{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:38:45Z","timestamp":1790649525938,"version":"4.1.0"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T00:00:00Z","timestamp":1549324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.00142","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T04:20:47Z","timestamp":1549340447000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Comparative Assessment of Aspergillosis by Virtual Infection Modeling in Murine and Human Lung"],"prefix":"10.3389","volume":"10","author":[{"given":"Marco","family":"Blickensdorf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Timme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc Thilo","family":"Figge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,2,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1126\/science.1069492","article-title":"Systems biology: a brief overview","volume":"295","author":"Kitano","year":"2002","journal-title":"Science"},{"key":"B2","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.cell.2005.04.020","article-title":"Systems biology: its practice and challenges","volume":"121","author":"Aderem","year":"2005","journal-title":"Cell"},{"key":"B3","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1146\/annurev.genom.2.1.343","article-title":"A new approach to decoding life: systems biology","volume":"2","author":"Ideker","year":"2001","journal-title":"Annu Rev Genomics Hum Genet."},{"key":"B4","doi-asserted-by":"publisher","first-page":"108","DOI":"10.3389\/fmicb.2012.00108","article-title":"Systems biology of fungal infection","volume":"3","author":"Horn","year":"2012","journal-title":"Front Microbiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1002\/cyto.a.22638","article-title":"Image-based systems biology of infection","volume":"87","author":"Medyukhina","year":"2015","journal-title":"Cytom Part A"},{"key":"B6","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1111\/j.1742-4658.2008.06843.x","article-title":"Systems biology: experimental design","volume":"276","author":"Kreutz","year":"2009","journal-title":"FEBS J."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pmed.1000245","article-title":"Can animal models of disease reliably inform human studies?","volume":"7","author":"Bart","year":"2010","journal-title":"PLoS Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.4049\/JIMMUNOL.172.5.2731","article-title":"Of mice and not men: differences between mouse and human immunology","volume":"172","author":"Mestas","year":"2004","journal-title":"J Immunol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"e1003479","DOI":"10.1371\/journal.pcbi.1003479","article-title":"A virtual infection model quantifies innate effector mechanisms and Candida albicans immune escape in human blood","volume":"10","author":"H\u00fcnniger","year":"2014","journal-title":"PLoS Comput Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmicb.2015.00608","article-title":"Bottom-up modeling approach for the quantitative estimation of parameters in pathogen-host interactions","volume":"6","author":"Lehnert","year":"2015","journal-title":"Front Microbiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.mib.2010.04.009","article-title":"Interaction of phagocytes with filamentous fungi","volume":"13","author":"Brakhage","year":"2010","journal-title":"Curr Opin Microbiol."},{"key":"B12","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1128\/CMR.12.2.310","article-title":"Aspergillus fumigatus and Aspergillosis","volume":"12","author":"Latge","year":"1999","journal-title":"Clin Microbiol Rev."},{"key":"B13","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/S0966-842X(01)02104-7","article-title":"The pathobiology of Aspergillus fumigatus","volume":"9","author":"Latg\u00e9","year":"2001","journal-title":"Trends Microbiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1128\/CMR.00055-08","article-title":"Pathogenesis of Aspergillus fumigatus in invasive Aspergillosis","volume":"22","author":"Dagenais","year":"2009","journal-title":"Clin Microbiol Rev."},{"key":"B15","volume-title":"Morphometry of the Human Lung","author":"Weibel","year":"2013"},{"key":"B16","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/j.micinf.2009.07.002","article-title":"The innate immune response to Aspergillus fumigatus at the alveolar surface","volume":"11","author":"Balloy","year":"2009","journal-title":"FEMS Microbiol Rev."