{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T03:07:16Z","timestamp":1790132836189,"version":"4.0.1"},"reference-count":84,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T00:00:00Z","timestamp":1548288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.00034","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T08:28:54Z","timestamp":1548318534000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":68,"title":["The Diagnosis and Blistering Mechanisms of Mucous Membrane Pemphigoid"],"prefix":"10.3389","volume":"10","author":[{"given":"Mayumi","family":"Kamaguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,1,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1001\/archderm.138.3.370","article-title":"The first international consensus on mucous membrane pemphigoid: definition, diagnostic criteria, pathogenic factors, medical treatment, and prognostic indicators","volume":"138","author":"Chan","year":"2002","journal-title":"Arch Dermatol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/S0140-6736(12)61140-4","article-title":"Pemphigoid diseases","volume":"381","author":"Schmidt","year":"2013","journal-title":"Lancet"},{"key":"B3","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.jaad.2014.08.024","article-title":"Definitions and outcome measures for mucous membrane pemphigoid: recommendations of an international panel of experts","volume":"72","author":"Murrell","year":"2015","journal-title":"J Am Acad Dermatol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1111\/odi.12193","article-title":"Urban legend series: mucous membrane pemphigoid","volume":"20","author":"Di Zenzo","year":"2014","journal-title":"Oral Dis."},{"key":"B5","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1046\/j.1365-2133.2001.04471.x","article-title":"Cicatricial pemphigoid: IgA and IgG autoantibodies target epitopes on both intra- and extracellular domains of bullous pemphigoid antigen 180","volume":"145","author":"Schmidt","year":"2001","journal-title":"Br J Dermatol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1111\/1523-1747.ep12329728","article-title":"Cicatricial pemphigoid autoantibodies react with multiple sites on the BP180 extracellular domain","volume":"106","author":"Balding","year":"1996","journal-title":"J Invest Dermatol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1172\/JCI116033","article-title":"Epiligrin, the major human keratinocyte integrin ligand, is a target in both an acquired autoimmune and an inherited subepidermal blistering skin disease","volume":"90","author":"Domloge-Hultsch","year":"1992","journal-title":"J Clin Invest"},{"key":"B8","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1111\/1523-1747.ep12323431","article-title":"Anti-basement membrane autoantibodies in patients with anti-epiligrin cicatricial pemphigoid bind the \u03b1 subunit of laminin 5","volume":"105","author":"Kirtschig","year":"1995","journal-title":"J Invest Dermatol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1111\/j.1365-2133.2009.09508.x","article-title":"Circulating IgA and IgE autoantibodies in antilaminin-332 mucous membrane pemphigoid","volume":"162","author":"Natsuga","year":"2010","journal-title":"Br J Dermatol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"14714","DOI":"10.1073\/pnas.93.25.14714","article-title":"Ocular cicatricial pemphigoid antigen: partial sequence and biochemical characterization","volume":"93","author":"Tyagi","year":"1996","journal-title":"Proc Natl Acad Sci USA."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2824","DOI":"10.4049\/jimmunol.165.5.2824","article-title":"The autoantibodies to alpha 6 beta 4 integrin of patients affected by ocular cicatricial pemphigoid recognize predominantly epitopes within the large cytoplasmic domain of human beta 4","volume":"165","author":"Bhol","year":"2000","journal-title":"J Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2631","DOI":"10.1038\/sj.jid.5700465","article-title":"Antigen specificity in subsets of mucous membrane pemphigoid","volume":"126","author":"Rashid","year":"2006","journal-title":"J Invest Dermatol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"768","DOI":"10.2340\/00015555-2311","article-title":"Autoantibody profile of a cohort of 78 Italian patients with mucous membrane pemphigoid: correlation between reactivity profile and clinical involvement","volume":"96","author":"Cozzani","year":"2016","journal-title":"Acta Derm Venerol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1111\/exd.13415","article-title":"In vitro and in vivo models to investigate the pathomechanisms and novel treatments for pemphigoid diseases","volume":"26","author":"Bieber","year":"2017","journal-title":"Exp Dermatol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1684\/ejd.2016.2772","article-title":"Integrin \u03b24 is a major target antigen in pure ocular mucous membrane pemphigoid","volume":"26","author":"Li","year":"2016","journal-title":"Eur J