{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:40:05Z","timestamp":1790620805270,"version":"4.1.0"},"reference-count":170,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T00:00:00Z","timestamp":1555545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371744"],"award-info":[{"award-number":["81371744"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773333"],"award-info":[{"award-number":["81773333"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.00856","type":"journal-article","created":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T00:35:35Z","timestamp":1555547735000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":145,"title":["The Emerging Epigenetic Role of CD8+T Cells in Autoimmune Diseases: A Systematic Review"],"prefix":"10.3389","volume":"10","author":[{"given":"Qiancheng","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,4,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1038\/nrendo.2013.161","article-title":"Clinical implications of shared genetics and pathogenesis in autoimmune diseases","volume":"9","author":"Zhernakova","year":"2013","journal-title":"Nat Rev Endocrinol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.jaut.2009.03.007","article-title":"The genetics and epigenetics of autoimmune diseases","volume":"33","author":"Hewagama","year":"2009","journal-title":"J Autoimm."},{"key":"B3","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.biopha.2016.12.072","article-title":"Epigenetic modifications and epigenetic based medication implementations of autoimmune diseases","volume":"87","author":"Ahmadi","year":"2017","journal-title":"Biomed Pharmacother."},{"key":"B4","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1586\/eci.11.88","article-title":"Etiology of autoimmune disease: past, present and future","volume":"8","author":"Alzabin","year":"2012","journal-title":"Expert Rev Clin Immu."},{"key":"B5","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.jaut.2013.06.004","article-title":"Promotion and prevention of autoimmune disease by CD8+T cells","volume":"45","author":"Gravano","year":"2013","journal-title":"J Autoimm."},{"key":"B6","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1002\/ana.21744","article-title":"Pathogenic CD8(+) T cells in multiple sclerosis","volume":"66","author":"Friese","year":"2009","journal-title":"Ann Neurol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"849573","DOI":"10.1155\/2015\/849573","article-title":"Epigenetic control of interferon-gamma expression in CD8 T Cells","volume":"2015","author":"de","year":"2015","journal-title":"J Immunol Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1038\/ni.3688","article-title":"Early transcriptional and epigenetic regulation of CD8(+) T cell differentiation revealed by single-cell RNA sequencing","volume":"18","author":"Kakaradov","year":"2017","journal-title":"Nat Immunol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.autrev.2015.05.008","article-title":"Epigenetics in autoimmune diseases: pathogenesis and prospects for therapy","volume":"14","author":"Zhang","year":"2015","journal-title":"Autoimmun Rev."},{"key":"B10","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/cmi.2010.78","article-title":"The epigenetics of autoimmunity","volume":"8","author":"Meda","year":"2011","journal-title":"Cell Mol Immunol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.clim.2014.12.013","article-title":"Epigenetic control of autoimmune diseases: From bench to bedside","volume":"157","author":"Picascia","year":"2015","journal-title":"Clin Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.molmed.2011.07.005","article-title":"Epigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseases","volume":"17","author":"Hedrich","year":"2011","journal-title":"Trends Mol Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.autrev.2012.07.011","article-title":"Potential roles for CD8(+) T cells in rheumatoid arthritis","volume":"12","author":"Carvalheiro","year":"2013","journal-title":"Autoimmun Rev."},{"key":"B14","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.immuni.2011.07.010","article-title":"CD8(+) T cells: foot soldiers of the immune system","volume":"35","author":"Zhang","year":"2011","journal-title":"Immunity."},{"key":"B15","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.immuni.2006.07.001","article-title":"Inflaming the CD8(+) T cell response","volume":"25","author":"Haring","year":"2006","journal-title":"Immunity."},{"key":"B16","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.immuni.2007.04.013","article-title":"Initial T cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8(+) T cell response to infection","volume":"26","author":"Badovinac","year":"2007","journal-title":"Immunity."},{"key":"B17","doi-asserted-by":"publisher","first-page":"5538","DOI":"10.4049\/jimmunol.168.11.5538","article-title":"Differentiation of human CD8(+) T cells from a memory to memory\/effector phenotype","volume":"168","author":"Tomiyama","year":"2002","journal-title":"J Immunol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"S71","DOI":"10.1016\/j.jhep.2016.01.026","article-title":"Adaptive immunity in HBV infection","volume":"64","author":"Bertoletti","year":"2016","journal-title":"J Hepatol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.virol.2010.05.004","article-title":"IFNgamma-producing, virus-specific CD8+ effector cells acquire the ability to produce IL-10 as a result of entry into the infected lung environment","volume":"404","author":"Palmer","year":"2010","journal-title":"Virology."},{"key":"B20","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1159\/000249333","article-title":"Infantile seborrheic dermatitis","volume":"172","author":"Oranje","year":"1986","journal-title":"Dermatologica."