{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:29:29Z","timestamp":1787318969794,"version":"build-2736575974"},"reference-count":77,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T00:00:00Z","timestamp":1545264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS091183"],"award-info":[{"award-number":["NS091183"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2018.03022","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T23:30:59Z","timestamp":1545262259000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":57,"title":["Fine Tuning the Cytokine Storm by IFN and IL-10 Following Neurotropic Coronavirus Encephalomyelitis"],"prefix":"10.3389","volume":"9","author":[{"given":"Carine","family":"Savarin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia C.","family":"Bergmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,12,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.coviro.2014.12.009","article-title":"II, Mcgavern DB","volume":"11","author":"Swanson","year":"2015","journal-title":"Curr Opin Virol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1038\/nrn.2016.140","article-title":"Keeping it in check: chronic viral infection and antiviral immunity in the brain","volume":"17","author":"Miller","year":"2016","journal-title":"Nat Rev Neurosci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1212\/01.wnl.0000257832.38943.2b","article-title":"Reactivation of JC virus and development of PML in patients with multiple sclerosis","volume":"68","author":"Khalili","year":"2007","journal-title":"Neurology"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2622","DOI":"10.1056\/NEJMct071462","article-title":"Natalizumab for multiple sclerosis","volume":"356","author":"Ransohoff","year":"2007","journal-title":"NE J Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/BF03210848","article-title":"Murine coronavirus neuropathogenesis: determinants of virulence","volume":"16","author":"Cowley","year":"2010","journal-title":"J Neurovirol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/nrmicro1343","article-title":"Coronavirus infection of the central nervous system: host-virus stand-off","volume":"4","author":"Bergmann","year":"2006","journal-title":"Nat Rev Microbiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1615\/CritRevImmunol.v30.i2.20","article-title":"The pathogenesis of murine coronavirus infection of the central nervous system","volume":"30","author":"Lane","year":"2010","journal-title":"Cri Rev Immunol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/B978-0-12-385885-6.00009-2","article-title":"Coronavirus pathogenesis","volume":"81","author":"Weiss","year":"2011","journal-title":"Adv Virus Res."},{"key":"B9","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1128\/JVI.58.3.869-875.1986","article-title":"Pathogenicity of antigenic variants of murine coronavirus JHM selected with monoclonal antibodies","volume":"58","author":"Fleming","year":"1986","journal-title":"J Virol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1128\/JVI.02272-13","article-title":"Ifit2 deficiency results in uncontrolled neurotropic coronavirus replication and enhanced encephalitis via impaired alpha\/beta interferon induction in macrophages","volume":"88","author":"Butchi","year":"2014","journal-title":"J Virol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1007\/s12026-007-0079-y","article-title":"Pathogenesis of acute and chronic central nervous system infection with variants of mouse hepatitis virus, strain JHM","volume":"39","author":"Templeton","year":"2007","journal-title":"Immunol Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"4878","DOI":"10.1128\/JVI.00051-10","article-title":"Monocytes regulate T cell migration through the glia limitans during acute viral encephalitis","volume":"84","author":"Savarin","year":"2010","journal-title":"J Virol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2278","DOI":"10.4049\/jimmunol.165.4.2278","article-title":"CD4 and CD8 T cells have redundant but not identical roles in virus-induced demyelination","volume":"165","author":"Wu","year":"2000","journal-title":"J Immunol."