Dermatol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1007\/s12016-017-8633-4","article-title":"Autoimmune subepidermal bullous diseases of the skin and mucosae: clinical features, diagnosis, and management","volume":"381","author":"Amber","year":"2017","journal-title":"Clin Rev Allergy Immunol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.oooo.2013.12.402","article-title":"Diagnosis of oral mucous membrane pemphigoid by means of combined serologic testing","volume":"117","author":"Hayakawa","year":"2014","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"e119","DOI":"10.1111\/bjd.15925","article-title":"Oral mucosa is a useful substrate for detecting autoantibodies of mucous membrane pemphigoid","volume":"178","author":"Kamaguchi","year":"2017","journal-title":"Br J Dermatol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.oooo.2015.01.024","article-title":"World Workshop on oral medicine VI: a systematic review of the treatment of mucous membrane pemphigoid","volume":"120","author":"Taylor","year":"2015","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"2170","DOI":"10.4049\/jimmunol.170.4.2170","article-title":"Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3","volume":"170","author":"Tsunoda","year":"2003","journal-title":"J Immunol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1111\/j.0022-202X.2005.23714.x","article-title":"In vitro keratinocyte dissociation assay for evaluation of the pathogenicity of anti-desmoglein 3 IgG autoantibodies in pemphigus vulgaris","volume":"124","author":"Ishii","year":"2005","journal-title":"J Invest Dermatol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"2422","DOI":"10.2174\/1381612821666150316122502","article-title":"Animal models to investigate pathomechanisms and evaluate novel treatments for autoimmune bullous dermatoses","volume":"21","author":"Iwata","year":"2015","journal-title":"Curr Pharm Des"},{"key":"B23","doi-asserted-by":"publisher","first-page":"603","DOI":"10.3389\/fimmu.2017.00603","article-title":"Mechanisms of autoantibody-induced pathology","volume":"8","author":"Ludwig","year":"2017","journal-title":"Front Immunol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1038\/s41374-018-0113-9","article-title":"The direct binding of collagen XVII and collagen IV is disrupted by pemphigoid autoantibodies","volume":"99","author":"Kamaguchi","year":"2018","journal-title":"Lab Invest."},{"key":"B25","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.bjoms.2007.07.200","article-title":"Oral mucosal diseases: mucous membrane pemphigoid","volume":"46","author":"Scully","year":"2008","journal-title":"Br J Oral Maxillofac Surg."},{"key":"B26","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.jaad.2009.02.012","article-title":"Histopathology of anti-laminin 5 mucous membrane pemphigoid","volume":"61","author":"Rose","year":"2009","journal-title":"J Am Acad Dermatol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3389\/fmed.2018.00020","article-title":"Direct immunofluorescence using non-lesional buccal mucosa in mucous membrane pemphigoid","volume":"5","author":"Kamaguchi","year":"2018","journal-title":"Front Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"660","DOI":"10.2340\/00015555-2938","article-title":"Structured diagnostic approach and risk assessment in mucous membrane pemphigoid with oesophageal involvement","volume":"98","author":"Benoit","year":"2018","journal-title":"Acta Derm Venerol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1902\/jop.2004.75.10.1302","article-title":"Analysis of antigens targeted by circulating IgG and IgA antibodies in patients with mucous membrane pemphigoid predominantly affecting the oral cavity","volume":"75","author":"Carrozzo","year":"2004","journal-title":"J Periodontol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1016\/0190-9622(91)70152-R","article-title":"Salt-split human skin substrate for the immunofluorescent screening of serum from patients with cicatricial pemphigoid and a new method of immunoprecipitation with IgA antibodies","volume":"24","author":"Sarret","year":"1991","journal-title":"J Am Acad Dermatol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/0190-9622(92)70161-8","article-title":"Immunofluorescence on split skin for the detection and differentiation of basement membrane zone autoantibodies","volume":"27","author":"Gammon","year":"1992","journal-title":"J Am Acad Dermatol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1111\/1523-1747.ep12338088","article-title":"A highly sensitive enzyme-linked immunosorbent assay for the detection of circulating anti-BP180 autoantibodies in patients with bullous pemphigoid","volume":"109","author":"Zillikens","year":"1997","journal-title":"J Invest Dermatol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/S0923-1811(02)00109-3","article-title":"BP180 ELISA using bacterial recombinant NC16a protein as a diagnostic and monitoring tool for bullous pemphigoid","volume":"30","author":"Kobayashi","year":"2002","journal-title":"J Dermatol