{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T17:49:49Z","timestamp":1792259389736,"version":"4.4.0"},"reference-count":74,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T00:00:00Z","timestamp":1555372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DE 016306"],"award-info":[{"award-number":["DE 016306"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DE 017968"],"award-info":[{"award-number":["DE 017968"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DE 021172"],"award-info":[{"award-number":["DE 021172"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.00728","type":"journal-article","created":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T04:58:28Z","timestamp":1555390708000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":133,"title":["Aggregatibacter actinomycetemcomitans (Aa) Under the Radar: Myths and Misunderstandings of Aa and Its Role in Aggressive Periodontitis"],"prefix":"10.3389","volume":"10","author":[{"given":"Daniel H.","family":"Fine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amey G.","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senthil K.","family":"Velusamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,4,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1600-0722.1976.tb00454.x","article-title":"The predominant cultivable organisms in juvenile periodontitis","volume":"84","author":"Slots","year":"1976","journal-title":"Scand J Dent Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1902\/jop.1976.47.7.373","article-title":"Studies of the microbiology of periodontosis","volume":"47","author":"Newman","year":"1976","journal-title":"J Periodontol."},{"key":"B3","first-page":"191","article-title":"Untersuchungen uber,enschliche aktinomykose","volume":"1912","author":"Klinger","year":"1912","journal-title":"Centralblat Bacteriol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1093\/clinids\/11.1.46","article-title":"Infection due to Actinobacillus actinomycetemcomitans: 15 cases and review","volume":"11","author":"Kaplan","year":"1989","journal-title":"Rev Infect Dis"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1600-051X.1985.tb01348.x","article-title":"Actinobacillus actinomycetemcomitans in human periodontal disease","volume":"12","author":"Zambon","year":"1985","journal-title":"J Clin Periodontol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2850","DOI":"10.1128\/JCM.00729-13","article-title":"A consortium of Aggregatibacter actinomycetemcomitans, Streptococcus parasanguinis, and Filifactor alocis is present in sites prior to bone loss in a longitudinal study of localized aggressive periodontitis","volume":"51","author":"Fine","year":"2013","journal-title":"J Clin Microbiol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"3859","DOI":"10.1128\/JCM.00653-07","article-title":"Aggregatibacter actinomycetemcomitans and its relationship to initiation of localized aggressive periodontitis: longitudinal cohort study of initially healthy adolescents","volume":"45","author":"Fine","year":"2007","journal-title":"J Clin Microbiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1111\/j.1600-0757.1999.tb00161.x","article-title":"Virulence factors of Actinobacillus actinomycetemcomitans","volume":"20","author":"Fives-Taylor","year":"1999","journal-title":"Periodontol 2000."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.13188\/2377-987X.1000005","article-title":"Colonization and persistence of labeled and \u201cforeign\u201d strains of inoculated into the mouths of rhesus monkeys","volume":"2","author":"Fine","year":"2015","journal-title":"J Oral Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1016\/0003-9969(67)90190-2","article-title":"Microbial population shifts in developing human plaque","volume":"12","author":"Ritz","year":"1967","journal-title":"Archs Oral Biol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1111\/j.1600-0757.1994.tb00018.x","article-title":"The structure of dental plaque","volume":"5","author":"Listgarten","year":"1994","journal-title":"Periodontol 2000."},{"key":"B12","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1177\/00220345870660052401","article-title":"Bacteriology of human gingivitis","volume":"66","author":"Moore","year":"1987","journal-title":"J Dent Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1099\/13500872-145-6-1335","article-title":"Phenotypic variation in Actinobacillus actinomycetemcomitans during laboratory growth: implications for virulence","volume":"145","author":"Fine","year":"1999","journal-title":"Microbiology."