},{"key":"B17","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/nrmicro.2017.90","article-title":"Aspergillus fumigatus morphology and dynamic host interactions","volume":"15","author":"Van De Veerdonk","year":"2017","journal-title":"Nat Rev Microbiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3109\/13693786.2010.505204","article-title":"Clinical risk factors for invasive aspergillosis","volume":"49","author":"Baddley","year":"2011","journal-title":"Med Mycol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s00281-014-0474-0","article-title":"Fungal immunology: from simple to very complex concepts","volume":"37","author":"Latg\u00e9","year":"2015","journal-title":"Semin Immunopathol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"51919","DOI":"10.1080\/13693780500051919","volume":"43","author":"Clemons","year":"2005","journal-title":"Med Mycol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"203","DOI":"10.3314\/jjmm.43.203","article-title":"A new experimental murine aspergillosis model to identify strains of Aspergillus fumigatus with reduced virulence","volume":"43","author":"Sarfati","year":"2002","journal-title":"Nippon Ishinkin Gakkai Zasshi"},{"key":"B22","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1128\/AAC.01279-12","article-title":"Posaconazole pharmacodynamic target determination against wild-type and Cyp51 mutant isolates of Aspergillus fumigatus in an in vivo model of invasive pulmonary aspergillosis","volume":"57","author":"Lepak","year":"2013","journal-title":"Antimicrob Agents Chemother."},{"key":"B23","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1128\/IAI.61.5.1650-1656.1993","article-title":"The alkaline protease of Aspergillus fumigatus is not a virulence determinant in two murine models of invasive pulmonary aspergillosis","volume":"61","author":"Tang","year":"1993","journal-title":"Infect Immun."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1080\/21505594.2017.1339007","article-title":"Treatment of Cyclosporin A retains host defense against invasive pulmonary aspergillosis in a non-immunosuppressive murine model by preserving the myeloid cell population","volume":"8","author":"Wong","year":"2017","journal-title":"Virulence"},{"key":"B25","first-page":"156","article-title":"Typical levels of airborne fungal spores in houses without obvious moisture problems during a rainy season in Florida, USA","volume":"18","author":"Codina","year":"2008","journal-title":"J Investig Allergol Clin Immunol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"e111630","DOI":"10.1371\/journal.pone.0111630","article-title":"Agent-based model of human alveoli predicts chemotactic signaling by epithelial cells during early Aspergillus fumigatus infection","volume":"9","author":"Pollm\u00e4cher","year":"2014","journal-title":"PLoS ONE"},{"key":"B27","doi-asserted-by":"publisher","first-page":"503","DOI":"10.3389\/fmicb.2015.00503","article-title":"Deciphering chemokine properties by a hybrid agent-based model of Aspergillus fumigatus infection in human alveoli","volume":"6","author":"Pollm\u00e4cher","year":"2015","journal-title":"Front Microbiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1159\/000147509","article-title":"Morphological evidence for migration of particle-laden macrophages through the interalveolar pores of Kohn in the murine lung","volume":"147","author":"Pe\u00e3o","year":"1993","journal-title":"Cells Tissues Organs"},{"key":"B29","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1165\/rcmb.2007-0120OC","article-title":"Alveolar dynamics during respiration: are the pores of Kohn a pathway to recruitment?","volume":"38","author":"Namati","year":"2008","journal-title":"Am J Respir Cell Mol Biol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmicb.2017.00841","article-title":"Rodent models of invasive aspergillosis due to Aspergillus fumigatus: Still a long path toward standardization","volume":"8","author":"Desoubeaux","year":"2017","journal-title":"Front Microbiol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"3474","DOI":"10.1128\/AAC.45.12.3474-3481.2001","article-title":"Quantitative PCR assay to measure Aspergillus fumigatus burden in a murine model of disseminated aspergillosis: demonstration of efficacy of caspofungin acetate","volume":"45","author":"Bowman","year":"2001","journal-title":"Antimicrob Agents Chemother."},{"key":"B32","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1111\/j.1469-0691.2005.01349.x","article-title":"Comparison of three methodologies for the determination of pulmonary fungal burden in experimental murine aspergillosis","volume":"12","author":"Sheppard","year":"2006","journal-title":"Clin Microbiol Infect."