Sci"},{"key":"B34","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1111\/j.1365-2133.2004.06082.x","article-title":"Evaluation of a BP180-NC16a enzyme-linked immunosorbent assay in the initial diagnosis of bullous pemphigoid","volume":"151","author":"Sakuma-Oyama","year":"2004","journal-title":"Br J Dermatol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1111\/j.1600-0625.2007.00592.x","article-title":"Enzyme-linked immunosorbent assay using multimers of the 16th non-collagenous domain of the BP180 antigen for sensitive and specific detection of pemphigoid autoantibodies","volume":"16","author":"Sitaru","year":"2007","journal-title":"Exp Dermatol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.jdermsci.2016.12.007","article-title":"Validation of chemiluminescent enzyme immunoassay in detection of autoantibodies in pemphigus and pemphigoid","volume":"85","author":"Fujio","year":"2017","journal-title":"J Dermatol Sci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1684\/ejd.2015.2692","article-title":"Diagnostic performance of the \u201cMESACUP anti-Skin profile TEST","volume":"26","author":"Horv\u00e1th","year":"2016","journal-title":"Eur J Dermatol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.1016\/j.jid.2016.06.622","article-title":"Autoantibody profile differentiates between inflammatory and non-inflammatory bullous pemphigoid","volume":"136","author":"Izumi","year":"2016","journal-title":"J Invest Dermatol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1111\/bjd.14351","article-title":"Salivary IgA and IgG antibodies to bullous pemphigoid 180 noncollagenous domain 16a as diagnostic biomarkers in mucous membrane pemphigoid","volume":"174","author":"Ali","year":"2016","journal-title":"Br J Dermatol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1902\/jop.2014.130428","article-title":"A stab-and-roll biopsy technique to maintain gingival epithelium for desquamative gingivitis","volume":"85","author":"Endo","year":"2014","journal-title":"J Periodontol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.jaad.2017.05.016","article-title":"Multiple and repeated sampling increases the sensitivity of direct immunofluorescence testing for the diagnosis of mucous membrane pemphigoid","volume":"77","author":"Shimanovich","year":"2017","journal-title":"J Am Acad Dermatol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1111\/jop.12732","article-title":"Immunohistochemical diagnosis of mucous membrane pemphigoid","volume":"47","author":"Shimanovich","year":"2018","journal-title":"J Oral Pathol Med."},{"key":"B43","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/bjd.17202","article-title":"Sensitive and specific assay for the serological diagnosis of anti-laminin 332 mucous membrane pemphigoid","volume":"180","author":"Goletz","year":"2018","journal-title":"Br J Dermatol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1001\/jamadermatol.2013.1434","article-title":"Prevalence and clinical significance of anti-laminin 332 autoantibodies detected by a novel enzyme-linked immunosorbent assay in mucous membrane pemphigoid","volume":"149","author":"Bernard","year":"2013","journal-title":"JAMA Dermatol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/s13023-018-0855-x","article-title":"Molecular diagnosis of anti-laminin 332 (epiligrin) mucous membrane pemphigoid","volume":"13","author":"Chiorean","year":"2018","journal-title":"Orphanet J Rare Dis"},{"key":"B46","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1046\/j.1523-1747.1999.00501.x","article-title":"IgA antibodies of cicatricial pemphigoid sera specifically react with C-terminus of BP180","volume":"112","author":"Nie","year":"1999","journal-title":"J Invest Dermatol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1006\/jaut.2002.0589","article-title":"A highly sensitive and simple assay for the detection of circulating autoantibodies against full-length bullous pemphigoid antigen 180","volume":"18","author":"Schmidt","year":"2002","journal-title":"J Autoimmun."},{"key":"B48","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.jdermsci.2017.07.005","article-title":"Detection of mucous membrane pemphigoid autoantibodies by full-length BP180 enzyme-linked immunosorbent assay","volume":"88","author":"Izumi","year":"2017","journal-title":"J Dermatol Sci"},{"key":"B49","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1111\/jop.12780","article-title":"The identification of autoantigens in mucous membrane pemphigoid using immortalized oral mucosal keratinocytes","volume":"48","author":"Kamaguchi","year":"2018","journal-title":"J Oral Pathol Med"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17313","article-title":"Normal human skin is superior to monkey esophagus substrate for detection of circulating BP180-NC16A-specific immunoglobulin G antibodies in bullous pemphigoid","author":"Emtenani","year":"2018","journal-title":"Br J Dermatol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.ophtha.2017.10.004","article-title":"Mucous membrane