{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T10:21:05Z","timestamp":1787912465587,"version":"build-2784847793"},"reference-count":128,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T00:00:00Z","timestamp":1548374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000341","name":"Arthritis Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.00046","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T04:19:21Z","timestamp":1548389961000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Targeting Tregs in Juvenile Idiopathic Arthritis and Juvenile Dermatomyositis\u2014Insights From Other Diseases"],"prefix":"10.3389","volume":"10","author":[{"given":"Romy E.","family":"Hoeppli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Pesenacker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,1,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1038\/nri2785","article-title":"FOXP3+ regulatory T cells in the human immune system","volume":"10","author":"Sakaguchi","year":"2010","journal-title":"Nat Rev Immunol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/nyas.13011","article-title":"From IPEX syndrome to FOXP3 mutation: a lesson on immune dysregulation","volume":"1417","author":"Bacchetta","year":"2016","journal-title":"Ann N Y Acad Sci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"585","DOI":"10.3389\/fimmu.2018.00585","article-title":"Regulatory T-Cells: potential regulator of tissue repair and regeneration","volume":"9","author":"Li","year":"2018","journal-title":"Front Immunol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.pcl.2018.03.005","article-title":"Juvenile idiopathic arthritis: oligoarthritis and polyarthritis","volume":"65","author":"Crayne","year":"2018","journal-title":"Pediatr Clin North Am."},{"key":"B5","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1111\/joim.12444","article-title":"The juvenile idiopathic inflammatory myopathies: pathogenesis, clinical and autoantibody phenotypes, and outcomes","volume":"280","author":"Rider","year":"2016","journal-title":"J Intern Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e13","DOI":"10.1017\/erm.2013.14","article-title":"T regulatory cells in childhood arthritis\u2013novel insights","volume":"15","author":"Pesenacker","year":"2013","journal-title":"Expert Rev Mol Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.3389\/fimmu.2018.02273","article-title":"Foxp3 molecular dynamics in treg in juvenile idiopathic arthritis","volume":"9","author":"Copland","year":"2018","journal-title":"Front Immunol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1136\/annrheumdis-2015-208992","article-title":"TCR repertoire sequencing identifies synovial Treg cell clonotypes in the bloodstream during active inflammation in human arthritis","volume":"76","author":"Rossetti","year":"2017","journal-title":"Ann Rheum Dis."},{"key":"B9","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3389\/fimmu.2017.00103","article-title":"CD161(+) Tconv and CD161(+) Treg share a transcriptional and functional phenotype despite limited overlap in TCRbeta repertoire","volume":"8","author":"Duurland","year":"2017","journal-title":"Front Immunol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1002\/art.39606","article-title":"Next-generation sequencing reveals restriction and clonotypic expansion of treg cells in juvenile idiopathic arthritis","volume":"68","author":"Henderson","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"5616","DOI":"10.4049\/jimmunol.1500391","article-title":"Synovial regulatory T cells occupy a discrete TCR niche in human arthritis and require local signals to stabilize FOXP3 protein expression","volume":"195","author":"Bending","year":"2015","journal-title":"J Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1182\/blood-2015-06-649145","article-title":"Autologous stem cell transplantation aids autoimmune patients by functional renewal and TCR diversification of regulatory T cells","volume":"127","author":"Delemarre","year":"2016","journal-title":"Blood"},{"key":"B13","doi-asserted-by":"publisher","first-page":"2699","DOI":"10.4049\/jimmunol.1400599","article-title":"Hypomethylation at the regulatory T cell-specific demethylated region in CD25hi T cells is decoupled from FOXP3 expression at the inflamed site in childhood arthritis","volume":"193","author":"Bending","year":"2014","journal-title":"J Immunol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1172\/JCI83987","article-title":"T regulatory cell chemokine production mediates pathogenic T cell attraction and suppression","volume":"126","author":"Patterson","year":"2016","journal-title":"J Clin Invest."