{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:24:18Z","timestamp":1790630658533,"version":"4.1.0"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T00:00:00Z","timestamp":1554163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.00643","type":"journal-article","created":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T15:30:16Z","timestamp":1554219016000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Saccharomyces boulardii Strain CNCM I-745 Modifies the Mononuclear Phagocytes Response in the Small Intestine of Mice Following Salmonella Typhimurium Infection"],"prefix":"10.3389","volume":"10","author":[{"given":"Lidia","family":"Ib\u00e1\u00f1ez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolphe","family":"Pontier-Bres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Larbret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akila","family":"Rekima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Verhasselt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine","family":"Blin-Wakkach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Czerucka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,4,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.it.2011.06.003","article-title":"Intestinal CD103+ dendritic cells: master regulators of tolerance?","volume":"32","author":"Scott","year":"2011","journal-title":"Trends Immunol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/372190a0","article-title":"Adhesion between epithelial cells and T-lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin","volume":"372","author":"Cepek","year":"1994","journal-title":"Nature"},{"key":"B3","doi-asserted-by":"publisher","first-page":"803","DOI":"10.4049\/jimmunol.176.2.803","article-title":"CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes","volume":"176","author":"Jang","year":"2006","journal-title":"J Immunol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"3101","DOI":"10.1084\/jem.20091925","article-title":"Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions","volume":"206","author":"Schulz","year":"2009","journal-title":"J Exp Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.it.2013.02.001","article-title":"Intestinal macrophages: well educated exceptions from the rule","volume":"34","author":"Zigmond","year":"2013","journal-title":"Trends Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/mi.2012.89","article-title":"Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors","volume":"6","author":"Bain","year":"2013","journal-title":"Nature"},{"key":"B7","first-page":"5","article-title":"Fetal monocytes and the origins of tissue-resident macropahges","volume-title":"Cell Immunol.","author":"Hoeffel","year":"2018"},{"key":"B8","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1038\/ni.2967","article-title":"Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice","volume":"15","author":"Bain","year":"2014","journal-title":"Nat Immunol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1111\/j.1440-1746.1995.tb01589.x","article-title":"Direct evidence of monocyte recruitment to inflammatory bowel disease mucosa","volume":"10","author":"Grimm","year":"1995","journal-title":"J Gastroenterol Hepatol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"6843","DOI":"10.4049\/jimmunol.0903987","article-title":"An independent subset of TLR expressing CCR2-dependent macrophages promotes colonic inflammation","volume":"184","author":"Platt","year":"2010","journal-title":"J Immunol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/j.immuni.2009.06.025","article-title":"Intestinal lamina propria dendrtitic cell susets have different origin and functions","volume":"31","author":"Varol","year":"2009","journal-title":"Immunity"},{"key":"B12","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1126\/science.1102901","article-title":"CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance","volume":"307","author":"Niess","year":"2005","journal-title":"Science"},{"key":"B13","doi-asserted-by":"publisher","first-page":"2841","DOI":"10.1084\/jem.20061884","article-title":"Dynamic imaging of dendritic cell extension into small bowel lumen in response to epithelial cell TRL engagement","volume":"203","author":"Chieppa","year":"2006","journal-title":"J Exp Med"},{"key":"B14","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.immuni.2008.09.004","article-title":"Gr1(+) inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondii","volume":"29","author":"Dunay","year":"2008","journal-title":"Immunity"},{"key":"B15","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.immuni.2012.05.013","article-title":"Interleukin-15-dependent NKp46+ innate lymphoid cells control intestinal inflammation by recruiting inflammatory monocytes","volume":"37","author":"Schultess","year":"2012","journal-title":"Immunity"},{"key":"B16","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.immuni.2011.04.013","article-title":"The Nod2 sensor promotes intestinal pathogen eradication via the chemokine CCL2-dependent recruitment of inflammatory monocytes","volume":"34","author":"Kim","year":"2011","journal-title":"Immunity."},{"key":"B17","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.chom.2011.11.013","article-title":"Salmonella gut invasion involves TTSS-2-dependent epithelial traversal, basolateral exit and uptake by epithelium-sampling lamina propria phagocytes","volume":"11","author":"Muller","year":"2012","journal-title":"Cell Host Microbes"},{"key":"B18","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.imlet.2007.07.007","article-title":"Monocyte and dendritic cell recruitment and activation during oral Salmonella infection","volume":"112","author":"Wick","year":"2007","journal-title":"Immunol Let"},{"key":"B19","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.immuni.2009.08.010","article-title":"Origin of lamina propria dendritic cell network","volume":"31","author":"Bogunovic","year":"2009","journal-title":"Immunity"},{"key":"B20","doi-asserted-by":"publisher","first-page":"335","DOI":"10.4049\/jimmunol.1502559","article-title":"CX3CR1+ cell-mediated Salmonella exclusion protects the mucosa during the early stage of infection","volume":"198","author":"Man","year":"2017","journal-title":"J Immunol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"131","DOI":"10.4161\/gmic.1.3.11711","article-title":"CX3CR1 is critical for Salmonella-induced migration of dendritic cells into the intestinal lumen","volume":"1","author":"Nicoletti","year":"2010","journal-title":"Gut Microbes"},{"key":"B22","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/S1286-4579(02)01592-7","article-title":"Experimental effects of Saccharomyces boulardii on diarrheal pathogens","volume":"4","author":"Czerucka","year":"2002","journal-title":"Microbes