{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:36:58Z","timestamp":1790422618605,"version":"4.1.0"},"reference-count":101,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T00:00:00Z","timestamp":1548115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.00011","type":"journal-article","created":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T02:31:29Z","timestamp":1548124289000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":44,"title":["Dendritic Cell Subsets and Effector Function in Idiopathic and Connective Tissue Disease-Associated Pulmonary Arterial Hypertension"],"prefix":"10.3389","volume":"10","author":[{"given":"Denise","family":"van Uden","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Boomars","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam","family":"Kool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,1,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1093\/eurheartj\/ehv317","article-title":"2015 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: the joint task force for the diagnosis and treatment of pulmonary hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT)","volume":"37","author":"Gali\u00e8","year":"2016","journal-title":"Eur Heart J"},{"key":"B2","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.vph.2008.06.003","article-title":"Endothelial cell dysfunction and cross talk between endothelium and smooth muscle cells in pulmonary arterial hypertension","volume":"49","author":"Humbert","year":"2008","journal-title":"Vascul Pharmacol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1183\/09059180.00008211","article-title":"REVEAL: a contemporary US pulmonary arterial hypertension registry","volume":"21","author":"McGoon","year":"2012","journal-title":"Eur Respir Rev."},{"key":"B4","doi-asserted-by":"publisher","first-page":"854941","DOI":"10.1155\/2012\/854941","article-title":"Pulmonary arterial hypertension in systemic lupus erythematosus: current status and future direction","volume":"2012","author":"Dhala","year":"2012","journal-title":"Clin Dev Immunol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2147\/OARRR.S123549","article-title":"Systemic lupus erythematosus and pulmonary arterial hypertension: links, risks, and management strategies","volume":"9","author":"Tselios","year":"2017","journal-title":"Open Access Rheumatol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1378\/chest.10-0260","article-title":"Characterization of connective tissue disease-associated pulmonary arterial hypertension from REVEAL: identifying systemic sclerosis as a unique phenotype","volume":"138","author":"Chung","year":"2010","journal-title":"Chest"},{"key":"B7","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1164\/rccm.201105-0927OC","article-title":"Pulmonary lymphoid neogenesis in idiopathic pulmonary arterial hypertension","volume":"185","author":"Perros","year":"2012","journal-title":"Am J Respir Crit Care Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/S0046-8177(97)90032-0","article-title":"Pathogenesis and evolution of plexiform lesions in pulmonary hypertension associated with scleroderma and human immunodeficiency virus infection","volume":"28","author":"Cool","year":"1997","journal-title":"Hum Pathol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.it.2012.04.006","article-title":"Tertiary lymphoid organs in infection and autoimmunity","volume":"33","author":"Neyt","year":"2012","journal-title":"Trends Immunol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/ki.2008.191","article-title":"Analysis and classification of B-cell infiltrates in lupus and ANCA-associated nephritis","volume":"74","author":"Steinmetz","year":"2008","journal-title":"Kidney Int."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.4049\/jimmunol.1001983","article-title":"In situ B cell-mediated immune responses and tubulointerstitial inflammation in human lupus nephritis","volume":"186","author":"Chang","year":"2011","journal-title":"J Immunol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1038\/nri2832","article-title":"New insights into the development of lymphoid tissues","volume":"10","author":"van de Pavert","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"2339","DOI":"10.1084\/jem.20090410","article-title":"Dendritic cells are crucial for maintenance of tertiary lymphoid structures in the lung of influenza virus-infected mice","volume":"206","author":"GeurtsvanKessel","year":"2009","journal-title":"J Exp Med"},{"key":"B14","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.2353\/ajpath.2010.090723","article-title":"Dendritic cells produce CXCL13 and participate in the development of murine small intestine lymphoid tissues","volume":"176","author":"McDonald","year":"2010","journal-title":"Am J Pathol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.immuni.2011.05.013","article-title":"The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells, and systemic autoimmunity","volume":"35","author":"Kool","year":"2011","journal-title":"Immunity"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.4049\/jimmunol.167.3.1179","article-title":"IL-15 