":"2013","journal-title":"J Neurochem"},{"key":"B4","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1097\/QAD.0000000000000605","article-title":"Cell-to-cell contact facilitates HIV transmission from lymphocytes to astrocytes via CXCR4","volume":"29","author":"Li","year":"2015","journal-title":"AIDS"},{"key":"B5","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/nrneurol.2016.53","article-title":"HIV-associated neurocognitive disorder - pathogenesis and prospects for treatment","volume":"12","author":"Saylor","year":"2016","journal-title":"Nat Rev Neurol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/nrn3638","article-title":"Inflammasomes in the CNS","volume":"15","author":"Walsh","year":"2014","journal-title":"Nat Rev Neurosci"},{"key":"B7","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1111\/j.1600-065X.2011.01046.x","article-title":"The inflammasome: an integrated view","volume":"243","author":"Gross","year":"2011","journal-title":"Immunol Rev"},{"key":"B8","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/ni.2237","article-title":"Regulation of inflammasome signaling","volume":"13","author":"Rathinam","year":"2012","journal-title":"Nat Immunol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1007\/s12026-016-8873-z","article-title":"Inflammasomes and its importance in viral infections","volume":"64","author":"Shrivastava","year":"2016","journal-title":"Immunol Res"},{"key":"B10","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3389\/fncel.2017.00063","article-title":"NLRP3 inflammasome in neurological diseases, from functions to therapies","volume":"11","author":"Song","year":"2017","journal-title":"Front Cell Neurosci"},{"key":"B11","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/1742-4690-11-35","article-title":"Rapid inflammasome activation in microglia contributes to brain disease in HIV\/AIDS","volume":"11","author":"Walsh","year":"2014","journal-title":"Retrovirology"},{"key":"B12","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s11481-016-9708-3","article-title":"HIV-1 viral protein R activates NLRP3 inflammasome in microglia: implications for HIV-1 associated neuroinflammation","volume":"12","author":"Mamik","year":"2017","journal-title":"J Neuroimmune Pharmacol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"3834","DOI":"10.1038\/s41598-017-04130-9","article-title":"Pyroptosis, superinfection, and the maintenance of the latent reservoir in HIV-1 infection","volume":"7","author":"Wodarz","year":"2017","journal-title":"Sci Rep"},{"key":"B14","doi-asserted-by":"publisher","first-page":"214","DOI":"10.3389\/fimmu.2018.00214","article-title":"The NLRP3 inflammasome is upregulated in HIV-infected antiretroviral therapy-treated individuals with defective immune recovery","volume":"9","author":"Bandera","year":"2018","journal-title":"Front Immunol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nature09663.","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"},{"key":"B16","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s12977-015-0169-1","article-title":"Apoptosis-induced activation of HIV-1 in latently infected cell lines","volume":"12","author":"Khan","year":"2015","journal-title":"Retrovirology"},{"key":"B17","doi-asserted-by":"publisher","first-page":"4358","DOI":"10.4049\/jimmunol.1301170","article-title":"The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity","volume":"191","author":"Park","year":"2013","journal-title":"J Immunol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/cdd.2012.81","article-title":"The pathways of mitophagy for quality control and clearance of mitochondria","volume":"20","author":"Ashrafi","year":"2013","journal-title":"Cell Death Differ"},{"key":"B19","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/j.cell.2015.12.057","article-title":"NF-kappaB restricts inflammasome activation via elimination of damaged mitochondria","volume":"164","author":"Zhong","year":"2016","journal-title":"Cell"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1080\/15548627.2018.1466014","article-title":"Viral strategies for triggering and manipulating mitophagy","volume":"14","author":"Zhang","year":"2018","journal-title":"Autophagy"},{"key":"B21","doi-asserted-by":"publisher","first-page":"7925","DOI":"10.1128\/JVI.75.17.7925-7933.2001","article-title":"Highly productive infection with pseudotyped human immunodeficiency virus type 1 (HIV-1) indicates no intracellular restrictions to HIV-1 replication in primary human astrocytes","volume":"75","author":"Canki","year":"2001","journal-title":"J Virol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"345","DOI":"10.3389\/fcimb.2017.00345","article-title":"Astrocyte apoptosis and HIV replication are modulated in host cells coinfected with trypanosoma cruzi","volume":"7","author":"Urquiza","year":"2017","journal-title":"Front