{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T18:16:36Z","timestamp":1778350596649,"version":"3.51.4"},"reference-count":90,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T00:00:00Z","timestamp":1549238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.00118","type":"journal-article","created":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T04:28:07Z","timestamp":1549254487000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Amblyomma sculptum Salivary PGE2 Modulates the Dendritic Cell-Rickettsia rickettsii Interactions in vitro and in vivo"],"prefix":"10.3389","volume":"10","author":[{"given":"Eliane","family":"Esteves","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna","family":"Bizzarro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Borges","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Ram\u00edrez-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula Ferranti","family":"Peti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan Henrique Depieri","family":"Cataneo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pryscilla Fanini","family":"Wowk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolfo Pessato","family":"Tim\u00f3teo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo Bahia","family":"Labruna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Ismael","family":"Silva Junior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9lio Lopes","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00facia Helena","family":"Faccioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9a Cristina","family":"Foga\u00e7a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Arterio","family":"Sorgi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anderson","family":"S\u00e1-Nunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,2,4]]},"reference":[{"key":"B1","first-page":"560","volume-title":"Biology of Ticks","author":"Sonenshine","year":"2013"},{"key":"B2","doi-asserted-by":"publisher","first-page":"S67","DOI":"10.1017\/S0031182004006468","article-title":"Tick salivary glands: function, physiology and future","volume":"129","author":"Bowman","year":"2004","journal-title":"Parasitology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"281","DOI":"10.3389\/fcimb.2017.00281","article-title":"The essential role of tick salivary glands and saliva in tick feeding and pathogen transmission","volume":"7","author":"Simo","year":"2017","journal-title":"Front Cell Infect Microbiol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.jprot.2015.07.005","article-title":"Modulation of host immunity by tick saliva","volume":"128","author":"Kotal","year":"2015","journal-title":"J Proteomics"},{"key":"B5","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.2741\/3363","article-title":"The role of saliva in tick feeding","volume":"14","author":"Francischetti","year":"2009","journal-title":"Front Biosci"},{"key":"B6","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1017\/S0031182004005967","article-title":"The global importance of ticks","volume":"129","author":"Jongejan","year":"2004","journal-title":"Parasitology"},{"key":"B7","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.pt.2012.07.003","article-title":"Ticks and tick-borne diseases: a One Health perspective","volume":"28","author":"Dantas-Torres","year":"2012","journal-title":"Trends Parasitol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1756-3305-6-16","article-title":"Vector-borne helminths of dogs and humans in Europe","volume":"6","author":"Otranto","year":"2013","journal-title":"Parasit Vectors"},{"key":"B9","first-page":"3","article-title":"Non-viraemic tickborne virus transmission: mechanism and significance","volume-title":"Modern Acarology","author":"Nuttall","year":"1991"},{"key":"B10","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/S1473-3099(07)70261-X","article-title":"Rocky Mountain spotted fever","volume":"7","author":"Dantas-Torres","year":"2007","journal-title":"Lancet Infect Dis"},{"key":"B11","doi-asserted-by":"publisher","first-page":"S39","DOI":"10.1086\/518145","article-title":"Rickettsiae and rickettsial infections: the current state of knowledge","volume":"45","author":"Walker","year":"2007","journal-title":"Clin Infect Dis"},{"key":"B12","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1111\/j.1749-6632.2009.04516.x","article-title":"Ecology of rickettsia in South America","volume":"1166","author":"Labruna","year":"2009","journal-title":"Ann N Y Acad Sci"},{"key":"B13","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1196\/annals.1374.044","article-title":"Brazilian