pemphigoid with ocular involvement: the clinical phenotype and its relationship to direct immunofluorescence findings","volume":"125","author":"Ong","year":"2018","journal-title":"Ophthalmology"},{"key":"B52","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.ophtha.2003.03.001","article-title":"Mucous membrane pemphigoid and pseudopemphigoid","volume":"111","author":"Thorne","year":"2004","journal-title":"Ophthalmology"},{"key":"B53","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/BF00181996","article-title":"The value of biopsies in the evaluation of chronic progressive conjunctival cicatrisation","volume":"232","author":"Bernauer","year":"1994","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0190-9622(94)70010-9","article-title":"The sensitivity and specificity of direct immunofluorescence testing in disorders of mucous membranes","volume":"30","author":"Helander","year":"1994","journal-title":"J Am Acad Dermatol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1046\/j.1365-2133.1998.02168.x","article-title":"Mucous membrane pemphigoid: a dual circulating antibody response with IgG and IgA signifies a more severe and persistent disease","volume":"138","author":"Setterfield","year":"1998","journal-title":"Br J Dermatol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1111\/bjd.16679","article-title":"Peripheral eosinophilia in bullous pemphigoid: prevalence and influence on the clinical manifestation","volume":"179","author":"Kridin","year":"2018","journal-title":"Br J Dermatol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1159\/000443330","article-title":"Three cases of bullous pemphigoid associated with dipeptidyl peptidase-4 inhibitors - one due to linagliptin","volume":"232","author":"Mendon\u00e7a","year":"2016","journal-title":"Dermatology"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.3389\/fimmu.2018.01030","article-title":"Gliptin accountability in mucous membrane pemphigoid induction in 24 out of 313 patients","volume":"9","author":"Gaudin","year":"2018","journal-title":"Front Immunol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1016\/j.jid.2017.11.023","article-title":"HLA-DQB1*03:01 as a biomarker for genetic susceptibility to bullous pemphigoid induced by DPP-4 inhibitors","volume":"138","author":"Ujiie","year":"2017","journal-title":"J Invest Dermatol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"11579","DOI":"10.1073\/pnas.88.24.11579","article-title":"Association of DQw7 (DQB1*0301) with ocular cicatricial pemphigoid","volume":"88","author":"Ahmed","year":"1991","journal-title":"Proc Natl Acad Sci USA."},{"key":"B61","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1046\/j.1365-2133.2001.04380.x","article-title":"Mucous membrane pemphigoid: HLA-DQB1*0301 is associated with all clinical sites of involvement and may be linked to antibasement membrane IgG production","volume":"145","author":"Setterfield","year":"2001","journal-title":"Br J Dermatol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1111\/j.1365-2133.2005.06998.x","article-title":"Bullous pemphigoid antigen II (BP180) and its soluble extracellular domains are major autoantigens in mucous membrane pemphigoid: the pathogenic relevance to HLA class II alleles and disease severity","volume":"154","author":"Oyama","year":"2006","journal-title":"Br J Dermatol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1038\/s41433-018-0092-5","article-title":"HLA alleles in British Caucasians with mucous membrane pemphigoid","volume":"32","author":"H\u00fcbner","year":"2018","journal-title":"Eye"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1046\/j.1523-1747.2002.19529.x","article-title":"Severity and phenotype of bullous pemphigoid relate to autoantibody profile against the NH2- and COOH-terminal regions of the BP180 ectodomain","volume":"119","author":"Hofmann","year":"2002","journal-title":"J Invest Dermatol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"479","DOI":"10.3389\/fimmu.2018.00479","article-title":"Mucosal involvement in bullous pemphigoid is mostly associated with disease severity and to absence of anti-BP230 autoantibody","volume":"9","author":"Clap\u00e9","year":"2018","journal-title":"Front Immunol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1016\/j.jid.2017.03.037","article-title":"Experimental laminin 332 mucous membrane pemphigoid critically involves C5aR1 and reflects clinical and immunopathological characteristics of the human disease","volume":"137","author":"Heppe","year":"2017","journal-title":"J Invest Dermatol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1172\/JCI118942","article-title":"Passive transfer of anti-laminin 5 antibodies induces subepidermal blisters in neonatal mice","volume":"98","author":"Lazarova","year":"1996","journal-title":"J Clin Invest."