},{"key":"B21","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/s41467-018-02865-1","article-title":"Activated CD8(+) T cell extracellular vesicles prevent tumour progression by targeting of lesional mesenchymal cells","volume":"9","author":"Seo","year":"2018","journal-title":"Nat Commun."},{"key":"B22","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1016\/j.immuni.2014.11.012","article-title":"Granzyme B promotes cytotoxic lymphocyte transmigration via basement membrane remodeling","volume":"41","author":"Prakash","year":"2014","journal-title":"Immunity."},{"key":"B23","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1159\/000339429","article-title":"Role of the MicroRNA-17-92 cluster in the endothelial differentiation of stem cells","volume":"49","author":"Treguer","year":"2012","journal-title":"J Vasc Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.trim.2011.08.009","article-title":"FOXP3(+) regulatory T cells: From suppression of rejection to induction of renal allograft tolerance","volume":"26","author":"Dummer","year":"2012","journal-title":"Transpl Immunol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1038\/cmi.2015.57","article-title":"Analysis of CD8+ Treg cells in patients with ovarian cancer: a possible mechanism for immune impairment","volume":"12","author":"Zhang","year":"2015","journal-title":"Cell Mol Immunol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1158\/2326-6066.CIR-13-0121","article-title":"Disruption of CD8(+) treg activity results in expansion of T follicular helper cells and enhanced antitumor immunity","volume":"2","author":"Arias","year":"2014","journal-title":"Cancer Immunol Res."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1097\/TP.0000000000002258","article-title":"Advances on CD8+ treg cells and their potential in transplantation","volume":"102","author":"Bezie","year":"2018","journal-title":"Transplantation."},{"key":"B28","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1002\/eji.201343583","article-title":"CD8(+) Treg cells suppress CD8(+) T cell-responses by IL-10-dependent mechanism during H5N1 influenza virus infection","volume":"44","author":"Zou","year":"2014","journal-title":"Eur J Immunol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"21089","DOI":"10.1073\/pnas.1320999110","article-title":"Genetic disruption of CD8(+) Treg activity enhances the immune response to viral infection","volume":"110","author":"Holderried","year":"2013","journal-title":"Proc Natl Acad Sci USA."},{"key":"B30","doi-asserted-by":"publisher","first-page":"6947","DOI":"10.1158\/1078-0432.CCR-07-0842","article-title":"CD8(+) Foxp3(+) regulatory T cells mediate immunosuppression in prostate cancer","volume":"13","author":"Kiniwa","year":"2007","journal-title":"Clin Cancer Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1093\/intimm\/dxw025","article-title":"Roles of regulatory T cells in cancer immunity","volume":"28","author":"Takeuchi","year":"2016","journal-title":"Int Immunol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.it.2011.01.004","article-title":"Cytokines and the inception of CD8 T cell responses","volume":"32","author":"Cox","year":"2011","journal-title":"Trends Immunol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1038\/ni1268","article-title":"Effector and memory CD8(+) T cell fate coupled by T-bet and eomesodermin","volume":"6","author":"Intlekofer","year":"2005","journal-title":"Nat Immunol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1126\/science.1090148","article-title":"Control of effector CD8(+) T cell function by the transcription factor Eomesodermin","volume":"302","author":"Pearce","year":"2003","journal-title":"Science."},{"key":"B35","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.it.2017.04.002","article-title":"Mechanisms and dynamics of T cell-mediated cytotoxicity in vivo","volume":"38","author":"Halle","year":"2017","journal-title":"Trends Immunol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1016\/j.immuni.2016.10.018","article-title":"The chemokine receptor CX3CR1 defines three antigen-experienced CD8 T cell subsets with distinct roles in immune surveillance and homeostasis","volume":"45","author":"Gerlach","year":"2016","journal-title":"Immunity."},{"key":"B37","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/nature11098","article-title":"Generalized Levy walks and the role of chemokines in migration of effector CD8(+) T cells","volume":"486","author":"Harris","year":"2012","journal-title":"Nature."},{"key":"B38","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.immuni.2015.12.022","article-title":"Central nervous system stromal cells control local CD8(+) T cell responses during virus-induced neuroinflammation","volume":"44","author":"Cupovic","year":"2016","journal-title":"Immunity."},{"key":"B39","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.jaci.2016.10.013","article-title":"Oxidative stress drives CD8(+) T-cell skin trafficking in patients with vitiligo through CXCL16 upregulation by activating the unfolded protein response in keratinocytes","volume":"140","author":"Li","year":"2017","journal-title":"J Allergy Clin Immun."},{"key":"B40","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1159\/000457944","article-title":"Epigenetic alterations in cellular immunity: new insights into autoimmune diseases","volume":"41","author":"Wang","year":"2017","journal-title":"Cell Physiol Biochem."},{"key":"B41","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1002\/jcb.20447","article-title":"Physical and functional interactions between the human DNMT3L protein and members of the de novo methyltransferase family","volume":"95","author":"Chen","year":"2005","journal-title":"J Cell Biochem."},{"key":"B42","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.bbrc.2009.04.023","article-title":"CpG island methylation pattern in different human tissues and its correlation with gene expression","volume":"383","author":"Fan","year":"2009","journal-title":"Biochem Bioph Res Co."