{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:29:47Z","timestamp":1792020587820,"version":"4.4.0"},"reference-count":99,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T00:00:00Z","timestamp":1555027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.00809","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T00:40:30Z","timestamp":1555029630000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Response Modifiers: Tweaking the Immune Response Against Influenza A Virus"],"prefix":"10.3389","volume":"10","author":[{"given":"Husni","family":"Elbahesh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Gerlach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulietta","family":"Saletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guus F.","family":"Rimmelzwaan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,4,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.3390\/v4091438","article-title":"Evasion of influenza A viruses from innate and adaptive immune responses","volume":"4","author":"van de Sandt","year":"2012","journal-title":"Viruses"},{"key":"B2","doi-asserted-by":"publisher","first-page":"320","DOI":"10.3389\/fimmu.2018.00320","article-title":"Host immune response to influenza A virus infection","volume":"9","author":"Chen","year":"2018","journal-title":"Front Immunol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1111\/j.1600-065X.2008.00737.x","article-title":"Innate immunity to virus infection","volume":"227","author":"Takeuchi","year":"2009","journal-title":"Immunol Rev"},{"key":"B4","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.immuni.2010.03.012","article-title":"Intracellular toll-like receptors","volume":"32","author":"Blasius","year":"2010","journal-title":"Immunity"},{"key":"B5","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.it.2010.11.004","article-title":"Inflammasomes as mediators of immunity against influenza virus","volume":"32","author":"Pang","year":"2011","journal-title":"Trends Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s00441-010-1043-z","article-title":"Respiratory epithelial cells in innate immunity to influenza virus infection","volume":"343","author":"Sanders","year":"2011","journal-title":"Cell Tissue Res"},{"key":"B7","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.coviro.2012.02.013","article-title":"Pathogenesis of influenza virus infections: the good, the bad and the ugly","volume":"2","author":"Kuiken","year":"2012","journal-title":"Curr Opin Virol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S1473-3099(13)70286-X","article-title":"Pathogenesis of influenza-induced acute respiratory distress syndrome","volume":"14","author":"Short","year":"2014","journal-title":"Lancet Infect Dis"},{"key":"B9","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1097\/QCO.0000000000000113","article-title":"Developments in the treatment of severe influenza: lessons from the pandemic of 2009 and new prospects for therapy","volume":"27","author":"Zambon","year":"2014","journal-title":"Curr Opin Infect Dis"},{"key":"B10","doi-asserted-by":"publisher","first-page":"2667","DOI":"10.1056\/NEJMoa054512","article-title":"Brief report - Oseltamivir resistance during treatment of influenza A (H5N1) infection","volume":"353","author":"de Jong","year":"2005","journal-title":"N Engl J Med"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1093\/infdis\/jis509","article-title":"Determinants of antiviral effectiveness in influenza virus A subtype H5N1","volume":"206","author":"Chan","year":"2012","journal-title":"J Infect Dis"},{"key":"B12","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1016\/S0140-6736(13)61125-3","article-title":"Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance","volume":"381","author":"Hu","year":"2013","journal-title":"Lancet"},{"key":"B13","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.ebiom.2016.02.021","article-title":"Safety and upper respiratory pharmacokinetics of the hemagglutinin stalk-binding antibody VIS410 support treatment and prophylaxis based on population modeling of seasonal influenza A outbreaks","volume":"5","author":"Wollacott","year":"2016","journal-title":"EBioMedicine"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofx163.1352","article-title":"A phase 2a study to evaluate the safety of MEDI8852 in outpatient adults with acute, uncomplicated influenza, A.","volume":"4","author":"Ali","year":"2017","journal-title":"Open Forum Infect Dis"},{"key":"B15","doi-asserted-by":"publisher","first-page":"e01154","DOI":"10.1128\/AAC.01154-17","article-title":"Phase 2 randomized trial of the safety and efficacy of MHAA4549A, a broadly neutralizing monoclonal antibody, in a human influenza A virus challenge