},{"key":"B14","doi-asserted-by":"crossref","first-page":"7358","DOI":"10.4049\/jimmunol.162.12.7358","article-title":"Antibody prevents virus reactivation within the central nervous system","volume":"162","author":"Lin","year":"1999","journal-title":"J Immunol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"5254","DOI":"10.4049\/jimmunol.167.9.5254","article-title":"Antibody is required for clearance of infectious murine hepatitis virus A59 from the central nervous system, but not the liver","volume":"167","author":"Matthews","year":"2001","journal-title":"J Immunol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/j.biochi.2007.02.009","article-title":"Type I interferon response in the central nervous system","volume":"89","author":"Paul","year":"2007","journal-title":"Biochimie"},{"key":"B17","doi-asserted-by":"publisher","first-page":"12432","DOI":"10.1128\/JVI.01267-08","article-title":"Memory CD4+ T-cell-mediated protection from lethal coronavirus encephalomyelitis","volume":"82","author":"Savarin","year":"2008","journal-title":"J Virol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1182\/blood-2006-05-023770","article-title":"Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon","volume":"109","author":"Cervantes-Barragan","year":"2007","journal-title":"Blood"},{"key":"B19","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1128\/JVI.01794-07","article-title":"Type I interferons are essential in controlling neurotropic coronavirus infection irrespective of functional CD8 T cells","volume":"82","author":"Ireland","year":"2008","journal-title":"J Virol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1089\/vim.2018.0101","article-title":"Intercellular communication is key for protective ifnalpha\/beta signaling during viral central nervous system infection","author":"Hwang","year":"2018","journal-title":"Viral Immunol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1523\/JNEUROSCI.4178-07.2008","article-title":"A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function","volume":"28","author":"Cahoy","year":"2008","journal-title":"J Neuroscience"},{"key":"B22","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.it.2015.08.002","article-title":"Immune Surveillance of the CNS following Infection and Injury","volume":"36","author":"Russo","year":"2015","journal-title":"Trends Immunol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.cytogfr.2016.03.006","article-title":"Brain heterogeneity leads to differential innate immune responses and modulates pathogenesis of viral infections","volume":"30","author":"Zegenhagen","year":"2016","journal-title":"Cytokine Growth Fac Rev."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1002\/glia.22375","article-title":"Oligodendroglia are limited in type I interferon induction and responsiveness in vivo","volume":"60","author":"Kapil","year":"2012","journal-title":"Glia"},{"key":"B25","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1002\/glia.20625","article-title":"Induction of class I antigen processing components in oligodendroglia and microglia during viral encephalomyelitis","volume":"56","author":"Malone","year":"2008","journal-title":"Glia"},{"key":"B26","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1128\/JVI.01901-17","article-title":"Alpha\/Beta Interferon (IFN-alpha\/beta) signaling in astrocytes mediates protection against viral encephalomyelitis and regulates IFN-gamma-dependent responses","author":"Hwang","year":"","journal-title":"J Virol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/82_2014_397","article-title":"The effector T cell response to influenza infection","volume":"386","author":"Hufford","year":"2015","journal-title":"Curr Topics Microbiol Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"E282","DOI":"10.3390\/v8100282","article-title":"The immune response in measles: virus control, clearance and protective immunity","volume":"8","author":"Griffin","year":"","journal-title":"Viruses"},{"key":"B29","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/978-94-024-0942-0_7","article-title":"Immunobiology and Host Response to HEV","volume":"948","author":"Zhou","year":"2016","journal-title":"Adv Exp Med Biol."},{"key":"B30","doi-asserted-by":"crossref","first-page":"8771","DOI":"10.1128\/JVI.73.10.8771-8780.1999","article-title":"Macrophage infiltration, but not apoptosis, is correlated with immune-mediated demyelination following murine infection with a neurotropic coronavirus","volume":"73","author":"Wu","year":"1999","journal-title":"J Virol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1128\/JVI.78.4.1739-1750.2004","article-title":"Perforin and gamma interferon-mediated control of coronavirus central nervous system infection by CD8 T cells in the absence of CD4 T cells","volume":"78","author":"Bergmann","year":"2004","journal-title":"J Virol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1007\/s11481-010-9202-2","article-title":"Pathogenesis of murine coronavirus in the central nervous system","volume":"5","author":"Bender","year":"2010","journal-title":"J Neuroimmune Pharmacol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"2416","DOI":"10.1128\/JVI.06797-11","article-title":"CD4 T cells promote CD8 T cell immunity at the priming and effector site during viral encephalitis","volume":"86","author":"Phares","year":"2012","journal-title":"J Virol."