},{"key":"B14","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1128\/IAI.57.10.3194-3203.1989","article-title":"Coaggregation of Fusobacterium nucleatum, Selenomonas flueggei, Selenomonas infelix, Selenomonas noxia, and Selenomonas sputigena with strains from 11 genera of oral bacteria","volume":"57","author":"Kolenbrander","year":"1989","journal-title":"Infect Immun."},{"key":"B15","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/j.1600-0757.2006.00187.x","article-title":"Bacterial interactions and successions during plaque development","volume":"42","author":"Kolenbrander","year":"2006","journal-title":"Periodontol 2000."},{"key":"B16","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1038\/nrmicro2381","article-title":"Oral multispecies biofilm development and the key role of cell-cell distance","volume":"8","author":"Kolenbrander","year":"2010","journal-title":"Nat Rev Microbiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1111\/j.1399-302X.1988.tb00082.x","article-title":"Actinobacillus actinomycetemcomitans fimbriae","volume":"3","author":"Rosan","year":"1988","journal-title":"Oral Microbiol Immunol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.1073\/pnas.051436598","article-title":"Phylogeny of genes for secretion of NTPases: identification of the widespread tadA subfamily and development of a diagnostic key for gene classification","volume":"98","author":"Planet","year":"2001","journal-title":"Proc Natl Acad Sci USA."},{"key":"B19","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/ng1154","article-title":"The widespread colonization island of Actnobacillus actinomycetemcomitans","volume":"34","author":"Planet","year":"2003","journal-title":"Nat Genet."},{"key":"B20","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1128\/IAI.67.6.2901-2908.1999","article-title":"Identification of rough-colony-specific outer membrane proteins in Actinobacillus actinomycetemcomitans","volume":"67","author":"Haase","year":"1999","journal-title":"Infect Immun."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1099\/ijs.0.64207-0","article-title":"Reclassification of Actinobacillus actinomycetemcomitans, Haemophilus paraphrophilus and Heamophilus segnis as Aggregatibacter actinomycetemcomitans gen. nov., comb. nov., Aggregatibacter aphrophilus comb. nov. and Aggregatibacter segnis comb. nov., and emended description of Aggregatibacter aphrophilus to include V factor-dependent and V factor-independent isolates","volume":"56","author":"Norskov-Lauritsen","year":"2006","journal-title":"Int J Syst Evol Microbiol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/S0966-842X(01)02161-8","article-title":"Genes for tight adherence of Actinobacillus actinomycetemcomitans: from plaque to plague to pond scum","volume":"9","author":"Kachlany","year":"2001","journal-title":"Trends Microbiol."},{"key":"B23","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1128\/JCM.38.3.1196-1199.2000","article-title":"Acquisition and colonization stability of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in children","volume":"38","author":"Lamell","year":"2000","journal-title":"J Clin Microbiol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1177\/002203450208100112","article-title":"The microbiota of young children from tooth and tongue samples","volume":"81","author":"Tanner","year":"2002","journal-title":"J Dent Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1111\/j.1399-302X.1996.tb00200.x","article-title":"Likelihood of transmitting Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in families with periodontitis","volume":"11","author":"Asikainen","year":"1996","journal-title":"Oral Microbiol Immunol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"2384","DOI":"10.1128\/IAI.71.5.2384-2393.2003","article-title":"Aae, an autotransporter involved in adhesion of actinobaciillus actinomyctemcomitans to epithelial cells","volume":"71","author":"Rose","year":"2003","journal-title":"Infect Immun."},{"key":"B27","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1111\/j.1600-0757.2006.00189.x","article-title":"How we got attached to Actinobacillus actinomycetemcomitans: a model for infectious diseases","volume":"42","author":"Fine","year":"2006","journal-title":"Periodontol 2000."