model","volume":"61","author":"McBride","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"B16","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.celrep.2015.01.011","article-title":"Angiopoietin-like 4 increases pulmonary tissue leakiness and damage during influenza pneumonia","volume":"10","author":"Li","year":"2015","journal-title":"Cell Rep"},{"key":"B17","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1093\/cid\/ciu887","article-title":"Treatment with anti-C5a antibody improves the outcome of H7N9 virus infection in African green monkeys","volume":"60","author":"Sun","year":"2015","journal-title":"Clin Infect Dis"},{"key":"B18","doi-asserted-by":"publisher","first-page":"4918","DOI":"10.4049\/jimmunol.181.7.4918","article-title":"CD8 T cells utilize TRAIL to control influenza virus infection","volume":"181","author":"Brincks","year":"2008","journal-title":"J Immunol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"3065","DOI":"10.1084\/jem.20080201","article-title":"Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand","volume":"205","author":"Herold","year":"2008","journal-title":"J Exp Med"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2566","DOI":"10.1002\/1521-4141(200109)31:9<2566::AID-IMMU2566>3.0.CO;2-L","article-title":"Inhibition of tumor necrosis factor reduces the severity of virus-specific lung immunopathology","volume":"31","author":"Hussell","year":"2001","journal-title":"Eur J Immunol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"e25333","DOI":"10.1371\/journal.pone.0025333","article-title":"Antiviral activity and increased host defense against influenza infection elicited by the human cathelicidin LL-37","volume":"6","author":"Barlow","year":"2011","journal-title":"PLoS ONE"},{"key":"B22","doi-asserted-by":"publisher","first-page":"4875","DOI":"10.1038\/s41598-017-04777-4","article-title":"Inhibition of highly pathogenic avian influenza (HPAI) virus by a peptide derived from vFLIP through its direct destabilization of viruses","volume":"7","author":"Moon","year":"2017","journal-title":"Sci Rep"},{"key":"B23","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1515\/hsz-2011-0270","article-title":"Small molecule inhibitors of the c-Jun N-terminal kinase (JNK) possess antiviral activity against highly pathogenic avian and human pandemic influenza A viruses","volume":"393","author":"Nacken","year":"2012","journal-title":"Biol Chem"},{"key":"B24","doi-asserted-by":"publisher","first-page":"2479","DOI":"10.1016\/j.bbadis.2014.04.017","article-title":"Regulatory roles of c-jun in H5N1 influenza virus replication and host inflammation","volume":"1842","author":"Xie","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"B25","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1074\/jbc.M113.469239","article-title":"Inhibition of p38 mitogen-activated protein kinase impairs influenza virus-induced primary and secondary host gene responses and protects mice from lethal H5N1 infection","volume":"289","author":"Borgeling","year":"2014","journal-title":"J Biol Chem"},{"key":"B26","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.antiviral.2017.03.024","article-title":"The MEK-inhibitor CI-1040 displays a broad anti-influenza virus activity in vitro and provides a prolonged treatment window compared to standard of care in vivo","volume":"142","author":"Haasbach","year":"2017","journal-title":"Antiviral Res"},{"key":"B27","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.antiviral.2013.06.008","article-title":"The NF-kappaB inhibitor SC75741 protects mice against highly pathogenic avian influenza A virus","volume":"99","author":"Haasbach","year":"2013","journal-title":"Antiviral Res"},{"key":"B28","doi-asserted-by":"publisher","first-page":"3679","DOI":"10.1038\/s41467-018-06119-y","article-title":"Phosphoproteomic-based kinase profiling early in influenza virus infection identifies GRK2 as antiviral drug target","volume":"9","author":"Yanguez","year":"2018","journal-title":"Nat Commun"},{"key":"B29","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.antiviral.2018.08.010","article-title":"Transient inhibition of sphingosine kinases confers protection to influenza A virus infected mice","volume":"158","author":"Xia","year":"2018","journal-title":"Antiviral Res"},{"key":"B30","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1172\/JCI61667","article-title":"PAR1 contributes to influenza A virus pathogenicity in mice","volume":"123","author":"Khoufache","year":"2013","journal-title":"J Clin Invest"},{"key":"B31","doi-asserted-by":"publisher","first-page":"2965","DOI":"10.1128\/AAC.00219-07","article-title":"Increased survival after gemfibrozil treatment of severe mouse