{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T23:39:40Z","timestamp":1792539580953,"version":"4.5.0"},"reference-count":96,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T00:00:00Z","timestamp":1544745600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.02965","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T04:54:39Z","timestamp":1544763279000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":225,"title":["Hidradenitis Suppurativa: A Systematic Review Integrating Inflammatory Pathways Into a Cohesive Pathogenic Model"],"prefix":"10.3389","volume":"9","author":[{"given":"Allard R. J. V.","family":"Vossen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hessel H.","family":"van der Zee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Errol P.","family":"Prens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,12,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1111\/jdv.12966","article-title":"European S1 guideline for the treatment of hidradenitis suppurativa\/acne inversa","volume":"29","author":"Zouboulis","year":"2015","journal-title":"J Eur Acad Dermatol Venereol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"75","DOI":"10.12788\/j.sder.2017.016","article-title":"Quality of life considerations and pain management in hidradenitis suppurativa","volume":"36","author":"Jemec","year":"2017","journal-title":"Semin Cutan Med Surg."},{"key":"B3","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.jaad.2017.03.016","article-title":"Gene expression of sphingolipid metabolism pathways is altered in hidradenitis suppurativa","volume":"77","author":"Dany","year":"2017","journal-title":"J Am Acad Dermatol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1001\/jama.2017.16691","article-title":"Hidradenitis suppurativa: advances in diagnosis and treatment","volume":"318","author":"Saunte","year":"2017","journal-title":"JAMA"},{"key":"B5","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1080\/08820139.2016.1230867","article-title":"Interferon-gamma (IFN-gamma) is elevated in wound exudate from hidradenitis suppurativa","volume":"46","author":"Banerjee","year":"2017","journal-title":"Immunol Invest."},{"key":"B6","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1111\/j.1600-0625.2009.00915.x","article-title":"Hidradenitis suppurativa (acne inversa): early inflammatory events at terminal follicles and at interfollicular epidermis","volume":"19","author":"Von Laffert","year":"2010","journal-title":"Exp Dermatol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1111\/j.1365-2133.2010.10034.x","article-title":"Hidradenitis suppurativa\/acne inversa: bilocated epithelial hyperplasia with very different sequelae","volume":"164","author":"Von Laffert","year":"2011","journal-title":"Br J Dermatol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1111\/j.1365-2133.2009.09198.x","article-title":"Objective scoring of hidradenitis suppurativa reflecting the role of tobacco smoking and obesity","volume":"161","author":"Sartorius","year":"2009","journal-title":"Br J Dermatol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jaad.2016.08.031","article-title":"Inflammatory bowel disease is associated with hidradenitis suppurativa: results from a multicenter cross-sectional study","volume":"76","author":"Deckers","year":"2017","journal-title":"J Am Acad Dermatol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1111\/j.1365-2133.2011.10254.x","article-title":"Elevated levels of tumour necrosis factor (TNF)-\u03b1, interleukin (IL)-1\u03b2 and IL-10 in hidradenitis suppurativa skin: a rationale for targeting TNF-\u03b1 and IL-1\u03b2","volume":"164","author":"Van Der Zee","year":"2011","journal-title":"Brit J Dermatol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1111\/bjd.14075","article-title":"Dysregulated cytokine expression in lesional and nonlesional skin in hidradenitis suppurativa","volume":"173","author":"Kelly","year":"2015","journal-title":"Br J Dermatol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2389","DOI":"10.1016\/j.jid.2017.05.033","article-title":"Hidradenitis suppurativa is characterized by dysregulation of the Th17:Treg cell axis, which is corrected by anti-TNF therapy","volume":"137","author":"Moran","year":"2017","journal-title":"J Invest Dermatol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1111\/j.1365-2133.2011.10765.x","article-title":"Immunohistological pointers to a possible role for excessive cathelicidin (LL-37) expression by apocrine sweat glands in the pathogenesis of hidradenitis suppurativa\/acne inversa","volume":"166","author":"Emelianov","year":"2012","journal-title":"Br