{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T09:38:36Z","timestamp":1774431516944,"version":"3.50.1"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T00:00:00Z","timestamp":1554249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.00645","type":"journal-article","created":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T04:41:50Z","timestamp":1554266510000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Field Testing Integrated Interventions for Schistosomiasis Elimination in the People's Republic of China: Outcomes of a Multifactorial Cluster-Randomized Controlled Trial"],"prefix":"10.3389","volume":"10","author":[{"given":"Gail M.","family":"Williams","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue-Sheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darren J.","family":"Gray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng-Yuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald A.","family":"Harn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa M.","family":"Shollenberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng-Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinglin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeng","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Gang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Lan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Driguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Harvie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen G.","family":"Ross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald P.","family":"McManus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,4,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e1053","DOI":"10.1371\/journal.pntd.0001053","article-title":"Schistosomiasis research in the dongting lake region and its impact on local and national treatment and control in China","volume":"5","author":"McManus","year":"2011","journal-title":"PLoS Negl Trop Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1128\/CMR.00044-09","article-title":"Schistosomiasis in the People's Republic of China: the era of the three Gorges dam","volume":"23","author":"McManus","year":"2010","journal-title":"Clin Micro Rev."},{"key":"B3","doi-asserted-by":"publisher","first-page":"e2849","DOI":"10.1371\/journal.pntd.0002849","article-title":"Reduction patterns of acute schistosomiasis in the People's Republic of China","volume":"8","author":"Li","year":"2014","journal-title":"PLoS Negl Trop Dis."},{"key":"B4","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1186\/1756-3305-5-275","article-title":"Factors impacting on progress towards elimination of transmission of schistosomiasis japonica in China","volume":"5","author":"Zhou","year":"2012","journal-title":"Parasit Vectors."},{"key":"B5","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0065-308X(10)72006-6","article-title":"Schistosomiasis japonica: control and research needs","volume":"72","author":"Zhou","year":"2010","journal-title":"Adv Parasitol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/S1383-5769(99)00004-5","article-title":"Schistosomiasis control in China","volume":"48","author":"Minggang","year":"1999","journal-title":"Parasitol Int."},{"key":"B7","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.actatropica.2014.12.004","article-title":"Schistosomiasis transmission and control in China","volume":"143","author":"Zou","year":"2015","journal-title":"Acta Trop."},{"key":"B8","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s00436-014-4225-x","article-title":"Research and control of advanced schistosomiasis japonica in China","volume":"114","author":"Wu","year":"2015","journal-title":"Parasitol Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"611","DOI":"10.16250\/j.32.1374.2016246","article-title":"Endemic situation of schistosomiasis in the People's Republic of China in 2015","volume":"28","author":"Zhang","year":"2016","journal-title":"Chin J Schisto Control."},{"key":"B10","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s40249-017-0271-9","article-title":"Approaches being used in the national schistosomiasis elimination programme in China: a review","volume":"6","author":"Sun","year":"2017","journal-title":"Infect Dis Poverty."},{"key":"B11","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.actatropica.2013.08.017","article-title":"Potential schistosomiasis foci in China: a prospective study for schistosomiasis surveillance and response","volume":"141","author":"Qian","year":"2015","journal-title":"Acta Trop."},{"key":"B12","doi-asserted-by":"publisher","first-page":"e0005661","DOI":"10.1371\/journal.pntd.0005661","article-title":"Impact of the Three Gorges project on ecological environment changes and snail distribution in Dongting Lake area","volume":"11","author":"Li","year":"2017","journal-title":"PLoS Negl Trop Dis."},{"key":"B13","doi-asserted-by":"publisher","first-page":"e2123","DOI":"10.1371\/journal.pntd.0002123","article-title":"Transmission risks of schistosomiasis japonica: extraction from back-propagation artificial neural network and logistic regression model","volume":"7","author":"Xu","year":"2013","journal-title":"PLoS Negl Trop Dis."},{"key":"B14","first-page":"e1053","article-title":"Schistosomiasis research in the Dongting Lake region and its impact on local and national treatment and control in China","volume":"5","author":"McManus","year":"2011"},{"key":"B15","doi-asserted-by":"publisher","first-page":"54","DOI":"10.4269\/ajtmh.13-0467","article-title":"Schistosomiasis elimination strategies and potential role of a vaccine in achieving global health goals","volume":"90","author":"Mo","year":"2014","journal-title":"Am J Trop Med Hyg."