influenza","volume":"51","author":"Budd","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"B32","doi-asserted-by":"publisher","first-page":"5306","DOI":"10.1073\/pnas.0900655106","article-title":"TNF\/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection.","volume":"106","author":"Aldridge","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"B33","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1111\/j.1750-2659.2010.00155.x","article-title":"Peroxisome proliferator-activated receptor and AMP-activated protein kinase agonists protect against lethal influenza virus challenge in mice","volume":"4","author":"Moseley","year":"2010","journal-title":"Influenza Other Respir Viruses"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.3389\/fimmu.2018.01946","article-title":"Treating influenza infection, from now and into the future","volume":"9","author":"Davidson","year":"2018","journal-title":"Front Immunol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"32999","DOI":"10.1074\/jbc.M110.108175","article-title":"Angiopoietin-like 4 interacts with matrix proteins to modulate wound healing","volume":"285","author":"Goh","year":"2010","journal-title":"J Biol Chem"},{"key":"B36","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s00011-013-0678-0","article-title":"Role of Angptl4 in vascular permeability and inflammation","volume":"63","author":"Guo","year":"2014","journal-title":"Inflamm Res"},{"key":"B37","doi-asserted-by":"publisher","first-page":"e1000115","DOI":"10.1371\/journal.ppat.1000115","article-title":"H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice","volume":"4","author":"Perrone","year":"2008","journal-title":"PLoS Pathog"},{"key":"B38","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.ajpath.2011.03.013","article-title":"Excessive neutrophils and neutrophil extracellular traps contribute to acute lung injury of influenza pneumonitis","volume":"179","author":"Narasaraju","year":"2011","journal-title":"Am J Pathol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1038\/cdd.2009.96","article-title":"Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps","volume":"16","author":"Yousefi","year":"2009","journal-title":"Cell Death Differ"},{"key":"B40","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/S1359-6101(00)00026-5","article-title":"Molecular pathogenesis of influenza A virus infection and virus-induced regulation of cytokine gene expression","volume":"12","author":"Julkunen","year":"2001","journal-title":"Cytokine Growth Factor Rev"},{"key":"B41","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.bbrc.2013.10.100","article-title":"Relevance of signaling molecules for apoptosis induction on influenza A virus replication","volume":"441","author":"Iwai","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"B42","doi-asserted-by":"publisher","first-page":"2736","DOI":"10.1128\/JVI.02336-06","article-title":"Role of host cytokine responses in the pathogenesis of avian H5N1 influenza viruses in mice","volume":"81","author":"Szretter","year":"2007","journal-title":"J Virol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.it.2009.09.004","article-title":"Innate immune responses to influenza A H5N1: friend or foe?","volume":"30","author":"Peiris","year":"2009","journal-title":"Trends Immunol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1007\/s00281-017-0636-y","article-title":"New fronts emerge in the influenza cytokine storm","volume":"39","author":"Guo","year":"2017","journal-title":"Semin Immunopathol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3390\/ph9030053","article-title":"The role of antimicrobial peptides in influenza virus infection and their potential as antiviral and immunomodulatory therapy","volume":"9","author":"Hsieh","year":"2016","journal-title":"Pharmaceuticals"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.4155\/fmc.12.94","article-title":"Therapeutic peptides","volume":"4","author":"Albericio","year":"2012","journal-title":"Future Med Chem"},{"key":"B47","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1189\/jlb.0403147","article-title":"Cathelicidins, multifunctional peptides of the innate immunity","volume":"75","author":"Zanetti","year":"2004","journal-title":"J Leukoc Biol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1038\/ncb1980","article-title":"FLIP-mediated autophagy regulation in cell death control","volume":"11","author":"Lee","year":"2009","journal-title":"Nat Cell Biol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"4650","DOI":"10.1021\/bi00068a024","article-title":"The tyrosine kinase inhibitor tyrphostin blocks the cellular actions of nerve growth factor","volume":"32","author":"Ohmichi","year":"1993","journal-title":"Biochemistry"},{"key":"B50","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1128\/JVI.77.1.460-469.2003","article-title":"Role