},{"key":"B43","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1186\/ar3484","article-title":"The role of epigenetic variation in the pathogenesis of systemic lupus erythematosus","volume":"13","author":"Hughes","year":"2011","journal-title":"Arthritis Res Ther."},{"key":"B44","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S1521-6616(03)00205-5","article-title":"Methylation and demethylation in the regulation of genes, cells, and responses in the immune system","volume":"109","author":"Fitzpatrick","year":"2003","journal-title":"Clin Immunol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"10","DOI":"10.2302\/kjm.60.10","article-title":"Epigenetics and autoimmunity, with special emphasis on methylation","volume":"60","author":"Renaudineau","year":"2011","journal-title":"Keio J Med."},{"key":"B46","doi-asserted-by":"publisher","first-page":"35791","DOI":"10.1074\/jbc.C200408200","article-title":"Promoter-specific activation and demethylation by MBD2\/demethylase","volume":"277","author":"Detich","year":"2002","journal-title":"J Biol Chem."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/bies.201600178","article-title":"DNA demethylation pathways: additional players and regulators","volume":"39","author":"Bochtler","year":"2017","journal-title":"Bioessays."},{"key":"B48","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1038\/onc.2015.122","article-title":"Hepatitis B virus X protein induces EpCAM expression via active DNA demethylation directed by RelA in complex with EZH2 and TET2","volume":"35","author":"Fan","year":"2016","journal-title":"Oncogene."},{"key":"B49","doi-asserted-by":"publisher","first-page":"8764384","DOI":"10.1155\/2018\/8764384","article-title":"Methylation-demethylation dynamics: implications of changes in acute kidney injury","volume":"2018","author":"Chakraborty","year":"2018","journal-title":"Anal Cell Pathol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1002\/dmrr.2375","article-title":"Epigenetics in autoimmune diseases with focus on type 1 diabetes","volume":"29","author":"Dang","year":"2013","journal-title":"Diabetes-Metab Res."},{"key":"B51","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1007\/s12016-009-8173-7","article-title":"Epigenetic histone code and autoimmunity","volume":"39","author":"Dieker","year":"2010","journal-title":"Clin Rev Allerg Immu."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/08916934.2015.1086996","article-title":"Epigenetics changes associated to environmental triggers in autoimmunity","volume":"49","author":"Canas","year":"2016","journal-title":"Autoimmunity."},{"key":"B53","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","article-title":"Chromatin modifications and their function","volume":"128","author":"Kouzarides","year":"2007","journal-title":"Cell."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1016\/j.autrev.2016.09.003","article-title":"The role of microRNAs in the pathogenesis of autoimmune diseases","volume":"15","author":"Chen","year":"2016","journal-title":"Autoimmun Rev."},{"key":"B55","doi-asserted-by":"publisher","first-page":"24r","DOI":"10.1203\/pdr.0b013e3180457684","article-title":"Epigenetics and microRNAs","volume":"61","author":"Chuang","year":"2007","journal-title":"Pediatr Res."},{"key":"B56","doi-asserted-by":"publisher","first-page":"J207","DOI":"10.1016\/j.jaut.2009.12.006","article-title":"Epigenetics and autoimmunity","volume":"34","author":"Brooks","year":"2010","journal-title":"J Autoimm."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.4161\/cbt.6.8.4486","article-title":"DNA methylation regulates microRNA expression","volume":"6","author":"Han","year":"2007","journal-title":"Cancer Biol Ther."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1158\/0008-5472.CAN-05-3632","article-title":"Rapid alteration of microRNA levels by histone deacetylase inhibition","volume":"66","author":"Scott","year":"2006","journal-title":"Cancer Research."},{"key":"B59","doi-asserted-by":"publisher","first-page":"264","DOI":"10.14348\/molcells.2018.0076","article-title":"Cooperative instruction of signaling and metabolic pathways on the epigenetic landscape","volume":"41","author":"Kim","year":"2018","journal-title":"Mol Cells."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1038\/ncb3629","article-title":"The impact of cellular metabolism on chromatin dynamics and epigenetics","volume":"19","author":"Reid","year":"2017","journal-title":"Nat Cell Biol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"3169","DOI":"10.1002\/jcp.24054","article-title":"Metaboloepigenetics: interrelationships between energy metabolism and epigenetic control of gene expression","volume":"227","author":"Donohoe","year":"2012","journal-title":"J Cell Physiol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.molcel.2016.05.029","article-title":"Interplay between metabolism and epigenetics: a nuclear adaptation to environmental changes","volume":"62","author":"Etchegaray","year":"2016","journal-title":"Mol Cell."},{"key":"B63","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1161\/CIRCRESAHA.116.303936","article-title":"Epigenetics and metabolism","volume":"116","author":"Keating","year":"2015","journal-title":"Circ Res."},{"key":"B64","doi-asserted-by":"publisher","first-page":"3353","DOI":"10.1007\/s00018-018-2864-2","article-title":"Crosstalk between metabolism and epigenetic modifications in autoimmune diseases: a comprehensive overview","volume":"75","author":"Wang","year":"2018","journal-title":"Cell Mol Life Sci."},{"key":"B65","doi-asserted-by":"publisher","first-page":"256","DOI":"10.3109\/08916934.2013.834495","article-title":"Metabolic control of the epigenome in systemic Lupus erythematosus","volume":"47","author":"Oaks","year":"2014","journal-title":"Autoimmunity."