{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:09:12Z","timestamp":1790201352988,"version":"4.1.0"},"reference-count":70,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T00:00:00Z","timestamp":1551916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.00381","type":"journal-article","created":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T16:03:16Z","timestamp":1551974596000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":48,"title":["Autoantibody Biomarker Discovery in Primary Open Angle Glaucoma Using Serological Proteome Analysis (SERPA)"],"prefix":"10.3389","volume":"10","author":[{"given":"Vanessa M.","family":"Beutgen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natarajan","family":"Perumal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Pfeiffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz H.","family":"Grus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,3,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"4254","DOI":"10.1167\/iovs.06-0299","article-title":"Variations in primary open-angle glaucoma prevalence by age, gender, and race: a Bayesian meta-analysis","volume":"47","author":"Rudnicka","year":"2006","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology."},{"key":"B3","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1007\/s00347-004-1150-x","article-title":"[Results of the \u201cOcular hypertension treatment study\u201d]","volume":"102","author":"Pfeiffer","year":"2005","journal-title":"Der Ophthalmol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"30505","DOI":"10.1038\/srep30505","article-title":"Effects of induction and inhibition of matrix cross-linking on remodeling of the aqueous outflow resistance by ocular trabecular meshwork cells","volume":"6","author":"Yang","year":"2016","journal-title":"Sci Rep."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1167\/iovs.16-19672","article-title":"TGFbeta2 induces the formation of cross-linked actin networks (CLANs) in human trabecular meshwork cells through the smad and non-smad dependent pathways","volume":"58","author":"Montecchi-Palmer","year":"2017","journal-title":"Invest Ophthalmol Vis. Sci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2386","DOI":"10.1016\/j.ajpath.2012.02.030","article-title":"Connective tissue growth factor causes glaucoma by modifying the actin cytoskeleton of the trabecular meshwork","volume":"180","author":"Junglas","year":"2012","journal-title":"Am J Pathol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1167\/iovs.04-0832","article-title":"Retinal ganglion cell apoptosis in glaucoma is related to intraocular pressure and IOP-induced effects on extracellular matrix","volume":"46","author":"Guo","year":"2005","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B8","unstructured":"Number of ganglion cells in glaucoma eyes compared with threshold visual field tests in the same persons7418\n            Kerrigan-BaumrindLA\n            QuigleyHA\n            PeaseME\n            KerriganDF\n            MitchellRS\n          10711689Invest Ophthalmol Vis Sci.412000"},{"key":"B9","unstructured":"Complex autoantibody repertoires in patients with glaucoma1327\n            GrusFH\n            JoachimSC\n            HoffmannEM\n            PfeifferN\n          14990890Mol Vis.102004"},{"key":"B10","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1167\/iovs.05-0685","article-title":"Serum autoantibodies to alpha-fodrin are present in glaucoma patients from Germany and the United States","volume":"47","author":"Grus","year":"2006","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1080\/02713680701375183","article-title":"Antibodies to alpha B-crystallin, vimentin, and heat shock protein 70 in aqueous humor of patients with normal tension glaucoma and IgG antibody patterns against retinal antigen in aqueous humor","volume":"32","author":"Joachim","year":"2007","journal-title":"Curr Eye Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/S0002-9394(14)70059-5","article-title":"Increased incidence of paraproteinemia and autoantibodies in patients with normal-pressure glaucoma","volume":"117","author":"Wax","year":"1994","journal-title":"Am J Ophthalmol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0002-9394(99)80084-1","article-title":"Anti-Ro\/SS-A positivity and heat shock protein antibodies in patients with normal-pressure glaucoma","volume":"125","author":"Wax","year":"1998","journal-title":"Am J Ophthalmol."},{"key":"B14","first-page":"2277","article-title":"Autoantibodies to small heat shock proteins in glaucoma","volume":"39","author":"Tezel","year":"1998","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B15","unstructured":"Retinal ganglion cells recognized by serum autoantibody against gamma-enolase found in glaucoma patients165765\n            MaruyamaI\n            OhguroH\n            IkedaY\n          10845582Invest Ophthalmol Vis Sci.412000"},{"key":"B16","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1007\/s00417-007-0737-8","article-title":"Sera of glaucoma patients show autoantibodies against myelin basic protein and complex autoantibody profiles against human optic nerve antigens","volume":"246","author":"Joachim","year":"2008","journal-title":"Graefe Arch Clin Exp Ophthalmol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2599","DOI":"10.1002\/art.21252","article-title":"Protective autoantibodies: role in homeostasis, clinical importance, and therapeutic potential","volume":"52","author":"Shoenfeld","year":"2005","journal-title":"Arthritis Rheumat."