spotted fever: a case series from an endemic area in southeastern Brazil: clinical aspects","volume":"1078","author":"Angerami","year":"2006","journal-title":"Ann N Y Acad Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s40409-016-0077-4","article-title":"An update on the epidemiological situation of spotted fever in Brazil","volume":"22","author":"de Oliveira","year":"2016","journal-title":"J Venom Anim Toxins Incl Trop Dis"},{"key":"B15","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.ttbdis.2013.11.004","article-title":"Reassessment of the taxonomic status of Amblyomma cajennense (Fabricius, 1787) with the description of three new species, Amblyomma tonelliae n. sp., Amblyomma interandinum n. sp. and Amblyomma patinoi n. sp., and reinstatement of Amblyomma mixtum, and Amblyomma sculptum (Ixodida: Ixodidae)","volume":"5","author":"Nava","year":"2014","journal-title":"Ticks Tick Borne Dis"},{"key":"B16","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3389\/fcimb.2013.00027","article-title":"Ecology, biology and distribution of spotted-fever tick vectors in Brazil","volume":"3","author":"Szabo","year":"2013","journal-title":"Front Cell Infect Microbiol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/nature14052","article-title":"Commensal-dendritic-cell interaction specifies a unique protective skin immune signature","volume":"520","author":"Naik","year":"2015","journal-title":"Nature"},{"key":"B18","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1038\/nri3646","article-title":"Mechanisms regulating skin immunity and inflammation","volume":"14","author":"Pasparakis","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/nri3683","article-title":"The origins and functions of dendritic cells and macrophages in the skin","volume":"14","author":"Malissen","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/j.immuni.2012.03.018","article-title":"Human epidermal Langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells","volume":"36","author":"Seneschal","year":"2012","journal-title":"Immunity"},{"key":"B21","doi-asserted-by":"publisher","first-page":"350","DOI":"10.3389\/fimmu.2018.00350","article-title":"Mechanisms of tolerance induction by dendritic cells in vivo","volume":"9","author":"Hasegawa","year":"2018","journal-title":"Front Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"4535","DOI":"10.4049\/jimmunol.179.7.4535","article-title":"Skin-derived dendritic cells can mediate deletional tolerance of class I-Restricted self-reactive T cells","volume":"179","author":"Waithman","year":"2007","journal-title":"J Immunol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/nri.2016.116","article-title":"Dendritic cell migration in health and disease","volume":"17","author":"Worbs","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.immuni.2008.08.008","article-title":"In vivo induction of immune responses to pathogens by conventional dendritic cells","volume":"29","author":"Lopez-Bravo","year":"2008","journal-title":"Immunity"},{"key":"B25","first-page":"467","article-title":"The location of tick salivary antigens, complement and immunoglobulin in the skin of guinea-pigs infested with Dermacentor andersoni larvae","volume":"38","author":"Allen","year":"1979","journal-title":"Immunology"},{"key":"B26","doi-asserted-by":"crossref","first-page":"563","DOI":"10.4049\/jimmunol.122.2.563","article-title":"Langerhans cells trap tick salivary gland antigens in tick-resistant guinea pigs","volume":"122","author":"Allen","year":"1979","journal-title":"J Immunol"},{"key":"B27","first-page":"157","article-title":"Langerhans cells present tick antigens to lymph node cells from tick-sensitized guinea-pigs","volume":"55","author":"Nithiuthai","year":"1985","journal-title":"Immunology"},{"key":"B28","first-page":"153","article-title":"Effects of ultraviolet irradiation on the acquisition and expression of tick resistance in guinea-pigs","volume":"51","author":"Nithiuthai","year":"1984","journal-title":"Immunology"},{"key":"B29","first-page":"133","article-title":"Significant changes in epidermal Langerhans cells of guinea-pigs infested with ticks (Dermacentor andersoni)","volume":"51","author":"Nithiuthai","year":"1984","journal-title":"Immunology"},{"key":"B30","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1111\/j.1365-2567.2004.02079.x","article-title":"Tick saliva inhibits differentiation, maturation and function of murine bone-marrow-derived dendritic