{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:03:34Z","timestamp":1791594214646,"version":"4.3.4"},"reference-count":103,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T00:00:00Z","timestamp":1550188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.00182","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T04:27:21Z","timestamp":1550204841000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":62,"title":["Alarmins of the S100-Family in Juvenile Autoimmune and Auto-Inflammatory Diseases"],"prefix":"10.3389","volume":"10","author":[{"given":"Dirk","family":"Holzinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Tenbrock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,2,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"38R","DOI":"10.1203\/PDR.0b013e31819dbd0a","article-title":"An integrated classification of pediatric inflammatory diseases, based on the concepts of autoinflammation and the immunological disease continuum","volume":"65","author":"McGonagle","year":"2009","journal-title":"Pediatr Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2711","DOI":"10.1172\/JCI62423","article-title":"Alarmins: awaiting a clinical response","volume":"122","author":"Chan","year":"2012","journal-title":"J Clin Invest."},{"key":"B3","doi-asserted-by":"publisher","first-page":"e297","DOI":"10.1371\/journal.pmed.0030297","article-title":"A proposed classification of the immunological diseases","volume":"3","author":"McGonagle","year":"2006","journal-title":"PLoS Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1038\/ni.3790","article-title":"A guiding map for inflammation","volume":"18","author":"Netea","year":"2017","journal-title":"Nat Immunol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1146\/annurev.immunol.21.120601.141126","article-title":"Toll-like receptors","volume":"21","author":"Takeda","year":"2003","journal-title":"Annu Rev Immunol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1146\/annurev.immunol.021908.132603","article-title":"HMGB1 and RAGE in inflammation and cancer","volume":"28","author":"Sims","year":"2010","journal-title":"Annu Rev Immunol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1189\/jlb.1008647","article-title":"The endogenous Toll-like receptor 4 agonist S100A8\/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer","volume":"86","author":"Ehrchen","year":"2009","journal-title":"J Leukoc Biol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/nrrheum.2016.162","article-title":"The danger from within: alarmins in arthritis","volume":"12","author":"Nefla","year":"2016","journal-title":"Nat Rev Rheumatol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"5598","DOI":"10.1073\/pnas.0400937101","article-title":"Recognition of single-stranded RNA viruses by Toll-like receptor 7","volume":"101","author":"Lund","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"B10","doi-asserted-by":"publisher","first-page":"2598","DOI":"10.1002\/art.10540","article-title":"High mobility group box chromosomal protein 1: a novel proinflammatory mediator in synovitis","volume":"46","author":"Kokkola","year":"2002","journal-title":"Arthritis Rheumatism"},{"key":"B11","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1172\/JCI2465","article-title":"Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue","volume":"102","author":"Schett","year":"1998","journal-title":"J Clin Invest."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1126\/science.1064890","article-title":"Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus","volume":"294","author":"Blanco","year":"2001","journal-title":"Science"},{"key":"B13","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1084\/jem.20151876","article-title":"Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus","volume":"213","author":"Caielli","year":"2016","journal-title":"J Exp Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1136\/annrheumdis-2017-211898","article-title":"European evidence-based recommendations for the diagnosis and treatment of childhood-onset lupus nephritis: the SHARE initiative","volume":"76","author":"Groot","year":"2017","journal-title":"Ann Rheumatic Dis"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/j.bbrc.2004.07.096","article-title":"S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature)","volume":"322","author":"Marenholz","year":"2004","journal-title":"Biochem Biophys Res Commun."},{"key":"B16","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/0006-291X(65)90320-7","article-title":"A soluble protein characteristic of the nervous system","volume":"19","author":"Moore","year":"1965","journal-title":"Biochem Biophys Res Commun."},{"key":"B17","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1042\/BJ20060195","article-title":"Calcium-dependent and -independent interactions of the S100 protein family","volume":"396","author":"Santamaria-Kisiel","year":"2006","journal-title":"Biochem J."