{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:59:36Z","timestamp":1790873976300,"version":"4.1.0"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T00:00:00Z","timestamp":1551657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.00257","type":"journal-article","created":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T04:34:15Z","timestamp":1551674055000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Age-Associated Heterogeneity of Ty21a-Induced T Cell Responses to HLA-E Restricted Salmonella Typhi Antigen Presentation"],"prefix":"10.3389","volume":"10","author":[{"given":"Mark E.","family":"Rudolph","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica A.","family":"McArthur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence S.","family":"Magder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin S.","family":"Barnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilbur H.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo B.","family":"Sztein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,3,4]]},"reference":[{"key":"B1","first-page":"898","article-title":"Addressing the global disease burden of typhoid fever","volume-title":"JAMA.","author":"Bhutta","year":"2009"},{"key":"B2","first-page":"346","article-title":"The global burden of typhoid fever","volume-title":"Bull World Health Organ.","author":"Crump","year":"2004"},{"key":"B3","first-page":"241","article-title":"Global trends in typhoid and paratyphoid Fever","volume-title":"Clin Infect Dis.","author":"Crump","year":"2010"},{"key":"B4","first-page":"1114","volume-title":"Typhoid Fever Vaccines.","author":"Levine","year":"2018"},{"key":"B5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005376","article-title":"The burden of typhoid fever in low- and middle-income countries: a meta-regression approach","volume-title":"PLoS Negl Trop Dis.","author":"Antill\u00f3n","year":"2017"},{"key":"B6","first-page":"1055","article-title":"Evaluation of immune responses to an oral typhoid vaccine, Ty21a, in children from 2 to 5 years of age in Bangladesh","volume-title":"Vaccine.","author":"Bhuiyan","year":"2014"},{"key":"B7","first-page":"214","article-title":"Impact of age and drug resistance on mortality in typhoid fever","volume-title":"Arch Dis Child.","author":"Bhutta","year":"1996"},{"key":"B8","first-page":"326","article-title":"Bacteremic typhoid fever in children in an urban slum, Bangladesh","volume-title":"Emerg Infect Dis.","author":"Brooks","year":"2005"},{"key":"B9","first-page":"452","article-title":"Immune responses and protection in children in developing countries induced by oral vaccines","volume-title":"Vaccine.","author":"Qadri","year":"2013"},{"key":"B10","first-page":"62","article-title":"Salmonella Typhi-specific multifunctional CD8+ T cells play a dominant role in protection from typhoid fever in humans","volume-title":"J Transl Med.","author":"Fresnay","year":"2016"},{"key":"B11","first-page":"208","article-title":"Importance of Salmonella Typhi-responsive CD8+ T cell immunity in a human typhoid fever challenge model","volume-title":"Front Immunol.","author":"Fresnay","year":"2017"},{"key":"B12","first-page":"S15","article-title":"Cell-mediated immunity and antibody responses elicited by attenuated Salmonella enterica Serovar Typhi strains used as live oral vaccines in humans","volume-title":"Clin Infect Dis.","author":"Sztein","year":"2007"},{"key":"B13","doi-asserted-by":"publisher","first-page":"a029546","DOI":"10.1101\/cshperspect.a029546","article-title":"Is a human CD8 T-cell vaccine possible, and if so, what would it take?","volume":"10","author":"Sztein","year":"2017","journal-title":"Cold Spring Harb Perspect Biol."