{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:02:32Z","timestamp":1793898152711,"version":"4.8.0"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T00:00:00Z","timestamp":1545091200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.02996","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T03:35:17Z","timestamp":1545104117000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":44,"title":["Linagliptin Attenuates the Cardiac Dysfunction Associated With Experimental Sepsis in Mice With Pre-existing Type 2 Diabetes by Inhibiting NF-\u03baB"],"prefix":"10.3389","volume":"9","author":[{"given":"Sura","family":"Al Zoubi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fausto","family":"Chiazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debora","family":"Collotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad M.","family":"Yaqoob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Collino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Thiemermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,12,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"B2","article-title":"The septic heart current understanding of molecular mechanisms and clinical implications","volume-title":"Chest","author":"Martin","year":""},{"key":"B3","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1161\/CIRCULATIONAHA.106.678359","article-title":"Sepsis and the heart","volume":"116","author":"Merx","year":"2007","journal-title":"Circulation"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/cc7157","article-title":"Incidence, organ dysfunction and mortality in severe sepsis: a Spanish multicentre study","volume":"12","author":"Blanco","year":"2008","journal-title":"Crit Care"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1097\/00003246-200107000-00002","article-title":"Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care","volume":"29","author":"Angus","year":"2001","journal-title":"Crit Care Med"},{"key":"B6","year":"2016","journal-title":"Global Report on Diabetes"},{"key":"B7","doi-asserted-by":"publisher","first-page":"3","DOI":"10.2337\/diaclin.34.1.3","article-title":"Standards of medical care in diabetes-\u22122016 abridged for primary care providers","volume":"34","year":"2016","journal-title":"Clin Diabetes"},{"key":"B8","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/0002-9149(72)90595-4","article-title":"New type of cardiomyopathy associated with diabetic glomerulosclerosis","volume":"30","author":"Rubler","year":"1972","journal-title":"Am J Cardiol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"946","DOI":"10.2337\/db08-1192","article-title":"Location of arterial stif fening differs in those with impaired fasting glucose versus diabetes: implications for left ventricular hypertrophy from the multi-ethnic study of Atherosclerosis","volume":"58","author":"Rerkpattanapipat","year":"2009","journal-title":"Diabetes"},{"key":"B10","doi-asserted-by":"publisher","first-page":"27","DOI":"10.4103\/2230-8210.94253","article-title":"Infections in patients with diabetes mellitus : a review of pathogenesis","volume":"16","author":"Casqueiro","year":"2012","journal-title":"Indian J Endocrinol Metab"},{"key":"B11","doi-asserted-by":"publisher","first-page":"771","DOI":"10.2337\/dc10-1185","article-title":"Diabetes and sepsis: preclinical findings and clinical relevance","volume":"34","author":"Schuetz","year":"2011","journal-title":"Diabetes Care"},{"key":"B12","doi-asserted-by":"publisher","first-page":"2251","DOI":"10.2337\/dc06-2417","article-title":"Type 2 diabetes and pneumonia outcomes: a population-based cohort study","volume":"30","author":"Kornum","year":"2007","journal-title":"Diabetes Care"},{"key":"B13","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/s00125-006-0570-3","article-title":"Influence of diabetes and hyperglycaemia on infectious disease hospitalisation and outcome","volume":"50","author":"Benfield","year":"2007","journal-title":"Diabetol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1086\/427699","article-title":"Diabetes mellitus as a risk and prognostic factor for community-acquired bacteremia due to enterobacteria : a 10-year, population-based study among adults","volume":"40","author":"Thomsen","year":"2005","journal-title":"Clin Infect Dis"},{"key":"B15","doi-asserted-by":"publisher","first-page":"R12","DOI":"10.1186\/cc8866","article-title":"Insulin-treated diabetes is not associated with increased mortality in critically ill patients","volume":"14","author":"Vincent","year":"2010","journal-title":"Crit Care"},{"key":"B16","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/cc7717","article-title":"The effect of diabetes mellitus on organ dysfunction with sepsis : an epidemiological study","volume":"13","author":"Esper","year":"2009","journal-title":"Crit Care"},{"key":"B17","doi-asserted-by":"publisher","first-page":"e1026","DOI":"10.1097\/CCM.0000000000002590","article-title":"Diabetes is not associated with increased 90-day mortality risk in critically ill patients with sepsis","volume":"45","author":"van Vught","year":"2017","journal-title":"Crit Care Med"},{"key":"B18","doi-asserted-by":"publisher","first-page":"810","DOI":"10.2337\/diacare.28.4.810","article-title":"The