J Dermatol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.jaad.2009.06.050","article-title":"Infliximab therapy for patients with moderate to severe hidradenitis suppurativa: a randomized, double-blind, placebo-controlled crossover trial","volume":"62","author":"Grant","year":"2010","journal-title":"J Am Acad Dermatol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1111\/j.1365-2133.2011.10698.x","article-title":"Adalimumab (antitumour necrosis factor-alpha) treatment of hidradenitis suppurativa ameliorates skin inflammation: an in situ and ex vivo study","volume":"166","author":"Van Der Zee","year":"2012","journal-title":"Br J Dermatol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1126\/science.1196284","article-title":"Gamma-secretase gene mutations in familial acne inversa","volume":"330","author":"Wang","year":"2010","journal-title":"Science"},{"key":"B17","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.devcel.2004.09.014","article-title":"gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis","volume":"7","author":"Pan","year":"2004","journal-title":"Dev Cell"},{"key":"B18","doi-asserted-by":"publisher","first-page":"264","DOI":"10.7326\/0003-4819-151-4-200908180-00135","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"151","author":"Moher","year":"2009","journal-title":"Ann Intern Med."},{"key":"B19","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1111\/bjd.14383","article-title":"PSTPIP1 gene mutation in a pyoderma gangrenosum, acne and suppurative hidradenitis (PASH) syndrome","volume":"175","author":"Calderon-Castrat","year":"2016","journal-title":"Br J Dermatol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1111\/bjd.15076","article-title":"NCSTN mutations in hidradenitis suppurativa\/acne inversa do not influence cytokine production by peripheral blood mononuclear cells","volume":"176","author":"Xu","year":"2017","journal-title":"Br J Dermatol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/1346-8138.13572","article-title":"Hidradenitis suppurativa is not associated with the metabolic syndrome based on body type: a cross-sectional study","volume":"44","author":"Vossen","year":"2017","journal-title":"J Dermatol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1001\/2013.jamadermatol.717","article-title":"Identification of a homozygous PSTPIP1 mutation in a patient with a PAPA-like syndrome responding to canakinumab treatment","volume":"149","author":"Geusau","year":"2013","journal-title":"JAMA Dermatol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.cyto.2013.03.008","article-title":"Haplotypes of IL-12Rbeta1 impact on the clinical phenotype of hidradenitis suppurativa","volume":"62","author":"Giatrakos","year":"2013","journal-title":"Cytokine"},{"key":"B24","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1001\/jamadermatol.2013.2907","article-title":"Pyogenic arthritis, pyoderma gangrenosum, acne, and hidradenitis suppurativa (PAPASH): a new autoinflammatory syndrome associated with a novel mutation of the PSTPIP1 gene","volume":"149","author":"Marzano","year":"2013","journal-title":"JAMA Dermatol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1111\/j.1365-2133.2012.11174.x","article-title":"A novel splice site mutation in NCSTN underlies a Japanese family with hidradenitis suppurativa","volume":"168","author":"Nomura","year":"2013","journal-title":"Br J Dermatol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1111\/j.1468-3083.2012.04627.x","article-title":"Two novel mutations of the NCSTN gene in Chinese familial acne inverse","volume":"27","author":"Zhang","year":"2013","journal-title":"J Eur Acad Dermatol Venereol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"3844","DOI":"10.1111\/febs.12912","article-title":"Proline-serine-threonine phosphatase interacting protein 1 inhibition of T-cell receptor signaling depends on its SH3 domain","volume":"281","author":"Marcos","year":"2014","journal-title":"FEBS J."