is expressed by dendritic cells in response to type I IFN, double-stranded RNA, or lipopolysaccharide and promotes dendritic cell activation","volume":"167","author":"Mattei","year":"2001","journal-title":"J Immunol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1002\/eji.200939209","article-title":"RelB\/p50 regulates CCL19 production, but fails to promote human DC maturation","volume":"39","author":"Gasparini","year":"2009","journal-title":"Eur J Immunol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"220","DOI":"10.3109\/08916934.2013.850495","article-title":"Autoantigens: novel forms and presentation to the immune system","volume":"47","author":"Doyle","year":"2014","journal-title":"Autoimmunity"},{"key":"B19","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1007\/s10875-009-9322-8","article-title":"Impairment of monocyte-derived dendritic cells in idiopathic pulmonary arterial hypertension","volume":"29","author":"Wang","year":"2009","journal-title":"J Clin Immunol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1177\/0961203308089410","article-title":"Systemic lupus erythematosus patients have increased number of circulating plasmacytoid dendritic cells, but decreased myeloid dendritic cells with deficient CD83 expression","volume":"17","author":"Jin","year":"2008","journal-title":"Lupus"},{"key":"B21","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.yexmp.2013.06.003","article-title":"Active systemic lupus erythematosus is associated with decreased blood conventional dendritic cells","volume":"95","author":"Khan","year":"2013","journal-title":"Exp Mol Pathol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1111\/j.1365-2249.2005.02897.x","article-title":"Reduced blood BDCA-2+ (lymphoid) and CD11c+ (myeloid) dendritic cells in systemic lupus erythematosus","volume":"142","author":"Migita","year":"2005","journal-title":"Clin Exp Immunol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"2524","DOI":"10.1002\/art.11225","article-title":"Expression of the markers BDCA-2 and BDCA-4 and production of interferon-alpha by plasmacytoid dendritic cells in systemic lupus erythematosus","volume":"48","author":"Blomberg","year":"2003","journal-title":"Arthritis Rheum"},{"key":"B24","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s00011-017-1106-7","article-title":"Increased frequencies of circulating CXCL10-, CXCL8- and CCL4-producing monocytes and Siglec-3-expressing myeloid dendritic cells in systemic sclerosis patients","volume":"67","author":"Carvalheiro","year":"2018","journal-title":"Inflamm Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1136\/ard.2009.128207","article-title":"Distinct evolution of TLR-mediated dendritic cell cytokine secretion in patients with limited and diffuse cutaneous systemic sclerosis","volume":"69","author":"van Bon","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"B26","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1002\/art.33325","article-title":"A rare polymorphism in the gene for Toll-like receptor 2 is associated with systemic sclerosis phenotype and increases the production of inflammatory mediators","volume":"64","author":"Broen","year":"2012","journal-title":"Arthritis Rheum"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1701214","DOI":"10.1183\/13993003.01214-2017","article-title":"The inflammatory cell landscape in the lungs of patients with idiopathic pulmonary arterial hypertension","volume":"51","author":"Marsh","year":"2018","journal-title":"Eur Respir J"},{"key":"B28","doi-asserted-by":"publisher","first-page":"3773","DOI":"10.4049\/jimmunol.174.6.3773","article-title":"CD1a and CD1c activate intrathyroidal T cells during Graves' disease and Hashimoto's thyroiditis","volume":"174","author":"Roura-Mir","year":"2005","journal-title":"J Immunol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"eaam8458","DOI":"10.1126\/scitranslmed.aam8458","article-title":"Plasmacytoid dendritic cells promote systemic sclerosis with a key role for TLR8","volume":"10","author":"Ah Kioon","year":"2018","journal-title":"Sci Transl Med."},{"key":"B30","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1056\/NEJMoa1114576","article-title":"Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis","volume":"370","author":"van Bon","year":"2014","journal-title":"N Engl J Med"},{"key":"B31","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/S0002-9440(10)61689-6","article-title":"Plasmacytoid dendritic cells (natural interferon- alpha\/beta-producing cells) accumulate in cutaneous lupus erythematosus lesions","volume":"159","author":"Farkas","year":"2001","journal-title":"Am J Pathol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1006\/clim.2002.5253","article-title":"Circulating monocytes from patients with primary pulmonary hypertension are hyporesponsive","volume":"104","author":"Raychaudhuri","year":"2002","journal-title":"Clin