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1093\/rheumatology\/kev101","article-title":"Methotrexate treatment affects effector but not regulatory T cells in juvenile idiopathic arthritis","volume":"54","author":"Bulatovic Calasan","year":"2015","journal-title":"Rheumatology"},{"key":"B16","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s12969-018-0253-x","article-title":"The transcription factor CREM drives an inflammatory phenotype of T cells in oligoarticular juvenile idiopathic arthritis","volume":"16","author":"Ohl","year":"2018","journal-title":"Pediatr Rheumatol Online J."},{"key":"B17","doi-asserted-by":"publisher","first-page":"3538","DOI":"10.1182\/blood-2010-12-328187","article-title":"Functional human regulatory T cells fail to control autoimmune inflammation due to PKB\/c-akt hyperactivation in effector cells","volume":"118","author":"Wehrens","year":"2011","journal-title":"Blood"},{"key":"B18","doi-asserted-by":"publisher","first-page":"3153","DOI":"10.1002\/art.30503","article-title":"Impaired suppression of synovial fluid CD4+CD25- T cells from patients with juvenile idiopathic arthritis by CD4+CD25+ Treg cells","volume":"63","author":"Haufe","year":"2011","journal-title":"Arthritis Rheum."},{"key":"B19","doi-asserted-by":"publisher","first-page":"e105353","DOI":"10.1371\/journal.pone.0105353","article-title":"Increased presence of FOXP3+ regulatory T cells in inflamed muscle of patients with active juvenile dermatomyositis compared to peripheral blood","volume":"9","author":"Vercoulen","year":"2014","journal-title":"PLoS ONE"},{"key":"B20","doi-asserted-by":"publisher","first-page":"258ra142","DOI":"10.1126\/scitranslmed.3009925","article-title":"Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy","volume":"6","author":"Villalta","year":"2014","journal-title":"Sci Transl Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s13075-016-0974-5","article-title":"Effects of conventional immunosuppressive treatment on CD244+ (CD28null) and FOXP3+ T cells in the inflamed muscle of patients with polymyositis and dermatomyositis","volume":"18","author":"Pandya","year":"2016","journal-title":"Arthritis Res Ther."},{"key":"B22","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1186\/ar4198","article-title":"Adult and juvenile dermatomyositis: are the distinct clinical features explained by our current understanding of serological subgroups and pathogenic mechanisms?","volume":"15","author":"Tansley","year":"2013","journal-title":"Arthritis Res Ther."},{"key":"B23","doi-asserted-by":"publisher","first-page":"117","DOI":"10.3899\/jrheum.160293","article-title":"Gene expression profiling in blood and affected muscle tissues reveals differential activation pathways in patients with new-onset juvenile and adult dermatomyositis","volume":"44","author":"Lopez De Padilla","year":"2017","journal-title":"J Rheumatol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1002\/art.40328","article-title":"Myogenic progenitor cells exhibit type I interferon-driven proangiogenic properties and molecular signature during juvenile dermatomyositis","volume":"70","author":"Gitiaux","year":"2018","journal-title":"Arthritis Rheumatol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1097\/BOR.0b013e3282efe261","article-title":"A gene expression approach to study perturbed pathways in myositis","volume":"19","author":"Greenberg","year":"2007","journal-title":"Curr Opin Rheumatol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/1755-8794-5-53","article-title":"Genomic signatures characterize leukocyte infiltration in myositis muscles","volume":"5","author":"Zhu","year":"2012","journal-title":"BMC Med Genomics"},{"key":"B27","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.berh.2017.12.003","article-title":"Juvenile dermatomyositis: latest advances","volume":"31","author":"Wu","year":"2017","journal-title":"Best Pract Res Clin Rheumatol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"768","DOI":"10.3389\/fphys.2018.00768","article-title":"The role of T lymphocytes in skeletal muscle repair from traumatic and contraction-induced injury","volume":"9","author":"Deyhle","year":"2018","journal-title":"Front Physiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"3259","DOI":"10.1002\/art.38184","article-title":"Aberrant muscle antigen exposure in mice is sufficient to cause myositis in a Treg cell-deficient milieu","volume":"65","author":"Young","year":"2013","journal-title":"Arthritis Rheum."