},{"key":"B66","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.cmet.2015.08.024","article-title":"Histone methylation dynamics and gene regulation occur through the sensing of one-carbon metabolism","volume":"22","author":"Mentch","year":"2015","journal-title":"Cell Metab."},{"key":"B67","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3109\/08916934.2012.732133","article-title":"Lupus autoimmunity altered by cellular methylation metabolism","volume":"46","author":"Yang","year":"2013","journal-title":"Autoimmunity."},{"key":"B68","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1093\/ajcn\/55.1.131","article-title":"The pathogenesis of homocysteinemia: interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine","volume":"55","author":"Selhub","year":"1992","journal-title":"Am J Clin Nutr."},{"key":"B69","doi-asserted-by":"publisher","first-page":"E4108","DOI":"10.3390\/ijms19124108","article-title":"Metabolic signaling into chromatin modifications in the regulation of gene expression","volume":"19","author":"Gao","year":"2018","journal-title":"Int J Mol Sci."},{"key":"B70","doi-asserted-by":"crossref","first-page":"10822","DOI":"10.1016\/S0021-9258(19)70381-0","article-title":"S-Adenosylmethionine and S-adenosylhomocystein metabolism in isolated rat liver","volume":"255","author":"Hoffman","year":"1980","journal-title":"J Biol Chem."},{"key":"B71","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/0955-2863(90)90070-2","article-title":"Methionine metabolism in mammals","volume":"1","author":"Finkelstein","year":"1990","journal-title":"J Nutr Biochem."},{"key":"B72","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.trsl.2011.01.009","article-title":"Diabetes mellitus, a microRNA-related disease?","volume":"157","author":"Guay","year":"2011","journal-title":"Transl Res."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1042\/BST20140135","article-title":"Protein acetylation as a means to regulate protein function in tune with metabolic state","volume":"42","author":"Shi","year":"2014","journal-title":"Biochem Soc T."},{"key":"B74","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1021\/cb500846u","article-title":"Metabolic regulation of histone post-translational modifications","volume":"10","author":"Fan","year":"2015","journal-title":"ACS Chem Biol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.cmet.2014.06.004","article-title":"Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation","volume":"20","author":"Lee","year":"2014","journal-title":"Cell Metab."},{"key":"B76","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.ceb.2015.02.003","article-title":"Acetyl-CoA and the regulation of metabolism: mechanisms and consequences","volume":"33","author":"Shi","year":"2015","journal-title":"Curr Opin Cell Biol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.molcel.2011.05.004","article-title":"Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes","volume":"42","author":"Cai","year":"2011","journal-title":"Mol Cell."},{"key":"B78","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1042\/bj1150609a","article-title":"The redox state of free nicotinamide-adenine dinucleotide phosphate in the cytoplasm of rat liver","volume":"115","author":"Veech","year":"1969","journal-title":"Biochem J."},{"key":"B79","doi-asserted-by":"publisher","first-page":"417","DOI":"10.2119\/molmed.2011.00055","article-title":"HDAC inhibition in lupus models","volume":"17","author":"Reilly","year":"2011","journal-title":"Mol Med."},{"key":"B80","doi-asserted-by":"publisher","first-page":"575","DOI":"10.7150\/ijbs.7.575","article-title":"Mammalian sirtuins and energy metabolism","volume":"7","author":"Li","year":"2011","journal-title":"Int J Biol Sci."},{"key":"B81","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1146\/annurev-cellbio-100814-125544","article-title":"Metabolism and epigenetics","volume":"31","author":"Janke","year":"2015","journal-title":"Annu Rev Cell Dev Bi."},{"key":"B82","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.cell.2008.07.002","article-title":"The NAD(+)-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control","volume":"134","author":"Nakahata","year":"2008","journal-title":"Cell."},{"key":"B83","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/j.cmet.2011.08.014","article-title":"Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice","volume":"14","author":"Yoshino","year":"2011","journal-title":"Cell Metab."},{"key":"B84","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.cmet.2015.04.002","article-title":"SIRT1-Mediated eNAMPT secretion from adipose tissue regulates hypothalamic NAD(+) and function in mice","volume":"21","author":"Yoon","year":"2015","journal-title":"Cell Metab."},{"key":"B85","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1016\/j.cell.2013.11.037","article-title":"Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging","volume":"155","author":"Gomes","year":"2013","journal-title":"Cell."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.2741\/4283","article-title":"Calorie restriction and NAD(+)\/sirtuin counteract the hallmarks of aging","volume":"19","author":"Michan","year":"2014","journal-title":"Front Biosci Landmrk."},{"key":"B87","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.cbpa.2015.10.030","article-title":"Metabolic control of methylation and acetylation","volume":"30","author":"Su","year":"2016","journal-title":"Curr Opin Chem Biol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1007\/s12016-009-8172-8","article-title":"Epigenetic therapeutics in autoimmune disease","volume":"39","author":"Szyf","year":"2010","journal-title":"Clin Rev Allerg Immu."