},{"key":"B28","doi-asserted-by":"publisher","first-page":"2703","DOI":"10.1182\/blood-2013-07-516948","article-title":"The F-BAR protein PSTPIP1 controls extracellular matrix degradation and filopodia formation in macrophages","volume":"123","author":"Starnes","year":"2014","journal-title":"Blood"},{"key":"B29","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1111\/ced.12585","article-title":"Pyoderma gangrenosum, acne and ulcerative colitis in a patient with a novel mutation in the PSTPIP1 gene","volume":"40","author":"Zeeli","year":"2015","journal-title":"Clin Exp Dermatol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1016\/j.jid.2016.04.021","article-title":"High copy numbers of beta-defensin cluster on 8p23.1, confer genetic susceptibility, and modulate the physical course of hidradenitis suppurativa\/acne inversa","volume":"136","author":"Giamarellos-Bourboulis","year":"2016","journal-title":"J Invest Dermatol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1111\/bjd.14223","article-title":"Nicastrin mutations in familial acne inversa impact keratinocyte proliferation and differentiation through the Notch and phosphoinositide 3-kinase\/AKT signalling pathways","volume":"174","author":"Xiao","year":"2016","journal-title":"Br J Dermatol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1089\/gtmb.2016.0112","article-title":"Different contributions of CDKAL1, KIF21B, and LRRK2\/MUC19 polymorphisms to SAPHO syndrome, rheumatoid arthritis, ankylosing spondylitis, and seronegative spondyloarthropathy","volume":"21","author":"Li","year":"2017","journal-title":"Genet Test Mol Biomarkers"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1111\/bjd.15226","article-title":"Autoinflammation in pyoderma gangrenosum and its syndromic form (pyoderma gangrenosum, acne and suppurative hidradenitis)","volume":"176","author":"Marzano","year":"2017","journal-title":"Br J Dermatol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1111\/bjd.15424","article-title":"Lipocalin-2 is expressed by activated granulocytes and keratinocytes in affected skin and reflects disease activity in acne inversa\/hidradenitis suppurativa","volume":"177","author":"Wolk","year":"2017","journal-title":"Br J Dermatol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"301","DOI":"10.2340\/00015555-1492","article-title":"Tumour necrosis factor-alpha and matrix metalloproteinase-2 are expressed strongly in hidradenitis suppurativa","volume":"93","author":"Mozeika","year":"2013","journal-title":"Acta Derm Venereol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/j.jaad.2015.08.052","article-title":"Correlation of inflammatory serum markers with disease severity in patients with hidradenitis suppurativa (HS)","volume":"73","author":"Hessam","year":"2015","journal-title":"J Am Acad Dermatol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/s00403-017-1769-5","article-title":"IL-36 cytokines are increased in acne and hidradenitis suppurativa","volume":"309","author":"Di Caprio","year":"2017","journal-title":"Arch Dermatol Res."},{"key":"B38","doi-asserted-by":"publisher","first-page":"2450401","DOI":"10.1155\/2017\/2450401","article-title":"The clinical significance of increased serum proinflammatory cytokines, C-reactive protein, and erythrocyte sedimentation rate in patients with hidradenitis suppurativa","volume":"2017","author":"Jimenez-Gallo","year":"2017","journal-title":"Mediators Inflamm."},{"key":"B39","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/j.jaad.2016.10.042","article-title":"Increased interleukin (IL)-17 serum levels in patients with hidradenitis suppurativa: implications for treatment with anti-IL-17 agents","volume":"76","author":"Matusiak","year":"2017","journal-title":"J Am Acad Dermatol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1159\/000475925","article-title":"Serum anticytokine autoantibody levels are not increased in hidradenitis suppurativa: a case-control pilot study","volume":"233","author":"Theut Riis","year":"2017","journal-title":"Dermatology"},{"key":"B41","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1111\/jdv.14389","article-title":"Increased expression of the interleukin-36 cytokines in lesions of hidradenitis suppurativa","volume":"31","author":"Thomi","year":"2017","journal-title":"J Eur Acad Dermatol Venereol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1111\/bjd.15458","article-title":"Interleukin-32 is highly expressed in lesions of hidradenitis suppurativa","volume":"177","author":"Thomi","year":"2017","journal-title":"Br J Dermatol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1990","DOI":"10.3201\/eid2012.140064","article-title":"Bacterial pathogens associated with hidradenitis suppurativa, France","volume":"20","author":"Guet-Revillet","year":"2014","journal-title":"Emerg Infect Dis."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1016\/j.jid.2016.04.036","article-title":"Intrinsic defect in keratinocyte function leads to inflammation in hidradenitis suppurativa","volume":"136","author":"Hotz","year":"2016","journal-title":"J Invest Dermatol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1093\/cid\/cix285","article-title":"The microbiological landscape of anaerobic infections in hidradenitis suppurativa: a prospective metagenomic study","volume":"65","author":"Guet-Revillet","year":"2017","journal-title":"Clin Infect Dis."