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1128\/IAI.73.4.1947-1953.2005","article-title":"The Actinobacillus actinomycetemcomitans autotransporter adhesin Aae exhibits specificity for buccal epithelial cells from humans and old world primates","volume":"73","author":"Fine","year":"2005","journal-title":"Infect Immun."},{"key":"B29","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/j.1600-051X.2005.00805.x","article-title":"Transmission of periodontal bacteria and models of infection","volume":"32","author":"Van Winkelhoff","year":"2005","journal-title":"J Clin Periodontal."},{"key":"B30","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1128\/CMR.17.3.581-611.2004","article-title":"Phase and antigenic variation in bacteria","volume":"17","author":"van der Woude","year":"2004","journal-title":"Clin Microbiol Rev."},{"key":"B31","doi-asserted-by":"publisher","first-page":"7295","DOI":"10.1073\/pnas.1237223100","article-title":"Tight-adherence genes of Actinobacillus actinomycetemcomitans are required for virulence in a rat model","volume":"100","author":"Schreiner","year":"2003","journal-title":"Proc Natl Acad Sci USA."},{"key":"B32","doi-asserted-by":"publisher","first-page":"4464","DOI":"10.1128\/JCM.00964-10","article-title":"Aggregatibacter actinomycetemcomitans as an early colonizer of oral tissues: epithelium as a reservoir?","volume":"48","author":"Fine","year":"2010","journal-title":"J Clin Microbiol"},{"key":"B33","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1128\/IAI.14.4.1022-1027.1976","article-title":"Initial colonization of teeth in monkeys as related to diet","volume":"14","author":"Kilian","year":"1976","journal-title":"Infect Immun."},{"key":"B34","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1128\/JCM.15.4.606-609.1982","article-title":"elective medium for isolation of Actinobacillus actinomycetems","volume":"15","author":"Slots","year":"1982","journal-title":"J Clin Microbiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"6407","DOI":"10.1128\/JB.00554-07","article-title":"A novel exclusion mechanism for carbon resource partitioning in Aggregatibacter actinomycetemcomitans","volume":"189","author":"Brown","year":"2007","journal-title":"J Bacteriol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"e7864","DOI":"10.1371\/journal.pone.0007864","article-title":"Characterization of the L-lactate dehydrogenase from Aggregatibacter actinomycetemcomitans","volume":"4","author":"Brown","year":"2009","journal-title":"PLoS ONE."},{"key":"B37","doi-asserted-by":"publisher","first-page":"7819","DOI":"10.1073\/pnas.1400586111","article-title":"Bacterial fight-and-flight responses enhance virulence in a polymicrobial infection","volume":"111","author":"Stacy","year":"2014","journal-title":"Proc Natl Acad Sci USA."},{"key":"B38","doi-asserted-by":"publisher","first-page":"e1002012","DOI":"10.1371\/journal.ppat.1002012","article-title":"Metabolite cross-feeding enhances virulence in a model polymicrobial infection","volume":"7","author":"Ramsey","year":"2011","journal-title":"PLoS Pathog."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.12688\/f1000research.9050.1","article-title":"CoNet app: inference of biological association networks using Cytoscape","volume":"5","author":"Faust","year":"2016","journal-title":"F1000Res"},{"key":"B40","volume-title":"Lactate and Leukotoxin Promote Colonization of Aggregatibacter in Rhesus Monkeys.","author":"Fine","year":"2018"},{"key":"B41","first-page":"1","article-title":"Fine structure of the developing epithelial attachment to teeth","volume":"2","author":"Schroeder","year":"1971","journal-title":"Monogr Dev Biol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1111\/j.1600-0757.1997.tb00097.x","article-title":"The gingival tissues: the architecture of periodontal protection. Periodontol 2000","volume":"13","author":"Schroeder","year":"1997"},{"key":"B43","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1146\/annurev.immunol.20.083001.084359","article-title":"Innate immune recognition","volume":"20","author":"Janeway","year":"2002","journal-title":"Ann Rev Immunol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1111\/prd.12222","article-title":"The periodontal war: microbes and immunity","volume":"75","author":"Ebersole","year":"2017","journal-title":"Periodontol 2000"},{"key":"B45","first-page":"235","article-title":"Pathogenesis of inflammatory periodontal disease. A summary of current work","volume":"34","author":"Page","year":"1976","journal-title":"Lab Invest."