of protein kinase C betaII in influenza virus entry via late endosomes","volume":"77","author":"Sieczkarski","year":"2003","journal-title":"J Virol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.2217\/fvl.11.90","article-title":"From virus entry to release: the diverse functions of PI3K during RNA virus infections","volume":"6","author":"Ehrhardt","year":"2011","journal-title":"Future Virol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1111\/j.1462-5822.2010.01556.x","article-title":"Influenza A virus-induced early activation of ERK and PI3K mediates V-ATPase-dependent intracellular pH change required for fusion","volume":"13","author":"Marjuki","year":"2011","journal-title":"Cell Microbiol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.antiviral.2013.04.008","article-title":"Development of cellular signaling pathway inhibitors as new antivirals against influenza","volume":"98","author":"Planz","year":"2013","journal-title":"Antiviral Res"},{"key":"B54","doi-asserted-by":"publisher","first-page":"6714","DOI":"10.1128\/JVI.00530-14","article-title":"Novel roles of focal adhesion kinase in cytoplasmic entry and replication of influenza A viruses","volume":"88","author":"Elbahesh","year":"2014","journal-title":"J Virol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.bbrc.2016.06.111","article-title":"A novel p38 mitogen activated protein kinase (MAPK) specific inhibitor suppresses respiratory syncytial virus and influenza A virus replication by inhibiting virus-induced p38 MAPK activation","volume":"477","author":"Choi","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"B56","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.virol.2016.10.002","article-title":"Focal adhesion kinase (FAK) regulates polymerase activity of multiple influenza A virus subtypes","volume":"499","author":"Elbahesh","year":"2016","journal-title":"Virology"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.virol.2018.09.020","article-title":"Role of c-Jun terminal kinase (JNK) activation in influenza A virus-induced autophagy and replication","volume":"526","author":"Zhang","year":"2018","journal-title":"Virology"},{"key":"B58","doi-asserted-by":"publisher","first-page":"171","DOI":"10.3390\/v11020171","article-title":"Influenza virus infections and cellular kinases","volume":"11","author":"Meineke","year":"2019","journal-title":"Viruses"},{"key":"B59","doi-asserted-by":"publisher","first-page":"11359","DOI":"10.1128\/JVI.00804-10","article-title":"Toll-like receptor 4-mediated activation of p38 mitogen-activated protein kinase is a determinant of respiratory virus entry and tropism","volume":"84","author":"Marchant","year":"2010","journal-title":"J Virol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.antiviral.2011.08.002","article-title":"Antiviral activity of the MEK-inhibitor U0126 against pandemic H1N1v and highly pathogenic avian influenza virus in vitro and in vivo","volume":"92","author":"Droebner","year":"2011","journal-title":"Antiviral Res"},{"key":"B61","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.antiviral.2013.03.006","article-title":"Combination of MEK inhibitors and oseltamivir leads to synergistic antiviral effects after influenza A virus infection in vitro","volume":"98","author":"Haasbach","year":"2013","journal-title":"Antiviral Res"},{"key":"B62","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/S1074-7613(00)80146-6","article-title":"JNK2 and IKKbeta are required for activating the innate response to viral infection","volume":"11","author":"Chu","year":"1999","journal-title":"Immunity"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1111\/cmi.12005","article-title":"Influenza A virus-encoded NS1 virulence factor protein inhibits innate immune response by targeting IKK.","volume":"14","author":"Gao","year":"2012","journal-title":"Cell Microbiol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"5858","DOI":"10.1016\/j.bmcl.2007.08.022","article-title":"A novel class of potent NF-kappaB signaling inhibitors","volume":"17","author":"Leban","year":"2007","journal-title":"Bioorg Med Chem Lett"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1111\/cmi.12108","article-title":"The NF-kappaB inhibitor SC75741 efficiently blocks influenza virus propagation and confers a high barrier for development of viral resistance","volume":"15","author":"Ehrhardt","year":"2013","journal-title":"Cell Microbiol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1089\/ars.2014.5876","article-title":"GRK2 in the heart: a GPCR kinase and beyond","volume":"21","author":"Huang","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"B67","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.tibs.2010.08.001","article-title":"Regulation