},{"key":"B18","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jprot.2013.02.030","article-title":"Serological Proteome Analysis (SERPA) as a tool for the identification of new candidate autoantigens in type 1 diabetes","volume":"82","author":"Massa","year":"2013","journal-title":"J Proteomics."},{"key":"B19","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.1002\/pmic.200300732","article-title":"New antigenic candidates in multiple sclerosis: identification by serological proteome analysis","volume":"4","author":"Almeras","year":"2004","journal-title":"Proteomics."},{"key":"B20","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s12014-017-9141-5","article-title":"Serum proteomic-based analysis identifying autoantibodies against PRDX2 and PRDX3 as potential diagnostic biomarkers in nasopharyngeal carcinoma","volume":"14","author":"Lin","year":"2017","journal-title":"Clin Proteomics."},{"key":"B21","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s12967-015-0751-2","article-title":"Autoantibody signatures defined by serological proteome analysis in sera from patients with cholangiocarcinoma","volume":"14","author":"Mustafa","year":"2016","journal-title":"J Transl Med."},{"key":"B22","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1002\/1615-9861(200107)1:7<890::AID-PROT890>3.0.CO;2-Z","article-title":"Identification of tumor antigens in renal cell carcinoma by serological proteome analysis","volume":"1","author":"Klade","year":"2001","journal-title":"Proteomics."},{"key":"B23","doi-asserted-by":"publisher","first-page":"49","DOI":"10.2174\/138161282001140113123707","article-title":"Protein microarrays for studies of drug mechanisms and biomarker discovery in the era of systems biology","volume":"20","author":"Tu","year":"2014","journal-title":"Curr Pharmaceut Des."},{"key":"B24","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/978-1-61779-424-7_14","article-title":"The use of antigen microarrays in antibody profiling","volume":"815","author":"Papp","year":"2012","journal-title":"Methods Mol Biol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1373\/clinchem.2016.254649","article-title":"Waste, Leaks, and Failures in the Biomarker Pipeline","volume":"63","author":"Ioannidis","year":"2017","journal-title":"Clin Chem."},{"key":"B26","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1136\/bjophthalmol-2016-EGSguideline.002","article-title":"European Glaucoma Society Terminology and Guidelines for Glaucoma, 4th Edition\u2014Chapter 2: classification and terminology supported by the EGS Foundation: Part 1: foreword; introduction; glossary; Chapter 2 classification and terminology","volume":"101","author":"Blanco","year":"2017","journal-title":"Br J Ophthalmol."},{"key":"B27","unstructured":"Muller and macrophage-like cell interactions in an organotypic culture of porcine neuroretina214856\n            Fernandez-BuenoI\n            PastorJC\n            GayosoMJ\n            AlcaldeI\n            GarciaMT\n          19052655Mol Vis.142008"},{"key":"B28","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.exer.2005.03.014","article-title":"The pig eye as a novel model of glaucoma","volume":"81","author":"Ruiz-Ederra","year":"2005","journal-title":"Exp Eye Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1167\/iovs.05-1393","article-title":"Ultrastructural and biochemical evaluation of the porcine anterior chamber perfusion model","volume":"47","author":"Bachmann","year":"2006","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.1002\/pmic.201300039","article-title":"Characterization of lacrimal proline-rich protein 4 (PRR4) in human tear proteome","volume":"14","author":"Perumal","year":"2014","journal-title":"Proteomics."},{"key":"B31","doi-asserted-by":"publisher","first-page":"4350","DOI":"10.1073\/pnas.76.9.4350","article-title":"Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications","volume":"76","author":"Towbin","year":"1979","journal-title":"Proc Nat Acad Sci USA."},{"key":"B32","doi-asserted-by":"publisher","first-page":"2856","DOI":"10.1038\/nprot.2006.468","article-title":"In-gel digestion for mass spectrometric characterization of proteins and proteomes","volume":"1","author":"Shevchenko","year":"2006","journal-title":"Nat Protocols."},{"key":"B33","doi-asserted-by":"publisher","first-page":"3370","DOI":"10.1002\/pmic.201400239","article-title":"Characterization of human reflex tear proteome reveals high expression of lacrimal proline-rich protein 4 (PRR4)","volume":"15","author":"Perumal","year":"2015","journal-title":"Proteomics."},{"key":"B34","doi-asserted-by":"publisher","first-page":"3177","DOI":"10.1016\/j.jprot.2012.03.018","article-title":"Longitudinal analysis of taurine induced effects on the tear proteome of contact lens wearers and dry eye patients using a RP-RP-Capillary-HPLC-MALDI TOF\/TOF MS approach","volume":"75","author":"Funke","year":"2012","journal-title":"J Proteomics."