relation between hyperglycemia and outcomes in 2,471 patients admitted to the hospital with community-acquired pneumonia","volume":"28","author":"McAlister","year":"2005","journal-title":"Diabetes Care"},{"key":"B19","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1097\/00003246-200007000-00001","article-title":"Diabetic patients have a decreased incidence of acute respiratory distress syndrome","volume":"28","author":"Moss","year":"2000","journal-title":"Crit Care Med"},{"key":"B20","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1097\/ALN.0000000000000192","article-title":"Obesity-induced hyperleptinemia improves survival and immune response in a murine model of sepsis","volume":"121","author":"Siegl","year":"2014","journal-title":"Anesthesiology"},{"key":"B21","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1093\/nar\/gkv1118","article-title":"Twenty years of the MEROPS database of proteolytic enzymes, their substrates and inhibitors","volume":"44","author":"Rawlings","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"B22","unstructured":"Effect of Dipeptidyl Peptidase-4 inhibitors on adenosine deaminase Ac- tivity in Type-2 Diabetes Mellitus48993\n            JhajhariaS\n            PradhanT\n            EkkaA\n            DasAK\n          Biomed Res252014"},{"key":"B23","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3109\/s10165-005-0452-4","article-title":"T-cell activation via CD26 and caveolin-1 in rheumatoid synovium","volume":"16","author":"Ohnuma","year":"2006","journal-title":"Mod Rheumatol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/cei.12781","article-title":"Cut to the chase : a review of CD26 \/ dipeptidyl peptidase-4' s (DPP4) entanglement in the immune system","volume":"185","author":"Klemann","year":"2016","journal-title":"Clin Exp Immunol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"10117","DOI":"10.1074\/jbc.M609157200","article-title":"Caveolin-1 Triggers T-cell Activation via CD26 in Association","volume":"282","author":"Ohnuma","year":"2007","journal-title":"J Biol Chem"},{"key":"B26","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1111\/j.1365-2249.2004.02591.x","article-title":"Macrophages are a source of extracellular adenosine deaminase-2 during inflammatory responses","volume":"138","author":"Conlon","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.2337\/db10-1707","article-title":"Dipeptidyl peptidase 4 is a novel adipokine potentially linking obesity to the metabolic syndrome","volume":"60","author":"Lamers","year":"2011","journal-title":"Diabetes"},{"key":"B28","doi-asserted-by":"publisher","first-page":"2553","DOI":"10.1210\/jc.2012-4288","article-title":"CD26\/DPP4 Levels in peripheral blood and T Cells in patients with Type 2 diabetes mellitus","volume":"98","author":"Kang","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"B29","doi-asserted-by":"publisher","first-page":"729","DOI":"10.3892\/mmr.2011.707","article-title":"Increased hepatic expression of dipeptidyl peptidase-4 in non-alcoholic fatty liver disease and its association with insulin resistance and glucose metabolism","volume":"5","author":"Miyazaki","year":"2012","journal-title":"Mol Med Rep"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1164\/rccm.201002-0240OC","article-title":"Protective role of peroxisome proliferator-activated receptor-\u03b2\/\u03b4 in septic shock","volume":"182","author":"Kapoor","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1242\/dmm.011908","article-title":"Erythropoietin attenuates cardiac dysfunction in experimental sepsis in mice via activation of the \u03b2-common receptor","volume":"6","author":"Khan","year":"2013","journal-title":"Dis Model Mech"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1242\/dmm.012435","article-title":"Inhibition of I B kinase reduces the multiple organ dysfunction caused by sepsis in the mouse","volume":"6","author":"Coldewey","year":"2013","journal-title":"Dis Model Mech"},{"key":"B33","doi-asserted-by":"publisher","first-page":"H1036","DOI":"10.1152\/ajpheart.00340.2014","article-title":"Cardiac-specific suppression of NF-\u03baB signaling prevents diabetic cardiomyopathy via inhibition of the renin-angiotensin system","volume":"307","author":"Thomas","year":"2014","journal-title":"Am J Physiol Circ Physiol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1161\/CIRCRESAHA.106.142851","article-title":"Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity","volume":"100","author":"Kim","year":"2007","journal-title":"Circ Res"},{"key":"B35","doi-asserted-by":"publisher","first-page":"249","DOI":"10.2337\/db09-0801","article-title":"Hyperglycemia-induced reactive oxygen species increase expression of the receptor for advanced glycation end products (RAGE) and RAGE ligands","volume":"59","author":"Yao","year":"2010","journal-title":"Diabetes"},{"key":"B36","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1681\/ASN.2015060670","article-title":"I\u03baB Kinase inhibitor attenuates sepsis-induced cardiac dysfunction in CKD","volume":"28","author":"Chen","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/3480637","article-title":"Maladaptive modulations of nlrp3 inflammasome and