{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T13:54:51Z","timestamp":1782309291644,"version":"3.54.5"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T00:00:00Z","timestamp":1554336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-136808"],"award-info":[{"award-number":["MOP-136808"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN 418756-12"],"award-info":[{"award-number":["RGPIN 418756-12"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","award":["905-231134"],"award-info":[{"award-number":["905-231134"]}],"id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.00699","type":"journal-article","created":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T04:50:22Z","timestamp":1554353422000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["N-Linked Glycosylation Regulates CD22 Organization and Function"],"prefix":"10.3389","volume":"10","author":[{"given":"Laabiah","family":"Wasim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fathima Hifza Mohamed","family":"Buhari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myuran","family":"Yoganathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor","family":"Sicard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June","family":"Ere\u00f1o-Orbea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Julien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bebhinn","family":"Treanor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,4,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1146\/annurev.immunol.021908.132541","article-title":"B cell signaling and fate decision","volume":"28","author":"Kurosaki","year":"2010","journal-title":"Annu Rev Immunol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1038\/381751a0","article-title":"Clonal selection and learning in the antibody system","volume":"381","author":"Rajewsky","year":"1996","journal-title":"Nature"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1126\/science.1086907","article-title":"Predominant autoantibody production by early human B cell precursors","volume":"301","author":"Wardemann","year":"2003","journal-title":"Science"},{"key":"B4","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/nri.2017.24","article-title":"Altered B cell signalling in autoimmunity","volume":"17","author":"Rawlings","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"835","DOI":"10.3389\/fimmu.2018.00835","article-title":"Targeting B cells and plasma cells in autoimmune diseases","volume":"9","author":"Hofmann","year":"2018","journal-title":"Front Immunol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"3288","DOI":"10.1038\/s41467-018-05771-8","article-title":"Galectin-9 binds IgM-BCR to regulate B cell signaling","volume":"9","author":"Cao","year":"2018","journal-title":"Nat Commun."},{"key":"B7","doi-asserted-by":"publisher","first-page":"6416","DOI":"10.1074\/jbc.272.10.6416","article-title":"Molecular definition of a novel human galectin which is immunogenic in patients with Hodgkin's disease","volume":"272","author":"Tureci","year":"1997","journal-title":"J Biol Chem."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e17","DOI":"10.1017\/S1462399408000719","article-title":"Galectins: structure, function and therapeutic potential","volume":"10","author":"Yang","year":"2008","journal-title":"Expert Rev Mol Med"},{"key":"B9","doi-asserted-by":"crossref","first-page":"4715","DOI":"10.4049\/jimmunol.150.11.4715","article-title":"a B cell-specific receptor, mediates adhesion and signal transduction","volume":"150","author":"Clark","year":"1993","journal-title":"J Immunol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/S0960-9822(06)00057-1","article-title":"CD22 is a negative regulator of B-cell receptor signalling","volume":"7","author":"Nitschke","year":"1997","journal-title":"Curr Biol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"96","DOI":"10.3389\/fimmu.2011.00096","article-title":"Regulation of B cell functions by the sialic acid-binding receptors siglec-G and CD22","volume":"2","author":"Jellusova","year":"2011","journal-title":"Front Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1007\/s002510050584","article-title":"Polymorphisms in the Cd22 gene of inbred mouse strains","volume":"49","author":"Lajaunias","year":"1999","journal-title":"Immunogenetics."