},{"key":"B68","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1006\/clim.2000.4845","article-title":"Fab fragments directed against laminin 5 induce subepidermal blisters in neonatal mice","volume":"95","author":"Lazarova","year":"2000","journal-title":"Clin Immunol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1046\/j.1523-1747.2000.00829.x","article-title":"Human anti-laminin 5 autoantibodies induce subepidermal blisters in an experimental human skin graft model","volume":"114","author":"Lazarova","year":"2000","journal-title":"J Invest Dermatol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"2480","DOI":"10.1172\/JCI116856","article-title":"A passive transfer model of the organ-specific autoimmune disease, bullous pemphigoid, using antibodies generated against the hemidesmosomal antigen, BP180","volume":"92","author":"Liu","year":"1993","journal-title":"J Clin Invest."},{"key":"B71","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1038\/nm1496","article-title":"Humanization of autoantigen","volume":"13","author":"Nishie","year":"2007","journal-title":"Nat Med."},{"key":"B72","doi-asserted-by":"publisher","first-page":"2166","DOI":"10.4049\/jimmunol.0903101","article-title":"A novel active mouse model for bullous pemphigoid targeting humanized pathogenic antigen","volume":"184","author":"Ujiie","year":"2010","journal-title":"J Immunol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1016\/j.ajpath.2014.05.007","article-title":"Fc\u03b3 receptors III and IV mediate tissue destruction in a novel adult mouse model of bullous pemphigoid","volume":"184","author":"Schulze","year":"2014","journal-title":"Am J Pathol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s00795-015-0128-x","article-title":"Anti-BP180-type mucous membrane pemphigoid immunoglobulin G shows heterogeneity of internalization of BP180\/collagen XVII into keratinocyte cytoplasm","volume":"49","author":"Imanishi","year":"2015","journal-title":"Med Mol Morphol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1111\/1523-1747.ep12470554","article-title":"Effects of pemphigus antibody on the regeneration of cell-cell contact in keratinocyte cultures grown in low to normal Ca++ concentration","volume":"89","author":"Kitajima","year":"1987","journal-title":"J Invest Dermatol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1038\/jid.2008.305","article-title":"IgG from patients with bullous pemphigoid depletes cultured keratinocytes of the 180-kDa bullous pemphigoid antigen (Type XVII collagen) and weakens cell attachment","volume":"129","author":"Iwata","year":"2009","journal-title":"J Invest Dermatol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1111\/exd.12146","article-title":"Bullous pemphigoid: role of complement and mechanisms for blister formation within the lamina lucida","volume":"22","author":"Iwata","year":"2013","journal-title":"Exp Dermatol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1172\/JCI117826","article-title":"The role of complement in experimental bullous pemphigoid","volume":"95","author":"Liu","year":"1995","journal-title":"J Clin Invest."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1172\/JCI119639","article-title":"A major role for neutrophils in experimental bullous pemphigoid","volume":"100","author":"Liu","year":"1997","journal-title":"J Clin Invest."},{"key":"B80","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1111\/exd.13367","article-title":"Complement-independent blistering mechanisms in bullous pemphigoid","volume":"26","author":"Iwata","year":"2017","journal-title":"Exp Dermatol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1016\/j.jid.2018.03.002","article-title":"High expression of collagen XVII compensates for its depletion induced by pemphigoid IgG in the oral mucosa","volume":"138","author":"Kamaguchi","year":"2018","journal-title":"J Invest Dermatol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/j.jid.2015.11.030","article-title":"Epitope-dependent pathogenicity of antibodies targeting a major bullous pemphigoid autoantigen collagen XVII\/BP180","volume":"136","author":"Wada","year":"2016","journal-title":"J Invest Dermatol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1111\/exd.13331","article-title":"Autoantibodies of non-inflammatory bullous pemphigoid hardly deplete type XVII collagen of keratinocytes","volume":"381","author":"Imafuku","year":"2017","journal-title":"Exp Dermatol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1046\/j.0022-202X.2003.22126.x","article-title":"Characterization of the anti-BP180 autoantibody reactivity profile and epitope mapping in bullous pemphigoid patients","volume":"122","author":"Di Zenzo","year":"2004","journal-title":"J Invest Dermatol."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00034\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T08:28:58Z","timestamp":1548318538000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00034\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,24]]},"references-count":84,"alternative-id":["10.3389\/fimmu.2019.00034"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.00034","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,24]]},"article-number":"34"}}