},{"key":"B34","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1128\/JVI.71.1.383-391.1997","article-title":"Mouse hepatitis virus is cleared from the central nervous systems of mice lacking perforin-mediated cytolysis","volume":"71","author":"Lin","year":"1997","journal-title":"J Virol."},{"key":"B35","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.4049\/jimmunol.162.3.1641","article-title":"IFN-gamma is required for viral clearance from central nervous system oligodendroglia","volume":"162","author":"Parra","year":"1999","journal-title":"J Immunol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"796","DOI":"10.2353\/ajpath.2006.050496","article-title":"Inhibition of interferon-gamma signaling in oligodendroglia delays coronavirus clearance without altering demyelination","volume":"168","author":"Gonzalez","year":"2006","journal-title":"Am J Pathol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"5430","DOI":"10.4049\/jimmunol.0803557","article-title":"Target-dependent B7-H1 regulation contributes to clearance of central nervous system infection and dampens morbidity","volume":"182","author":"Phares","year":"2009","journal-title":"J Immunol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"5607","DOI":"10.4049\/jimmunol.1001984","article-title":"Enhanced antiviral T cell function in the absence of B7-H1 is insufficient to prevent persistence but exacerbates axonal bystander damage during viral encephalomyelitis","volume":"185","author":"Phares","year":"2010","journal-title":"J Immunol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1128\/JVI.74.3.1415-1424.2000","article-title":"A central role for CD4(+) T cells and RANTES in virus-induced central nervous system inflammation and demyelination","volume":"74","author":"Lane","year":"2000","journal-title":"J Virol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.4049\/jimmunol.168.4.1547","article-title":"Cutting edge: CD8 T cell-mediated demyelination is IFN-gamma dependent in mice infected with a neurotropic coronavirus","volume":"168","author":"Pewe","year":"2002","journal-title":"J Immunol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"7329","DOI":"10.1128\/JVI.76.14.7329-7333.2002","article-title":"CD4 T-cell-mediated demyelination is increased in the absence of gamma interferon in mice infected with mouse hepatitis virus","volume":"76","author":"Pewe","year":"2002","journal-title":"J Virol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"2759","DOI":"10.4049\/jimmunol.164.5.2759","article-title":"IFN-gamma shapes immune invasion of the central nervous system via regulation of chemokines","volume":"164","author":"Tran","year":"2000","journal-title":"J Immunol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1038\/nature01355","article-title":"Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain","volume":"421","author":"Cua","year":"2003","journal-title":"Nature"},{"key":"B44","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/1742-2094-9-104","article-title":"IFN-gamma protects from lethal IL-17 mediated viral encephalomyelitis independent of neutrophils","volume":"9","author":"Savarin","year":"2012","journal-title":"J Neuroinflammation"},{"key":"B45","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1006\/viro.1995.0021","article-title":"Activation of astrocytes in the spinal cord of mice chronically infected with a neurotropic coronavirus","volume":"213","author":"Sun","year":"1995","journal-title":"Virology"},{"key":"B46","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1128\/JVI.71.3.2202-2210.1997","article-title":"Disassociation between the in vitro and in vivo effects of nitric oxide on a neurotropic murine coronavirus","volume":"71","author":"Lane","year":"1997","journal-title":"J Virol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"7683","DOI":"10.1128\/JVI.74.16.7683-7686.2000","article-title":"Coronavirus-induced demyelination occurs in the absence of inducible nitric oxide synthase","volume":"74","author":"Wu","year":"","journal-title":"J Virol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/2051-5960-2-3","article-title":"SIRT1 