},{"key":"B89","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1111\/imr.12205","article-title":"The interface between transcriptional and epigenetic control of effector and memory CD8(+) T-cell differentiation","volume":"261","author":"Gray","year":"2014","journal-title":"Immunol Rev."},{"key":"B90","doi-asserted-by":"publisher","first-page":"3419","DOI":"10.4049\/jimmunol.1301395","article-title":"Global DNA Methylation remodeling accompanies CD8 T cell effector function","volume":"191","author":"Scharer","year":"2013","journal-title":"J Immunol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"6648","DOI":"10.4049\/jimmunol.0803320","article-title":"Cutting edge: TCR stimulation is sufficient for induction of Foxp3 expression in the absence of DNA methyltransferase 1","volume":"182","author":"Josefowicz","year":"2009","journal-title":"J Immunol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"4083","DOI":"10.4049\/jimmunol.176.7.4083","article-title":"Rapid demethylation of the IFN-gamma gene occurs in memory but not naive CD8 T cells","volume":"176","author":"Kersh","year":"2006","journal-title":"J Immunol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1002\/eji.201545550","article-title":"Generating long-lived CD8(+) T-cell memory: insights from epigenetic programs","volume":"46","author":"Dogra","year":"2016","journal-title":"Eur J Immunol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.3389\/fimmu.2018.02181","article-title":"Early everolimus initiation fails to counteract the cytotoxic response mediated by CD8(+) T and NK cells in heart transplant patients","volume":"9","author":"Diaz-Molina","year":"2018","journal-title":"Front Immunol."},{"key":"B95","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/nature08155","article-title":"mTOR regulates memory CD8 T-cell differentiation","volume":"460","author":"Araki","year":"2009","journal-title":"Nature."},{"key":"B96","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.immuni.2011.04.006","article-title":"A central role for mTOR kinase in homeostatic proliferation induced CD8(+) T cell memory and tumor immunity","volume":"34","author":"Li","year":"2011","journal-title":"Immunity."},{"key":"B97","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/nri3173","article-title":"The molecular basis of the memory T cell response: differential gene expression and its epigenetic regulation","volume":"12","author":"Weng","year":"2012","journal-title":"Nat Rev Immunol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"8102","DOI":"10.4049\/jimmunol.180.12.8102","article-title":"Histone acetylation facilitates rapid and robust memory CD8 T cell response through differential expression of effector molecules (eomesodermin and its targets: perforin and granzyme B)","volume":"180","author":"Araki","year":"2008","journal-title":"J Immunol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"937","DOI":"10.4049\/jimmunol.1601102","article-title":"Epigenetic networks regulate the transcriptional program in memory and terminally differentiated CD8(+) T cells","volume":"198","author":"Rodriguez","year":"2017","journal-title":"J Immunol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/s13148-015-0152-7","article-title":"Genome-wide DNA methylation profiling of CD8+T cells shows a distinct epigenetic signature to CD4+T cells in multiple sclerosis patients","volume":"7","author":"Maltby","year":"2015","journal-title":"Clin Epigenetics."},{"key":"B101","doi-asserted-by":"publisher","first-page":"1932","DOI":"10.1038\/s41375-018-0062-8","article-title":"Histone deacetylase (HDAC) inhibitor ACY241 enhances anti-tumor activities of antigen-specific central memory cytotoxic T lymphocytes against multiple myeloma and solid tumors","volume":"32","author":"Bae","year":"2018","journal-title":"Leukemia."},{"key":"B102","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1038\/ni.1797","article-title":"An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a","volume":"10","author":"Ebert","year":"2009","journal-title":"Nat Immunol."},{"key":"B103","doi-asserted-by":"publisher","first-page":"e77983","DOI":"10.1371\/journal.pone.0077983","article-title":"MicroRNA-34a enhances T cell activation by targeting diacylglycerol kinase zeta","volume":"8","author":"Shin","year":"2013","journal-title":"PLoS ONE."},{"key":"B104","doi-asserted-by":"publisher","first-page":"6142","DOI":"10.18632\/oncotarget.14046","article-title":"Dysregulated miR34a\/diacylglycerol kinase zeta interaction enhances T-cell activation in acquired aplastic anemia","volume":"8","author":"Sun","year":"2017","journal-title":"Oncotarget."},{"key":"B105","doi-asserted-by":"publisher","first-page":"16399","DOI":"10.1038\/srep16399","article-title":"miR-150 regulates differentiation and cytolytic effector function in CD8+T cells","volume":"5","author":"Smith","year":"2015","journal-title":"Sci Rep."},{"key":"B106","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1534\/genetics.115.179176","article-title":"MicroRNAs and their targets are differentially regulated in adult and neonatal mouse CD8+T Cells","volume":"201","author":"Wissink","year":"2015","journal-title":"Genetics."},{"key":"B107","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.1002\/ijc.30912","article-title":"MiR-15a\/16 deficiency enhances anti-tumor immunity of glioma-infiltrating CD8+T cells through targeting mTOR","volume":"141","author":"Yang","year":"2017","journal-title":"Int J Cancer."},{"key":"B108","doi-asserted-by":"publisher","first-page":"183828","DOI":"10.1371\/journal.pone.0183828","article-title":"miR-625-3p is upregulated in CD8+T cells during early immune reconstitution after allogeneic stem cell transplantation","volume":"12","author":"Verma","year":"2017","journal-title":"PLoS ONE."},{"key":"B109","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1016\/j.bbrc.2017.11.120","article-title":"MicroRNA-140 suppresses osteosarcoma tumor growth by enhancing anti-tumor immune response and blocking mTOR signaling","volume":"495","author":"Ji","year":"2018","journal-title":"Biochem Bioph Res Co."