Cell Infect Microbiol"},{"key":"B23","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1128\/JVI.59.2.284-291.1986","article-title":"Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone","volume":"59","author":"Adachi","year":"1986","journal-title":"J Virol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.4161\/hv.25813","article-title":"Oxidative stress induced by HIV-1 reverse transcriptase modulates the enzyme's performance in gene immunization","volume":"9","author":"Isaguliants","year":"2013","journal-title":"Hum Vaccin Immunother"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1111\/j.1471-4159.2008.05479.x","article-title":"HIV-1 viral envelope glycoprotein gp120 produces oxidative stress and regulates the functional expression of multidrug resistance protein-1 (Mrp1) in glial cells","volume":"106","author":"Ronaldson","year":"2008","journal-title":"J Neurochem"},{"key":"B26","doi-asserted-by":"publisher","first-page":"8910396","DOI":"10.1155\/2016\/8910396","article-title":"Oxidative stress during HIV infection: mechanisms and consequences","volume":"2016","author":"Ivanov","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"B27","doi-asserted-by":"publisher","first-page":"15038","DOI":"10.1073\/pnas.0601945103","article-title":"Selective fluorescent imaging of superoxide in vivo using ethidium-based probes","volume":"103","author":"Robinson","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"B28","doi-asserted-by":"publisher","first-page":"15514","DOI":"10.1073\/pnas.1414859111","article-title":"Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy","volume":"111","author":"Yu","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"B29","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/j.molcel.2016.02.021","article-title":"Clean Up after Yourself","volume":"61","author":"Lepelley","year":"2016","journal-title":"Mol Cell"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/15548627.2015.1100356","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)","volume":"12","author":"Klionsky","year":"2016","journal-title":"Autophagy"},{"key":"B31","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S0076-6879(08)03612-4","article-title":"Monitoring autophagic degradation of p62\/SQSTM1","volume":"452","author":"Bjorkoy","year":"2009","journal-title":"Methods Enzymol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nrm3028","article-title":"Mechanisms of mitophagy","volume":"12","author":"Youle","year":"2011","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"452","DOI":"10.4161\/auto.4451","article-title":"Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3","volume":"3","author":"Kimura","year":"2007","journal-title":"Autophagy"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003722","article-title":"Hepatitis B virus disrupts mitochondrial dynamics: induces fission and mitophagy to attenuate apoptosis","author":"Kim","year":"2013","journal-title":"PLoS Pathog"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2006-7-10-r100","article-title":"CellProfiler: image analysis software for identifying and quantifying cell phenotypes","author":"Carpenter","year":"2006","journal-title":"Genome Biol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.bbamcr.2012.02.012","article-title":"Mitochondrial morphology in mitophagy and macroautophagy","volume":"1833","author":"Gomes","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"B37","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/nature12043","article-title":"Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization","volume":"496","author":"Sarraf","year":"2013","journal-title":"Nature"},{"key":"B38","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.tcb.2014.01.001","article-title":"Parkin and mitochondrial quality control: toward assembling the puzzle","volume":"24","author":"Winklhofer","year":"2014","journal-title":"Trends Cell Biol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.ceb.2015.01.002","article-title":"PINK1\/Parkin-mediated mitophagy in mammalian cells","volume":"33","author":"Eiyama","year":"2015","journal-title":"Curr Opin Cell Biol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1111\/imr.12286","article-title":"Initiation and perpetuation of NLRP3 inflammasome activation and assembly","volume":"265","author":"Elliott","year":"2015","journal-title":"Immunol Rev"},{"key":"B41","doi-asserted-by":"publisher","first-page":"2183026","DOI":"10.1155\/2016\/2183026","article-title":"ROS-Mediated NLRP3 inflammasome activation in brain, heart, kidney, and testis ischemia\/reperfusion injury","volume":"2016","author":"Minutoli","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"B42","doi-asserted-by":"publisher","first-page":"77","DOI":"10.4110\/in.2017.17.2.77","article-title":"Mitochondrial control of innate