},{"key":"B18","doi-asserted-by":"crossref","first-page":"7706","DOI":"10.1016\/S0021-9258(20)89506-4","article-title":"Identification of p8,14 as a highly abundant heterodimeric calcium binding protein complex of myeloid cells","volume":"266","author":"Edgeworth","year":"1991","journal-title":"J Biol Chem."},{"key":"B19","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/S1471-4906(03)00062-0","article-title":"Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules","volume":"24","author":"Roth","year":"2003","journal-title":"Trends Immunol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1515\/BC.2005.051","article-title":"Molecular basis of the complex formation between the two calcium-binding proteins S100A8 (MRP8) and S100A9 (MRP14)","volume":"386","author":"Leukert","year":"2005","journal-title":"Biol Chem."},{"key":"B21","doi-asserted-by":"publisher","first-page":"4260","DOI":"10.1182\/blood-2004-02-0446","article-title":"MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes","volume":"104","author":"Vogl","year":"2004","journal-title":"Blood"},{"key":"B22","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1038\/s41584-018-0058-9","article-title":"S100 proteins in rheumatic diseases","volume":"14","author":"Austermann","year":"2018","journal-title":"Nat Rev Rheumatol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"9496","DOI":"10.1074\/jbc.272.14.9496","article-title":"Myeloid-related protein (MRP) 8 and MRP14, calcium-binding proteins of the S100 family, are secreted by activated monocytes via a novel, tubulin-dependent pathway","volume":"272","author":"Rammes","year":"1997","journal-title":"J Biol Chem."},{"key":"B24","doi-asserted-by":"publisher","first-page":"6915","DOI":"10.1038\/ncomms7915","article-title":"Extracellular MRP8\/14 is a regulator of beta2 integrin-dependent neutrophil slow rolling and adhesion","volume":"6","author":"Pruenster","year":"2015","journal-title":"Nat Commun."},{"key":"B25","doi-asserted-by":"publisher","first-page":"296149","DOI":"10.1155\/2015\/296149","article-title":"Secretion of S100A8, S100A9, and S100A12 by neutrophils involves reactive oxygen species and potassium efflux","volume":"2015","author":"Tardif","year":"2015","journal-title":"J Immunol Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"2955","DOI":"10.1182\/blood-2004-07-2520","article-title":"Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells","volume":"105","author":"Viemann","year":"2005","journal-title":"Blood"},{"key":"B27","doi-asserted-by":"publisher","first-page":"575","DOI":"10.4049\/jimmunol.1401085","article-title":"Transcriptome assessment reveals a dominant role for TLR4 in the activation of human monocytes by the alarmin MRP8","volume":"194","author":"Fassl","year":"2015","journal-title":"J Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1136\/ard.2007.077800","article-title":"Myeloid-related proteins S100A8\/S100A9 regulate joint inflammation and cartilage destruction during antigen-induced arthritis","volume":"67","author":"van Lent","year":"2008","journal-title":"Ann Rheumatic Dis"},{"key":"B29","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1038\/ni.3745","article-title":"S100-alarmin-induced innate immune programming protects newborn infants from sepsis","volume":"18","author":"Ulas","year":"2017","journal-title":"Nat Immunol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.1016\/j.celrep.2014.11.020","article-title":"Alarmins MRP8 and MRP14 induce stress tolerance in phagocytes under sterile inflammatory conditions","volume":"9","author":"Austermann","year":"2014","journal-title":"Cell Rep."},{"key":"B31","doi-asserted-by":"publisher","first-page":"7184","DOI":"10.4049\/jimmunol.177.10.7184","article-title":"Extracellular heat shock protein-70 induces endotoxin tolerance in THP-1 cells","volume":"177","author":"Aneja","year":"2006","journal-title":"J Immunol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1038\/nri2506","article-title":"Myeloid-derived suppressor cells as regulators of the immune system","volume":"9","author":"Gabrilovich","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"e29333","DOI":"10.1371\/journal.pone.0029333","article-title":"Constitutive neutrophil apoptosis: regulation by cell concentration via S100 A8\/9 and the MEK-ERK pathway","volume":"7","author":"Atallah","year":"2012","journal-title":"PLoS ONE"},{"key":"B34","doi-asserted-by":"publisher","first-page":"e97","DOI":"10.1371\/journal.pbio.1000097","article-title":"Identification of human S100A9 as a novel target for treatment of autoimmune disease via binding to quinoline-3-carboxamides","volume":"7","author":"Bjork","year":"2009","journal-title":"PLoS Biol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1160\/TH16-06-0434","article-title":"S100A9 induces monocyte\/ macrophage migration via EMMPRIN","volume":"117","author":"Alexaki","year":"2017","journal-title":"Thromb Haemost."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1038\/nm1638","article-title":"Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock","volume":"13","author":"Vogl","year":"2007","journal-title":"Nat Med."