},{"key":"B110","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1097\/MAJ.0b013e3182831726","article-title":"Lymphocyte-platelet crosstalk in Graves' disease","volume":"347","author":"Kuznik","year":"2014","journal-title":"Am J Med Sci."},{"key":"B111","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1046\/j.1365-2249.2002.01818.x","article-title":"The effects of CD40- and interleukin (IL-4)-activated CD23(+) cells on the production of IL-10 by mononuclear cells in Graves' disease: the role of CD8(+) cells","volume":"128","author":"Uchimura","year":"2002","journal-title":"Clin Exp Immunol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1007\/s12026-014-8529-9","article-title":"Immune regulation of multiple sclerosis by CD8+T cells","volume":"59","author":"Sinha","year":"2014","journal-title":"Immunol Res."},{"key":"B113","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1007\/s12026-011-8222-1","article-title":"CD8(+) T cells in systemic sclerosis","volume":"50","author":"Fuschiotti","year":"2011","journal-title":"Immunol Res."},{"key":"B114","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1002\/art.24432","article-title":"Effector CD8+ T cells in systemic sclerosis patients produce abnormally high levels of interleukin-13 associated with increased skin fibrosis","volume":"60","author":"Fuschiotti","year":"2009","journal-title":"Arthritis Rheum."},{"key":"B115","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.coi.2005.09.014","article-title":"CD8(+) T cells in autoimmunity","volume":"17","author":"Walter","year":"2005","journal-title":"Curr Opin Immunol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"3652","DOI":"10.4049\/jimmunol.172.6.3652","article-title":"Demethylation of promoter regulatory elements contributes to perforin overexpression in CD4(+) lupus T cells","volume":"172","author":"Kaplan","year":"2004","journal-title":"J Immunol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.4049\/jimmunol.176.4.2095","article-title":"Accelerated macrophage apoptosis induces autoantibody formation and organ damage in systemic lupus erythematosus","volume":"176","author":"Denny","year":"2006","journal-title":"J Immunol."},{"key":"B118","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1111\/ejh.12327","article-title":"Abnormalities of quantities and functions of linker for activations of T cells in severe aplastic anemia","volume":"93","author":"Sheng","year":"2014","journal-title":"Eur J Haematol."},{"key":"B119","doi-asserted-by":"publisher","first-page":"2220","DOI":"10.1038\/jid.2009.32","article-title":"Autoimmune destruction of skin melanocytes by perilesional T cells from vitiligo patients","volume":"129","author":"van den Boorn","year":"2009","journal-title":"J Invest Dermatol."},{"key":"B120","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.autrev.2014.01.013","article-title":"Diagnosis and classification of Graves' disease","volume":"13","author":"Menconi","year":"2014","journal-title":"Autoimmun Rev."},{"key":"B121","doi-asserted-by":"publisher","first-page":"2544","DOI":"10.1001\/jama.2015.16535","article-title":"Management of graves disease a review","volume":"314","author":"Burch","year":"2015","journal-title":"JAMA."},{"key":"B122","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1055\/s-0033-1361088","article-title":"microRNA Expressions in CD4+and CD8+T-cell subsets in autoimmune thyroid diseases","volume":"122","author":"Bernecker","year":"2014","journal-title":"Exp Clin Endocr Diab."},{"key":"B123","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.jaut.2015.09.006","article-title":"Epigenetic profiling in CD4+and CD8+T cells from Graves' disease patients reveals changes in genes associated with T cell receptor signaling","volume":"67","author":"Limbach","year":"2016","journal-title":"J Autoimm."},{"key":"B124","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/bmt.2014.277","article-title":"Autologous hematopoietic SCT normalizes miR-16,-155 and-142-3p expression in multiple sclerosis patients","volume":"50","author":"Arruda","year":"2015","journal-title":"Bone Marrow Transpl."},{"key":"B125","doi-asserted-by":"publisher","first-page":"e24604","DOI":"10.1371\/journal.pone.0024604","article-title":"Glatiramer acetate treatment normalizes deregulated microRNA expression in relapsing remitting multiple sclerosis","volume":"6","author":"Waschbisch","year":"2011","journal-title":"PLoS ONE."},{"key":"B126","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1038\/embor.2008.224","article-title":"miR-142-3p restricts cAMP production in CD4(+)CD25(-) T cells and CD4(+)CD25(+) T-REG cells by targeting AC9 mRNA","volume":"10","author":"Huang","year":"2009","journal-title":"Embo Rep."},{"key":"B127","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1016\/j.jid.2017.12.003","article-title":"Genome-wide DNA methylation analysis in systemic sclerosis reveals hypomethylation of IFN-associated genes in CD4(+) and CD8(+) T cells","volume":"138","author":"Ding","year":"2018","journal-title":"J Invest Dermatol."},{"key":"B128","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1158\/0008-5472.CAN-05-2731","article-title":"Identification of the IFITM family as a new molecular marker in human colorectal tumors","volume":"66","author":"Andreu","year":"2006","journal-title":"Cancer Research."},{"key":"B129","doi-asserted-by":"publisher","first-page":"e106153","DOI":"10.1371\/journal.pone.0106153","article-title":"MicroRNA-29b modulates innate and antigen-specific immune responses in mouse models of autoimmunity","volume":"9","author":"Salama","year":"2014","journal-title":"PLoS ONE."