},{"key":"B30","doi-asserted-by":"publisher","first-page":"989","DOI":"10.2353\/ajpath.2009.080422","article-title":"Role of regulatory T cells in a new mouse model of experimental autoimmune myositis","volume":"174","author":"Allenbach","year":"2009","journal-title":"Am J Pathol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"eaat5861","DOI":"10.1126\/sciimmunol.aat5861","article-title":"Molecular diversification of regulatory T cells in nonlymphoid tissues","volume":"3","author":"DiSpirito","year":"2018","journal-title":"Sci Immunol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1002\/eji.201344205","article-title":"Control of tissue-localized immune responses by human regulatory T cells","volume":"45","author":"Pesenacker","year":"2015","journal-title":"Eur J Immunol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"2459","DOI":"10.3899\/jrheum.140347","article-title":"Extension study of participants from the trial of early aggressive therapy in juvenile idiopathic arthritis","volume":"41","author":"Wallace","year":"2014","journal-title":"J Rheumatol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1136\/annrheumdis-2017-211751","article-title":"Abatacept in the treatment of adult dermatomyositis and polymyositis: a randomised, phase IIb treatment delayed-start trial","volume":"77","author":"Tjarnlund","year":"2018","journal-title":"Ann Rheum Dis."},{"key":"B35","doi-asserted-by":"publisher","first-page":"3554","DOI":"10.1002\/art.21389","article-title":"Patterns of clinical remission in select categories of juvenile idiopathic arthritis","volume":"52","author":"Wallace","year":"2005","journal-title":"Arthritis Rheum."},{"key":"B36","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1007\/s11926-013-0406-3","article-title":"Current developments in the use of biomarkers for juvenile idiopathic arthritis","volume":"16","author":"Duurland","year":"2014","journal-title":"Curr Rheumatol Rep."},{"key":"B37","doi-asserted-by":"publisher","first-page":"2509","DOI":"10.1073\/pnas.1424792112","article-title":"Low expression of CD39 on regulatory T cells as a biomarker for resistance to methotrexate therapy in rheumatoid arthritis","volume":"112","author":"Peres","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"B38","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1016\/j.jaci.2018.04.026","article-title":"Regulatory T cells as a biomarker for response to adalimumab in rheumatoid arthritis","volume":"142","author":"Nguyen","year":"2018","journal-title":"J Allergy Clin Immunol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"472624","DOI":"10.1155\/2014\/472624","article-title":"Soluble IL-2 receptor: a biomarker for assessing myositis activity","volume":"2014","author":"Tournadre","year":"2014","journal-title":"Dis Markers"},{"key":"B40","doi-asserted-by":"publisher","first-page":"e0156055","DOI":"10.1371\/journal.pone.0156055","article-title":"Gene expression deconvolution for uncovering molecular signatures in response to therapy in juvenile idiopathic arthritis","volume":"11","author":"Cui","year":"2016","journal-title":"PLoS ONE"},{"key":"B41","doi-asserted-by":"publisher","first-page":"R100","DOI":"10.1186\/ar4280","article-title":"Genomic characterization of remission in juvenile idiopathic arthritis","volume":"15","author":"Jiang","year":"2013","journal-title":"Arthritis Res Ther."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1093\/rheumatology\/kex206","article-title":"Transcriptional profiles of JIA patient blood with subsequent poor response to methotrexate","volume":"56","author":"Moncrieffe","year":"2017","journal-title":"Rheumatology"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.1016\/j.celrep.2015.08.046","article-title":"Inhibition of super-enhancer activity in autoinflammatory site-derived T Cells reduces disease-associated gene expression","volume":"12","author":"Peeters","year":"2015","journal-title":"Cell Rep."},{"key":"B44","doi-asserted-by":"publisher","first-page":"13845","DOI":"10.1073\/pnas.1524056113","article-title":"Epipolymorphisms associated with the clinical outcome of autoimmune arthritis affect CD4+ T cell activation pathways","volume":"113","author":"Spreafico","year":"2016","journal-title":"Proc Natl Acad Sci USA."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.2337\/db15-0572","article-title":"A Treg gene signature is a specific and sensitive biomarker to identify children with new onset type 1 diabetes","volume":"65","author":"Pesenacker","year":"2016","journal-title":"Diabetes"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1136\/annrheumdis-2016-210511","article-title":"How common is clinically inactive disease in a prospective cohort of patients with juvenile idiopathic arthritis? The importance of definition","volume":"76","author":"Shoop-Worrall","year":"2017","journal-title":"Ann Rheum Dis."},{"key":"B47","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1136\/annrheumdis-2017-212141","article-title":"Development of a consensus core dataset in juvenile dermatomyositis for clinical use to inform research","volume":"77","author":"McCann","year":"2018","journal-title":"Ann Rheum Dis."