},{"key":"B46","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.jmb.2005.03.082","article-title":"Structural analysis of dispersin B, a biofilm-releasing glycoside hydrolase from the periodontopathogen Actinobacillus actinomycetemcomitans","volume":"349","author":"Ramasubbu","year":"2005","journal-title":"J Mol Biol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1128\/JB.185.4.1399-1404.2003","article-title":"Biofilm growth and detachment of Actinobacillus actinomycetemcomitans","volume":"185","author":"Kaplan","year":"2003","journal-title":"J Bacteriol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1177\/0022034509359403","article-title":"Biofilm dispersal: mechanisms, clinical implications and potential therapeutic uses","volume":"89","author":"Kaplan","year":"2010","journal-title":"J Dent Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"4693","DOI":"10.1128\/JB.185.16.4693-4698.2003","article-title":"Detachment of Actinobacillus actinomycetemcomitans biofilm cells by an endogenous \u03b2-hexosaminidase activity","volume":"185","author":"Kaplan","year":"2003","journal-title":"J Bacteriol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/nrmicro.2015.8","article-title":"The biogeography of polymicrobial infection","volume":"14","author":"Stacy","year":"2016","journal-title":"Nat Rev Microbiol."},{"key":"B51","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1128\/JCM.34.6.1576-1578.1996","article-title":"Highly toxic clone of Actinobacillus actinomycetemcomitans in geographically widespread cases of juvenile periodontitis in adolescents of African origin","volume":"34","author":"Haubek","year":"1996","journal-title":"J Clin Microbiol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1177\/2380084417695543","article-title":"Aggregatibacter actinomycetemcomitans in African Americans with localized aggressive periodontitis","volume":"2","author":"Burgess","year":"2017","journal-title":"JDR Clin Trans Res."},{"key":"B53","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1177\/0022034512456039","article-title":"Microbiological characterization in children with aggressive periodontitis","volume":"91","author":"Shaddox","year":"2012","journal-title":"J Dent Res"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1111\/jcpe.12463","article-title":"Oral microbiome in chinese patients with aggressive periodontitis and their family members","volume":"42","author":"Li","year":"2015","journal-title":"J Clin Periodontol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1111\/j.1600-0765.1978.tb00188.x","article-title":"Interaction of inflammatory cells and oral microorganisms. V. Electron microscopic and biochemical study on the mechanisms of release of lysosomal constituents from human polymorphonuclear leukocytes exposed to dental plaque","volume":"13","author":"Baehni","year":"1978","journal-title":"J Periodontal Res."},{"key":"B56","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1128\/IAI.25.1.427-439.1979","article-title":"Extraction and partial characterization of a leukotoxin from a plaque-derived Gram-negative microorganism","volume":"25","author":"Tsai","year":"1979","journal-title":"Infect Immun."},{"key":"B57","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1128\/IAI.16.3.1013-1023.1977","article-title":"Interaction of inflammatory cells and oral microorganisms. IV. In vitro release of lysosomal constituents from polymorphonuclear leukocytes exposed to supragingival and subgingival bacterial plaque","volume":"16","author":"Taichman","year":"1977","journal-title":"Infect Immun."},{"key":"B58","doi-asserted-by":"crossref","first-page":"15451","DOI":"10.1016\/S0021-9258(19)84850-0","article-title":"Analysis of the Actinobacillus actinomycetemcomitans leukotoxin gene","volume":"264","author":"Lally","year":"1989","journal-title":"J Biol Chem."},{"key":"B59","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1128\/IAI.57.5.1465-1469.1989","article-title":"Cloning and expression of the leukotoxin gene from Actinobacillus actinomycetemcomitans","volume":"57","author":"Koldrubetz","year":"1989","journal-title":"Infect Immun."},{"key":"B60","doi-asserted-by":"publisher","first-page":"6094","DOI":"10.1128\/IAI.68.11.6094-6100.2000","article-title":"Secretion of RTX leukotoxin by Actinobacillus actinomycetemcomitans","volume":"68","author":"Kachlany","year":"2000","journal-title":"Infect Immun."