Immunol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"e12106","DOI":"10.1371\/journal.pone.0012106","article-title":"Limited systemic sclerosis patients with pulmonary arterial hypertension show biomarkers of inflammation and vascular injury","volume":"5","author":"Pendergrass","year":"2010","journal-title":"PLoS ONE"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1007\/s10067-017-3597-6","article-title":"CD16-positive circulating monocytes and fibrotic manifestations of systemic sclerosis","volume":"36","author":"Lescoat","year":"2017","journal-title":"Clin Rheumatol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1378\/chest.14-1678","article-title":"T-helper 17 cell polarization in pulmonary arterial hypertension","volume":"147","author":"Hautefort","year":"2015","journal-title":"Chest"},{"key":"B36","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1164\/rccm.201202-0335OC","article-title":"Immune and inflammatory cell involvement in the pathology of idiopathic pulmonary arterial hypertension","volume":"186","author":"Savai","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.2353\/ajpath.2006.050125","article-title":"Type I interferon production by tertiary lymphoid tissue developing in response to 2,6,10,14-tetramethyl-pentadecane (pristane)","volume":"168","author":"Nacionales","year":"2006","journal-title":"Am J Pathol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.1084\/jem.20091472","article-title":"Induced bronchus-associated lymphoid tissue serves as a general priming site for T cells and is maintained by dendritic cells","volume":"206","author":"Halle","year":"2009","journal-title":"J Exp Med"},{"key":"B39","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.celrep.2018.03.072","article-title":"Manifold roles of CCR7 and its ligands in the induction and maintenance of bronchus-associated lymphoid tissue","volume":"23","author":"Fleige","year":"2018","journal-title":"Cell Rep"},{"key":"B40","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/nri3712","article-title":"Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny","volume":"14","author":"Guilliams","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/imm.12888","article-title":"Human dendritic cell subsets: an update","volume":"154","author":"Collin","year":"2018","journal-title":"Immunology"},{"key":"B42","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.immuni.2016.08.015","article-title":"Unsupervised high-dimensional analysis aligns dendritic cells across tissues and species","volume":"45","author":"Guilliams","year":"2016","journal-title":"Immunity"},{"key":"B43","doi-asserted-by":"publisher","first-page":"eaah4573","DOI":"10.1126\/science.aah4573","article-title":"Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors","volume":"356","author":"Villani","year":"2017","journal-title":"Science"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.immuni.2017.11.001","article-title":"High-dimensional phenotypic mapping of human dendritic cells reveals interindividual variation and tissue specialization","volume":"47","author":"Alc\u00e1ntara-Hern\u00e1ndez","year":"2017","journal-title":"Immunity"},{"key":"B45","doi-asserted-by":"publisher","first-page":"L50","DOI":"10.1152\/ajplung.00048.2010","article-title":"Lack of CCR7 induces pulmonary hypertension involving perivascular leukocyte infiltration and inflammation","volume":"301","author":"Larsen","year":"2011","journal-title":"Am J Physiol Lung Cell Mol Physiol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1161\/CIRCULATIONAHA.109.933762","article-title":"Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension","volume":"122","author":"Soon","year":"2010","journal-title":"Circulation"},{"key":"B47","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1161\/CIRCRESAHA.108.182014","article-title":"Interleukin-6 overexpression induces pulmonary hypertension","volume":"104","author":"Steiner","year":"2009","journal-title":"Circ Res"},{"key":"B48","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1465-9921-10-6","article-title":"Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice","volume":"10","author":"Savale","year":"2009","journal-title":"Respir Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"2045893217735820","DOI":"10.1177\/2045893217735820","article-title":"Clinical trial protocol for TRANSFORM-UK: a therapeutic open-label study of tocilizumab in the treatment of pulmonary arterial hypertension","volume":"8","author":"Hern\u00e1ndez-S\u00e1nchez","year":"2018","journal-title":"Pulm Circ"},{"key":"B50","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1002\/art.37742","article-title":"Correlation of interferon-inducible chemokine plasma levels with disease severity in systemic sclerosis","volume":"65","author":"Liu","year":"2013","journal-title":"Arthritis Rheum"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1136\/ard.2009.121400","article-title":"Type I interferon system activation and association with disease manifestations in systemic sclerosis","volume":"69","author":"Eloranta","year":"2010","journal-title":"Ann Rheum Dis."