},{"key":"B33","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1080\/13693780410001712034","article-title":"Value of an inhalational model of invasive aspergillosis","volume":"42","author":"Steinbach","year":"2004","journal-title":"Med Mycol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1002\/ar.20747","article-title":"Stereological estimates of alveolar number and size and capillary length and surface area in mice lungs","volume":"292","author":"Knust","year":"2009","journal-title":"Anat Rec."},{"key":"B35","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/rr199","article-title":"Measuring the lung function in the mouse: the challenge of size","volume":"4","author":"Irvin","year":"2003","journal-title":"Respir Res."},{"key":"B36","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1164\/ajrccm\/146.2.454","article-title":"Distribution of lung cell numbers and volumes between alveolar and nonalveolar tissue","volume":"146","author":"Stone","year":"1992","journal-title":"Am Rev Respir Dis."},{"key":"B37","doi-asserted-by":"publisher","first-page":"8760","DOI":"10.1038\/srep08760","article-title":"Synchrotron X-ray imaging of pulmonary alveoli in respiration in live intact mice","volume":"5","author":"Chang","year":"2015","journal-title":"Sci Rep."},{"key":"B38","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1152\/japplphysiol.01214.2000","article-title":"Comparison of rat and mouse pulmonary tissue mechanical properties and histology","volume":"92","author":"Faffe","year":"2002","journal-title":"J Appl Physiol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1080\/02786829308959603","article-title":"Lower respiratory tract structure of laboratory animals and humans: dosimetry implications","volume":"18","author":"Miller","year":"1993","journal-title":"Aerosol Sci Technol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1152\/japplphysiol.00736.2010","article-title":"Quantitative assessment of lung microstructure in healthy mice using an MR-based 3He lung morphometry technique","volume":"109","author":"Osmanagic","year":"2010","journal-title":"J Appl Physiol."},{"key":"B41","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1152\/jappl.1994.77.3.1060","article-title":"Alveolar septal structure in different species","volume":"77","author":"Mercer","year":"1994","journal-title":"J Appl Physiol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1165\/ajrcmb\/6.2.235","article-title":"Allometric relationships of cell numbers and size in the mammalian lung","volume":"6","author":"Stone","year":"1992","journal-title":"Am J Respir Cell Mol Biol."},{"key":"B43","first-page":"L715","article-title":"GM-CSF enhances lung growth and causes alveolar type II epithelial cell hyperplasia in transgenic mice","volume":"273","author":"Huffman Reed","year":"1997","journal-title":"Am J Physiol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1002\/ar.21543","article-title":"Alveolar epithelial type II cells and their microenvironment in the Caveolin-1-deficient mouse","volume":"295","author":"Jung","year":"2012","journal-title":"Anat Rec."},{"key":"B45","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3109\/01902148509057528","article-title":"A Quantitative study of the development of interalveolar pores in the postnatal mouse","volume":"9","author":"Henry","year":"1985","journal-title":"Exp Lung Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1084\/jem.149.6.1504","article-title":"Origin, Kinetics, and characteristics of pulmonary macrophages in the normal steady state","volume":"149","author":"van oud Alblas","year":"1979","journal-title":"J Exp Med."},{"key":"B47","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1002\/aja.1001910407","article-title":"Comparative morphology and morphometry of alveolar macrophages from six species","volume":"191","author":"Haley","year":"1991","journal-title":"Am J Anat."