{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:21:46Z","timestamp":1790626906309,"version":"4.1.0"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T00:00:00Z","timestamp":1551744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003549","name":"Orsz\u00e1gos Tudom\u00e1nyos Kutat\u00e1si Alapprogramok","doi-asserted-by":"publisher","award":["K108429"],"award-info":[{"award-number":["K108429"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.00366","type":"journal-article","created":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T12:49:29Z","timestamp":1551790169000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Differential Effects of the Absence of Nkx2-3 and MAdCAM-1 on the Distribution of Intestinal Type 3 Innate Lymphoid Cells and Postnatal SILT Formation in Mice"],"prefix":"10.3389","volume":"10","author":[{"given":"D\u00f3ra","family":"Vojkovics","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Kellermayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanni","family":"G\u00e1bris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Schippers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gergely","family":"Berta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Korn\u00e9lia","family":"Farkas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Balogh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,3,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"342","DOI":"10.3389\/fimmu.2016.00342","article-title":"Development and function of secondary and tertiary lymphoid organs in the small intestine and the colon","volume":"7","author":"Buettner","year":"2016","journal-title":"Front Immunol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1038\/nri1054","article-title":"Organogenesis of lymphoid tissues","volume":"3","author":"Mebius","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/ni1022","article-title":"An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells","volume":"5","author":"Eberl","year":"2004","journal-title":"Nat Immunol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"11019","DOI":"10.1073\/pnas.93.20.11019","article-title":"A developmental switch in lymphocyte homing receptor and endothelial vascular addressin expression regulates lymphocyte homing and permits CD4+ CD3- cells to colonize lymph nodes","volume":"93","author":"Mebius","year":"1996","journal-title":"Proc Nat Acad Sci USA"},{"key":"B5","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1093\/intimm\/9.4.507","article-title":"Three distinctive steps in Peyer's patch formation of Mmurine embryo","volume":"9","author":"Adachi","year":"1997","journal-title":"Int Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"3702","DOI":"10.4049\/jimmunol.166.6.3702","article-title":"Compartmentalization of Peyer's patch anlagen before lymphocyte eEntry","volume":"166","author":"Hashi","year":"2001","journal-title":"J Immunol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/3-540-30657-9_3","article-title":"Lymphoid tissue inducer cells in intestinal immunity","volume":"308","author":"Ivanov","year":"2006","journal-title":"Curr Top Microbiol Immunol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1093\/emboj\/19.9.2015","article-title":"NKX2.3 is required for MAdCAM-1 expression and homing of lymphocytes in spleen and mucosa-associated lymphoid tissue","volume":"19","author":"Pabst","year":"2000","journal-title":"EMBO J"},{"key":"B9","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1002\/(SICI)1097-0177(199705)209:1<29::AID-AJA3>3.0.CO;2-Z","article-title":"The mouse Nkx2-3 homeodomain gene is expressed in gut mesenchyme during pre- and postnatal mouse development","volume":"209","author":"Pabst","year":"1997","journal-title":"Dev Dynam"},{"key":"B10","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1002\/bies.20528","article-title":"Development and function of the mammalian spleen","volume":"29","author":"Brendolan","year":"2007","journal-title":"Bioessays"},{"key":"B11","doi-asserted-by":"publisher","first-page":"6981","DOI":"10.4049\/jimmunol.1003770","article-title":"Transcription Factor Nkx2-3 controls the vascular identity and lymphocyte homing in the spleen","volume":"186","author":"Cz\u00f6mp\u00f6ly","year":"2011","journal-title":"J Immunol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"5284","DOI":"10.4049\/jimmunol.1402016","article-title":"Absence of Nkx2-3 homeodomain transcription factor reprograms the endothelial addressin preference for lymphocyte homing in Peyer's patches","volume":"193","author":"Kellermayer","year":"2014","journal-title":"J Immunol"},{"key":"B13","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1242\/dev.126.10.2215","article-title":"Targeted disruption of the homeobox transcription factor Nkx2-3 in mice results in postnatal lethality and abnormal development of small intestine and spleen","volume":"126","author":"Pabst","year":"1999","journal-title":"Development"},{"key":"B14","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1006\/dbio.2000.9749","article-title":"Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera","volume":"224","author":"Wang","year":"2000","journal-title":"Dev