{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:02:59Z","timestamp":1777478579212,"version":"3.51.4"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DP3 DK085708-01"],"award-info":[{"award-number":["DP3 DK085708-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.00068","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T14:11:37Z","timestamp":1549030297000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["The Autoimmune Disorder Susceptibility Gene CLEC16A Restrains NK Cell Function in YTS NK Cell Line and Clec16a Knockout Mice"],"prefix":"10.3389","volume":"10","author":[{"given":"Rahul","family":"Pandey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Bakay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather S.","family":"Hain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan","family":"Strenkowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasiya","family":"Yermakova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jake A.","family":"Kushner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan S.","family":"Orange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakon","family":"Hakonarson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,2,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/nature05911","article-title":"Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls","volume":"447","author":"Burton","year":"2007","journal-title":"Nature"},{"key":"B2","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/nature06010","article-title":"A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene","volume":"448","author":"Hakonarson","year":"2007","journal-title":"Nature"},{"key":"B3","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/ng2068","article-title":"Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes","volume":"39","author":"Todd","year":"2007","journal-title":"Nat Genet."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1038\/ng.249","article-title":"Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci","volume":"40","author":"Cooper","year":"2008","journal-title":"Nat Genet."},{"key":"B5","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1038\/ng.381","article-title":"Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes","volume":"41","author":"Barrett","year":"2009","journal-title":"Nat Genet."},{"key":"B6","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/gene.2010.59","article-title":"Exploring the CLEC16A gene reveals a MS-associated variant with correlation to the relative expression of CLEC16A isoforms in thymus","volume":"12","author":"Mero","year":"2011","journal-title":"Genes Immun"},{"key":"B7","doi-asserted-by":"publisher","first-page":"3310","DOI":"10.1210\/jc.2008-0821","article-title":"Polymorphisms in CLEC16A and CIITA at 16p13 are associated with primary adrenal insufficiency","volume":"93","author":"Skinningsrud","year":"2008","journal-title":"J Clin Endocrinol Metab."},{"key":"B8","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1038\/gene.2011.89","article-title":"Association of primary biliary cirrhosis with variants in the CLEC16A, SOCS1, SPIB and SIAE immunomodulatory genes","volume":"13","author":"Hirschfield","year":"2012","journal-title":"Genes Immun."},{"key":"B9","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/ng.789","article-title":"Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis","volume":"43","author":"Mells","year":"2011","journal-title":"Nat Genet."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1136\/ard.2009.114934","article-title":"A CLEC16A variant confers risk for juvenile idiopathic arthritis and anti-cyclic citrullinated peptide antibody negative rheumatoid arthritis","volume":"69","author":"Skinningsrud","year":"2010","journal-title":"Ann Rheum Dis."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2192","DOI":"10.1038\/jid.2012.129","article-title":"Follow-up study of the first genome-wide association scan in alopecia areata: IL13 and KIAA0350 as susceptibility loci supported with genome-wide significance","volume":"132","author":"Jagielska","year":"2012","journal-title":"J Invest Dermatol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1016\/j.immuni.2015.04.011","article-title":"The Autoimmunity-associated gene CLEC16A modulates thymic epithelial cell autophagy and alters T cell selection","volume":"42","author":"Schuster","year":"2015","journal-title":"Immunity"},{"key":"B13","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1083\/jcb.200911126","article-title":"The novel endosomal membrane protein Ema interacts with the class C Vps-HOPSs complex to promote endosomal maturation","volume":"188","author":"Kim","year":"2010","journal-title":"J Cell Biol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"E1072","DOI":"10.1073\/pnas.1120320109","article-title":"DiAntonio, Drosophila golgi membrane protein ema promotes autophagosomal growth and function","volume":"109","author":"Kim","year":"2012","journal-title":"Proc Natl Acad Sci USA."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1016\/j.cell.2014.05.016","article-title":"The diabetes susceptibility gene Clec16a regulates mitophagy","volume":"157","author":"Soleimanpour","year":"2014","journal-title":"Cell"},{"key":"B16","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.yexcr.2017.02.017","article-title":"Human CLEC16A regulates autophagy through modulating mTOR activity","volume":"352","author":"Tam","year":"2017","journal-title":"Exp Cell Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/ni1581","article-title":"Up on the tightrope: natural killer cell activation and inhibition","volume":"9","author":"Lanier","year":"2008","journal-title":"Nat Immunol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1111\/j.1365-2567.2010.03360.x","article-title":"Natural killer cells in human autoimmune diseases","volume":"131","author":"Schleinitz","year":"2010","journal-title":"Immunology"},{"key":"B19","doi-asserted-by":"publisher","first-page":"e0203952","DOI":"10.1371\/journal.pone.0203952","article-title":"CLEC16A regulates splenocyte and NK cell function in part through MEK signaling","volume":"13","author":"Pandey","year":"2018","journal-title":"PLoS ONE"},{"key":"B20","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1111\/j.0300-9475.2004.01475.x","article-title":"Activation of natural killer cells: underlying molecular mechanisms revealed","volume":"60","author":"Backstrom","year":"2004","journal-title":"Scand J Immunol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2470","DOI":"10.1091\/mbc.e04-11-1014","article-title":"CART: an Hrs\/actinin-4\/BERP\/myosin V protein complex required for efficient receptor recycling","volume":"16","author":"Yan","year":"2005","journal-title":"Mol Biol Cell"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1016\/j.yexcr.2008.10.013","article-title":"ESCRT proteins in physiology and disease","volume":"315","author":"Stuffers","year":"2009","journal-title":"Exp Cell Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1111\/j.1600-0854.2011.01242.x","article-title":"How ubiquitin functions with ESCRTs","volume":"12","author":"Shields","year":"2011","journal-title":"Traffic"},{"key":"B24","doi-asserted-by":"publisher","first-page":"19630","DOI":"10.1074\/jbc.M110.209338","article-title":"Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane","volume":"286","author":"Yoshii","year":"2011","journal-title":"J Biol Chem."