cardioprotective pathways are involved in diet-induced exacerbation of myocardial ischemia\/reperfusion injury in mice","volume":"2016","author":"Mastrocola","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"B38","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1002\/jnr.490290309","article-title":"Polymorphonuclear leukocyte infiltration into cerebral focal ischemic tissue: myeloperoxidase activity assay and histologic verification","volume":"29","author":"Barone","year":"1991","journal-title":"J Neurosci Res Cell Sci"},{"key":"B39","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/S1473-3099(02)00437-1","article-title":"Ageing and infection","volume":"2","author":"Gavazzi","year":"2002","journal-title":"Lancet Infect Dis"},{"key":"B40","doi-asserted-by":"publisher","first-page":"4","DOI":"10.4161\/viru.27372","article-title":"Epidemiology of severe sepsis epidemiology of severe sepsis","volume":"5594","author":"Mayr","year":"2014","journal-title":"Virulence"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1097\/CCM.0000000000003271","article-title":"Translational sepsis research","volume":"46","author":"Lewis","year":"2018","journal-title":"Crit Care Med"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12933-017-0544-4","article-title":"Dipeptidyl peptidase - 4 (DPP - 4) inhibition with linagliptin reduces western diet - induced myocardial TRAF3IP2 expression, inflammation and fibrosis in female mice","volume":"16","author":"Aroor","year":"2017","journal-title":"Cardiovasc Diabetol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"4070","DOI":"10.1111\/bph.13686","article-title":"Sitagliptin reduces inflammation, fibrosis and preserves diastolic function in a rat model of heart failure with preserved ejection fraction","volume":"174","author":"Esposito","year":"2017","journal-title":"Br J Pharmacol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1007\/s00395-015-0465-x","article-title":"Gliptin and GLP-1 analog treatment improves survival and vascular inflammation\/dysfunction in animals with lipopolysaccharide-induced endotoxemia","volume":"110","author":"Steven","year":"2015","journal-title":"Basic Res Cardiol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1111\/bph.13549","article-title":"Glucagon-like peptide-1 receptor signalling reduces microvascular thrombosis, nitro-oxidative stress and platelet activation in endotoxaemic mice","volume":"174","author":"Steven","year":"2017","journal-title":"Br J Pharm"},{"key":"B46","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1093\/cvr\/cvs246","article-title":"Glucose-independent improvement of vascular dysfunction in experimental sepsis by dipeptidyl-peptidase 4 inhibition","volume":"96","author":"Kr\u00f6ller-Sch\u00f6n","year":"2012","journal-title":"Cardiovasc Res"},{"key":"B47","doi-asserted-by":"publisher","first-page":"2609","DOI":"10.3892\/etm.2016.3255","article-title":"Sitagliptin attenuates inflammatory responses in lipopolysaccharide - stimulated cardiomyocytes via nuclear factor-\u03baB pathway inhibition","volume":"11","author":"Lin","year":"2016","journal-title":"Exp Ther Med"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12931-017-0660-4","article-title":"Vildagliptin ameliorates pulmonary fibrosis in lipopolysaccharide-induced lung injury by inhibiting endothelial-to-mesenchymal transition","volume":"18","author":"Suzuki","year":"2017","journal-title":"Respir Res"},{"key":"B49","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/S1097-2765(02)00450-1","article-title":"TNF-Induced recruitment and activation of the ikk complex require Cdc37 and Hsp90","volume":"9","author":"Chen","year":"2002","journal-title":"Mol Cell"},{"key":"B50","doi-asserted-by":"publisher","first-page":"R1","DOI":"10.1152\/ajpregu.00323.2002","article-title":"Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase","volume":"284","author":"Fleming","year":"2003","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1161\/01.RES.0000016837.26733.BE","article-title":"Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release","volume":"90","author":"Fontana","year":"2002","journal-title":"Circ Res"},{"key":"B52","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1152\/ajpcell.00575.2007","article-title":"High glucose-induced IKK-Hsp-90 interaction contributes to endothelial dysfunction","volume":"296","author":"Mohan","year":"2009","journal-title":"Am J Physiol Cell Physiol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"37277","DOI":"10.1038\/srep37277","article-title":"The synthetic antimicrobial peptide 19-2.5 attenuates septic cardiomyopathy and prevents down-regulation of SERCA2 in polymicrobial sepsis","volume":"6","author":"Martin","year":"2016","journal-title":"Sci Rep"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.02996\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T03:35:27Z","timestamp":1545104127000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.02996\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,18]]},"references-count":53,"alternative-id":["10.3389\/fimmu.2018.02996"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.02996","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,18]]},"article-number":"2996"}}