},{"key":"B14","first-page":"516","article-title":"Complex adaptive immunity to enteric fevers in humans: lessons learned and the path forward","volume-title":"Front Immunol.","author":"Sztein","year":"2014"},{"key":"B15","first-page":"274","article-title":"Accumulation of memory T cells from childhood to old age: central and effector memory cells in CD4(+) versus effector memory and terminally differentiated memory cells in CD8(+) compartment","volume-title":"Mech Ageing Dev.","author":"Saule","year":"2006"},{"key":"B16","first-page":"88","article-title":"T-cell subsets in healthy teenagers: transition to the adult phenotype","volume-title":"Clin Immunol Immunopathol.","author":"Tollerud","year":"1990"},{"key":"B17","first-page":"498","article-title":"Differences between pediatric and adult T cell responses to in vitro Staphylococcal enterotoxin B stimulation","volume-title":"Front Immunol.","author":"Rudolph","year":"2018"},{"key":"B18","first-page":"2689","article-title":"Age-related decrease in TCR repertoire diversity measured with deep and normalized sequence profiling","volume-title":"J Immunol.","author":"Britanova","year":"2014"},{"key":"B19","first-page":"814","article-title":"Spatial map of human T cell compartmentalization and maintenance over decades of life","volume-title":"Cell.","author":"Thome","year":"2014"},{"key":"B20","first-page":"95","article-title":"Refined characterization and reference values of the pediatric T- and B-cell compartments","volume-title":"Clin Immunol.","author":"van Gent","year":"2009"},{"key":"B21","first-page":"1304","article-title":"Antigen-specific memory T cell responses after vaccination with an oral killed cholera vaccine in Bangladeshi children and comparison to responses in patients with naturally acquired cholera","volume-title":"Clin Vaccine Immunol.","author":"Arifuzzaman","year":"2012"},{"key":"B22","first-page":"S143","article-title":"Humoral and cell-mediated immune responses in children and adults after 1 and 2 doses of varicella vaccine","volume-title":"J Infect Dis.","author":"Watson","year":"2008"},{"key":"B23","first-page":"1049","article-title":"Large-scale field trial of Ty21a live oral typhoid vaccine in enteric-coated capsule formulation","volume-title":"Lancet.","author":"Levine","year":"1987"},{"key":"B24","first-page":"891","article-title":"Comparison of enteric-coated capsules and liquid formulation of Ty21a typhoid vaccine in randomised controlled field trial","volume-title":"Lancet.","author":"Levine","year":"1990"},{"key":"B25","first-page":"100","article-title":"Functions of nonclassical MHC and non-MHC-encoded class I molecules","volume-title":"Curr Opin Immunol.","author":"Braud","year":"1999"},{"key":"B26","first-page":"1473","article-title":"HLA-E-dependent presentation of Mtb-derived antigen to human CD8+ T cells","volume-title":"J Exp Med.","author":"Heinzel","year":"2002"},{"key":"B27","first-page":"2695396","article-title":"Characteristics of HLA-E restricted T-cell responses and their role in infectious diseases","volume-title":"J Immunol Res.","author":"Joosten","year":"2016"},{"key":"B28","first-page":"5","article-title":"Peptide binding characteristics of the non-classical class Ib MHC molecule HLA-E assessed by a recombinant random peptide approach","volume-title":"BMC Immunol.","author":"Stevens","year":"2001"},{"key":"B29","first-page":"49","article-title":"The role of MHC-E in T cell immunity is conserved among humans, rhesus macaques, and cynomolgus macaques","volume-title":"J Immunol.","author":"Wu","year":"2018"},{"key":"B30","first-page":"5852","article-title":"Identification of a human HLA-E-restricted CD8+ T cell subset in volunteers immunized with Salmonella enterica serovar Typhi strain Ty21a typhoid vaccine","volume-title":"J Immunol.","author":"Salerno-Gon\u00e7alves","year":"2004"},{"key":"B31","first-page":"1305","article-title":"Ex vivo kinetics of early and long-term multifunctional human leukocyte antigen E-specific CD8+ cells in volunteers immunized with the Ty21a typhoid vaccine","volume-title":"Clin Vaccine Immunol.","author":"Salerno-Goncalves","year":"2010"},{"key":"B32","first-page":"e38408","article-title":"Heterogeneity of multifunctional IL-17A producing S. Typhi-specific CD8+ T cells in volunteers following Ty21a typhoid immunization","volume-title":"PLoS ONE.","author":"McArthur","year":"2012"},{"key":"B33","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.4049\/jimmunol.155.8.3987","article-title":"Cytotoxic T lymphocytes after oral immunization with attenuated vaccine strains of Salmonella typhi in humans","volume":"155","author":"Sztein","year":"1995","journal-title":"J Immunol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1093\/infdis\/170.6.1508","article-title":"Cytokine production patterns and lymphoproliferative responses in volunteers orally immunized with attenuated vaccine strains of Salmonella typhi","volume":"170","author":"Sztein","year":"1994","journal-title":"J Infect Dis."