},{"key":"B25","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/nature10251","article-title":"Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis","volume":"476","author":"Sawcer","year":"2011","journal-title":"Nature"},{"key":"B26","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1056\/NEJMoa073493","article-title":"Risk alleles for multiple sclerosis identified by a genomewide study","volume":"357","author":"Hafler","year":"2007","journal-title":"N Engl J Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1038\/ejhg.2009.50","article-title":"Specific association of a CLEC16A\/KIAA0350 polymorphism with NOD2\/CARD15(-) Crohn's disease patients","volume":"17","author":"M\u00e1rquez","year":"2009","journal-title":"Eur J Hum Genet."},{"key":"B28","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1136\/ard.2008.098376","article-title":"Chromosomal region 16p13: further evidence of increased predisposition to immune diseases","volume":"69","author":"Mart\u00ednez","year":"2010","journal-title":"Ann Rheum Dis."},{"key":"B29","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s11064-011-0581-4","article-title":"Involvement of CLEC16A in activation of astrocytes after LPS treated","volume":"37","author":"Wu","year":"2012","journal-title":"Neurochem Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1111\/cei.12240","article-title":"Functional evaluation of the role of C-type lectin domain family 16A at the chromosome 16p13 locus","volume":"175","author":"Zouk","year":"2014","journal-title":"Clin Exp Immunol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"265","DOI":"10.2337\/db17-0321","article-title":"Clec16a, Nrdp1, and USP8 form a ubiquitin-dependent tripartite complex that regulates beta-cell mitophagy","volume":"67","author":"Pearson","year":"2018","journal-title":"Diabetes"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1038\/ni1268","article-title":"Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin","volume":"6","author":"Intlekofer","year":"2005","journal-title":"Nat Immunol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"4465","DOI":"10.1073\/pnas.012025199","article-title":"Large-scale analysis of the human and mouse transcriptomes","volume":"99","author":"Su","year":"2002","journal-title":"Proc Natl Acad Sci USA."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2009-10-11-r130","article-title":"BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources","author":"Wu","year":"2009","journal-title":"Genome Biol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jim.2004.08.008","article-title":"CD107a as a functional marker for the identification of natural killer cell activity","volume":"294","author":"Alter","year":"2004","journal-title":"J Immunol Methods"},{"key":"B36","doi-asserted-by":"publisher","first-page":"10346","DOI":"10.1073\/pnas.0604236103","article-title":"CD28-stimulated ERK2 phosphorylation is required for polarization of the microtubule organizing center and granules in YTS NK cells","volume":"103","author":"Chen","year":"2006","journal-title":"Proc Natl Acad Sci USA."},{"key":"B37","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/cdd.2013.26","article-title":"Molecular mechanisms of natural killer cell activation in response to cellular stress","volume":"21","author":"Chan","year":"2014","journal-title":"Cell Death Differ."},{"key":"B38","doi-asserted-by":"publisher","first-page":"694948","DOI":"10.1155\/2014\/694948","volume":"2014","author":"Mattana","year":"2014","journal-title":"Mediator Inflamm."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2815","DOI":"10.1093\/hmg\/dds098","article-title":"Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes","volume":"21","author":"Wallace","year":"2012","journal-title":"Hum Mol Genet."},{"key":"B40","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/gene.2008.82","article-title":"CD226 Gly307Ser association with multiple autoimmune diseases","volume":"10","author":"Hafler","year":"2009","journal-title":"Genes Immun."},{"key":"B41","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.humimm.2012.10.009","article-title":"CD226 Gly307Ser association with multiple autoimmune diseases: a meta-analysis","volume":"74","author":"Qiu","year":"2013","journal-title":"Hum Immunol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1101\/gad.989602","article-title":"When cell biology meets development: endocytic regulation of signaling pathways","volume":"16","author":"Seto","year":"2002","journal-title":"Genes Dev."},{"key":"B43","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1038\/ncb1740","article-title":"Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking","volume":"10","author":"Liang","year":"2008","journal-title":"Nat Cell Biol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"3663","DOI":"10.1242\/jcs.02502","article-title":"Drosophila Vps16A is required for trafficking to lysosomes and biogenesis of pigment granules","volume":"118","author":"Pulipparacharuvil","year":"2005","journal-title":"J Cell Sci."},{"key":"B45","doi-asserted-by":"publisher","first-page":"159","DOI":"10.3389\/fimmu.2014.00159","article-title":"Cross-talks between natural killer cells and distinct subsets of dendritic cells","volume":"5","author":"Ferlazzo","year":"2014","journal-title":"Front Immunol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1006\/abio.2000.4478","article-title":"Generation of mammalian cells stably expressing multiple genes at predetermined levels","volume":"280","author":"Liu","year":"2000","journal-title":"Analyt Biochem."},{"key":"B47","doi-asserted-by":"publisher","first-page":"14151","DOI":"10.1073\/pnas.1835830100","article-title":"The mature activating natural killer cell immunologic synapse is formed in distinct stages","volume":"100","author":"Orange","year":"2003","journal-title":"Proc Natl Acad Sci USA."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00068\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T14:11:39Z","timestamp":1549030299000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00068\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,1]]},"references-count":47,"alternative-id":["10.3389\/fimmu.2019.00068"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.00068","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,1]]},"article-number":"68"}}