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.4049\/jimmunol.166.3.1951","article-title":"A model to predict cell-mediated immune regulatory mechanisms during human infection with Mycobacterium tuberculosis","volume":"166","author":"Wigginton","year":"2001","journal-title":"J Immunol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2018.00560","article-title":"Predictive virtual infection modeling of fungal immune evasion in human whole blood","volume":"9","author":"Prau\u00dfe","year":"2018","journal-title":"Front Immunol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2018.00667","article-title":"Quantitative simulations predict treatment strategies against fungal infections in virtual neutropenic patients","volume":"9","author":"Timme","year":"2018","journal-title":"Front Immunol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3389\/fmicb.2012.00129","article-title":"Agent-based modeling approach of immune defense against spores of opportunistic human pathogenic fungi","volume":"3","author":"Tokarski","year":"2012","journal-title":"Front Microbiol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s12918-016-0275-2","article-title":"A computational model of invasive aspergillosis in the lung and the role of iron","volume":"10","author":"Oremland","year":"2016","journal-title":"BMC Syst Biol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"13958","DOI":"10.1038\/srep13958","article-title":"In silico modeling of spore inhalation reveals fungal persistence following low dose exposure","volume":"5","author":"Tanaka","year":"2015","journal-title":"Sci Rep."},{"key":"B54","doi-asserted-by":"publisher","first-page":"27807","DOI":"10.1038\/srep27807","article-title":"Deciphering the counterplay of Aspergillus fumigatus infection and host inflammation by evolutionary games on graphs","volume":"6","author":"Pollm\u00e4cher","year":"2016","journal-title":"Sci Rep."},{"key":"B55","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1093\/infdis\/163.3.579","article-title":"Granulocyte Colony-Stimulating Factor enhances the phagocytic and bactericidal activity of normal and defective human neutrophils","volume":"163","author":"Roilides","year":"1991","journal-title":"J Infect Dis."},{"key":"B56","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1086\/600380","article-title":"Essential role for neutrophils but not alveolar macrophages at early time points following Aspergillus fumigatus infection","volume":"200","author":"Mircescu","year":"2009","journal-title":"J Infect Dis."},{"key":"B57","doi-asserted-by":"publisher","first-page":"S42","DOI":"10.1513\/AnnalsATS.201410-442MG","article-title":"A human breathing lung-on-a-chip","volume":"12","author":"Huh","year":"2015","journal-title":"Ann Am Thorac Soc."},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.4155\/fsoa-2016-0038","article-title":"Organ-on-chip models: new opportunities for biomedical research","author":"Mosig","year":"2016","journal-title":"Futur Sci. OA"},{"key":"B59","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/nmeth.3697","article-title":"Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro","volume":"13","author":"Benam","year":"2016","journal-title":"Nat Methods"},{"key":"B60","doi-asserted-by":"publisher","first-page":"3348","DOI":"10.4049\/jimmunol.170.6.3348","article-title":"CXCR2 regulates respiratory syncytial virus-induced airway hyperreactivity and mucus overproduction","volume":"170","author":"Miller","year":"2003","journal-title":"J Immunol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1038\/nri2620","article-title":"Complement regulators and inhibitory proteins","volume":"9","author":"Zipfel","year":"2009","journal-title":"Nat Rev Immunol."},{"key":"B62","doi-asserted-by":"crossref","first-page":"3412","DOI":"10.1128\/IAI.57.11.3412-3417.1989","article-title":"Activation of C3 and binding to Aspergillus fumigatus conidia and hyphae","volume":"57","author":"Kozel","year":"1989","journal-title":"Infect Immun"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.4049\/jimmunol.168.4.1919","article-title":"Expression and function of the C5a receptor in rat alveolar epithelial cells","volume":"168","author":"Riedemann","year":"2002","journal-title":"J Immunol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1111\/j.1462-5822.2010.01517.x","article-title":"Aspergillus fumigatus: contours of an opportunistic human pathogen","volume":"12","author":"McCormick","year":"2010","journal-title":"Cell Microbiol."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00142\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T12:06:51Z","timestamp":1606392411000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00142\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,5]]},"references-count":64,"alternative-id":["10.3389\/fimmu.2019.00142"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.00142","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,5]]},"article-number":"142"}}