},{"key":"B46","doi-asserted-by":"publisher","first-page":"493","DOI":"10.2340\/00015555-2591","article-title":"Bacterial colonization in hidradenitis suppurativa\/acne inversa: a cross-sectional study of 50 patients and review of the literature","volume":"97","author":"Nikolakis","year":"2017","journal-title":"Acta Derm Venereol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1111\/bjd.15007","article-title":"Bacterial biofilm in chronic lesions of hidradenitis suppurativa","volume":"176","author":"Ring","year":"2017","journal-title":"Br J Dermatol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1001\/jamadermatol.2017.0904","article-title":"The follicular skin microbiome in patients with hidradenitis suppurativa and healthy controls","volume":"153","author":"Ring","year":"2017","journal-title":"JAMA Dermatol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1111\/bjd.13090","article-title":"Risk factors, clinical course and long-term prognosis in hidradenitis suppurativa: a cross-sectional study","volume":"171","author":"Kromann","year":"2014","journal-title":"Br J Dermatol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1111\/jdv.12857","article-title":"Verneuil's disease, innate immunity and vitamin D: a pilot study","volume":"29","author":"Guillet","year":"2015","journal-title":"J Eur Acad Dermatol Venereol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1159\/000472252","article-title":"Should hidradenitis suppurativa be included in dermatoses showing koebnerization? Is it friction or fiction?","volume":"233","author":"Boer","year":"2017","journal-title":"Dermatology"},{"key":"B52","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.jaad.2016.07.024","article-title":"Menses and pregnancy affect symptoms in hidradenitis suppurativa: a cross-sectional study","volume":"76","author":"Vossen","year":"2017","journal-title":"J Am Acad Dermatol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/35079107","article-title":"Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease","volume":"411","author":"Hugot","year":"2001","journal-title":"Nature"},{"key":"B54","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/35079114","article-title":"A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease","volume":"411","author":"Ogura","year":"2001","journal-title":"Nature"},{"key":"B55","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.autrev.2017.02.013","article-title":"IBD immunopathogenesis: a comprehensive review of inflammatory molecules","volume":"16","author":"Park","year":"2017","journal-title":"Autoimmun Rev."},{"key":"B56","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/S0889-857X(05)70179-4","article-title":"Gonadal and adrenal sex steroids in ankylosing spondylitis","volume":"26","author":"Gooren","year":"2000","journal-title":"Rheum Dis Clin North Am."},{"key":"B57","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.rdc.2014.07.005","article-title":"Genetics, environment, and gene-environment interactions in the development of systemic rheumatic diseases","volume":"40","author":"Sparks","year":"2014","journal-title":"Rheum Dis Clin North Am."},{"key":"B58","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.3899\/jrheum.140353","article-title":"Current smoking is associated with incident ankylosing spondylitis \u2013 the HUNT population-based Norwegian health study","volume":"41","author":"Videm","year":"2014","journal-title":"J Rheumatol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1111\/cei.12670","article-title":"The interleukin (IL)-23\/IL-17 axis in ankylosing spondylitis: new advances and potentials for treatment","volume":"183","author":"Jethwa","year":"2016","journal-title":"Clin Exp Immunol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1097\/BOR.0000000000000297","article-title":"Ankylosing spondylitis: beyond genome-wide association studies","volume":"28","author":"O'rielly","year":"2016","journal-title":"Curr Opin Rheumatol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.clim.2017.07.011","article-title":"Solving the pathogenesis of ankylosing spondylitis","volume":"186","author":"Brown","year":"2017","journal-title":"Clin Immunol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"e163","DOI":"10.1038\/cti.2017.49","article-title":"Progress of genome-wide association studies of ankylosing spondylitis","volume":"6","author":"Li","year":"2017","journal-title":"Clin Transl Immunol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"3596","DOI":"10.1002\/art.21393","article-title":"Evidence for common genetic control in pathways of inflammation for Crohn's disease and psoriatic arthritis","volume":"52","author":"Ho","year":"2005","journal-title":"Arthritis Rheum."