},{"key":"B48","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1136\/ard.2006.061853","article-title":"Blood and synovial fluid cytokine signatures in patients with juvenile idiopathic arthritis: a cross-sectional study","volume":"66","author":"de Jager","year":"2007","journal-title":"Ann Rheum Dis."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3310\/hta20340","article-title":"The clinical effectiveness and cost-effectiveness of abatacept, adalimumab, etanercept and tocilizumab for treating juvenile idiopathic arthritis: a systematic review and economic evaluation","volume":"20","author":"Shepherd","year":"2016","journal-title":"Health Technol Assess."},{"key":"B50","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s12969-017-0174-0","article-title":"Biologic therapies for refractory juvenile dermatomyositis: five years of experience of the childhood arthritis and rheumatology research alliance in North America","volume":"15","author":"Spencer","year":"2017","journal-title":"Pediatr Rheumatol Online J."},{"key":"B51","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1002\/acr.22198","article-title":"Pilot study of etanercept in patients with refractory juvenile dermatomyositis","volume":"66","author":"Rouster-Stevens","year":"2014","journal-title":"Arthritis Care Res"},{"key":"B52","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1097\/RHU.0000000000000514","article-title":"Successful treatment of refractory juvenile dermatomyositis with adalimumab","volume":"23","author":"Wang","year":"2017","journal-title":"J Clin Rheumatol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1080\/14397595.2018.1467257","article-title":"Current diagnosis and treatment of polymyositis and dermatomyositis","volume":"28","author":"Sasaki","year":"","journal-title":"Mod Rheumatol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"151","DOI":"10.2147\/IJGM.S154835","article-title":"Nephritis, cerebritis, and myositis after adalimumab therapy in a patient with rheumatoid arthritis: a case report","volume":"11","author":"Omran","year":"2018","journal-title":"Int J Gen Med."},{"key":"B55","doi-asserted-by":"publisher","first-page":"179180","DOI":"10.1155\/2014\/179180","article-title":"New onset of dermatomyositis\/polymyositis during anti-TNF-alpha therapies: a systematic literature review","volume":"2014","author":"Brunasso","year":"2014","journal-title":"ScientificWorldJournal"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1001\/jamadermatol.2013.5220","article-title":"Dermatomyositis induced by anti-tumor necrosis factor in a patient with juvenile idiopathic arthritis","volume":"149","author":"Liu","year":"2013","journal-title":"JAMA Dermatol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1080\/09546630802441234","article-title":"Induction and exacerbation of psoriasis with TNF-blockade therapy: a review and analysis of 127 cases","volume":"20","author":"Ko","year":"2009","journal-title":"J Dermatolog Treat."},{"key":"B58","doi-asserted-by":"publisher","first-page":"155","DOI":"10.3389\/fimmu.2013.00155","article-title":"Role of cytokines in thymus- versus peripherally derived-regulatory T cell differentiation and function","volume":"4","author":"Goldstein","year":"2013","journal-title":"Front Immunol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/nm.4018","article-title":"Reply to suppressive activity of human regulatory T cells is maintained in the presence of TNF","volume":"22","author":"Nie","year":"2016","journal-title":"Nat Med."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1002\/art.23460","article-title":"Suppressor activity among CD4+,CD25++ T cells is discriminated by membrane-bound tumor necrosis factor alpha","volume":"58","author":"Wang","year":"2008","journal-title":"Arthritis Rheum."},{"key":"B61","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/nm.4019","article-title":"Suppressive activity of human regulatory T cells is maintained in the presence of TNF","volume":"22","author":"Zaragoza","year":"2016","journal-title":"Nat Med."},{"key":"B62","doi-asserted-by":"publisher","first-page":"12079","DOI":"10.1038\/s41598-018-30621-4","article-title":"TNFR2 ligation in human T regulatory cells enhances IL2-induced cell proliferation through the non-canonical NF-kappaB pathway","volume":"8","author":"Wang","year":"2018","journal-title":"Sci Rep."