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.1172\/JCI89867","article-title":"Autoinhibitory regulation of S100A8\/S100A9 alarmin activity locally restricts sterile inflammation","volume":"128","author":"Vogl","year":"2018","journal-title":"J Clin Invest."},{"key":"B38","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/330080a0","article-title":"Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis","volume":"330","author":"Odink","year":"1987","journal-title":"Nature"},{"key":"B39","first-page":"2523","article-title":"Expression of myeloid related proteins (MRP) 8 and 14 and the MRP8\/14 heterodimer in rheumatoid arthritis synovial membrane","volume":"26","author":"Youssef","year":"1999","journal-title":"J Rheumatol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1002\/art.10988","article-title":"Increased perivascular synovial membrane expression of myeloid-related proteins in psoriatic arthritis","volume":"48","author":"Kane","year":"2003","journal-title":"Arthritis Rheumatism"},{"key":"B41","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s13075-018-1584-1","article-title":"Fcgamma receptor-mediated influx of S100A8\/A9-producing neutrophils as inducer of bone erosion during antigen-induced arthritis","volume":"20","author":"Di Ceglie","year":"2018","journal-title":"Arthritis Res Ther."},{"key":"B42","doi-asserted-by":"publisher","first-page":"3353","DOI":"10.1002\/art.27654","article-title":"S100A8 causes a shift toward expression of activatory Fcgamma receptors on macrophages via toll-like receptor 4 and regulates Fcgamma receptor expression in synovium during chronic experimental arthritis","volume":"62","author":"van Lent","year":"2010","journal-title":"Arthritis Rheumatism"},{"key":"B43","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.1002\/art.30418","article-title":"Tumor necrosis factor-interleukin-17 interplay induces S100A8, interleukin-1beta, and matrix metalloproteinases, and drives irreversible cartilage destruction in murine arthritis: rationale for combination treatment during arthritis","volume":"63","author":"Koenders","year":"2011","journal-title":"Arthritis Rheumatism"},{"key":"B44","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/nm.2150","article-title":"The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells","volume":"16","author":"Loser","year":"2010","journal-title":"Nat Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.it.2003.10.004","article-title":"Absence of S100A12 in mouse: implications for RAGE-S100A12 interaction","volume":"24","author":"Fuellen","year":"2003","journal-title":"Trends Immunol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1016\/S0140-6736(03)12986-8","article-title":"S100A12 (EN-RAGE) in monitoring Kawasaki disease","volume":"361","author":"Foell","year":"2003","journal-title":"Lancet"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1093\/rheumatology\/keg385","article-title":"Expression of the pro-inflammatory protein S100A12 (EN-RAGE) in rheumatoid and psoriatic arthritis","volume":"42","author":"Foell","year":"2003","journal-title":"Rheumatology"},{"key":"B48","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1136\/gut.52.6.847","article-title":"Neutrophil derived human S100A12 (EN-RAGE) is strongly expressed during chronic active inflammatory bowel disease","volume":"52","author":"Foell","year":"2003","journal-title":"Gut"},{"key":"B49","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1136\/ard.2003.005686","article-title":"Methotrexate treatment in juvenile idiopathic arthritis: when is the right time to stop?","volume":"63","author":"Foell","year":"2004","journal-title":"Ann Rheumatic Dis"},{"key":"B50","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1002\/path.1660","article-title":"Early recruitment of phagocytes contributes to the vascular inflammation of giant cell arteritis","volume":"204","author":"Foell","year":"2004","journal-title":"J Pathol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1136\/thorax.58.7.613","article-title":"Expression of S100A12 (EN-RAGE) in cystic fibrosis","volume":"58","author":"Foell","year":"2003","journal-title":"Thorax"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1002\/art.20125","article-title":"Monitoring neutrophil activation in juvenile rheumatoid arthritis by S100A12 serum concentrations","volume":"50","author":"Foell","year":"2004","journal-title":"Arthritis Rheumatism"},{"key":"B53","doi-asserted-by":"publisher","first-page":"A254","DOI":"10.1016\/S0016-5085(09)61153-7","article-title":"The Mediator S100a12 is critically involved in early inflammatory events of inflammatory bowel disease","volume":"136","author":"Foell","year":"2009","journal-title":"Gastroenterology"},{"key":"B54","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1111\/j.0906-6705.2005.00271.x","article-title":"Early activation of cutaneous vessels and epithelial cells is characteristic of acute systemic onset juvenile idiopathic arthritis","volume":"14","author":"Frosch","year":"2005","journal-title":"Exp Dermatol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"2622","DOI":"10.1002\/art.11177","article-title":"Expression of myeloid-related proteins 8 and 14 in systemic-onset juvenile rheumatoid arthritis","volume":"48","author":"Frosch","year":"2003","journal-title":"Arthritis Rheumatism"},{"key":"B56","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1136\/ard.2009.114363","article-title":"Neutrophil-derived S100A12 as novel biomarker of inflammation in familial Mediterranean fever","volume":"69","author":"Kallinich","year":"2010","journal-title":"Ann Rheumatic Dis."