},{"key":"B64","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1038\/ng.694","article-title":"A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1","volume":"42","author":"Strange","year":"2010","journal-title":"Nat Genet."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1136\/annrheumdis-2012-201299","article-title":"Obesity and the risk of psoriatic arthritis: a population-based study","volume":"71","author":"Love","year":"2012","journal-title":"Ann Rheum Dis."},{"key":"B66","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1089\/jir.2017.0105","article-title":"Bidirectional association between psoriasis and obesity: benefits and risks","volume":"38","author":"El-Boghdady","year":"2017","journal-title":"J Interferon Cytokine Res"},{"key":"B67","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1111\/1346-8138.14139","article-title":"Pathogenesis of psoriasis and development of treatment","volume":"45","author":"Ogawa","year":"2017","journal-title":"J Dermatol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1136\/annrheumdis-2017-211625","article-title":"Smoking paradox in the development of psoriatic arthritis among patients with psoriasis: a population-based study","volume":"77","author":"Nguyen","year":"2018","journal-title":"Ann Rheum Dis."},{"key":"B69","first-page":"4","article-title":"Smoking and skin disease","volume":"15","author":"Thomsen","year":"2010","journal-title":"Skin Therapy Lett."},{"key":"B70","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1111\/j.1610-0387.2011.07734.x","article-title":"Investigation of new co-factors in 49 patients with pyoderma gangrenosum","volume":"10","author":"Al Ghazal","year":"2012","journal-title":"J Dtsch Dermatol Ges."},{"key":"B71","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1097\/01.ASW.0000526605.34372.9e","article-title":"Pyoderma gangrenosum: a critical appraisal","volume":"30","author":"Shavit","year":"2017","journal-title":"Adv Skin Wound Care"},{"key":"B72","doi-asserted-by":"publisher","first-page":"289","DOI":"10.3109\/07853890.2010.547515","article-title":"Risk of asthma and autoimmune diseases and related conditions in patients hospitalized for obesity","volume":"44","author":"Hemminki","year":"2012","journal-title":"Ann Med."},{"key":"B73","doi-asserted-by":"publisher","first-page":"200","DOI":"10.3389\/fimmu.2017.00200","article-title":"Cytokine signatures in mucocutaneous and ocular Behcet's disease","volume":"8","author":"Lopalco","year":"2017","journal-title":"Front Immunol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1590\/abd1806-4841.20177359","article-title":"Behcet's disease: review with emphasis on dermatological aspects","volume":"92","author":"Scherrer","year":"2017","journal-title":"An Bras Dermatol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1007\/s00296-011-1813-2","article-title":"Meta-analysis of NOD2\/CARD15 polymorphisms with psoriasis and psoriatic arthritis","volume":"32","author":"Zhu","year":"2012","journal-title":"Rheumatol Int."},{"key":"B76","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1016\/j.jid.2017.04.024","article-title":"Hidradenitis suppurativa is associated with familial mediterranean fever-a population-based study","volume":"137","author":"Hodak","year":"2017","journal-title":"J Invest Dermatol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.clindermatol.2013.11.006","article-title":"Hidradenitis suppurrativa (acne inversa) as a systemic disease","volume":"32","author":"Dessinioti","year":"2014","journal-title":"Clin Dermatol."},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16768","article-title":"Current and future treatment of hidradenitis suppurativa","author":"Van Straalen","year":"2018","journal-title":"Br J Dermatol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"553","DOI":"10.2340\/00015555-1800","article-title":"The influence of body weight on the prevalence and severity of hidradenitis suppurativa","volume":"94","author":"Kromann","year":"2014","journal-title":"Acta Derm Venereol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/S0190-9622(98)70272-5","article-title":"Topical clindamycin versus systemic tetracycline in the treatment of hidradenitis suppurativa","volume":"39","author":"Jemec","year":"1998","journal-title":"J Am Acad Dermatol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/j.1365-2230.2009.03377.x","article-title":"Resorcinol peels as a possible self-treatment of painful nodules in hidradenitis