},{"key":"B63","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1002\/art.40413","article-title":"Selective activation of tumor necrosis factor receptor ii induces antiinflammatory responses and alleviates experimental arthritis","volume":"70","author":"Fischer","year":"2018","journal-title":"Arthritis Rheumatol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/cmi.2017.138","article-title":"Stimulation of TNF receptor type 2 expands regulatory T cells and ameliorates established collagen-induced arthritis in mice","volume":"16","author":"Lamontain","year":"2018","journal-title":"Cell Mol Immunol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"2728","DOI":"10.1002\/art.38755","article-title":"Selective tumor necrosis factor receptor I blockade is antiinflammatory and reveals immunoregulatory role of tumor necrosis factor receptor II in collagen-induced arthritis","volume":"66","author":"McCann","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"3129","DOI":"10.1002\/art.34565","article-title":"Th17 cells are restrained by Treg cells via the inhibition of interleukin-6 in patients with rheumatoid arthritis responding to anti-tumor necrosis factor antibody therapy","volume":"64","author":"McGovern","year":"2012","journal-title":"Arthritis Rheum."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1084\/jem.20151255","article-title":"Anti-TNF drives regulatory T cell expansion by paradoxically promoting membrane TNF-TNF-RII bindin\u2013g in rheumatoid arthritis","volume":"213","author":"Nguyen","year":"2016","journal-title":"J Exp Med."},{"key":"B68","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1002\/art.39418","article-title":"Self-sustained resistance to suppression of CD8+ Teff cells at the site of autoimmune inflammation can be reversed by tumor necrosis factor and interferon-gamma blockade","volume":"68","author":"Petrelli","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s40259-017-0231-8","article-title":"Immunogenicity of biologics in chronic inflammatory diseases: a systematic review","volume":"31","author":"Strand","year":"2017","journal-title":"BioDrugs"},{"key":"B70","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/j.1749-6632.2009.05070.x","article-title":"Ustekinumab: lessons learned from targeting interleukin-12\/23p40 in immune-mediated diseases","volume":"1182","author":"Elliott","year":"2009","journal-title":"Ann N Y Acad Sci."},{"key":"B71","doi-asserted-by":"publisher","first-page":"E134","DOI":"10.3390\/molecules22010134","article-title":"Therapeutic potential of targeting the Th17\/Treg axis in autoimmune disorders","volume":"22","author":"Fasching","year":"2017","journal-title":"Molecules"},{"key":"B72","doi-asserted-by":"publisher","first-page":"14751","DOI":"10.1073\/pnas.1003852107","article-title":"Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment","volume":"107","author":"Nistala","year":"2010","journal-title":"Proc Natl Acad Sci USA."},{"key":"B73","doi-asserted-by":"publisher","first-page":"2504","DOI":"10.1002\/art.30332","article-title":"Evidence of the transient nature of the Th17 phenotype of CD4+CD161+ T cells in the synovial fluid of patients with juvenile idiopathic arthritis","volume":"63","author":"Cosmi","year":"2011","journal-title":"Arthritis Rheum."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1002\/art.38647","article-title":"T cell expression of granulocyte-macrophage colony-stimulating factor in juvenile arthritis is contingent upon Th17 plasticity","volume":"66","author":"Piper","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1111\/bjd.12214","article-title":"Long-term safety of ustekinumab in patients with moderate-to-severe psoriasis: final results from 5 years of follow-up","volume":"168","author":"Papp","year":"2013","journal-title":"Br J Dermatol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"109","DOI":"10.2147\/PHMT.S75836","article-title":"Efficacy and safety of ustekinumab in adolescents","volume":"7","author":"Kellen","year":"2016","journal-title":"Pediatric Health Med Ther."},{"key":"B77","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1016\/S0140-6736(18)32167-6","article-title":"Efficacy and safety of ustekinumab, an IL-12 and IL-23 inhibitor, in patients with active systemic lupus erythematosus: results of a multicentre, double-blind, phase 2, randomised, controlled study","volume":"392","author":"van Vollenhoven","year":"2018","journal-title":"Lancet"},{"key":"B78","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1097\/RHU.0000000000000408","article-title":"Ustekinumab as a therapeutic option for children with refractory enthesitis-related arthritis","volume":"22","author":"Mannion","year":"2016","journal-title":"J Clin Rheumatol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1002\/acr.22645","article-title":"Maintenance of clinical efficacy and radiographic benefit through two years of ustekinumab therapy in patients with active psoriatic arthritis: results from a randomized, placebo-controlled phase III trial","volume":"67","author":"Kavanaugh","year":"2015","journal-title":"Arthritis Care Res (Hoboken)."