cells","volume":"114","author":"Cavassani","year":"2005","journal-title":"Immunology"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.4049\/jimmunol.179.3.1497","article-title":"Prostaglandin E2 is a major inhibitor of dendritic cell maturation and function in Ixodes scapularis saliva","volume":"179","author":"S\u00e1-Nunes","year":"2007","journal-title":"J Immunol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"6186","DOI":"10.4049\/jimmunol.180.9.6186","article-title":"Tick saliva inhibits dendritic cell migration, maturation, and function while promoting development of Th2 responses","volume":"180","author":"Skallova","year":"2008","journal-title":"J Immunol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1111\/j.1365-3024.2011.01332.x","article-title":"Effect of tick saliva on immune interactions between Borrelia afzelii and murine dendritic cells","volume":"33","author":"Slamova","year":"2011","journal-title":"Parasite Immunol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s13071-015-0634-7","article-title":"Immunosuppressive effects of Amblyomma cajennense tick saliva on murine bone marrow-derived dendritic cells","volume":"8","author":"Carvalho-Costa","year":"2015","journal-title":"Parasit Vectors"},{"key":"B35","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/j.ijpara.2007.10.006","article-title":"Tick saliva inhibits the chemotactic function of MIP-1\u03b1 and selectively impairs chemotaxis of immature dendritic cells by down-regulating cell-surface CCR5","volume":"38","author":"Oliveira","year":"2008","journal-title":"Int J Parasitol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"7422","DOI":"10.4049\/jimmunol.0900075","article-title":"The immunomodulatory action of sialostatin L on dendritic cells reveals its potential to interfere with autoimmunity","volume":"182","author":"S\u00e1-Nunes","year":"2009","journal-title":"J Immunol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"e31","DOI":"10.1371\/journal.ppat.0040031","article-title":"Salp15 binding to DC-SIGN inhibits cytokine expression by impairing both nucleosome remodeling and mRNA stabilization","volume":"4","author":"Hovius","year":"2008","journal-title":"PLoS Pathog"},{"key":"B38","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1186\/s13071-015-0887-1","article-title":"Tick sialostatins L and L2 differentially influence dendritic cell responses to Borrelia spirochetes","volume":"8","author":"Lieskovska","year":"2015","journal-title":"Parasit Vectors"},{"key":"B39","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1111\/pim.12162","article-title":"Tick salivary cystatin sialostatin L2 suppresses IFN responses in mouse dendritic cells","volume":"37","author":"Lieskovska","year":"2015","journal-title":"Parasite Immunol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"10960","DOI":"10.1074\/jbc.M110.205047","article-title":"Deconstructing tick saliva: non-protein molecules with potent immunomodulatory properties","volume":"286","author":"Oliveira","year":"2011","journal-title":"J Biol Chem"},{"key":"B41","doi-asserted-by":"publisher","first-page":"e1003450","DOI":"10.1371\/journal.ppat.1003450","article-title":"Novel immunomodulators from hard ticks selectively reprogramme human dendritic cell responses","volume":"9","author":"Preston","year":"2013","journal-title":"PLoS Pathog"},{"key":"B42","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1042\/BJ20100280","article-title":"Crystal structure and functional characterization of an immunomodulatory salivary cystatin from the soft tick Ornithodoros moubata","volume":"429","author":"Salat","year":"2010","journal-title":"Biochem J"},{"key":"B43","doi-asserted-by":"publisher","first-page":"288","DOI":"10.3389\/fcimb.2017.00288","article-title":"Salivary tick cystatin OmC2 targets lysosomal Cathepsins S and C in human dendritic cells","volume":"7","author":"Zavasnik-Bergant","year":"2017","journal-title":"Front Cell Infect Microbiol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0304-4017(01)00650-1","article-title":"The sex ratio of Amblyomma cajennense (Acari: Ixodidae) with notes on the male feeding period in the laboratory","volume":"105","author":"Pinter","year":"2002","journal-title":"Vet Parasitol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.ttbdis.2013.05.001","article-title":"Proteome of Rhipicephalus sanguineus tick saliva induced by the secretagogues pilocarpine and dopamine","volume":"4","author":"Oliveira","year":"2013","journal-title":"Ticks Tick Borne Dis"},{"key":"B46","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1196\/annals.1374.103","article-title":"Isolation