suppurativa","volume":"35","author":"Boer","year":"2010","journal-title":"Clin Exp Dermatol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1016\/j.jaad.2017.07.008","article-title":"Topical 15% resorcinol for hidradenitis suppurativa: an uncontrolled prospective trial with clinical and ultrasonographic follow-up","volume":"77","author":"Pascual","year":"2017","journal-title":"J Am Acad Dermatol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/j.jaad.2016.06.049","article-title":"Intralesional triamcinolone for flares of hidradenitis suppurativa (HS): a case series","volume":"75","author":"Riis","year":"2016","journal-title":"J Am Acad Dermatol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1179\/joc.2004.16.4.357","article-title":"Immunomodulating activity of rifampicin","volume":"16","author":"Ziglam","year":"2004","journal-title":"J Chemother."},{"key":"B85","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1086\/426545","article-title":"Nonantimicrobial effects of antibacterial agents","volume":"40","author":"Pasquale","year":"2005","journal-title":"Clin Infect Dis."},{"key":"B86","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.jaad.2005.10.004","article-title":"Tetracyclines: nonantibiotic properties and their clinical implications","volume":"54","author":"Sapadin","year":"2006","journal-title":"J Am Acad Dermatol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1159\/000228334","article-title":"Combination therapy with clindamycin and rifampicin for hidradenitis suppurativa: a series of 116 consecutive patients","volume":"219","author":"Gener","year":"2009","journal-title":"Dermatology"},{"key":"B88","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1159\/000321716","article-title":"Efficacy of rifampin-moxifloxacin-metronidazole combination therapy in hidradenitis suppurativa","volume":"222","author":"Join-Lambert","year":"2011","journal-title":"Dermatology"},{"key":"B89","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1111\/bjd.14338","article-title":"Ustekinumab in hidradenitis suppurativa: clinical results and a search for potential biomarkers in serum","volume":"174","author":"Blok","year":"2016","journal-title":"Br J Dermatol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1056\/NEJMoa1504370","article-title":"Two phase 3 trials of adalimumab for hidradenitis suppurativa","volume":"375","author":"Kimball","year":"2016","journal-title":"N Engl J Med."},{"key":"B91","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1001\/jamadermatol.2015.3903","article-title":"Safety and efficacy of anakinra in severe hidradenitis suppurativa: a randomized clinical trial","volume":"152","author":"Tzanetakou","year":"2016","journal-title":"JAMA Dermatol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.jid.2017.10.030","article-title":"MABp1 targeting IL-1alpha for moderate to severe hidradenitis suppurativa not eligible for adalimumab: a randomized study","volume":"138","author":"Kanni","year":"2018","journal-title":"J Invest Dermatol."},{"key":"B93","unstructured":"Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis84255\n            SchaferPH\n            PartonA\n            GandhiAK\n            CaponeL\n            AdamsM\n            WuL\n          10.1111\/j.1476-5381.2009.00559.x20050849Br J Pharmacol.1592010"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.06.046","article-title":"Apremilast for moderate hidradenitis suppurativa: results of a randomized controlled trial","author":"Vossen","year":"2018","journal-title":"J Am Acad Dermatol"},{"key":"B95","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.jaad.2009.12.018","article-title":"Deroofing: a tissue-saving surgical technique for the treatment of mild to moderate hidradenitis suppurativa lesions","volume":"63","author":"Van Der Zee","year":"2010","journal-title":"J Am Acad Dermatol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"S70","DOI":"10.1016\/j.jaad.2015.07.044","article-title":"Recurrence of hidradenitis suppurativa after surgical management: a systematic review and meta-analysis","volume":"73","author":"Mehdizadeh","year":"2015","journal-title":"J Am Acad Dermatol."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.02965\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T04:54:52Z","timestamp":1544763292000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.02965\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,14]]},"references-count":96,"alternative-id":["10.3389\/fimmu.2018.02965"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.02965","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,14]]},"article-number":"2965"}}