},{"key":"B52","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.hrtlng.2014.04.016","article-title":"Increased levels of plasma CXC-Chemokine Ligand 10:12 and 16 are associated with right ventricular function in patients with idiopathic pulmonary arterial hypertension","volume":"43","author":"Yang","year":"2014","journal-title":"Heart Lung"},{"key":"B53","doi-asserted-by":"publisher","first-page":"423","DOI":"10.3389\/fimmu.2015.00423","article-title":"Blood monocytes and their subsets: established features and open questions","volume":"6","author":"Ziegler-Heitbrock","year":"2015","journal-title":"Front Immunol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s12026-012-8297-3","article-title":"The three human monocyte subsets: implications for health and disease","volume":"53","author":"Wong","year":"2012","journal-title":"Immunol Res"},{"key":"B55","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1002\/art.33418","article-title":"The CD14(bright) CD16+ monocyte subset is expanded in rheumatoid arthritis and promotes expansion of the Th17 cell population","volume":"64","author":"Rossol","year":"2012","journal-title":"Arthritis Rheum."},{"key":"B56","doi-asserted-by":"publisher","first-page":"e16","DOI":"10.1182\/blood-2010-12-326355","article-title":"Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets","volume":"118","author":"Wong","year":"2011","journal-title":"Blood"},{"key":"B57","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1164\/ajrccm.165.4.2012112","article-title":"Chemokine RANTES in severe pulmonary arterial hypertension","volume":"165","author":"Dorfm\u00fcller","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"B58","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1111\/j.1440-1843.2006.00821.x","article-title":"Increased plasma monocyte chemoattractant protein-1 level in idiopathic pulmonary arterial hypertension","volume":"11","author":"Itoh","year":"2006","journal-title":"Respirology"},{"key":"B59","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/S0923-1811(00)00169-9","article-title":"Expression of monocyte chemoattractant protein-1 in the lesional skin of systemic sclerosis","volume":"26","author":"Yamamoto","year":"2001","journal-title":"J Dermatol Sci"},{"key":"B60","doi-asserted-by":"publisher","first-page":"2665","DOI":"10.1002\/1529-0131(200111)44:11<2665::AID-ART446>3.0.CO;2-S","article-title":"Overexpression of monocyte chemoattractant protein 1 in systemic sclerosis: role of platelet-derived growth factor and effects on monocyte chemotaxis and collagen synthesis","volume":"44","author":"Distler","year":"2001","journal-title":"Arthritis Rheum."},{"key":"B61","doi-asserted-by":"publisher","first-page":"760","DOI":"10.3899\/jrheum.080542","article-title":"Effect of bosentan on plasma markers of endothelial cell activity in patients with secondary pulmonary hypertension related to connective tissue diseases","volume":"36","author":"Cella","year":"2009","journal-title":"J Rheumatol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.jaut.2017.12.006","article-title":"Molecular mechanisms underpinning T helper 17 cell heterogeneity and functions in rheumatoid arthritis","volume":"87","author":"van Hamburg","year":"2018","journal-title":"J Autoimmun"},{"key":"B63","doi-asserted-by":"publisher","first-page":"E2677","DOI":"10.1073\/pnas.1424774112","article-title":"Interleukin-6\/interleukin-21 signaling axis is critical in the pathogenesis of pulmonary arterial hypertension","volume":"112","author":"Hashimoto-Kataoka","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"B64","doi-asserted-by":"publisher","first-page":"R4","DOI":"10.1186\/ar4430","article-title":"Increased frequency of Th17 cells in systemic sclerosis is related to disease activity and collagen overproduction","volume":"16","author":"Yang","year":"2014","journal-title":"Arthritis Res Ther."},{"key":"B65","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.1002\/1529-0131(200011)43:11<2455::AID-ANR12>3.0.CO;2-K","article-title":"Increased interleukin-17 production in patients with systemic sclerosis","volume":"43","author":"Kurasawa","year":"2000","journal-title":"Arthritis Rheum."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1002\/art.24499","article-title":"Th17 and natural Treg cell population dynamics in systemic lupus erythematosus","volume":"60","author":"Yang","year":"2009","journal-title":"Arthritis Rheum"},{"key":"B67","doi-asserted-by":"publisher","first-page":"e85032","DOI":"10.1371\/journal.pone.0085032","article-title":"IL-17A induces endothelial inflammation in systemic sclerosis via the ERK signaling pathway","volume":"8","author":"Xing","year":"2013","journal-title":"PLoS ONE"},{"key":"B68","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1002\/art.30159","article-title":"Lung tissues in patients with systemic sclerosis have gene expression patterns unique to pulmonary fibrosis and pulmonary hypertension","volume":"63","author":"Hsu","year":"2011","journal-title":"Arthritis