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1038\/s41598-017-01692-6","article-title":"Increased leukotoxin production: Characterization of 100 base pairs within the 530 base pair leukotoxin promoter region of Aggregatibacter actinomycetemcomitans","volume":"7","author":"Sampathkumar","year":"2017","journal-title":"Sci Rep."},{"key":"B62","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1128\/IAI.67.2.942-945.1999","article-title":"Cloning of the gene encoding the Actinobacillus actinomycetemcomitans serotype b OmpA-like outer membrane protein","volume":"67","author":"Komatsuzawa","year":"1999","journal-title":"Infect Immun."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1046\/j.1365-2958.2003.03748.x","article-title":"Outer membrane protein 100, a versatile virulence factor of Actinobacillus actinomycetemcomitans","volume":"50","author":"Asakawa","year":"2003","journal-title":"Mol Microbiol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"S103","DOI":"10.1002\/JPER.16-0712","article-title":"Classification and diagnosis of aggressive periodontitis","volume":"89","author":"Fine","year":"2018","journal-title":"J Periodontol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/S0140-6736(08)60135-X","article-title":"Risk of aggressive periodontitis in adolescent carriers of the JP2 clone of Aggregatibacter (Actinobacillus) actinomycetemcomitans in Morocco: a prospective longitudinal cohort study","volume":"371","author":"Haubek","year":"2008","journal-title":"Lancet."},{"key":"B66","doi-asserted-by":"publisher","first-page":"3153","DOI":"10.1021\/acs.jproteome.8b00263","article-title":"Interaction of inflammatory cells and oral microorganisms. V. Electron microscopic and biochemical study on the mechanisms of release of lysosomal constituents from human polymorphonuclear leukocytes exposed to dental plaque","volume":"17","author":"Bostanci","year":"2018","journal-title":"J Proteome Res."},{"key":"B67","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1128\/AEM.00797-17","article-title":"Defining genetic fitness determinants and creating genomic resources for an oral pathogen","volume":"83","author":"Narayanan","year":"2017","journal-title":"Appl Environ Microbiol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1902\/jop.1986.57.11.703","article-title":"Neutrophil function in localized juvenile periodontitis. Phagocytosis, superoxide production and specific granule release","volume":"57","author":"Van Dyke","year":"1986","journal-title":"J Periodontol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1902\/jop.2002.73.6.624","article-title":"Lactoferrin iron levels are reduced in saliva of patients with localized aggressive periodontitis","volume":"73","author":"Fine","year":"2002","journal-title":"J Periodontol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1902\/jop.2003.74.1.66","article-title":"Neutrophil-mediated tissue injury in periodontal disease pathogenesis: findings from localized aggressive periodontitis","volume":"74","author":"Kantarci","year":"2003","journal-title":"J Periodontol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1177\/0022034515577413","article-title":"Lactoferrin: a roadmap to the borderland between caries and periodontal disease","volume":"94","author":"Fine","year":"2015","journal-title":"J Dent Res."},{"key":"B72","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1902\/jop.2002.73.6.616","article-title":"Lactoferrin iron levels affect attachment of Actinobacillus actinomycetemcomitans to buccal epithelial cells","volume":"73","author":"Fine","year":"2002","journal-title":"J Periodontol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"e24422","DOI":"10.1371\/journal.pone.0024422","article-title":"Impaired phagocytosis in localized aggressive periodontitis: rescue by Resolvin E1","volume":"6","author":"Fredman","year":"2011","journal-title":"PLoS ONE."},{"key":"B74","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/nrmicro2873","article-title":"The keystone-pathogen hypothesis","volume":"10","author":"Hajishengallis","year":"2012","journal-title":"Nat Rev Microbiol."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00728\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T01:19:21Z","timestamp":1663291161000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00728\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,16]]},"references-count":74,"alternative-id":["10.3389\/fimmu.2019.00728"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.00728","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,16]]},"article-number":"728"}}