},{"key":"B57","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1002\/art.30149","article-title":"Efficacy and safety of anakinra therapy in pediatric and adult patients with the autoinflammatory Muckle-Wells syndrome","volume":"63","author":"Kuemmerle-Deschner","year":"2011","journal-title":"Arthritis Rheumatism"},{"key":"B58","doi-asserted-by":"publisher","first-page":"R64","DOI":"10.1186\/ar4237","article-title":"Treatment of Muckle-Wells syndrome: analysis of two IL-1-blocking regimens","volume":"15","author":"Kuemmerle-Deschner","year":"2013","journal-title":"Arthritis Res Ther."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1001\/jama.2010.375","article-title":"Methotrexate withdrawal at 6 vs 12 months in juvenile idiopathic arthritis in remission: a randomized clinical trial","volume":"303","author":"Foell","year":"2010","journal-title":"JAMA"},{"key":"B60","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1002\/acr.22248","article-title":"Validation of relapse risk biomarkers for routine use in patients with juvenile idiopathic arthritis","volume":"66","author":"Rothmund","year":"2014","journal-title":"Arthritis Care Res"},{"key":"B61","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1136\/ard.2011.152496","article-title":"MRP8 and MRP14, phagocyte-specific danger signals, are sensitive biomarkers of disease activity in cryopyrin-associated periodic syndromes","volume":"70","author":"Wittkowski","year":"2011","journal-title":"Ann Rheumatic Dis."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1002\/art.38296","article-title":"Effectiveness of first-line treatment with recombinant interleukin-1 receptor antagonist in steroid-naive patients with new-onset systemic juvenile idiopathic arthritis: results of a prospective cohort study","volume":"66","author":"Vastert","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1002\/1529-0131(200003)43:3&lt;628::AID-ANR20&gt;3.0.CO;2-X","article-title":"Myeloid-related proteins 8 and 14 are specifically secreted during interaction of phagocytes and activated endothelium and are useful markers for monitoring disease activity in pauciarticular-onset juvenile rheumatoid arthritis","volume":"43","author":"Frosch","year":"2000","journal-title":"Arthritis Rheumatism"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1136\/annrheumdis-2012-201329","article-title":"Phagocyte-specific S100 proteins and high-sensitivity C reactive protein as biomarkers for a risk-adapted treatment to maintain remission in juvenile idiopathic arthritis: a comparative study","volume":"71","author":"Gerss","year":"2012","journal-title":"Ann Rheumatic Dis"},{"key":"B65","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1186\/s13075-015-0723-1","article-title":"MRP8\/14 serum levels as a predictor of response to starting and stopping anti-TNF treatment in juvenile idiopathic arthritis","volume":"17","author":"Anink","year":"2015","journal-title":"Arthritis Res Ther."},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1002\/art.40727","article-title":"Serum S100A8\/A9 and S100A12 Levels in children with polyarticular forms of juvenile idiopathic arthritis: relationship to maintenance of clinical inactive disease during and flare after discontinuation of anti-TNF therapy","author":"Hinze","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"B67","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1093\/rheumatology\/ket152","article-title":"A subgroup of juvenile idiopathic arthritis patients who respond well to methotrexate are identified by the serum biomarker MRP8\/14 protein","volume":"52","author":"Moncrieffe","year":"2013","journal-title":"Rheumatology"},{"key":"B68","doi-asserted-by":"publisher","first-page":"547","DOI":"10.3899\/jrheum.170438","article-title":"S100A12 is associated with response to therapy in juvenile idiopathic arthritis","volume":"45","author":"Gohar","year":"2018","journal-title":"J Rheumatol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1016\/S0002-9440(10)63454-2","article-title":"Expression of calcium-binding proteins MRP8 and MRP14 in inflammatory muscle diseases","volume":"163","author":"Seeliger","year":"2003","journal-title":"Am J Pathol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"R131","DOI":"10.1186\/ar4311","article-title":"Myeloid related protein induces muscle derived inflammatory mediators in juvenile dermatomyositis","volume":"15","author":"Nistala","year":"2013","journal-title":"Arthritis Res Ther."