Biol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1073\/pnas.1603534113","article-title":"Myofibroblasts are distinguished from activated skin fibroblasts by the expression of AOC3 and other associated markers","volume":"12","author":"Hsia","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"B16","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1038\/ng.145","article-title":"Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease","volume":"40","author":"Fisher","year":"2018","journal-title":"Nat Gen"},{"key":"B17","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1038\/ng2061","article-title":"Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility","volume":"39","author":"Parkes","year":"2007","journal-title":"Nat Gen"},{"key":"B18","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1053\/j.gastro.2009.05.039","article-title":"Mucosal addressin cell adhesion molecule-1 controls plasma-cell migration and function in the small intestine of mice","volume":"137","author":"Schippers","year":"2009","journal-title":"Gastroenterol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1038\/ni.2002","article-title":"RORgammat+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota","volume":"12","author":"Sawa","year":"2011","journal-title":"Nat Immunol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"ji1801117","DOI":"10.4049\/jimmunol.1801117","article-title":"IL-22-independent protection from colitis in the absence of Nkx2.3 transcription factor in mice","volume":"202","author":"Kellermayer","year":"2019","journal-title":"J Immunol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.3389\/fimmu.2017.01296","article-title":"Innate lymphoid cells in intestinal inflammation","volume":"8","author":"Geremia","year":"2017","journal-title":"Front Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/gut.53.1.1","article-title":"Dysbiosis in inflammatory bowel disease","volume":"53","author":"Tamboli","year":"2004","journal-title":"Gut"},{"key":"B23","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/nri2340","article-title":"The genetics and immunopathogenesis of inflammatory bowel disease","volume":"8","author":"Cho","year":"2008","journal-title":"Nat Rev Immunol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.imlet.2017.04.008","article-title":"Innate lymphoid cells and their stromal microenvironments","volume":"189","author":"Kellermayer","year":"2017","journal-title":"Immunol Lett"},{"key":"B25","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/nature12240","article-title":"Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria","volume":"498","author":"Hepworth","year":"2013","journal-title":"Nature"},{"key":"B26","doi-asserted-by":"publisher","first-page":"891","DOI":"10.3389\/fimmu.2017.00891","article-title":"Anti-adhesiontherapies in inflammatory bowel disease-molecular and clinical aspects","volume":"8","author":"Zundler","year":"2017","journal-title":"Front Immunol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"4052","DOI":"10.4049\/jimmunol.181.6.4052","article-title":"Alpha4beta7\/MAdCAM-1 interactions play an essential role in transitioning cryptopatches into isolated lymphoid follicles and a nonessential role in cryptopatch formation","volume":"181","author":"Wang","year":"2008","journal-title":"J Immunol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"57","DOI":"10.4049\/jimmunol.168.1.57","article-title":"Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine","volume":"168","author":"Hamada","year":"2002","journal-title":"J Immunol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1002\/eji.200425432","article-title":"Cryptopatches and isolated lymphoid follicles: dynamic lymphoid tissues dispensable for the generation of intraepithelial lymphocytes","volume":"35","author":"Pabst","year":"2005","journal-title":"Eur J Immunol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1016\/j.ajpath.2011.06.004","article-title":"Distinct developmental requirements for isolated lymphoid follicle formation in the small and large intestine: RANKL is essential only in the small intestine","volume":"179","author":"Knoop","year":"2011","journal-title":"Am J Pathol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1084\/jem.189.9.1467","article-title":"Lymphocyte migration in lymphocyte function-associated antigen (LFA)-1-deficient mice","volume":"189","author":"Berlin-Rufenach","year":"1999","journal-title":"J Exp Med"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00366\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:45:44Z","timestamp":1663029944000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00366\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,5]]},"references-count":31,"alternative-id":["10.3389\/fimmu.2019.00366"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.00366","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,5]]},"article-number":"366"}}