of sphingosine kinase and sphingolipid signaling","volume":"36","author":"Pitson","year":"2011","journal-title":"Trends Biochem Sci"},{"key":"B68","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1016\/j.bbamem.2006.08.007","article-title":"Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases","volume":"1758","author":"Hait","year":"2006","journal-title":"Biochimica et Biophysica Acta (BBA) Biomembranes"},{"key":"B69","doi-asserted-by":"publisher","first-page":"e75005","DOI":"10.1371\/journal.pone.0075005","article-title":"Sphingosine kinase 1 serves as a pro-viral factor by regulating viral RNA synthesis and nuclear export of viral ribonucleoprotein complex upon influenza virus infection","volume":"8","author":"Seo","year":"2013","journal-title":"PLoS ONE"},{"key":"B70","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1172\/JCI17564","article-title":"PARticipation in inflammation","volume":"111","author":"Coughlin","year":"2003","journal-title":"J Clin Invest"},{"key":"B71","doi-asserted-by":"publisher","first-page":"L388","DOI":"10.1152\/ajplung.00286.2003","article-title":"Altered expression and in vivo lung function of protease-activated receptors during influenza A virus infection in mice","volume":"286","author":"Lan","year":"2004","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"B72","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1086\/505116","article-title":"Pandemic influenza: a potential role for statins in treatment and prophylaxis","volume":"43","author":"Fedson","year":"2006","journal-title":"Clin Infect Dis"},{"key":"B73","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.antiviral.2013.06.018","article-title":"Treating influenza with statins and other immunomodulatory agents","volume":"99","author":"Fedson","year":"2013","journal-title":"Antiviral Res"},{"key":"B74","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.1126\/science.309.5743.1976a","article-title":"Infectious disease. Old drugs losing effectiveness against flu; could statins fill gap?","volume":"309","author":"Enserink","year":"2005","journal-title":"Science"},{"key":"B75","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1378\/chest.06-1997","article-title":"Influenza and COPD mortality protection as pleiotropic, dose-dependent effects of statins","volume":"131","author":"Frost","year":"2007","journal-title":"Chest"},{"key":"B76","first-page":"409","article-title":"[Experience in the management of the severe form of human influenza A H1N1 pneumonia in an intensive care unit]","volume":"79","author":"Carrillo-Esper","year":"2011","journal-title":"Cir Cir"},{"key":"B77","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1093\/infdis\/jir695","article-title":"Association between use of statins and mortality among patients hospitalized with laboratory-confirmed influenza virus infections: a multistate study","volume":"205","author":"Vandermeer","year":"2012","journal-title":"J Infect Dis"},{"key":"B78","doi-asserted-by":"publisher","first-page":"e8087","DOI":"10.1371\/journal.pone.0008087","article-title":"Influenza morbidity and mortality in elderly patients receiving statins: a cohort study","volume":"4","author":"Kwong","year":"2009","journal-title":"PLoS ONE"},{"key":"B79","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1017\/S0950268810000105","article-title":"An assessment of the effect of statin use on the incidence of acute respiratory infections in England during winters 1998-1999 to 2005-2006","volume":"138","author":"Fleming","year":"2010","journal-title":"Epidemiol Infect"},{"key":"B80","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1038\/nature07151","article-title":"Drosophila RNAi screen identifies host genes important for influenza virus replication","volume":"454","author":"Hao","year":"2008","journal-title":"Nature"},{"key":"B81","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1016\/j.cell.2009.12.017","article-title":"The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus","volume":"139","author":"Brass","year":"2009","journal-title":"Cell"},{"key":"B82","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1016\/j.cell.2009.12.018","article-title":"A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection","volume":"139","author":"Shapira","year":"2009","journal-title":"Cell"},{"key":"B83","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.virol.2009.02.046","article-title":"The use of Random Homozygous Gene Perturbation to identify novel host-oriented targets for