},{"key":"B130","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/ijo.2013.98","article-title":"DNA hypomethylation of inflammation-associated genes in adipose tissue of female mice after multigenerational high fat diet feeding","volume":"38","author":"Ding","year":"2014","journal-title":"Int J Obesity."},{"key":"B131","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1007\/s12185-016-2061-8","article-title":"Abnormal histone acetylation of CD8(+) T cells in patients with severe aplastic anemia","volume":"104","author":"Qi","year":"2016","journal-title":"Int J Hematol."},{"key":"B132","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1210\/jc.2011-2178","article-title":"evidence of a combined cytotoxic thyroglobulin and thyroperoxidase epitope-specific cellular immunity in Hashimoto's thyroiditis","volume":"97","author":"Ehlers","year":"2012","journal-title":"J Clin Endocr Metab."},{"key":"B133","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1097\/01.bor.0000179942.27777.f8","article-title":"Cytotoxic T lymphocytes and autoimmunity","volume":"17","author":"Blanco","year":"2005","journal-title":"Curr Opin Rheumatol."},{"key":"B134","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1093\/brain\/awf059","article-title":"Oligoclonal expansion of memory CD8(+) T cells in cerebrospinal fluid from multiple sclerosis patients","volume":"125","author":"Jacobsen","year":"2002","journal-title":"Brain."},{"key":"B135","doi-asserted-by":"publisher","first-page":"2789","DOI":"10.1093\/brain\/awm214","article-title":"Multiple sclerosis: T-cell receptor expression in distinct brain regions","volume":"130","author":"Junker","year":"2007","journal-title":"Brain."},{"key":"B136","doi-asserted-by":"publisher","first-page":"4049","DOI":"10.1007\/s12035-016-9966-3","article-title":"DNA methylation: a new player in multiple sclerosis","volume":"54","author":"Li","year":"2017","journal-title":"Mol Neurobiol."},{"key":"B137","doi-asserted-by":"publisher","first-page":"e117403","DOI":"10.1371\/journal.pone.0117403","article-title":"Genome-wide DNA methylation profiles indicate CD8+T Cell hypermethylation in multiple sclerosis","volume":"10","author":"Bos","year":"2015","journal-title":"PLos ONE."},{"key":"B138","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.it.2008.04.004","article-title":"microRNAs and the immune response","volume":"29","author":"Lindsay","year":"2008","journal-title":"Trends Immunol."},{"key":"B139","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1038\/ni.f.209","article-title":"MicroRNAs: new regulators of immune cell development and function","volume":"9","author":"Baltimore","year":"2008","journal-title":"Nat Immunol."},{"key":"B140","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1177\/1352458513489853","article-title":"CRYAB modulates the activation of CD4(+) T cells from relapsing-remitting multiple sclerosis patients","volume":"19","author":"Quach","year":"2013","journal-title":"Mult Scler J."},{"key":"B141","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1002\/eji.200940032","article-title":"Altered expression of miR-17-5p in CD4(+) lymphocytes of relapsing-remitting multiple sclerosis patients","volume":"40","author":"Lindberg","year":"2010","journal-title":"Eur J Immunol."},{"key":"B142","doi-asserted-by":"publisher","first-page":"593720","DOI":"10.1155\/2012\/593720","article-title":"Epigenetics and autoimmune diseases","volume":"2012","author":"Quintero-Ronderos","year":"2012","journal-title":"Autoimmune Dis."},{"key":"B143","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.jneuroim.2010.06.009","article-title":"Altered miRNA expression in T regulatory cells in course of multiple sclerosis","volume":"226","author":"De Santis","year":"2010","journal-title":"J Neuroimmunol."},{"key":"B144","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.it.2005.09.004","article-title":"Scleroderma: from cell and molecular mechanisms to disease models","volume":"26","author":"Abraham","year":"2005","journal-title":"Trends Immunol."},{"key":"B145","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.biocel.2015.05.023","article-title":"Epigenetic mechanisms: an emerging role in pathogenesis and its therapeutic potential in systemic sclerosis","volume":"67","author":"Luo","year":"2015","journal-title":"Int J Biochem Cell B."},{"key":"B146","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nature09907","article-title":"A diverse range of gene products are effectors of the type I interferon antiviral response","volume":"472","author":"Schoggins","year":"2011","journal-title":"Nature."},{"key":"B147","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1136\/annrheumdis-2015-208410","article-title":"IFI44L promoter methylation as a blood biomarker for systemic lupus erythematosus","volume":"75","author":"Zhao","year":"2016","journal-title":"Ann Rheum Dis."},{"key":"B148","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1089\/jir.2006.26.462","article-title":"Differential gene induction by type I and type II Interferons and their combination","volume":"26","author":"Sanda","year":"2006","journal-title":"J Interf Cytok Res."},{"key":"B149","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/labinvest.2015.154","article-title":"Canonical Wnt signaling in systemic sclerosis","volume":"96","author":"Bergmann","year":"2016","journal-title":"Lab Invest."},{"key":"B150","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s00125-003-1089-5","article-title":"The role of T-cells in the pathogenesis of Type 1 diabetes: from cause to cure","volume":"46","author":"Roep","year":"2003","journal-title":"Diabetologia."},{"key":"B151","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.autrev.2008.04.008","article-title":"Autoimmune mechanisms in type 1 diabetes","volume":"7","author":"Knip","year":"2008","journal-title":"Autoimmun Rev."