{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T06:56:12Z","timestamp":1780556172856,"version":"3.54.1"},"reference-count":57,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T00:00:00Z","timestamp":1552262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000362","name":"Asthma UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000362","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000380","name":"Guy's and St Thomas' Charity","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000380","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.00402","type":"journal-article","created":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T04:14:36Z","timestamp":1552277676000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Transcriptional Analysis of the Human IgE-Expressing Plasma Cell Differentiation Pathway"],"prefix":"10.3389","volume":"10","author":[{"given":"Faruk","family":"Ramadani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"Bowen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah J.","family":"Gould","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Fear","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,3,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/nri2273","article-title":"IgE in allergy and asthma today","volume":"8","author":"Gould","year":"2008","journal-title":"Nat Rev Immunol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.jaci.2011.10.029","article-title":"The who, where, and when of IgE in allergic airway disease","volume":"129","author":"Dullaers","year":"2012","journal-title":"J Allergy Clin Immunol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.it.2014.11.002","article-title":"IgE responses in mouse and man and the persistence of IgE memory","volume":"36","author":"Gould","year":"2015","journal-title":"Trends Immunol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.immuni.2006.12.006","article-title":"Unique maturation program of the IgE response in vivo","volume":"26","author":"Erazo","year":"2007","journal-title":"Immunity."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1038\/ni.3508","article-title":"Autonomous membrane IgE signaling prevents IgE-memory formation","volume":"17","author":"Haniuda","year":"2016","journal-title":"Nat Immunol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2755","DOI":"10.1084\/jem.20131539","article-title":"The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response","volume":"210","author":"He","year":"2013","journal-title":"J Exp Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1111\/all.12911","article-title":"Ontogeny of human IgE-expressing B cells and plasma cells","volume":"72","author":"Ramadani","year":"2017","journal-title":"Allergy."},{"key":"B8","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/ni.2256","article-title":"IgE(+) memory B cells and plasma cells generated through a germinal-center pathway","volume":"13","author":"Talay","year":"2012","journal-title":"Nat Immunol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/j.immuni.2012.02.009","article-title":"Fluorescent in vivo detection reveals that IgE(+) B cells are restrained by an intrinsic cell fate predisposition","volume":"36","author":"Yang","year":"2012","journal-title":"Immunity."},{"key":"B10","doi-asserted-by":"publisher","first-page":"e21238","DOI":"10.7554\/eLife.21238","article-title":"Regulation of B cell fate by chronic activity of the IgE B cell receptor","volume":"5","author":"Yang","year":"2016","journal-title":"Elife."},{"key":"B11","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/j.immuni.2013.04.009","article-title":"Transcriptional regulation of germinal center B and plasma cell fates by dynamical control of IRF4","volume":"38","author":"Ochiai","year":"2013","journal-title":"Immunity."},{"key":"B12","doi-asserted-by":"crossref","first-page":"129","DOI":"10.4049\/jimmunol.148.1.129","article-title":"A new isoform of human membrane-bound IgE","volume":"148","author":"Peng","year":"1992","journal-title":"J Immunol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1084\/jem.176.1.233","article-title":"Two unusual forms of human immunoglobulin E encoded by alternative RNA splicing of epsilon heavy chain membrane exons","volume":"176","author":"Zhang","year":"1992","journal-title":"J Exp Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1111\/all.12679","article-title":"Intrinsic properties of germinal center-derived B cells promote their enhanced class switching to IgE","volume":"70","author":"Ramadani","year":"2015","journal-title":"Allergy."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1038\/nprot.2013.092","article-title":"Large-scale gene function analysis with the PANTHER classification system","volume":"8","author":"Mi","year":"2013","journal-title":"Nat Protoc."},{"key":"B16","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinformatics."},{"key":"B17","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/1752-0509-1-54","article-title":"Eigengene networks for studying the relationships between co-expression modules","volume":"1","author":"Langfelder","year":"2007","journal-title":"BMC Syst Biol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene expression omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.coi.2015.12.008","article-title":"Regulation of germinal center responses, memory B cells and plasma cell formation-an update","volume":"39","author":"Corcoran","year":"2016","journal-title":"Curr Opin Immunol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/nri3804","article-title":"Dynamics of B cells in germinal centres","volume":"15","author":"De Silva","year":"2015","journal-title":"Nat Rev Immunol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1038\/nri1572","article-title":"Regulation of plasma-cell development","volume":"5","author":"Shapiro-Shelef","year":"2005","journal-title":"Nat Rev Immunol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"5773","DOI":"10.4049\/jimmunol.1103720","article-title":"In vitro generation of long-lived human plasma cells","volume":"189","author":"Cocco","year":"2012","journal-title":"J Immunol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"5173","DOI":"10.1182\/blood-2009-07-235960","article-title":"An in vitro model of differentiation of memory B cells into plasmablasts and plasma cells including detailed phenotypic and molecular characterization","volume":"114","author":"Jourdan","year":"2009","journal-title":"Blood."},{"key":"B24","doi-asserted-by":"publisher","first-page":"2639","DOI":"10.1073\/pnas.0437996100","article-title":"Transcriptional analysis of the B cell germinal center reaction","volume":"100","author":"Klein","year":"2003","journal-title":"Proc Natl Acad Sci USA."},{"key":"B25","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1038\/ni.3154","article-title":"Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells","volume":"16","author":"Shi","year":"2015","journal-title":"Nat Immunol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/S0092-8674(01)00611-0","article-title":"XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor","volume":"107","author":"Yoshida","year":"2001","journal-title":"Cell."},{"key":"B27","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1146\/annurev.immunol.26.021607.090241","article-title":"Regulation and functions of Blimp-1 in T and B lymphocytes","volume":"26","author":"Martins","year":"2008","journal-title":"Annu Rev Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.immuni.2004.06.010","article-title":"XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation","volume":"21","author":"Shaffer","year":"2004","journal-title":"Immunity."},{"key":"B29","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1747-1028-7-10","article-title":"The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle","volume":"7","author":"Henley","year":"2012","journal-title":"Cell Div."},{"key":"B30","doi-asserted-by":"publisher","first-page":"3706","DOI":"10.1073\/pnas.96.7.3706","article-title":"GADD45 induction of a G2\/M cell cycle checkpoint","volume":"96","author":"Wang","year":"1999","journal-title":"Proc Natl Acad Sci USA."},{"key":"B31","doi-asserted-by":"publisher","first-page":"2892","DOI":"10.1038\/sj.onc.1202667","article-title":"Association with Cdc2 and inhibition of Cdc2\/Cyclin B1 kinase activity by the p53-regulated protein Gadd45","volume":"18","author":"Zhan","year":"1999","journal-title":"Oncogene."},{"key":"B32","doi-asserted-by":"publisher","first-page":"803","DOI":"10.3324\/haematol.10574","article-title":"TACI expression is associated with a mature bone marrow plasma cell signature and C-MAF overexpression in human myeloma cell lines","volume":"92","author":"Moreaux","year":"2007","journal-title":"Haematologica."},{"key":"B33","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1084\/jem.20031330","article-title":"BCMA is essential for the survival of long-lived bone marrow plasma cells","volume":"199","author":"O'Connor","year":"2004","journal-title":"J Exp Med."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.4049\/jimmunol.1600624","article-title":"Network analysis identifies proinflammatory plasma cell polarization for secretion of ISG15 in human autoimmunity","volume":"197","author":"Care","year":"2016","journal-title":"J Immunol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1016\/j.celrep.2015.01.023","article-title":"Self-restrained B cells arise following membrane IgE expression","volume":"10","author":"Laffleur","year":"2015","journal-title":"Cell Rep."},{"key":"B36","doi-asserted-by":"publisher","first-page":"161","DOI":"10.4110\/in.2015.15.3.161","article-title":"Early growth response-1 plays a non-redundant role in the differentiation of B cells into plasma cells","volume":"15","author":"Oh","year":"2015","journal-title":"Immune Netw."},{"key":"B37","doi-asserted-by":"publisher","first-page":"16484","DOI":"10.1073\/pnas.1417215111","article-title":"EGR2 is critical for peripheral naive T-cell differentiation and the T-cell response to influenza","volume":"111","author":"Du","year":"2014","journal-title":"Proc Natl Acad Sci USA."},{"key":"B38","doi-asserted-by":"publisher","first-page":"20455","DOI":"10.1074\/jbc.M114.634816","article-title":"Early growth response genes 2 and 3 regulate the expression of Bcl6 and differentiation of T follicular helper cells","volume":"290","author":"Ogbe","year":"2015","journal-title":"J Biol Chem."