of Rickettsia rickettsii and Rickettsia bellii in cell culture from the tick Amblyomma aureolatum in Brazil","volume":"1078","author":"Pinter","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"B47","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3109\/10520296409061219","article-title":"Staining rickettsiae in Yolk-Sac cultures","volume":"39","author":"Gimenez","year":"1964","journal-title":"Stain Technol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1002\/9780471729259.mc03a05s11","article-title":"Laboratory maintenance of Rickettsia rickettsii","author":"Ammerman","year":"2008","journal-title":"Curr Protoc Microbiol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1186\/1756-3305-6-329","article-title":"Effects of Aedes aegypti salivary components on dendritic cell and lymphocyte biology","volume":"6","author":"Bizzarro","year":"2013","journal-title":"Parasit Vectors"},{"key":"B50","doi-asserted-by":"publisher","first-page":"10981","DOI":"10.1038\/s41598-017-11496-3","article-title":"Dormant 5-lipoxygenase in inflammatory macrophages is triggered by exogenous arachidonic acid","volume":"7","author":"Sorgi","year":"2017","journal-title":"Sci Rep"},{"key":"B51","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s003000050436","article-title":"Experimental studies on the response of the fish (Notothenia coriiceps Richardson, 1844) to parasite (Pseudoterranova decipiens Krabbe, 1878) and other irritant stimuli at Antarctic temperatures","volume":"22","author":"Silva","year":"1999","journal-title":"Polar Biol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.vaccine.2015.01.017","article-title":"Enhanced protection against Rickettsia rickettsii infection in C3H\/HeN mice by immunization with a combination of a recombinant adhesin rAdr2 and a protein fragment rOmpB-4 derived from outer membrane protein B","volume":"33","author":"Gong","year":"2015","journal-title":"Vaccine"},{"key":"B53","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1080\/21645515.2015.1011572","article-title":"Rickettsia rickettsii outer membrane protein YbgF induces protective immunity in C3H\/HeN mice","volume":"11","author":"Gong","year":"2015","journal-title":"Hum Vaccin Immunother"},{"key":"B54","doi-asserted-by":"publisher","first-page":"e0124664","DOI":"10.1371\/journal.pone.0124664","article-title":"Chloroform-methanol Residue of Coxiella burnetii markedly potentiated the specific immunoprotection elicited by a recombinant protein fragment rOmpB-4 derived from outer membrane protein B of Rickettsia rickettsii in C3H\/HeN Mice","volume":"10","author":"Gong","year":"2015","journal-title":"PLoS ONE"},{"key":"B55","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1016\/j.vaccine.2014.02.057","article-title":"Surface protein Adr2 of Rickettsia rickettsii induced protective immunity against Rocky Mountain spotted fever in C3H\/HeN mice","volume":"32","author":"Gong","year":"2014","journal-title":"Vaccine"},{"key":"B56","doi-asserted-by":"publisher","first-page":"7204","DOI":"10.1016\/j.vaccine.2017.09.068","article-title":"Th1 epitope peptides induce protective immunity against Rickettsia rickettsii infection in C3H\/HeN mice","volume":"35","author":"Wang","year":"2017","journal-title":"Vaccine"},{"key":"B57","doi-asserted-by":"publisher","first-page":"ftv101","DOI":"10.1093\/femspd\/ftv101","article-title":"Failure of a heterologous recombinant Sca5\/OmpB protein-based vaccine to elicit effective protective immunity against Rickettsia rickettsii infections in C3H\/HeN mice","volume":"73","author":"Riley","year":"2015","journal-title":"Pathog Dis"},{"key":"B58","doi-asserted-by":"publisher","first-page":"3112","DOI":"10.1128\/IAI.00007-07","article-title":"Differential interaction of dendritic cells with Rickettsia conorii: impact on host susceptibility to murine spotted fever rickettsiosis","volume":"75","author":"Fang","year":"2007","journal-title":"Infect Immun"},{"key":"B59","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/nri2622","article-title":"Skin immune sentinels in health and disease","volume":"9","author":"Nestle","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s10493-010-9380-x","article-title":"Antigen-presenting cells in draining lymph nodes of goats repeatedly infested by the Cayenne tick Amblyomma cajennense nymphs","volume":"53","author":"Monteiro","year":"2011","journal-title":"Exp Appl Acarol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.3389\/fimmu.2018.01245","article-title":"An immunosuppressive tick salivary gland protein DsCystatin