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1016\/j.jaci.2015.04.016","article-title":"Single amino acid charge switch defines clinically distinct proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1)-associated inflammatory diseases","volume":"136","author":"Holzinger","year":"2015","journal-title":"J Allergy Clin Immunol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"3010","DOI":"10.1002\/art.39784","article-title":"Correlation of secretory activity of neutrophils with genotype in patients with familial mediterranean fever","volume":"68","author":"Gohar","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.clim.2012.11.008","article-title":"Phagocyte-derived S100 proteins in autoinflammation: putative role in pathogenesis and usefulness as biomarkers","volume":"147","author":"Kessel","year":"2013","journal-title":"Clin Immunol"},{"key":"B74","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/S1097-2765(03)00056-X","article-title":"Targeted disruption of pyrin, the FMF protein, causes heightened sensitivity to endotoxin and a defect in macrophage apoptosis","volume":"11","author":"Chae","year":"2003","journal-title":"Mol Cell"},{"key":"B75","doi-asserted-by":"publisher","first-page":"3924","DOI":"10.1002\/art.24137","article-title":"S100A12 is a novel molecular marker differentiating systemic-onset juvenile idiopathic arthritis from other causes of fever of unknown origin","volume":"58","author":"Wittkowski","year":"2008","journal-title":"Arthritis Rheumatism"},{"key":"B76","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1002\/art.24349","article-title":"The myeloid-related proteins 8 and 14 complex, a novel ligand of toll-like receptor 4, and interleukin-1beta form a positive feedback mechanism in systemic-onset juvenile idiopathic arthritis","volume":"60","author":"Frosch","year":"2009","journal-title":"Arthritis Rheumatism"},{"key":"B77","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1136\/annrheumdis-2011-200598","article-title":"The Toll-like receptor 4 agonist MRP8\/14 protein complex is a sensitive indicator for disease activity and predicts relapses in systemic-onset juvenile idiopathic arthritis","volume":"71","author":"Holzinger","year":"2012","journal-title":"Ann Rheumatic Dis"},{"key":"B78","doi-asserted-by":"publisher","first-page":"3762","DOI":"10.1002\/art.20631","article-title":"Proinflammatory S100 proteins in arthritis and autoimmune disease","volume":"50","author":"Foell","year":"2004","journal-title":"Arthritis Rheumatism"},{"key":"B79","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1016\/j.jaci.2012.07.043","article-title":"Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis syndrome is linked to dysregulated monocyte IL-1beta production","volume":"131","author":"Kolly","year":"2013","journal-title":"J Allergy Clin Immunol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1182\/blood.V98.3.851","article-title":"The familial Mediterranean fever protein, pyrin, associates with microtubules and colocalizes with actin filaments","volume":"98","author":"Mansfield","year":"2001","journal-title":"Blood"},{"key":"B81","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1097\/BOR.0000000000000314","article-title":"Alarming consequences - autoinflammatory disease spectrum due to mutations in proline-serine-threonine phosphatase-interacting protein 1","volume":"28","author":"Holzinger","year":"2016","journal-title":"Curr Opin Rheumatol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"13501","DOI":"10.1073\/pnas.2135380100","article-title":"Pyrin binds the PSTPIP1\/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway","volume":"100","author":"Shoham","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"B83","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.molcel.2007.08.029","article-title":"Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants","volume":"28","author":"Yu","year":"2007","journal-title":"Mol Cell"},{"key":"B84","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1093\/rheumatology\/kew031","article-title":"Disease activity accounts for long-term efficacy of IL-1 blockers in pyogenic sterile arthritis pyoderma gangrenosum and severe acne syndrome","volume":"55","author":"Omenetti","year":"2016","journal-title":"Rheumatology"},{"key":"B85","doi-asserted-by":"publisher","first-page":"36560","DOI":"10.1074\/jbc.M607594200","article-title":"Critical role for Cryopyrin\/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA","volume":"281","author":"Kanneganti","year":"2006","journal-title":"J Biol Chem"},{"key":"B86","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/nature04515","article-title":"Cryopyrin activates the inflammasome in response to toxins and ATP","volume":"440","author":"Mariathasan","year":"2006","journal-title":"Nature"},{"key":"B87","doi-asserted-by":"publisher","first-page":"2073","DOI":"10.1172\/JCI29404","article-title":"Gout: new insights into an old disease","volume":"116","author":"Martinon","year":"2006","journal-title":"J Clin Invest."