},{"key":"B39","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.ceb.2006.02.003","article-title":"The when and wheres of CDC25 phosphatases","volume":"18","author":"Boutros","year":"2006","journal-title":"Curr Opin Cell Biol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.bbagrm.2014.03.013","article-title":"Myc and cell cycle control","volume":"1849","author":"Bretones","year":"2015","journal-title":"Biochim Biophys Acta."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1158\/0008-5472.CAN-11-3992","article-title":"Ribosome biogenesis and control of cell proliferation: p53 is not alone","volume":"72","author":"Donati","year":"2012","journal-title":"Cancer Res."},{"key":"B42","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nrc1015","article-title":"Does the ribosome translate cancer?","volume":"3","author":"Ruggero","year":"2003","journal-title":"Nat Rev Cancer."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1126\/science.aau2599","article-title":"High-affinity allergen-specific human antibodies cloned from single IgE B cell transcriptomes","volume":"362","author":"Croote","year":"2018","journal-title":"Science."},{"key":"B44","doi-asserted-by":"publisher","first-page":"23629","DOI":"10.1074\/jbc.M114.569376","article-title":"Bcl-xL protein protects from C\/EBP homologous protein (CHOP)-dependent apoptosis during plasma cell differentiation","volume":"289","author":"Gaudette","year":"2014","journal-title":"J Biol Chem."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1126\/science.286.5445.1735","article-title":"Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity","volume":"286","author":"Bouillet","year":"1999","journal-title":"Science."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1038\/cdd.2015.8","article-title":"Combined loss of the BH3-only proteins Bim and Bmf restores B-cell development and function in TACI-Ig transgenic mice","volume":"22","author":"Woess","year":"2015","journal-title":"Cell Death Differ."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1182\/blood-2011-12-399808","article-title":"ASK1 promotes apoptosis of normal and malignant plasma cells","volume":"120","author":"Lin","year":"2012","journal-title":"Blood."},{"key":"B48","doi-asserted-by":"publisher","first-page":"22787","DOI":"10.1038\/srep22787","article-title":"FADD regulates NF-kappaB activation and promotes ubiquitination of cFLIPL to induce apoptosis","volume":"6","author":"Ranjan","year":"2016","journal-title":"Sci Rep."},{"key":"B49","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s12079-012-0166-2","article-title":"Apoptotic potential of Fas-associated death domain on regulation of cell death regulatory protein cFLIP and death receptor mediated apoptosis in HEK 293T cells","volume":"6","author":"Ranjan","year":"2012","journal-title":"J Cell Commun Signal."},{"key":"B50","doi-asserted-by":"publisher","first-page":"3655","DOI":"10.4049\/jimmunol.180.6.3655","article-title":"Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL","volume":"180","author":"Benson","year":"2008","journal-title":"J Immunol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"15401","DOI":"10.1073\/pnas.1200386109","article-title":"Deficiency in TNFRSF13B (TACI) expands T-follicular helper and germinal center B cells via increased ICOS-ligand expression but impairs plasma cell survival","volume":"109","author":"Ou","year":"2012","journal-title":"Proc Natl Acad Sci USA."},{"key":"B52","doi-asserted-by":"publisher","first-page":"3422","DOI":"10.1002\/1521-4141(200112)31:12<3422::AID-IMMU3422>3.0.CO;2-T","article-title":"Persistent IgE synthesis in the nasal mucosa of hay fever patients","volume":"31","author":"Smurthwaite","year":"2001","journal-title":"Eur J Immunol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.jaci.2009.06.047","article-title":"Induction of long-lived allergen-specific plasma cells by mucosal allergen challenge","volume":"124","author":"Luger","year":"2009","journal-title":"J Allergy Clin Immunol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1038\/nri1886","article-title":"Competence and competition: the challenge of becoming a long-lived plasma cell","volume":"6","author":"Radbruch","year":"2006","journal-title":"Nat Rev Immunol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/BF00863450","article-title":"Long-term immunosuppressive treatment of a child with Takayasu's arteritis and high IgE immunoglobulins","volume":"10","author":"Brunette","year":"1996","journal-title":"Pediatr Nephrol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1159\/000234834","article-title":"Kinetics of specific IgE antibody and total IgE responses in mice: the effect of immunosuppressive treatment","volume":"72","author":"Wyczolkowska","year":"1983","journal-title":"Int Arch Allergy Appl Immunol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/0008-8749(84)90330-7","article-title":"Long-lived IgE- and IgG-secreting cells in rodents manifesting persistent antibody responses","volume":"89","author":"Holt","year":"1984","journal-title":"Cell Immunol."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00402\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T11:04:54Z","timestamp":1694689494000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00402\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,11]]},"references-count":57,"alternative-id":["10.3389\/fimmu.2019.00402"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.00402","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,11]]},"article-number":"402"}}