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1074\/mcp.T500030-MCP200","article-title":"Parts per million mass accuracy on an Orbitrap mass spectrometer via lock mass injection into a C-trap","volume":"4","author":"Olsen","year":"2005","journal-title":"Mol Cell Proteomics."},{"key":"B36","doi-asserted-by":"publisher","first-page":"D447","DOI":"10.1093\/nar\/gkv1145","article-title":"2016 update of the PRIDE database and its related tools","volume":"44","author":"Vizcaino","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"B37","unstructured":"IgG antibody patterns in aqueous humor of patients with primary open angle glaucoma and pseudoexfoliation glaucoma15739\n            JoachimSC\n            WuenschigD\n            PfeifferN\n            GrusFH\n          17893658Mol Vis.132007"},{"key":"B38","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.bbi.2011.07.241","article-title":"New insights into autoantibody profiles from immune privileged sites in the eye: a glaucoma study","volume":"26","author":"Boehm","year":"2012","journal-title":"Brain Behav Immun."},{"key":"B39","doi-asserted-by":"publisher","first-page":"R40","DOI":"10.1186\/bcr2091","article-title":"Autoantibodies as potential biomarkers for breast cancer","volume":"10","author":"Zhong","year":"2008","journal-title":"Breast Cancer Res."},{"key":"B40","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1093\/annonc\/mdm007","article-title":"Autoantibodies in breast cancer: their use as an aid to early diagnosis","volume":"18","author":"Chapman","year":"2007","journal-title":"Ann Oncol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"5060","DOI":"10.1200\/JCO.2008.16.2388","article-title":"Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera","volume":"26","author":"Qiu","year":"2008","journal-title":"J Clin Oncol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3109\/10409238509082542","article-title":"Porin from bacterial and mitochondrial outer membranes","volume":"19","author":"Benz","year":"1985","journal-title":"CRC Crit Rev Biochem."},{"key":"B43","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/nrm2308","article-title":"The BCL-2 protein family: opposing activities that mediate cell death","volume":"9","author":"Youle","year":"2008","journal-title":"Nat Rev Mol Cell Biol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1928","DOI":"10.1038\/cdd.2012.71","article-title":"Disruption of the VDAC2-Bak interaction by Bcl-x(S) mediates efficient induction of apoptosis in melanoma cells","author":"Pl\u00f6tz","year":"2012","journal-title":"Cell Death Diff.19"},{"key":"B45","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1002\/jcp.24826","article-title":"The dysfunction of the trabecular meshwork during glaucoma course","volume":"230","author":"Sacc\u00e0","year":"2015","journal-title":"J Cell Physiol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.exer.2010.04.004","article-title":"Preliminary quantitative proteomic characterization of glaucomatous rat retinal ganglion cells","volume":"91","author":"Crabb","year":"2010","journal-title":"Exp Eye Res."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1021\/pr0500814","article-title":"The sentinel within: exploiting the immune system for cancer biomarkers","volume":"4","author":"Anderson","year":"2005","journal-title":"J Proteome Res."},{"key":"B48","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/ncprheum0895","article-title":"Nature and functions of autoantibodies","volume":"4","author":"Elkon","year":"2008","journal-title":"Nat Clin Pract. Rheumatol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.jneuroim.2010.06.001","article-title":"Antibodies against the voltage-dependent anion channel (VDAC) and its protective ligand hexokinase-I in children with autism","volume":"227","author":"Gonzalez-Gronow","year":"2010","journal-title":"J Neuroimmunol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/j.exer.2006.01.006","article-title":"Caldesmon effects on the actin cytoskeleton and cell adhesion in cultured HTM cells","volume":"82","author":"Grosheva","year":"2006","journal-title":"Exp Eye Res."},{"key":"B51","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/j.exer.2005.12.002","article-title":"Caldesmon transgene expression disrupts focal adhesions in HTM cells and increases outflow facility in organ-cultured human and monkey anterior segments","volume":"82","author":"Gabelt","year":"2006","journal-title":"Exp Eye Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1002\/9780470123089.ch6","article-title":"The phosphoglycerate mutases","volume":"62","author":"Fothergill-Gilmore","year":"1989","journal-title":"Adv Enzymol Relat Areas Mol Biol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.jneuroim.2009.11.014","article-title":"High prevalence of autoantibodies against phosphoglycerate mutase 1 in patients with autoimmune central nervous system diseases","volume":"219","author":"Kimura","year":"2010","journal-title":"J Neuroimmunol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.jneuroim.2010.11.003","article-title":"Identification of antibodies as biological markers in serum from multiple sclerosis patients by immunoproteomic approach","volume":"233","author":"Sakurai","year":"2011","journal-title":"J Neuroimmunol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.ejphar.2016.03.064","article-title":"Retinal ganglion cell death in glaucoma: exploring the role of neuroinflammation","volume":"787","author":"Russo","year":"2016","journal-title":"Eur J Pharmacol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"a017269","DOI":"10.1101\/cshperspect.a017269","article-title":"The complex role of neuroinflammation in glaucoma","volume":"4","author":"Soto","year":"2014","journal-title":"Cold Spring Harbor Perspect Med."