{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:47:05Z","timestamp":1790552825609,"version":"4.1.0"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T00:00:00Z","timestamp":1550620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.00283","type":"journal-article","created":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T04:34:47Z","timestamp":1550637287000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":62,"title":["LL37 Inhibits Aspergillus fumigatus Infection via Directly Binding to the Fungus and Preventing Excessive Inflammation"],"prefix":"10.3389","volume":"10","author":[{"given":"Xiao-Li","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Xiong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Rong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie-Lin","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruo-Xuan","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru-Jia","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-yun","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Ming","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Fu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,2,20]]},"reference":[{"key":"B1","first-page":"165rv113","article-title":"Hidden killers: human fungal infections","volume-title":"Sci Transl Med.","author":"Brown","year":"2012"},{"key":"B2","first-page":"1870","article-title":"Aspergillosis","volume-title":"N Engl J Med.","author":"Segal","year":"2009"},{"key":"B3","first-page":"1481","article-title":"Multiple-triazole-resistant aspergillosis","volume-title":"N Engl J Med.","author":"Verweij","year":"2007"},{"key":"B4","first-page":"1846","article-title":"Clinical implications of azole resistance in Aspergillus fumigatus, The Netherlands, 2007-2009","volume-title":"Emerg Infect Dis.","author":"van der Linden","year":"2011"},{"key":"B5","first-page":"493","article-title":"Azole resistance in Aspergillus fumigatus: a growing public health concern","volume-title":"Curr Opin Infect Dis.","author":"Vermeulen","year":"2013"},{"key":"B6","first-page":"52","article-title":"Inflammation in aspergillosis: the good, the bad, and the therapeutic","volume-title":"Ann N Y Acad Sci.","author":"Carvalho","year":"2012"},{"key":"B7","first-page":"39","article-title":"Cathelicidins, multifunctional peptides of the innate immunity","volume-title":"J Leukoc Biol.","author":"Zanetti","year":"2004"},{"key":"B8","first-page":"1138","article-title":"Antimicrobial peptide action on parasites","volume-title":"Curr Drug Targets","author":"Torrent","year":"2012"},{"key":"B9","first-page":"7738","article-title":"Roles of hydrophobicity and charge distribution of cationic antimicrobial peptides in peptide-membrane interactions","volume-title":"J Biol Chem.","author":"Yin","year":"2012"},{"key":"B10","first-page":"4895","article-title":"Little peptide, big effects: the role of LL-37 in inflammation and autoimmune disease","volume-title":"J Immunol.","author":"Kahlenberg","year":"2013"},{"key":"B11","first-page":"367","article-title":"Fungal allergens induce cathelicidin LL-37 expression in chronic rhinosinusitis patients in a nasal explant model","volume-title":"Am J Rhinol.","author":"Ooi","year":"2007"},{"key":"B12","first-page":"170","article-title":"Aspergillus fumigatus triggers innate immune response via NOD1 signaling in human corneal epithelial cells","volume-title":"Exp Eye Res.","author":"Zhang","year":"2014"},{"key":"B13","first-page":"547","article-title":"CARD9(S12N) facilitates the production of IL-5 by alveolar macrophages for the induction of type 2 immune responses","volume-title":"Nat Immunol.","author":"Xu","year":"2018"},{"key":"B14","first-page":"1781","article-title":"Dectin-3 Recognizes Glucuronoxylomannan of Cryptococcus neoformans Serotype AD and Cryptococcus gattii Serotype B to Initiate Host Defense Against Cryptococcosis","volume-title":"Front Immunol.","author":"Huang","year":"2018"},{"key":"B15","first-page":"e1005205","article-title":"Transcription factor SomA is required for adhesion, development and virulence of the human pathogen Aspergillus fumigatus","volume-title":"PLoS Pathog","author":"Lin","year":"2015"},{"key":"B16","first-page":"240","article-title":"Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus","volume-title":"EMBO Mol Med.","author":"Herbst","year":"2015"},{"key":"B17","first-page":"7435","article-title":"MicroRNA-101 targets MAPK phosphatase-1 to regulate the activation of MAPKs in macrophages","volume-title":"J Immunol.","author":"Zhu","year":"2010"},{"key":"B18","first-page":"e1004378","article-title":"Myeloid derived hypoxia inducible factor 