},{"key":"B35","doi-asserted-by":"crossref","first-page":"4951","DOI":"10.4049\/jimmunol.160.10.4951","article-title":"HLA-E surface expression depends on binding of TAP-dependent peptides derived from certain HLA class I signal sequences","volume":"160","author":"Lee","year":"1998","journal-title":"J Immunol."},{"key":"B36","first-page":"e0005291","article-title":"Impact of CD4+ T cell responses on clinical outcome following oral administration of wild-type enterotoxigenic Escherichia coli in humans","volume-title":"PLoS Negl Trop Dis.","author":"McArthur","year":"2017"},{"key":"B37","doi-asserted-by":"publisher","first-page":"e1004914","DOI":"10.1371\/journal.ppat.1004914","article-title":"Activation of Salmonella Typhi-specific regulatory T cells in typhoid disease in a wild-type S. Typhi challenge model","volume":"11","author":"McArthur","year":"2015","journal-title":"PLoS Pathog."},{"key":"B38","doi-asserted-by":"publisher","first-page":"e1005112","DOI":"10.1371\/journal.pcbi.1005112","article-title":"Cytofkit: A bioconductor package for an integrated mass cytometry data analysis pipeline","volume":"12","author":"Chen","year":"2016","journal-title":"PLoS Comput Biol."},{"key":"B39","first-page":"708","article-title":"Two subsets of memory T lymphocytes with distinct homing potentials and effector functions","volume-title":"Nature.","author":"Sallusto","year":"1999"},{"key":"B40","first-page":"271","article-title":"Human T cell aging and the impact of persistent viral infections","volume-title":"Front Immunol.","author":"Fulop","year":"2013"},{"key":"B41","doi-asserted-by":"publisher","first-page":"2797","DOI":"10.1002\/eji.201343751","article-title":"The who's who of T-cell differentiation: human memory T-cell subsets","volume":"43","author":"Mahnke","year":"2013","journal-title":"Eur J Immunol."},{"key":"B42","first-page":"1737","article-title":"The inducible costimulator augments Tc17 cell responses to self and tumor tissue","volume-title":"J Immunol.","author":"Nelson","year":"2015"},{"key":"B43","first-page":"29","article-title":"The diversity of the HLA-E-restricted peptide repertoire explains the immunological impact of the Arg107Gly mismatch","volume-title":"Immunogenetics.","author":"Celik","year":"2016"},{"key":"B44","first-page":"843","article-title":"Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major","volume-title":"Nat Med.","author":"Darrah","year":"2007"},{"key":"B45","first-page":"247","article-title":"T-cell quality in memory and protection: implications for vaccine design","volume-title":"Nat Rev Immunol.","author":"Seder","year":"2008"},{"key":"B46","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1742-4933-11-14","article-title":"Age-related differences in polyfunctional T cell responses","volume":"11","author":"Van Epps","year":"2014","journal-title":"Immun Ageing."},{"key":"B47","first-page":"1241","article-title":"Follicular CD8(+) T cells: origin, function and importance during HIV infection","volume-title":"Front Immunol.","author":"Perdomo-Celis","year":"2017"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00257\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T03:59:09Z","timestamp":1694663949000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00257\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,4]]},"references-count":47,"alternative-id":["10.3389\/fimmu.2019.00257"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.00257","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,4]]},"article-number":"257"}}