},{"key":"B57","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/S0161-6420(00)00525-X","article-title":"Serum autoantibodies to heat shock proteins in glaucoma patients from Japan and the United States","volume":"108","author":"Wax","year":"2001","journal-title":"Ophthalmology."},{"key":"B58","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1007\/s00417-004-1094-5","article-title":"Autoantibodies in patients with glaucoma: a comparison of IgG serum antibodies against retinal, optic nerve, and optic nerve head antigens","volume":"243","author":"Joachim","year":"2005","journal-title":"Graefe Arch Clin Exp Ophthalmol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s12886-015-0044-9","article-title":"Protective effect of 14-3-3 antibodies on stressed neuroretinal cells via the mitochondrial apoptosis pathway","volume":"15","author":"Bell","year":"2015","journal-title":"BMC Ophthalmol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"3552","DOI":"10.1523\/JNEUROSCI.20-10-03552.2000","article-title":"The mechanisms of hsp27 antibody-mediated apoptosis in retinal neuronal cells","volume":"20","author":"Tezel","year":"2000","journal-title":"J Neurosci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1172\/JCI119517","article-title":"Receptor-mediated cellular entry of nuclear localizing anti-DNA antibodies via myosin 1","volume":"100","author":"Yanase","year":"1997","journal-title":"J Clin Invest."},{"key":"B62","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1001\/archopht.1962.00960030647013","article-title":"Gamma-globulin in the trabecular meshwork of glaucomatous eyes","volume":"68","author":"Becker","year":"1962","journal-title":"Arch Ophthalmol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/S0161-6420(84)34248-8","article-title":"Trabecular meshwork cellularity in primary open-angle glaucoma and nonglaucomatous normals","volume":"91","author":"Alvarado","year":"1984","journal-title":"Ophthalmology."},{"key":"B64","unstructured":"Apoptosis in the trabecular meshwork of glaucomatous patients15136\n            BaleriolaJ\n            Garc\u00eda-FeijooJ\n            Mart\u00ednez-de-la-CasaJM\n            Fern\u00e1ndez-CruzA\n            de la RosaEJ\n            Fern\u00e1ndez-DurangoR\n          18728789Mol Vis.142008"},{"key":"B65","doi-asserted-by":"publisher","first-page":"827","DOI":"10.3980\/j.issn.2222-3959.2013.06.15","article-title":"Apoptosis in the iris and trabecular meshwork of medically treated and untreated primary open angle glaucoma patients","volume":"6","author":"Aktas","year":"2013","journal-title":"Int J Ophthalmol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.ymeth.2007.11.004","article-title":"Detection of apoptosis in vivo using antibodies against caspase-induced neo-epitopes","volume":"44","author":"Jakob","year":"2008","journal-title":"Methods."},{"key":"B67","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.coi.2004.09.001","article-title":"Post-translational modifications of self-antigens: implications for autoimmunity","volume":"16","author":"Anderton","year":"2004","journal-title":"Curr Opin Immunol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.imlet.2015.09.010","article-title":"Potential utility of autoantibodies as blood-based biomarkers for early detection and diagnosis of Parkinson's disease","volume":"168","author":"DeMarshall","year":"2015","journal-title":"Immunol Lett."},{"key":"B69","doi-asserted-by":"publisher","first-page":"523","DOI":"10.3233\/JAD-150053","article-title":"Autoantibodies toward the angiotensin 2 type 1 receptor: a novel autoantibody in Alzheimer's disease","volume":"47","author":"Giil","year":"2015","journal-title":"J Alzheimer Dis."},{"key":"B70","doi-asserted-by":"publisher","first-page":"344","DOI":"10.3109\/08916934.2015.1008464","article-title":"Antiphospholipid autoantibodies as blood biomarkers for detection of early stage Alzheimer's disease","volume":"48","author":"McIntyre","year":"2015","journal-title":"Autoimmunity."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00381\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T16:07:44Z","timestamp":1551974864000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00381\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,7]]},"references-count":70,"alternative-id":["10.3389\/fimmu.2019.00381"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.00381","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,7]]},"article-number":"381"}}