},{"key":"B80","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1038\/nm.3895","article-title":"IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases","volume":"21","author":"Teng","year":"2015","journal-title":"Nat Med."},{"key":"B81","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1097\/RHU.0000000000000430","article-title":"A rare case of amyopathic juvenile dermatomyositis associated with psoriasis successfully treated with ustekinumab","volume":"23","author":"Montoya","year":"2017","journal-title":"J Clin Rheumatol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1038\/nri2660","article-title":"Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspective","volume":"9","author":"Weaver","year":"2009","journal-title":"Nat Rev Immunol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"e6","DOI":"10.1136\/annrheumdis-2017-211622","article-title":"Ustekinumab inhibits Th1 and Th17 polarisation in a patient with giant cell arteritis","volume":"77","author":"Samson","year":"2018","journal-title":"Ann Rheum Dis."},{"key":"B84","doi-asserted-by":"publisher","first-page":"2102","DOI":"10.1002\/art.24601","article-title":"Subtype-specific peripheral blood gene expression profiles in recent-onset juvenile idiopathic arthritis","volume":"60","author":"Barnes","year":"2009","journal-title":"Arthritis Rheum."},{"key":"B85","doi-asserted-by":"publisher","first-page":"R131","DOI":"10.1186\/ar4311","article-title":"Myeloid related protein induces muscle derived inflammatory mediators in juvenile dermatomyositis","volume":"15","author":"Nistala","year":"2013","journal-title":"Arthritis Res Ther."},{"key":"B86","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.dib.2017.04.043","article-title":"In-depth immunophenotyping data of IL-6R on the human peripheral regulatory T cell (Treg) compartment","volume":"12","author":"Ferreira","year":"2017","journal-title":"Data Brief"},{"key":"B87","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.humimm.2015.12.004","article-title":"Transcriptome profiling of human FoxP3+ regulatory T cells","volume":"77","author":"Bhairavabhotla","year":"2016","journal-title":"Hum Immunol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"2647","DOI":"10.1182\/blood-2012-08-443473","article-title":"CD161 defines the subset of FoxP3+ T cells capable of producing proinflammatory cytokines","volume":"121","author":"Pesenacker","year":"2013","journal-title":"Blood"},{"key":"B89","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1002\/art.40466","article-title":"Subcutaneous abatacept in patients with polyarticular-course juvenile idiopathic arthritis: results from a phase III open-label study","volume":"70","author":"Brunner","year":"2018","journal-title":"Arthritis Rheumatol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1159\/000450948","article-title":"Immunosuppressive activity of abatacept on circulating T helper lymphocytes from juvenile idiopathic arthritis patients","volume":"171","author":"Maggi","year":"2016","journal-title":"Int Arch Allergy Immunol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"2759","DOI":"10.1002\/art.39234","article-title":"Long-term safety, efficacy, and quality of life in patients with juvenile idiopathic arthritis treated with intravenous abatacept for up to seven years","volume":"67","author":"Lovell","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/S0140-6736(08)60998-8","article-title":"Abatacept in children with juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled withdrawal trial","volume":"372","author":"Ruperto","year":"2008","journal-title":"Lancet"},{"key":"B93","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.jpeds.2011.11.057","article-title":"Abatacept and sodium thiosulfate for treatment of recalcitrant juvenile dermatomyositis complicated by ulceration and calcinosis","volume":"160","author":"Arabshahi","year":"2012","journal-title":"J Pediatr."},{"key":"B94","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jaut.2017.11.001","article-title":"A gene module associated with dysregulated TCR signaling pathways in CD4(+) T cell subsets in rheumatoid arthritis","volume":"89","author":"Sumitomo","year":"2018","journal-title":"J Autoimmun."},{"key":"B95","doi-asserted-by":"publisher","first-page":"3449","DOI":"10.2337\/db14-0047","article-title":"Reduction in CD4 central memory T-cell subset in costimulation modulator abatacept-treated patients with recent-onset type 1 diabetes is associated with slower C-peptide decline","volume":"63","author":"Orban","year":"2014","journal-title":"Diabetes"},{"key":"B96","doi-asserted-by":"publisher","first-page":"e0122198","DOI":"10.1371\/journal.pone.0122198","article-title":"Functional characterization of human T cell hyporesponsiveness induced by CTLA4-Ig","volume":"10","author":"Rochman","year":"2015","journal-title":"PLoS ONE"},{"key":"B97","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1186\/s13075-017-1364-3","article-title":"Abatacept reduces synovial regulatory T-cell expression in patients with psoriatic arthritis","volume":"19","author":"Szentpetery","year":"2017","journal-title":"Arthritis Res Ther."