Rheum"},{"key":"B69","doi-asserted-by":"publisher","first-page":"5904","DOI":"10.4049\/jimmunol.0900732","article-title":"Cutting edge: IL-23 receptor gfp reporter mice reveal distinct populations of IL-17-producing cells","volume":"182","author":"Awasthi","year":"2009","journal-title":"J Immunol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1016\/j.cell.2015.11.009","article-title":"Single-cell genomics unveils critical regulators of Th17 cell pathogenicity","volume":"163","author":"Gaublomme","year":"2015","journal-title":"Cell"},{"key":"B71","doi-asserted-by":"publisher","first-page":"046013","DOI":"10.1088\/1752-7155\/10\/4\/046013","article-title":"Th-17 cytokines and interstitial lung involvement in systemic sclerosis","volume":"10","author":"Rolla","year":"2016","journal-title":"J Breath Res."},{"key":"B72","doi-asserted-by":"publisher","first-page":"e0142476","DOI":"10.1371\/journal.pone.0142476","article-title":"Therapeutic benefits of induced pluripotent stem cells in monocrotaline-induced pulmonary arterial hypertension","volume":"11","author":"Huang","year":"2016","journal-title":"PLoS ONE"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1161\/CIRCULATIONAHA.108.827618","article-title":"Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells","volume":"119","author":"Eid","year":"2009","journal-title":"Circulation"},{"key":"B74","doi-asserted-by":"publisher","first-page":"2045894018780734","DOI":"10.1177\/2045894018780734","article-title":"Interleukin-6 trans-signaling contributes to chronic hypoxia-induced pulmonary hypertension","volume":"8","author":"Maston","year":"2018","journal-title":"Pulm Circ"},{"key":"B75","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1164\/rccm.201402-0322OC","article-title":"Proinflammatory signature of the dysfunctional endothelium in pulmonary hypertension. role of the macrophage migration inhibitory factor\/CD74 complex","volume":"192","author":"Le Hiress","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"B76","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/ni.3153","article-title":"IL-6 as a keystone cytokine in health and disease","volume":"16","author":"Hunter","year":"2015","journal-title":"Nat Immunol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"e5903","DOI":"10.1371\/journal.pone.0005903","article-title":"The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes","volume":"4","author":"Radstake","year":"2009","journal-title":"PLoS ONE"},{"key":"B78","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jaut.2017.12.007","article-title":"A cellular and molecular view of T helper 17 cell plasticity in autoimmunity","volume":"87","author":"Stadhouders","year":"2018","journal-title":"J Autoimmun."},{"key":"B79","doi-asserted-by":"publisher","first-page":"4306","DOI":"10.1172\/JCI60658","article-title":"Molecular pathogenesis of pulmonary arterial hypertension","volume":"122","author":"Rabinovitch","year":"2012","journal-title":"J Clin Invest"},{"key":"B80","doi-asserted-by":"publisher","first-page":"247372","DOI":"10.1155\/2014\/247372","article-title":"Effect of Th17 and Treg axis disorder on outcomes of pulmonary arterial hypertension in connective tissue diseases","volume":"2014","author":"Gaowa","year":"2014","journal-title":"Mediators Inflamm."},{"key":"B81","doi-asserted-by":"publisher","first-page":"eaan8289","DOI":"10.1126\/sciimmunol.aan8289","article-title":"Dynamics of the human antibody repertoire after B cell depletion in systemic sclerosis","volume":"2","author":"de Bourcy","year":"2017","journal-title":"Sci Immunol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/1465-9921-9-20","article-title":"Peripheral blood B lymphocytes derived from patients with idiopathic pulmonary arterial hypertension express a different RNA pattern compared with healthy controls: a cross sectional study","volume":"9","author":"Ulrich","year":"2008","journal-title":"Respir Res."},{"key":"B83","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1002\/eji.201747460","article-title":"Circulating plasmablasts are elevated and produce pathogenic anti-endothelial cell autoantibodies in idiopathic pulmonary arterial hypertension","volume":"48","author":"Blum","year":"2018","journal-title":"Eur J Immunol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1084\/jem.20081886","article-title":"Follicular helper T cells are required for systemic autoimmunity","volume":"206","author":"Linterman","year":"2009","journal-title":"J Exp Med"},{"key":"B85","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/nature03555","article-title":"A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity","volume":"435","author":"Vinuesa","year":"2005","journal-title":"Nature"},{"key":"B86","doi-asserted-by":"publisher","first-page":"aaf5307","DOI":"10.1126\/scitranslmed.aaf5307","article-title":"T follicular helper-like cells contribute to skin fibrosis","volume":"10","author":"Taylor","year":"2018","journal-title":"Sci Transl Med"},{"key":"B87","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1210\/jc.2011-2003","article-title":"Increased