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2987","DOI":"10.4049\/jimmunol.165.6.2987","article-title":"Dysregulated expression of the Cd22 gene as a result of a short interspersed nucleotide element insertion in Cd22a lupus-prone mice","volume":"165","author":"Mary","year":"2000","journal-title":"J Immunol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1093\/intimm\/dxh349","article-title":"Expression of aberrant forms of CD22 on B lymphocytes in Cd22a lupus-prone mice affects ligand binding","volume":"18","author":"Nitschke","year":"2006","journal-title":"Int Immunol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/nchembio713","article-title":"Homomultimeric complexes of CD22 in B cells revealed by protein-glycan cross-linking","volume":"1","author":"Han","year":"2005","journal-title":"Nat Chem Biol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1038\/s41467-017-00836-6","article-title":"Molecular basis of human CD22 function and therapeutic targeting","volume":"8","author":"Ereno-Orbea","year":"2017","journal-title":"Nat Commun."},{"key":"B17","doi-asserted-by":"publisher","first-page":"7543","DOI":"10.1074\/jbc.270.13.7543","article-title":"Binding of human plasma sialoglycoproteins by the B cell-specific lectin CD22","volume":"270","author":"Hanasaki","year":"1995","journal-title":"J Biol Chem."},{"key":"B18","doi-asserted-by":"publisher","first-page":"3236","DOI":"10.1073\/pnas.90.8.3236","article-title":"CD22 associates with the human surface IgM-B-cell antigen receptor complex","volume":"90","author":"Leprince","year":"1993","journal-title":"Proc Natl Acad Sci USA."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1074\/mcp.M900461-MCP200","article-title":"In situ trans ligands of CD22 identified by glycan-protein photocross-linking-enabled proteomics","volume":"9","author":"Ramya","year":"2010","journal-title":"Mol Cell Proteomics."},{"key":"B20","doi-asserted-by":"publisher","first-page":"4026","DOI":"10.1073\/pnas.92.9.4026","article-title":"Regulation of CD45 engagement by the B-cell receptor CD22","volume":"92","author":"Sgroi","year":"1995","journal-title":"Proc Natl Acad Sci USA."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1016\/0092-8674(91)90036-X","article-title":"The B lymphocyte adhesion molecule CD22 interacts with leukocyte common antigen CD45RO on T cells and alpha 2\u20136 sialyltransferase, CD75, on B cells","volume":"66","author":"Stamenkovic","year":"1991","journal-title":"Cell."},{"key":"B22","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1093\/glycob\/cwh126","article-title":"Cell surface sialic acids do not affect primary CD22 interactions with CD45 and surface IgM nor the rate of constitutive CD22 endocytosis","volume":"14","author":"Zhang","year":"2004","journal-title":"Glycobiology."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1002\/eji.1830230626","article-title":"Association of CD22 with the B cell antigen receptor","volume":"23","author":"Peaker","year":"1993","journal-title":"Eur J Immunol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"12402","DOI":"10.1073\/pnas.1304888110","article-title":"CD22 ligand-binding and signaling domains reciprocally regulate B-cell Ca2+ signaling","volume":"110","author":"Muller","year":"2013","journal-title":"Proc Natl Acad Sci USA."},{"key":"B25","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.immuni.2009.12.005","article-title":"The membrane skeleton controls diffusion dynamics and signaling through the B cell receptor","volume":"32","author":"Treanor","year":"2010","journal-title":"Immunity."},{"key":"B26","doi-asserted-by":"publisher","first-page":"2389","DOI":"10.1093\/bioinformatics\/btu202","article-title":"ThunderSTORM: a comprehensive ImageJ plug-in for PALM and STORM data analysis and super-resolution imaging","volume":"30","author":"Ovesny","year":"2014","journal-title":"Bioinformatics."},{"key":"B27","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.sbi.2014.08.008","article-title":"Quantitative analysis of single-molecule superresolution images","volume":"28","author":"Coltharp","year":"2014","journal-title":"Curr Opin Struct Biol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00418-011-0880-5","article-title":"Coordinate-based colocalization analysis of single-molecule localization microscopy data","volume":"137","author":"Malkusch","year":"2012","journal-title":"Histochem Cell Biol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"258","DOI":"10.15252\/embj.201593027","article-title":"Nanoscale organization and dynamics of the siglec CD22 cooperate with the cytoskeleton in restraining BCR signalling","volume":"35","author":"Gasparrini","year":"2016","journal-title":"EMBO J."