},{"key":"B88","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1177\/09680519060120040701","article-title":"NALP3: a key player in caspase-1 activation","volume":"12","author":"Sutterwala","year":"2006","journal-title":"J Endotoxin Res"},{"key":"B89","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/S1074-7613(04)00046-9","article-title":"NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder","volume":"20","author":"Agostini","year":"2004","journal-title":"Immunity"},{"key":"B90","doi-asserted-by":"publisher","first-page":"3340","DOI":"10.1002\/art.10688","article-title":"De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases","volume":"46","author":"Aksentijevich","year":"2002","journal-title":"Arthritis Rheumatism"},{"key":"B91","doi-asserted-by":"publisher","first-page":"3329","DOI":"10.1002\/art.20494","article-title":"Enhanced interleukin-1beta and interleukin-18 release in a patient with chronic infantile neurologic, cutaneous, articular syndrome","volume":"50","author":"Janssen","year":"2004","journal-title":"Arthritis Rheumatism"},{"key":"B92","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1084\/jem.20082481","article-title":"In vivo regulation of interleukin 1beta in patients with cryopyrin-associated periodic syndromes","volume":"206","author":"Lachmann","year":"2009","journal-title":"J Exp Med."},{"key":"B93","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1084\/jem.20050473","article-title":"Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade","volume":"201","author":"Pascual","year":"2005","journal-title":"J Exp Med."},{"key":"B94","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1093\/rheumatology\/kem271","article-title":"New insights in systemic juvenile idiopathic arthritis\u2013from pathophysiology to treatment","volume":"47","author":"Frosch","year":"2008","journal-title":"Rheumatology"},{"key":"B95","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1038\/nrrheum.2011.68","article-title":"Pathogenesis of systemic juvenile idiopathic arthritis: some answers, more questions","volume":"7","author":"Mellins","year":"2011","journal-title":"Nat Rev Rheumatol"},{"key":"B96","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1186\/s13075-016-1069-z","article-title":"Review of biomarkers in systemic juvenile idiopathic arthritis: helpful tools or just playing tricks?","volume":"18","author":"Gohar","year":"2016","journal-title":"Arthritis Res Ther."},{"key":"B97","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1038\/pr.2015.144","article-title":"Comparison of biomarkers for systemic juvenile idiopathic arthritis","volume":"78","author":"Shenoi","year":"2015","journal-title":"Pediatr Res"},{"key":"B98","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1038\/ncprheum0531","article-title":"Mechanisms of disease: a 'DAMP' view of inflammatory arthritis","volume":"3","author":"Foell","year":"2007","journal-title":"Nat Clin Practice Rheumatol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1136\/adc.2005.084731","article-title":"PFAPA syndrome: new clinical aspects disclosed","volume":"91","author":"Tasher","year":"2006","journal-title":"Archi Dis Childhood"},{"key":"B100","doi-asserted-by":"publisher","first-page":"15637","DOI":"10.1039\/C5CC07019H","article-title":"Development and evaluation of a non-peptidic ligand for the molecular imaging of inflammatory processes using S100A9 (MRP14) as a novel target","volume":"51","author":"Faust","year":"2015","journal-title":"Chem Commun."},{"key":"B101","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/s11307-017-1148-9","article-title":"A Non-Peptidic S100A9 specific ligand for optical imaging of phagocyte activity in vivo","volume":"20","author":"Voller","year":"2018","journal-title":"Mol Imaging Biol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1056\/NEJMoa1104318","article-title":"Placebo-controlled trial of oral laquinimod for multiple sclerosis","volume":"366","author":"Comi","year":"2012","journal-title":"N Engl J Med."},{"key":"B103","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1136\/gutjnl-2014-307118","article-title":"A phase II study of laquinimod in Crohn's disease","volume":"64","author":"D'Haens","year":"2015","journal-title":"Gut"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00182\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T17:18:50Z","timestamp":1694625530000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00182\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,15]]},"references-count":103,"alternative-id":["10.3389\/fimmu.2019.00182"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.00182","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,15]]},"article-number":"182"}}