frequency of follicular helper T cells in patients with autoimmune thyroid disease","volume":"97","author":"Zhu","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"B88","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1177\/0961203314567750","article-title":"Circulating CXCR5+CD4+helper T cells in systemic lupus erythematosus patients share phenotypic properties with germinal center follicular helper T cells and promote antibody production","volume":"24","author":"Zhang","year":"2015","journal-title":"Lupus"},{"key":"B89","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/S0002-9440(10)61762-2","article-title":"Thyroid autoimmune disease: demonstration of thyroid antigen-specific B cells and recombination-activating gene expression in chemokine-containing active intrathyroidal germinal centers","volume":"159","author":"Armengol","year":"2001","journal-title":"Am J Pathol"},{"key":"B90","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1183\/09031936.00181410","article-title":"Targets of anti-endothelial cell antibodies in pulmonary hypertension and scleroderma","volume":"39","author":"Dib","year":"2012","journal-title":"Eur Respir J."},{"key":"B91","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1136\/thx.2004.029082","article-title":"Anti-endothelial cell antibodies in idiopathic and systemic sclerosis associated pulmonary arterial hypertension","volume":"60","author":"Tamby","year":"2005","journal-title":"Thorax"},{"key":"B92","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1183\/09031936.00164209","article-title":"Prevalence of anti-endothelial cell antibodies in idiopathic pulmonary arterial hypertension","volume":"35","author":"Arends","year":"2010","journal-title":"Eur Respir J"},{"key":"B93","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1111\/cei.12166","article-title":"Immunoglobulin G anti-endothelial cell antibodies: inducers of endothelial cell apoptosis in pulmonary arterial hypertension?","volume":"174","author":"Arends","year":"2013","journal-title":"Clin Exp Immunol"},{"key":"B94","doi-asserted-by":"publisher","first-page":"463","DOI":"10.3109\/08916934.2013.812080","article-title":"Functional implications of IgG anti-endothelial cell antibodies in pulmonary arterial hypertension","volume":"46","author":"Arends","year":"2013","journal-title":"Autoimmunity"},{"key":"B95","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1136\/annrheumdis-2011-200195","article-title":"IgG from patients with pulmonary arterial hypertension and\/or systemic sclerosis binds to vascular smooth muscle cells and induces cell contraction","volume":"71","author":"Bussone","year":"2012","journal-title":"Ann Rheum Dis."},{"key":"B96","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1164\/rccm.201403-0442OC","article-title":"Vascular receptor autoantibodies in pulmonary arterial hypertension associated with systemic sclerosis","volume":"190","author":"Becker","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"B97","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.jash.2017.01.011","article-title":"Interleukin-6\u2212572C\/G polymorphism is associated with serum interleukin-6 levels and risk of idiopathic pulmonary arterial hypertension","volume":"11","author":"Fang","year":"2017","journal-title":"J Am Soc Hypertens"},{"key":"B98","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1097\/GIM.0b013e318172dcdf","article-title":"Synergistic heterozygosity for TGFbeta1 SNPs and BMPR2 mutations modulates the age at diagnosis and penetrance of familial pulmonary arterial hypertension","volume":"10","author":"Phillips","year":"2008","journal-title":"Genet Med"},{"key":"B99","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.1136\/ard.2009.127928","article-title":"Association of the TNFAIP3 rs5029939 variant with systemic sclerosis in the European Caucasian population","volume":"69","author":"Dieud\u00e9","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"B100","doi-asserted-by":"publisher","first-page":"8217","DOI":"10.1074\/jbc.R800032200","article-title":"A20: central gatekeeper in inflammation and immunity","volume":"284","author":"Coornaert","year":"2009","journal-title":"J Biol Chem."},{"key":"B101","doi-asserted-by":"publisher","first-page":"e75415","DOI":"10.1371\/journal.pone.0075415","article-title":"Nuclear factor kappa-B is activated in the pulmonary vessels of patients with end-stage idiopathic pulmonary arterial hypertension","volume":"8","author":"Price","year":"2013","journal-title":"PLoS ONE"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00011\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T02:31:31Z","timestamp":1548124291000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00011\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,22]]},"references-count":101,"alternative-id":["10.3389\/fimmu.2019.00011"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.00011","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,22]]},"article-number":"11"}}