},{"key":"B16","doi-asserted-by":"publisher","first-page":"e5900","DOI":"10.1371\/journal.pone.0005900","article-title":"A cluster-randomised intervention trial against Schistosoma japonicum in the peoples' republic of China: bovine and human transmission","volume":"4","author":"Gray","year":"2009","journal-title":"PLoS ONE."},{"key":"B17","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S0001-706X(02)00017-7","article-title":"Mathematical modelling of schistosomiasis japonica: comparison of control strategies in the People's Republic of China","volume":"82","author":"Williams","year":"2002","journal-title":"Acta Tropica."},{"key":"B18","doi-asserted-by":"publisher","first-page":"3617","DOI":"10.1016\/j.vaccine.2008.04.080","article-title":"DNA-based vaccines protect against zoonotic schistosomiasis in water buffalo","volume":"26","author":"Da'Dara","year":"2008","journal-title":"Vaccine."},{"key":"B19","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.ijpara.2014.05.005","article-title":"A multi-component integrated approach for the elimination of schistosomiasis in the People's Republic of China: design and baseline results of a 4-year cluster-randomised intervention trial","volume":"44","author":"Gray","year":"2014","journal-title":"Int J Parasitol."},{"key":"B20","first-page":"239","author":"Fisher","year":"1925","journal-title":"Statistical Methods for Research Workers."},{"key":"B21","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/j.ijpara.2012.06.002","article-title":"The insulin receptor is a transmission blocking veterinary vaccine target for zoonotic Schistosoma japonicum","volume":"42","author":"You","year":"2012","journal-title":"Int J Parasitol."},{"key":"B22","first-page":"408","author":"Keeling","year":"2008","journal-title":"Modeling Infectious Diseases in Humans and Animals."},{"key":"B23","doi-asserted-by":"publisher","first-page":"284","DOI":"10.3389\/fimmu.2019.00284","article-title":"Prime-boost vaccine regimen for SjTPI and SjC23 schistosome vaccines, increases efficacy in water buffalo in a field trial in China","volume":"10","author":"Li","year":"2019","journal-title":"Front Immunol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1289\/ehp.02110907","article-title":"Disease transmission models for public health decision making: toward an approach for designing intervention strategies for Schistosomiasis japonica","volume":"110","author":"Spear","year":"2002","journal-title":"Environ Health Perspect."},{"key":"B25","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/S0001-706X(02)00018-9","article-title":"A quantitative framework for a multi-group model of schistosomiasis japonicum transmission dynamics and control in Sichuan, China","volume":"82","author":"Liang","year":"2002","journal-title":"Acta Trop."},{"key":"B26","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1111\/j.1365-3156.2005.01386.x","article-title":"A multi-group model of Schistosoma japonicum transmission dynamics and control: model calibration and control prediction","volume":"10","author":"Liang","year":"2005","journal-title":"Trop Med Int Health."},{"key":"B27","doi-asserted-by":"publisher","first-page":"7110","DOI":"10.1073\/pnas.0701878104","article-title":"Environmental effects on parasitic disease transmission exemplified by schistosomiasis in western China","volume":"104","author":"Liang","year":"2007","journal-title":"Proc Natl Acad Sci USA."},{"key":"B28","doi-asserted-by":"publisher","first-page":"83","DOI":"10.4269\/ajtmh.2011.10-0574","article-title":"An integrated strategy for transmission control of Schistosoma japonicum in a marshland area of China: findings from a five-year longitudinal survey and mathematical modeling","volume":"85","author":"Zhou","year":"2011","journal-title":"Am J Trop Med Hyg."},{"key":"B29","author":"Zhou","year":"2018","journal-title":"Tropical Diseases in China: Schistosomiasis."},{"key":"B30","first-page":"18","author":"World Health","year":"2017","journal-title":"Regional Office for the Western Pacific. Expert Consultation to Accelerate Elimination of Asian Schistosomiasis, Shanghai, China, 22-23 May 2017:"},{"key":"B31","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/s41572-018-0013-8","article-title":"Schistosomiasis","volume":"4","author":"McManus","year":"2018","journal-title":"Nat Rev Dis Primers."},{"key":"B32","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3390\/tropicalmed3030081","article-title":"DNA diagnostics for schistosomiasis control","volume":"3","author":"Weerakoon","year":"2018","journal-title":"Trop Med Infect Dis."},{"key":"B33","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s40249-018-0390-y","article-title":"Real-time PCR diagnosis of Schistosoma japonicum in low transmission areas of China","volume":"7","author":"He","year":"2018","journal-title":"Infect Dis Poverty."},{"key":"B34","year":"2006","journal-title":"Preventive Chemotherapy in Human Helminthiasis: Coordinated Use of Anthelminthic Drugs in Control Interventions: A Manual for Health Professionals and Programme Managers"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00645\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T04:41:58Z","timestamp":1554266518000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00645\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,3]]},"references-count":34,"alternative-id":["10.3389\/fimmu.2019.00645"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.00645","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,3]]},"article-number":"645"}}