influenza","volume":"387","author":"Sui","year":"2009","journal-title":"Virology"},{"key":"B84","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1038\/nature08760","article-title":"Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication","volume":"463","author":"Karlas","year":"2010","journal-title":"Nature"},{"key":"B85","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1038\/nature08699","article-title":"Human host factors required for influenza virus replication","volume":"463","author":"Konig","year":"2010","journal-title":"Nature"},{"key":"B86","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/82_2014_409","article-title":"Antiviral effects of inhibiting host gene expression","volume":"386","author":"Tripp","year":"2015","journal-title":"Curr Top Microbiol Immunol"},{"key":"B87","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.coviro.2015.08.008","article-title":"Influenza virus-host interactomes as a basis for antiviral drug development","volume":"14","author":"Watanabe","year":"2015","journal-title":"Curr Opin Virol"},{"key":"B88","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.celrep.2018.03.045","article-title":"Genome-wide CRISPR\/Cas9 screen identifies host factors essential for influenza virus replication","volume":"23","author":"Han","year":"2018","journal-title":"Cell Rep"},{"key":"B89","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/j.drudis.2019.01.018","article-title":"Repurposing host-based therapeutics to control coronavirus and influenza virus","volume":"24","author":"Li","year":"2019","journal-title":"Drug Discov Today"},{"key":"B90","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3389\/fimmu.2019.00060","article-title":"Repurposing of drugs as novel influenza inhibitors from clinical gene expression infection signatures","volume":"10","author":"Pizzorno","year":"2019","journal-title":"Front Immunol"},{"key":"B91","doi-asserted-by":"publisher","first-page":"13876","DOI":"10.1038\/ncomms13876","article-title":"Comparative influenza protein interactomes identify the role of plakophilin 2 in virus restriction","volume":"8","author":"Wang","year":"2017","journal-title":"Nat Commun"},{"key":"B92","doi-asserted-by":"publisher","first-page":"e02002","DOI":"10.1128\/mBio.02002-18","article-title":"Network-guided discovery of influenza virus replication host factors","volume":"9","author":"Ackerman","year":"2018","journal-title":"MBio"},{"key":"B93","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.chom.2010.05.008","article-title":"Cellular networks involved in the influenza virus life cycle","volume":"7","author":"Watanabe","year":"2010","journal-title":"Cell Host Microbe"},{"key":"B94","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1039\/c2mb05416g","article-title":"Genetic screens for the control of influenza virus replication: from meta-analysis to drug discovery","volume":"8","author":"de Chassey","year":"2012","journal-title":"Mol Biosyst"},{"key":"B95","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/j.chom.2015.11.002","article-title":"Meta- and orthogonal integration of influenza \u201cOMICs\u201d data defines a role for UBR4 in virus budding","volume":"18","author":"Tripathi","year":"2015","journal-title":"Cell Host Microbe"},{"key":"B96","doi-asserted-by":"publisher","first-page":"4581","DOI":"10.4049\/jimmunol.1002241","article-title":"The magnitude of the T cell response to a clinically significant dose of influenza virus is regulated by TRAIL.","volume":"187","author":"Brincks","year":"2011","journal-title":"J Immunol"},{"key":"B97","doi-asserted-by":"publisher","first-page":"3864","DOI":"10.1038\/ncomms4864","article-title":"Pathogenic potential of interferon alphabeta in acute influenza infection","volume":"5","author":"Davidson","year":"2014","journal-title":"Nat Commun"},{"key":"B98","doi-asserted-by":"publisher","first-page":"e742","DOI":"10.1038\/cddis.2013.267","article-title":"Anticancer compound ABT-263 accelerates apoptosis in virus-infected cells and imbalances cytokine production and lowers survival rates of infected mice","volume":"4","author":"Kakkola","year":"2013","journal-title":"Cell Death Dis"},{"key":"B99","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3390\/v9100271","article-title":"Antiviral properties of chemical inhibitors of cellular anti-apoptotic Bcl-2 proteins","volume":"9","author":"Bulanova","year":"2017","journal-title":"Viruses"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00809\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T00:40:32Z","timestamp":1555029632000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00809\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,12]]},"references-count":99,"alternative-id":["10.3389\/fimmu.2019.00809"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.00809","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,12]]},"article-number":"809"}}