activating compounds reduce oxidative stress mediated neuronal loss in viral induced CNS demyelinating disease","volume":"2","author":"Khan","year":"2014","journal-title":"Acta Neuropathol Commun"},{"key":"B49","doi-asserted-by":"publisher","first-page":"5771","DOI":"10.4049\/jimmunol.180.9.5771","article-title":"IL-10: the master regulator of immunity to infection","volume":"180","author":"Couper","year":"2008","journal-title":"J Immunol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1186\/s12974-016-0763-8","article-title":"Balancing the immune response in the brain: IL-10 and its regulation","volume":"13","author":"Lobo-Silva","year":"2016","journal-title":"J Neuroinflammation"},{"key":"B51","doi-asserted-by":"publisher","first-page":"6702","DOI":"10.1128\/JVI.00200-11","article-title":"Shifting hierarchies of interleukin-10-producing T cell populations in the central nervous system during acute and persistent viral encephalomyelitis","volume":"85","author":"Puntambekar","year":"2011","journal-title":"J Virol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.virol.2008.12.014","article-title":"Role of regulatory T cells in coronavirus-induced acute encephalitis","volume":"385","author":"Anghelina","year":"2009","journal-title":"Virology"},{"key":"B53","doi-asserted-by":"publisher","first-page":"3642","DOI":"10.4049\/jimmunol.1003292","article-title":"Highly activated cytotoxic CD8 T cells express protective IL-10 at the peak of coronavirus-induced encephalitis","volume":"186","author":"Trandem","year":"2011","journal-title":"J Immunol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.jneuroim.2017.01.001","article-title":"Roles of regulatory T cells and IL-10 in virus-induced demyelination","volume":"308","author":"Perlman","year":"2017","journal-title":"J Neuroimmunol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1002\/glia.22880","article-title":"Interleukin-10 is a critical regulator of white matter lesion containment following viral induced demyelination","volume":"63","author":"Puntambekar","year":"2015","journal-title":"Glia"},{"key":"B56","doi-asserted-by":"publisher","first-page":"6822","DOI":"10.1128\/JVI.00510-11","article-title":"Virally expressed interleukin-10 ameliorates acute encephalomyelitis and chronic demyelination in coronavirus-infected mice","volume":"85","author":"Trandem","year":"2011","journal-title":"J Virol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"285","DOI":"10.4049\/jimmunol.1400058","article-title":"IL-27 limits central nervous system viral clearance by promoting IL-10 and enhances demyelination","volume":"193","author":"De Aquino","year":"2014","journal-title":"J Immunol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/B978-0-12-394299-9.00001-1","article-title":"The immunobiology of IL-27","volume":"115","author":"Hall","year":"2012","journal-title":"Adv Immunol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.cytogfr.2015.07.008","article-title":"The biology of interleukin-27 reveals unique pro- and anti-inflammatory functions in immunity","volume":"26","author":"Aparicio-Siegmund","year":"2015","journal-title":"Cytokine Growth Factor Rev"},{"key":"B60","doi-asserted-by":"publisher","first-page":"4391","DOI":"10.4049\/jimmunol.0903918","article-title":"Regulatory T cells inhibit T cell proliferation and decrease demyelination in mice chronically infected with a coronavirus","volume":"184","author":"Trandem","year":"2010","journal-title":"J Immunol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"370","DOI":"10.3389\/fimmu.2016.00370","article-title":"Differential regulation of self-reactive CD4(+) T cells in cervical lymph nodes and central nervous system during viral encephalomyelitis","volume":"7","author":"Savarin","year":"2016","journal-title":"Front Immunol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1084\/jem.20110236","article-title":"IFN-gamma- and IL-10-expressing virus epitope-specific Foxp3+ T reg cells in the central nervous system during encephalomyelitis","volume":"208","author":"Zhao","year":"2011","journal-title":"J Exp Med."