},{"key":"B98","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1080\/08830185.2018.1465943","article-title":"Regulatory T-cell dynamics with abatacept treatment in rheumatoid arthritis","volume":"37","author":"Langdon","year":"","journal-title":"Int Rev Immunol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1007\/s10875-011-9527-5","article-title":"CTLA-4-Ig therapy diminishes the frequency but enhances the function of Treg cells in patients with rheumatoid arthritis","volume":"31","author":"Alvarez-Quiroga","year":"2011","journal-title":"J Clin Immunol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1093\/rheumatology\/kev403","article-title":"Abatacept (CTLA-4Ig) treatment reduces T cell apoptosis and regulatory T cell suppression in patients with rheumatoid arthritis","volume":"55","author":"Bonelli","year":"2016","journal-title":"Rheumatology (Oxford)"},{"key":"B101","doi-asserted-by":"publisher","first-page":"252","DOI":"10.3389\/fimmu.2018.00252","article-title":"Clinical grade regulatory CD4(+) T cells (Tregs): moving toward cellular-based immunomodulatory therapies","volume":"9","author":"Duggleby","year":"2018","journal-title":"Front Immunol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"315ra189","DOI":"10.1126\/scitranslmed.aad4134","article-title":"Type 1 diabetes immunotherapy using polyclonal regulatory T cells","volume":"7","author":"Bluestone","year":"2015","journal-title":"Sci Transl Med."},{"key":"B103","doi-asserted-by":"publisher","first-page":"2505","DOI":"10.1172\/JCI90598","article-title":"Transplant trials with Tregs: perils and promises","volume":"127","author":"Tang","year":"2017","journal-title":"J Clin Invest."},{"key":"B104","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1182\/blood-2015-06-653667","article-title":"Umbilical cord blood-derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect","volume":"127","author":"Brunstein","year":"2016","journal-title":"Blood"},{"key":"B105","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1182\/blood-2010-07-293795","article-title":"Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics","volume":"117","author":"Brunstein","year":"2011","journal-title":"Blood"},{"key":"B106","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1111\/ajt.13456","article-title":"Discarded human thymus is a novel source of stable and long-lived therapeutic regulatory T cells","volume":"16","author":"Dijke","year":"2015","journal-title":"Am J Transplant."},{"key":"B107","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1111\/ajt.14936","article-title":"Tailoring the homing capacity of human Tregs for directed migration to sites of Th1-inflammation or intestinal regions","volume":"19","author":"Hoeppli","year":"2018","journal-title":"Am J Transplant."},{"key":"B108","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1097\/MOT.0000000000000566","article-title":"Taking regulatory T-cell therapy one step further","volume":"23","author":"Sicard","year":"2018","journal-title":"Curr Opin Organ Transplant."},{"key":"B109","doi-asserted-by":"publisher","first-page":"10044","DOI":"10.1038\/s41598-018-28346-5","article-title":"Intradermal injection of low dose human regulatory T cells inhibits skin inflammation in a humanized mouse model","volume":"8","author":"Landman","year":"2018","journal-title":"Sci Rep."},{"key":"B110","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1038\/s41577-018-0046-y","article-title":"Biology and regulation of IL-2: from molecular mechanisms to human therapy","volume":"18","author":"Spolski","year":"2018","journal-title":"Nat Rev Immunol."},{"key":"B111","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1053\/j.seminoncol.2018.04.001","article-title":"Combining computational and experimental biology to develop therapeutically valuable IL2 muteins","volume":"45","author":"Leon","year":"2018","journal-title":"Semin Oncol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1007\/s11892-016-0739-1","article-title":"Promoting immune regulation in type 1 diabetes using low-dose interleukin-2","volume":"16","author":"Dwyer","year":"2016","journal-title":"Curr Diab Rep."},{"key":"B113","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1136\/annrheumdis-2015-207776","article-title":"Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus","volume":"75","author":"von","year":"2015","journal-title":"Ann Rheum Dis."