1-alpha is required for protection against pulmonary Aspergillus fumigatus infection","volume-title":"PLoS Pathog.","author":"Shepardson","year":"2014"},{"key":"B19","first-page":"1996","article-title":"Antifungal action of human cathelicidin fragment (LL13-37) on Candida albicans","volume-title":"Peptides","author":"Wong","year":"2011"},{"key":"B20","first-page":"2240","article-title":"Fungicidal mechanisms of cathelicidins LL-37 and CATH-2 revealed by live-cell imaging","volume-title":"Antimicrob Agents Chemother","author":"Ordonez","year":"2014"},{"key":"B21","first-page":"581","article-title":"Responses of Candida albicans to the human antimicrobial peptide LL-37","volume-title":"J Microbiol.","author":"Tsai","year":"2014"},{"key":"B22","first-page":"950","article-title":"Fungicidal activity of five cathelicidin peptides against clinically isolated yeasts","volume-title":"J Antimicrob Chemother","author":"Benincasa","year":"2006"},{"key":"B23","first-page":"27","article-title":"Mechanisms of antimicrobial peptide action and resistance","volume-title":"Pharmacol Rev.","author":"Yeaman","year":"2003"},{"key":"B24","first-page":"2522","article-title":"Fully hydrated yeast cells imaged with electron microscopy","volume-title":"Biophys J.","author":"Peckys","year":"2011"},{"key":"B25","first-page":"e17755","article-title":"Human antimicrobial peptide LL-37 inhibits adhesion of Candida albicans by interacting with yeast cell-wall carbohydrates","volume-title":"PLoS ONE","author":"Tsai","year":"2011"},{"key":"B26","first-page":"963","article-title":"LL37 and hBD-3 elevate the beta-1,3-exoglucanase activity of Candida albicans Xog1p, resulting in reduced fungal adhesion to plastic","volume-title":"Biochem J.","author":"Chang","year":"2012"},{"key":"B27","first-page":"1636","article-title":"Endotoxin (lipopolysaccharide) neutralization by innate immunity host-defense peptides. Peptide properties and plausible modes of action","volume-title":"J Biol Chem.","author":"Rosenfeld","year":"2006"},{"key":"B28","first-page":"1829","article-title":"Cathelicidin antimicrobial peptides block dendritic cell TLR4 activation and allergic contact sensitization","volume-title":"J Immunol.","author":"Di","year":"2007"},{"key":"B29","first-page":"5497","article-title":"Host defense peptide LL-37 selectively reduces proinflammatory macrophage responses","volume-title":"J Immunol.","author":"Brown","year":"2011"},{"key":"B30","first-page":"1418","article-title":"Cathelicidins Inhibit Escherichia coli-Induced TLR2 and TLR4 Activation in a viability-dependent manner","volume-title":"J Immunol.","author":"Coorens","year":"2017"},{"key":"B31","first-page":"1442","article-title":"LL-37 directs macrophage differentiation toward macrophages with a proinflammatory signature","volume-title":"J Immunol.","author":"van","year":"2010"},{"key":"B32","first-page":"183","article-title":"Protective tolerance to fungi: the role of IL-10 and tryptophan catabolism","volume-title":"Trends Microbiol.","author":"Romani","year":"2006"},{"key":"B33","first-page":"S39","article-title":"The impact of the host on fungal infections","volume-title":"Am J Med","author":"Perfect","year":"2012"},{"key":"B34","first-page":"211","article-title":"Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease","volume-title":"Nature","author":"Romani","year":"2008"},{"key":"B35","first-page":"S50","article-title":"Aspergillus infections in cystic fibrosis","volume-title":"J Infect.","author":"King","year":"2016"},{"key":"B36","first-page":"1113","article-title":"Transfer of a cathelicidin peptide antibiotic gene restores bacterial killing in a cystic fibrosis xenograft model","volume-title":"J Clin Invest.","author":"Bals","year":"1999"},{"key":"B37","first-page":"6084","article-title":"Augmentation of innate host defense by expression of a cathelicidin antimicrobial peptide","volume-title":"Infect Immun","author":"Bals","year":"1999"},{"key":"B38","article-title":"The human cathelicidin antimicrobial peptide LL-37 promotes the growth of the pulmonary pathogen","volume-title":"Aspergillus fumigatus. Infect Immun.","author":"Sheehan","year":"2018"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00283\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T04:34:48Z","timestamp":1550637288000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00283\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,20]]},"references-count":38,"alternative-id":["10.3389\/fimmu.2019.00283"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.00283","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,20]]},"article-number":"283"}}