},{"key":"B152","doi-asserted-by":"publisher","first-page":"3182","DOI":"10.1128\/MCB.01433-10","article-title":"miR-29a and miR-29b contribute to pancreatic beta-cell-specific silencing of monocarboxylate transporter 1 (Mct1)","volume":"31","author":"Pullen","year":"2011","journal-title":"Mol Cell Biol."},{"key":"B153","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/gene.2016.29","article-title":"Survival of autoreactive T lymphocytes by microRNA-mediated regulation of apoptosis through TRAIL and Fas in type 1 diabetes","volume":"17","author":"de Jong","year":"2016","journal-title":"Genes Immun."},{"key":"B154","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jaut.2013.01.010","article-title":"The critical importance of epigenetics in autoimmunity","volume":"41","author":"Lu","year":"2013","journal-title":"J Autoimm."},{"key":"B155","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1002\/art.10234","article-title":"Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus","volume":"46","author":"Lu","year":"2002","journal-title":"Arthritis Rheum."},{"key":"B156","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1002\/art.20745","article-title":"Increase in activated CD8+T lymphocytes expressing perforin and granzyme B correlates with disease activity in patients with systemic lupus erythematosus","volume":"52","author":"Blanco","year":"2005","journal-title":"Arthritis Rheum."},{"key":"B157","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1586\/1744666X.2015.994507","article-title":"Autoimmune disease in the epigenetic era: how has epigenetics changed our understanding of disease and how can we expect the field to evolve?","volume":"11","author":"Jeffries","year":"2015","journal-title":"Expert Rev Clin Immu."},{"key":"B158","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1016\/S0140-6736(18)30485-9","article-title":"Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications: a single-arm, open-label, phase 1\/2 trial","volume":"391","author":"Lai","year":"2018","journal-title":"Lancet."},{"key":"B159","doi-asserted-by":"publisher","first-page":"4134","DOI":"10.4049\/jimmunol.1301859","article-title":"Mechanistic target of rapamycin complex 1 expands Th17 and IL-4(+) CD4-CD8-double-negative T cells and contracts regulatory T cells in systemic lupus erythematosus","volume":"192","author":"Kato","year":"2014","journal-title":"J Immunol."},{"key":"B160","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1038\/ni.3076","article-title":"Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses","volume":"16","author":"Shrestha","year":"2015","journal-title":"Nat Immunol."},{"key":"B161","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1002\/eji.201041130","article-title":"Rapamycin-sensitive signals control TCR\/CD28-driven Ifng, Il4 and Foxp3 transcription and promoter region methylation","volume":"41","author":"Tomasoni","year":"2011","journal-title":"Eur J Immunol."},{"key":"B162","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.clim.2015.03.024","article-title":"Oxidative stress and Treg depletion in lupus patients with anti-phospholipid syndrome","volume":"158","author":"Lai","year":"2015","journal-title":"Clin Immunol."},{"key":"B163","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.1002\/art.40223","article-title":"Metabolic control of immune system activation in rheumatic diseases","volume":"69","author":"Perl","year":"2017","journal-title":"Arthritis Rheumatol."},{"key":"B164","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1136\/annrheumdis-2013-203794","article-title":"HRES-1\/Rab4-mediated depletion of Drp1 impairs mitochondrial homeostasis and represents a target for treatment in SLE","volume":"73","author":"Caza","year":"2014","journal-title":"Ann Rheum Dis."},{"key":"B165","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1002\/art.38427","article-title":"Oxidative stress, T cell DNA methylation, and lupus","volume":"66","author":"Li","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"B166","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.it.2018.04.006","article-title":"Metabolism as a target for modulation in autoimmune diseases","volume":"39","author":"Huang","year":"2018","journal-title":"Trends Immunol."},{"key":"B167","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.4049\/jimmunol.182.3.1500","article-title":"Methylation status of CpG islands flanking a cAMP response element motif on the protein phosphatase 2Ac alpha promoter determines CREB binding and activity","volume":"182","author":"Sunahori","year":"2009","journal-title":"J Immunol."},{"key":"B168","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/nrrheum.2013.147","article-title":"Oxidative stress in the pathology and treatment of systemic lupus erythematosus","volume":"9","author":"Perl","year":"2013","journal-title":"Nat Rev Rheumatol."},{"key":"B169","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.3892\/mmr.2014.2344","article-title":"CD8(+)HLA-DR+ T cells are increased in patients with severe aplastic anemia","volume":"10","author":"Xing","year":"2014","journal-title":"Mol Med Rep."},{"key":"B170","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1016\/S0140-6736(18)30544-0","article-title":"CD8 T cells and mTOR: new concepts and targets for systemic lupus erythematosus","volume":"391","author":"Fernandez","year":"2018","journal-title":"Lancet."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00856\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T02:01:56Z","timestamp":1663293716000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.00856\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,18]]},"references-count":170,"alternative-id":["10.3389\/fimmu.2019.00856"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.00856","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,18]]},"article-number":"856"}}