interferes with toll-like receptor signaling by downregulating TRAF6","volume":"9","author":"Sun","year":"2018","journal-title":"Front Immunol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"4319","DOI":"10.4049\/jimmunol.166.7.4319","article-title":"Identification of an IL-2 binding protein in the saliva of the Lyme disease vector tick, Ixodes scapularis","volume":"166","author":"Gillespie","year":"2001","journal-title":"J Immunol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1111\/j.1365-3024.2006.00899.x","article-title":"Anti-tumour necrosis factor-\u03b1 activity in Ixodes ricinus saliva","volume":"28","author":"Konik","year":"2006","journal-title":"Parasite Immunol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1084\/jem.20072689","article-title":"Ticks produce highly selective chemokine binding proteins with antiinflammatory activity","volume":"205","author":"Deruaz","year":"2008","journal-title":"J Exp Med"},{"key":"B65","doi-asserted-by":"publisher","first-page":"2017.032","DOI":"10.14411\/fp.2017.032","article-title":"Anti-tumour necrosis factor activity in saliva of various tick species and its appearance during the feeding period","volume":"64","author":"Rezkova","year":"2017","journal-title":"Folia Parasit"},{"key":"B66","doi-asserted-by":"publisher","first-page":"S177","DOI":"10.1017\/S0031182004005633","article-title":"Tick-host interactions: saliva-activated transmission","volume":"129","author":"Nuttall","year":"2004","journal-title":"Parasitology"},{"key":"B67","doi-asserted-by":"publisher","first-page":"e0135175","DOI":"10.1371\/journal.pone.0135175","article-title":"Amblyomma maculatum feeding augments Rickettsia parkeri infection in a rhesus macaque model: a pilot study","volume":"10","author":"Banajee","year":"2015","journal-title":"PLoS ONE"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1093\/jme\/tjw125","article-title":"Effect of Amblyomma maculatum (Acari: Ixodidae) saliva on the acute cutaneous immune response to Rickettsia parkeri infection in a murine model","volume":"53","author":"Banajee","year":"2016","journal-title":"J Med Entomol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1603\/ME13248","article-title":"Feeding by Amblyomma maculatum (Acari: Ixodidae) enhances Rickettsia parkeri (Rickettsiales: Rickettsiaceae) infection in the skin","volume":"51","author":"Grasperge","year":"2014","journal-title":"J Med Entomol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s00430-017-0514-1","article-title":"Immune response against rickettsiae: lessons from murine infection models","volume":"206","author":"Osterloh","year":"2017","journal-title":"Med Microbiol Immunol"},{"key":"B71","doi-asserted-by":"publisher","first-page":"223","DOI":"10.2217\/17460913.3.2.223","article-title":"Ricketsial diseases: from Rickettsia-arthopod relationships to pathophysiology and animal models","volume":"3","author":"Bechach","year":"2008","journal-title":"Future Microbiol"},{"key":"B72","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/s11427-014-4720-4","article-title":"Protective immunity against Rickettsia heilongjiangensis in a C3H\/HeN mouse model mediated by outer membrane protein B-pulsed dendritic cells","volume":"58","author":"Meng","year":"2015","journal-title":"Sci China Life Sci."},{"key":"B73","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1086\/595833","article-title":"Rickettsiae stimulate dendritic cells through toll-like receptor 4, leading to enhanced NK cell activation in vivo","volume":"199","author":"Jordan","year":"2009","journal-title":"J Infect Dis"},{"key":"B74","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1086\/519686","article-title":"Rickettsiae-stimulated dendritic cells mediate protection against lethal rickettsial challenge in an animal model of spotted fever rickettsiosis","volume":"196","author":"Jordan","year":"2007","journal-title":"J Infect Dis."