},{"key":"B114","doi-asserted-by":"publisher","first-page":"e1002139","DOI":"10.1371\/journal.pmed.1002139","article-title":"Regulatory T cell responses in participants with type 1 diabetes after a single dose of interleukin-2: a non-randomised, open label, adaptive dose-finding trial","volume":"13","author":"Todd","year":"2016","journal-title":"PLoS Med."},{"key":"B115","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.jaut.2015.01.001","article-title":"Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients","volume":"58","author":"Rosenzwajg","year":"2015","journal-title":"J Autoimmun."},{"key":"B116","doi-asserted-by":"publisher","first-page":"179ra143","DOI":"10.1126\/scitranslmed.3005265","article-title":"Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease","volume":"5","author":"Matsuoka","year":"2013","journal-title":"Sci Transl Med."},{"key":"B117","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1182\/blood-2016-02-702852","article-title":"Efficacy, durability, and response predictors of low-dose interleukin-2 therapy for chronic graft-versus-host disease","volume":"128","author":"Koreth","year":"2016","journal-title":"Blood"},{"key":"B118","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1038\/s41591-018-0070-2","article-title":"A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism","volume":"24","author":"Trotta","year":"2018","journal-title":"Nat Med."},{"key":"B119","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1111\/imm.12008","article-title":"Interleukin-2\/anti-interleukin-2 monoclonal antibody immune complex suppresses collagen-induced arthritis in mice by fortifying interleukin-2\/STAT5 signalling pathways","volume":"137","author":"Lee","year":"2012","journal-title":"Immunology"},{"key":"B120","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.4049\/jimmunol.1701502","article-title":"IL-2-Anti-IL-2 monoclonal antibody immune complexes inhibit collagen-induced arthritis by augmenting regulatory T cell functions","volume":"201","author":"Yokoyama","year":"2018","journal-title":"J Immunol."},{"key":"B121","doi-asserted-by":"publisher","first-page":"8493767","DOI":"10.1155\/2016\/8493767","article-title":"Interleukin-2\/Anti-Interleukin-2 immune complex attenuates cardiac remodeling after myocardial infarction through expansion of regulatory T cells","volume":"2016","author":"Zeng","year":"2016","journal-title":"J Immunol Res."},{"key":"B122","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.4049\/jimmunol.1800578","article-title":"Engineering a single-agent cytokine\/antibody fusion that selectively expands regulatory T cells for autoimmune disease therapy","volume":"201","author":"Spangler","year":"2018","journal-title":"J Immunol."},{"key":"B123","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.jaut.2014.10.002","article-title":"Sustained in vivo signaling by long-lived IL-2 induces prolonged increases of regulatory T cells","volume":"56","author":"Bell","year":"2015","journal-title":"J Autoimmun."},{"key":"B124","doi-asserted-by":"publisher","first-page":"2579","DOI":"10.4049\/jimmunol.1800907","article-title":"IL-2\/CD25: a long-acting fusion protein that promotes immune tolerance by selectively targeting the IL-2 receptor on regulatory T cells","volume":"201","author":"Ward","year":"2018","journal-title":"J Immunol"},{"key":"B125","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.3389\/fimmu.2018.01435","article-title":"Immune cell dynamics unfolded by single-cell technologies","volume":"9","author":"Kunz","year":"2018","journal-title":"Front Immunol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.cell.2018.07.010","article-title":"Deep profiling of mouse splenic architecture with CODEX multiplexed imaging","volume":"174","author":"Goltsev","year":"2018","journal-title":"Cell"},{"key":"B127","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1586\/14737159.2015.1069182","article-title":"Recent developments in multiplexing techniques for immunohistochemistry","volume":"15","author":"Dixon","year":"2015","journal-title":"Expert Rev Mol Diagn."},{"key":"B128","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1900\/RDS.2012.9.359","article-title":"Immune-directed therapy for type 1 diabetes at the clinical level: the Immune Tolerance Network (ITN) experience","volume":"9","author":"Ehlers","year":"2012","journal-title":"Rev Diabet Stud."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00046\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T04:19:23Z","timestamp":1548389963000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00046\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,25]]},"references-count":128,"alternative-id":["10.3389\/fimmu.2019.00046"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.00046","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,25]]},"article-number":"46"}}