Infect"},{"key":"B23","doi-asserted-by":"publisher","first-page":"e8925","DOI":"10.1371\/journal.pone.0008925","article-title":"Interaction of Saccharomyces boulardii with Salmonella enterica serovar Typhimurium protects mice and modifies T84 cell response to the infection","volume":"5","author":"Martins","year":"2010","journal-title":"PLoS ONE"},{"key":"B24","doi-asserted-by":"publisher","first-page":"e103069","DOI":"10.1371\/journal.pone.0103069","article-title":"Saccharomyces boulardii modifies Salmonella typhimurium traffic and host immune responses along the intestinal tract","volume":"9","author":"Pontier-Bres","year":"2014","journal-title":"PLoS ONE"},{"key":"B25","doi-asserted-by":"publisher","first-page":"S71","DOI":"10.1016\/S0399-8320(10)70011-7","article-title":"Saccharomyces boulardii modulates dendritic cell properties and intestinal microbiota disruption after antibiotic treatment","volume":"34","author":"Collignon","year":"2010","journal-title":"Gastroenterol Clin Biol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1111\/j.1365-2249.2009.03878.x","article-title":"Saccharomyces boulardii inhibits lipopolysaccharide induced activation of human dendritic cells and T cell proliferation","volume":"156","author":"Thomas","year":"2009","journal-title":"Clin Exp Immunol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"G1083","DOI":"10.1152\/ajpgi.00217.2011","article-title":"Anti-inflammatory effects of Saccharomyces boulardii mediated by myeloid dendritic cells from patients with Crohn's disease and ulcerative colitis","volume":"301","author":"Thomas","year":"2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0016-5085(94)94403-2","article-title":"Saccharomyces boulardii inhibits secretagogue-mediated adenosine 3'5'-cyclic monophosphate induction in intestinal cells","volume":"106","author":"Czerucka","year":"1994","journal-title":"Gastroenterology"},{"key":"B29","doi-asserted-by":"publisher","first-page":"2839","DOI":"10.1128\/IAI.71.5.2839-2858.2003","article-title":"Pretratment of mice with streptomycin provides a Salmonella enterica serovar Typhimurium colitis model that allows analysis of both pathogen and host","volume":"5","author":"Barthel","year":"2003","journal-title":"Infect Immun"},{"key":"B30","doi-asserted-by":"publisher","first-page":"e244","DOI":"10.1371\/journal.pbio.0050244","article-title":"Salmonella enterica serovar Typhimurium exploits inflammation to compete with the intestinal microbiota","volume":"5","author":"Stecher","year":"2007","journal-title":"PLoS Biol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1084\/jem.20110994","article-title":"Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow","volume":"209","author":"Mansour","year":"2012","journal-title":"J Exp Med"},{"key":"B32","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1111\/j.1365-2672.1996.tb04325.x","article-title":"Effect of Saccharomyces boulardii against experimental oral infection with Salmonella typhimurium and Shigella flexneri in conventional and gnotobiotic mice","volume":"81","author":"Rodrigues","year":"1996","journal-title":"J Appl Bacteriol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1111\/j.1365-2036.2007.03442.x","article-title":"Review article: yeast as probiotics-Saccharomyces boulardii","volume":"26","author":"Czerucka","year":"2007","journal-title":"Aliment Pharmacol Ther."},{"key":"B34","first-page":"305","article-title":"Saccharomyces boulardii CNCM I-745","volume-title":"Gut Microbiota-a Full Fledged Organ","author":"Joly","year":"2017"},{"key":"B35","doi-asserted-by":"publisher","first-page":"2202","DOI":"10.3748\/wjg.v16.i18.2202","article-title":"Systemic review and meta-analysis of Saccharomyces boulardii in adults","volume":"16","author":"McFarland","year":"2010","journal-title":"World J Gastroenterol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1084\/jem.20070633","article-title":"Microbe sampling by mucosal dendritic cells is a discrete, MyD88-independent step in DettainvG S. typhimurium colitis","volume":"205","author":"Hapfelmeier","year":"2008","journal-title":"J Exp Med"},{"key":"B37","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1084\/jem.128.3.415","article-title":"The origin and kinetics of mononuclear phagocytes","volume":"128","author":"Van Furth","year":"1968","journal-title":"J Exp Med"},{"key":"B38","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.immuni.2014.06.013","article-title":"Origin and functionns of tissue macrophages","volume":"41","author":"Epelman","year":"2014","journal-title":"Immunity"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1038\/nm.4430","article-title":"Barrier-tissues macrophages: functional adaptation to environmental challenge","volume":"11","author":"Mowat","year":"2017","journal-title":"Nat Med"},{"key":"B40","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/B978-0-12-394590-7.00003-8","article-title":"Monocyte-mediated immune defense against murine Listeria monocytogenesis","volume":"113","author":"Serbina","year":"2012","journal-title":"Adv Immunol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/ni1309","article-title":"Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2","volume":"7","author":"Serbina","year":"2006","journal-title":"Nat Immunol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1146\/annurev.immunol.26.021607.090326","article-title":"Monocyte-mediated defense against microbial pathogens","volume":"26","author":"Serbina","year":"2008","journal-title":"Annu Rev Immunol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/j.it.2017.07.009","article-title":"The multifaced personality of intestinal CX3CR1 macrophages","volume":"12","author":"Regoli","year":"2017","journal-title":"Trends Immunol"},{"key":"B44","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1128\/IAI.51.2.668-674.1986","article-title":"Evidence for macrophage-mediated protection against lethal Candida albicans infection","volume":"51","author":"Bistoni","year":"1986","journal-title":"Infect Immun"},{"key":"B45","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.micinf.2009.03.010","article-title":"Dectin-1 is required for human dendritic cells to initiate immune response to Candida albicans through Syk activation","volume":"11","author":"Skrzypek","year":"2009","journal-title":"Microbes Infect"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00643\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T10:15:23Z","timestamp":1607163323000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00643\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,2]]},"references-count":45,"alternative-id":["10.3389\/fimmu.2019.00643"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.00643","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,2]]},"article-number":"643"}}