},{"key":"B63","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1186\/s12974-015-0426-1","article-title":"Self-reactive CD4+ T cells activated during viral-induced demyelination do not prevent clinical recovery","volume":"12","author":"Savarin","year":"2015","journal-title":"J Neuroinflammation"},{"key":"B64","doi-asserted-by":"publisher","first-page":"3678","DOI":"10.4049\/jimmunol.1102422","article-title":"Regulatory T cells selectively preserve immune privilege of self-antigens during viral central nervous system infection","volume":"188","author":"Cervantes-Barragan","year":"2012","journal-title":"J Immunol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"6106","DOI":"10.1038\/s41598-018-24378-z","article-title":"Intact interleukin-10 receptor signaling protects from hippocampal damage elicited by experimental neurotropic virus infection of SJL mice","volume":"8","author":"Uhde","year":"","journal-title":"Sci Rep"},{"key":"B66","doi-asserted-by":"publisher","first-page":"16053","DOI":"10.1073\/pnas.1418966111","article-title":"Interleukin 10 modulation of pathogenic Th17 cells during fatal alphavirus encephalomyelitis","volume":"111","author":"Kulcsar","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"B67","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1128\/JVI.01517-17","article-title":"Interleukin-10 modulation of virus clearance and disease in mice with alphaviral encephalomyelitis","author":"Martin","year":"","journal-title":"J Virol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"5344","DOI":"10.1038\/srep05344","article-title":"Protective role of TNF-alpha, IL-10 and IL-2 in mice infected with the Oshima strain of Tick-borne encephalitis virus","volume":"4","author":"Tun","year":"","journal-title":"Sci Rep"},{"key":"B69","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1002\/jmv.21688","article-title":"Immunomodulatory cytokines determine the outcome of Japanese encephalitis virus infection in mice","volume":"82","author":"Biswas","year":"2010","journal-title":"J Med Virol"},{"key":"B70","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.4049\/jimmunol.153.5.2258","article-title":"Interleukin-10 treatment can suppress stromal keratitis induced by herpes simplex virus type 1","volume":"153","author":"Tumpey","year":"1994","journal-title":"J Immunol"},{"key":"B71","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1002\/glia.20045","article-title":"Interleukin-10 attenuates production of HSV-induced inflammatory mediators by human microglia","volume":"47","author":"Marques","year":"2004","journal-title":"Glia"},{"key":"B72","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1111\/1348-0421.12227","article-title":"Cerebrospinal fluid Th1\/Th2 cytokine profiles in children with enterovirus 71-associated meningoencephalitis","volume":"59","author":"Li","year":"2015","journal-title":"Microbiol Immunol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"374","DOI":"10.7883\/yoken.JJID.2016.063","article-title":"Acute encephalitis syndrome in adults and its correlation with cytokine levels in the serum and cerebrospinal fluid","volume":"70","author":"Singh","year":"2017","journal-title":"Jpn J Infect Dis"},{"key":"B74","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1093\/infdis\/jiv771","article-title":"The Interleukin-1 balance during encephalitis is associated with clinical severity, blood-brain barrier permeability, neuroimaging changes, and disease outcome","volume":"213","author":"Michael","year":"2016","journal-title":"J Infect Dis"},{"key":"B75","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.neuroscience.2013.11.036","article-title":"Interleukin-10 mediates the neuroprotection of hyperbaric oxygen therapy against traumatic brain injury in mice","volume":"266","author":"Chen","year":"2014","journal-title":"Neuroscience"},{"key":"B76","doi-asserted-by":"publisher","first-page":"4541","DOI":"10.12659\/MSM.904364","article-title":"Cytokines Interleukin 4 (IL-4) and Interleukin 10 (IL-10) gene polymorphisms as potential host susceptibility factors in virus-induced encephalitis","volume":"23","author":"Yu","year":"2017","journal-title":"Med Sci Monit"},{"key":"B77","doi-asserted-by":"publisher","first-page":"e20173548","DOI":"10.1542\/peds.2017-3548","article-title":"IL-10RA Mutation as a risk factor of severe influenza-associated encephalopathy: a case report","volume":"141","author":"Ishige","year":"2018","journal-title":"Pediatrics"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.03022\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T05:31:50Z","timestamp":1694496710000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2018.03022\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,20]]},"references-count":77,"alternative-id":["10.3389\/fimmu.2018.03022"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2018.03022","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,20]]},"article-number":"3022"}}