immunity and inflammation","volume":"17","author":"Jin","year":"2017","journal-title":"Immune Netw"},{"key":"B43","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1093\/jb\/mvw098","article-title":"Mitochondrial function is required for extracellular ATP-induced NLRP3 inflammasome activation","volume":"161","author":"Sadatomi","year":"2017","journal-title":"J Biochem"},{"key":"B44","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1038\/cdd.2009.22","article-title":"Complex II inhibition by 3-NP causes mitochondrial fragmentation and neuronal cell death via an NMDA- and ROS-dependent pathway","volume":"16","author":"Liot","year":"2009","journal-title":"Cell Death Differ"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1016\/j.celrep.2014.10.046","article-title":"Parkin sensitizes toward apoptosis induced by mitochondrial depolarization through promoting degradation of Mcl-1","volume":"9","author":"Carroll","year":"2014","journal-title":"Cell Rep"},{"key":"B46","doi-asserted-by":"publisher","first-page":"2784","DOI":"10.1016\/j.bbamcr.2015.03.013","article-title":"Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses","volume":"1853","author":"Wei","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"B47","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1007\/s00018-015-2087-8","article-title":"Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy","volume":"73","author":"Hamacher-Brady","year":"2016","journal-title":"Cell Mol Life Sci"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1074\/jbc.M102671200","article-title":"Productive HIV-1 infection of primary CD4+ T cells induces mitochondrial membrane permeabilization leading to a caspase-independent cell death","volume":"277","author":"Petit","year":"2002","journal-title":"J Biol Chem"},{"key":"B49","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/S0006-291X(03)00629-6","article-title":"Mitochondria in HIV-1-induced apoptosis","volume":"304","author":"Arnoult","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"B50","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/nature12940","article-title":"Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection","volume":"505","author":"Doitsh","year":"2014","journal-title":"Nature"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1016\/j.celrep.2015.08.011","article-title":"Cell-to-cell transmission of HIV-1 is required to trigger pyroptotic death of lymphoid-tissue-derived CD4 T cells","volume":"12","author":"Galloway","year":"2015","journal-title":"Cell Rep"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1002\/glia.23310","article-title":"Astrocytes sustain long-term productive HIV-1 infection without establishment of reactivable viral latency","volume":"66","author":"Barat","year":"2018","journal-title":"Glia"},{"key":"B53","doi-asserted-by":"publisher","first-page":"6413","DOI":"10.1073\/pnas.1321114111","article-title":"Hepatitis C virus triggers mitochondrial fission and attenuates apoptosis to promote viral persistence","volume":"111","author":"Kim","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1038\/cr.2015.139","article-title":"Gasdermin D is an executor of pyroptosis and required for interleukin-1beta secretion","volume":"25","author":"He","year":"2015","journal-title":"Cell Res"},{"key":"B55","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1038\/ni.2563","article-title":"Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection","volume":"14","author":"Lupfer","year":"2013","journal-title":"Nat Immunol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1080\/15548627.2016.1183081","article-title":"SESN2\/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages","volume":"12","author":"Kim","year":"2016","journal-title":"Autophagy"},{"key":"B57","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/sj.emboj.7601963","article-title":"Fission and selective fusion govern mitochondrial segregation and elimination by autophagy","volume":"27","author":"Twig","year":"2008","journal-title":"EMBO J"},{"key":"B58","doi-asserted-by":"publisher","first-page":"27425","DOI":"10.1074\/jbc.M115.667063","article-title":"Rotenone-induced impairment of mitochondrial electron transport chain confers a selective priming signal for NLRP3 inflammasome activation","volume":"290","author":"Won","year":"2015","journal-title":"J Biol Chem"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.02633\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T15:28:30Z","timestamp":1605454110000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.02633\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,20]]},"references-count":58,"alternative-id":["10.3389\/fimmu.2018.02633"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.02633","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,20]]},"article-number":"2633"}}