},{"key":"B30","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1111\/j.1538-4632.2004.tb01127.x","article-title":"Constructing the spatial weights matrix using a local statistic","volume":"36","author":"Getis","year":"2004","journal-title":"Geograph Anal."},{"key":"B31","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1111\/j.1538-4632.1992.tb00261.x","article-title":"The analysis of spatial association by use of distance statistics","volume":"24","author":"Getis","year":"1992","journal-title":"Geograph Analy"},{"key":"B32","first-page":"226","article-title":"A density-based algorithm for discovering clusters in large spatial databases with noise","volume":"96","author":"Ester","year":"1996","journal-title":"KDD Proc"},{"key":"B33","doi-asserted-by":"publisher","first-page":"44315","DOI":"10.1074\/jbc.M105446200","article-title":"CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1","volume":"276","author":"Otipoby","year":"2001","journal-title":"J Biol Chem."},{"key":"B34","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S1074-7613(00)80094-1","article-title":"Modulation of B lymphocyte antigen receptor signal transduction by a CD19\/CD22 regulatory loop","volume":"11","author":"Fujimoto","year":"1999","journal-title":"Immunity."},{"key":"B35","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1083\/jcb.201504137","article-title":"Dynamics of the actin cytoskeleton mediates receptor cross talk: An emerging concept in tuning receptor signaling","volume":"212","author":"Mattila","year":"2016","journal-title":"J Cell Biol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1038\/s41590-018-0162-7","article-title":"TCRs are randomly distributed on the plasma membrane of resting antigen-experienced T cells","volume":"19","author":"Rossboth","year":"2018","journal-title":"Nat Immunol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"4995","DOI":"10.1242\/jcs.146340","article-title":"Nanoclustering as a dominant feature of plasma membrane organization","volume":"127","author":"Garcia-Parajo","year":"2014","journal-title":"J Cell Sci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1093\/intimm\/dxg042","article-title":"Class I HLA oligomerization at the surface of B cells is controlled by exogenous beta(2)-microglobulin: implications in activation of cytotoxic T lymphocytes","volume":"15","author":"Bodnar","year":"2003","journal-title":"Int Immunol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"6673","DOI":"10.4049\/jimmunol.176.11.6673","article-title":"Clustering class I MHC modulates sensitivity of T cell recognition","volume":"176","author":"Fooksman","year":"2006","journal-title":"J Immunol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.immuni.2012.11.019","article-title":"The actin and tetraspanin networks organize receptor nanoclusters to regulate B cell receptor-mediated signaling","volume":"38","author":"Mattila","year":"2013","journal-title":"Immunity."},{"key":"B41","doi-asserted-by":"publisher","first-page":"4872","DOI":"10.1016\/j.febslet.2010.09.045","article-title":"The dissociation activation model of B cell antigen receptor triggering","volume":"584","author":"Yang","year":"2010","journal-title":"FEBS Lett."},{"key":"B42","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/j.bbrc.2007.06.110","article-title":"Synthetic glycan ligand excludes CD22 from antigen receptor-containing lipid rafts","volume":"360","author":"Yu","year":"2007","journal-title":"Biochem Biophys Res Commun."},{"key":"B43","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/ni1283","article-title":"Ablation of CD22 in ligand-deficient mice restores B cell receptor signaling","volume":"7","author":"Collins","year":"2006","journal-title":"Nat Immunol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"4504","DOI":"10.1073\/pnas.95.8.4504","article-title":"Immune regulation by the ST6Gal sialyltransferase","volume":"95","author":"Hennet","year":"1998","journal-title":"Proc Natl Acad Sci USA."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00699\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T10:45:54Z","timestamp":1694774754000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00699\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,4]]},"references-count":44,"alternative-id":["10.3389\/fimmu.2019.00699"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.00699","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,4]]},"article-number":"699"}}