},{"key":"B75","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1128\/IAI.01361-15","article-title":"MyD88 mediates instructive signaling in dendritic cells and protective inflammatory response during rickettsial infection","volume":"84","author":"Bechelli","year":"2016","journal-title":"Infect Immun"},{"key":"B76","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/S1286-4579(02)01581-2","article-title":"Mechanisms of immunity against rickettsiae. New perspectives and opportunities offered by unusual intracellular parasites","volume":"4","author":"Valbuena","year":"2002","journal-title":"Microbes Infect"},{"key":"B77","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1749-6632.2003.tb07331.x","article-title":"Pathogenic mechanisms of diseases caused by Rickettsia","volume":"990","author":"Walker","year":"2003","journal-title":"Ann N Y Acad Sci"},{"key":"B78","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1046\/j.1365-2567.1999.00683.x","article-title":"Successive tick infestations selectively promote a T-helper 2 cytokine profile in mice","volume":"96","author":"Ferreira","year":"1999","journal-title":"Immunology"},{"key":"B79","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1046\/j.1365-3024.2001.00356.x","article-title":"Th2 polarization of the immune response of BALB\/c mice to Ixodes ricinus instars, importance of several antigens in activation of specific Th2 subpopulations","volume":"23","author":"Mejri","year":"2001","journal-title":"Parasite Immunol"},{"key":"B80","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1128\/IAI.65.8.3100-3106.1997","article-title":"Effects of Ixodes scapularis and Borrelia burgdorferi on modulation of the host immune response: induction of a TH2 cytokine response in Lyme disease-susceptible (C3H\/HeJ) mice but not in disease-resistant (BALB\/c) mice","volume":"65","author":"Zeidner","year":"1997","journal-title":"Infect Immun"},{"key":"B81","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s004360050699","article-title":"Cytokines (IL-4 and IFN-gamma) and antibodies (IgE and IgG2a) produced in mice infected with Borrelia burgdorferi sensu stricto via nymphs of Ixodes ricinus ticks or syringe inoculations","volume":"86","author":"Christe","year":"2000","journal-title":"Parasitol Res"},{"key":"B82","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1084\/jem.162.5.1726","article-title":"Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1","volume":"162","author":"Vitetta","year":"1985","journal-title":"J Exp Med."},{"key":"B83","doi-asserted-by":"crossref","first-page":"4538","DOI":"10.4049\/jimmunol.136.12.4538","article-title":"B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells","volume":"136","author":"Coffman","year":"1986","journal-title":"J Immunol"},{"key":"B84","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1128\/IAI.46.2.289-294.1984","article-title":"Production and characterization of monoclonal antibodies to Rickettsia rickettsii","volume":"46","author":"Lange","year":"1984","journal-title":"Infect Immun"},{"key":"B85","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1093\/infdis\/151.6.1052","article-title":"Characterization of monoclonal antibodies protecting mice against Rickettsia rickettsii","volume":"151","author":"Anacker","year":"1985","journal-title":"J Infect Dis."},{"key":"B86","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.4049\/jimmunol.147.8.2500","article-title":"Antigen-specific IGG2A production in response to prostaglandin E2, immune complexes, and IFN-gamma","volume":"147","author":"Stein","year":"1991","journal-title":"J Immunol"},{"key":"B87","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.4049\/jimmunol.145.8.2644","article-title":"Prostaglandin E2 promotes IL-4-induced IgE and IgG1 synthesis","volume":"145","author":"Roper","year":"1990","journal-title":"J Immunol"},{"key":"B88","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.4049\/jimmunol.149.9.2984","article-title":"Prostaglandin E2 and cAMP inhibit B lymphocyte activation and simultaneously promote IgE and IgG1 synthesis","volume":"149","author":"Roper","year":"1992","journal-title":"J Immunol"},{"key":"B89","doi-asserted-by":"crossref","first-page":"10978","DOI":"10.1073\/pnas.93.20.10978","article-title":"Prostaglandin E2 receptors of the EP2 and EP4 subtypes regulate activation and differentiation of mouse B lymphocytes to IgE-secreting cells","volume":"93","author":"Fedyk","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"B90","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.pt.2017.03.004","article-title":"Salivary prostaglandin E2: role in tick-induced allergy to red meat","volume":"33","author":"Cabezas-Cruz","year":"2017","journal-title":"Trends Parasitol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00118\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T11:03:53Z","timestamp":1694603033000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00118\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,4]]},"references-count":90,"alternative-id":["10.3389\/fimmu.2019.00118"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.00118","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,4]]},"article-number":"118"}}