{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:14:18Z","timestamp":1787026458029,"version":"build-2736575974"},"reference-count":83,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T00:00:00Z","timestamp":1557446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.01026","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T09:19:00Z","timestamp":1557479940000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":58,"title":["Autoantibodies in Systemic Lupus Erythematosus Target Mitochondrial RNA"],"prefix":"10.3389","volume":"10","author":[{"given":"Yann","family":"Becker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevi\u00e8ve","family":"Marcoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Allaeys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Sophie","family":"Julien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9e-Claude","family":"Loignon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadrien","family":"Benk-Fortin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Rollet-Labelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Rauch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Fortin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Boilard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,5,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.molcel.2012.12.026","article-title":"The tangled circuitry of metabolism and apoptosis","volume":"49","author":"Andersen","year":"2013","journal-title":"Mol Cell."},{"key":"B2","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1146\/annurev-genet-102108-134850","article-title":"The role of mitochondria in apoptosis*","volume":"43","author":"Wang","year":"2009","journal-title":"Annu Rev Genet."},{"key":"B3","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/387493a0","article-title":"An ancestral mitochondrial DNA resembling a eubacterial genome in miniature","volume":"387","author":"Lang","year":"1997","journal-title":"Nature"},{"key":"B4","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/24094","article-title":"The genome sequence of Rickettsia prowazekii and the origin of mitochondria","volume":"396","author":"Andersson","year":"1998","journal-title":"Nature"},{"key":"B5","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/nature12985","article-title":"Mitochondrial form and function","volume":"505","author":"Friedman","year":"2014","journal-title":"Nature"},{"key":"B6","first-page":"321","article-title":"Anti-phospholipid and anti-mitochondrial type M5 antibodies in systemic lupus erythematosus","volume":"3","author":"Tincani","year":"1985","journal-title":"Clin Exp Rheumatol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1159\/000346515","article-title":"Membrane invaginations in bacteria and mitochondria: common features and evolutionary scenarios","volume":"23","author":"Arechaga","year":"2013","journal-title":"J Mol Microbiol Biotechnol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1126\/science.1195491","article-title":"Intravascular danger signals guide neutrophils to sites of sterile inflammation","volume":"330","author":"McDonald","year":"2010","journal-title":"Science"},{"key":"B9","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/nature08780","article-title":"Circulating mitochondrial DAMPs cause inflammatory responses to injury","volume":"464","author":"Zhang","year":"2010","journal-title":"Nature"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1038\/cdd.2009.96","article-title":"Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps","volume":"16","author":"Yousefi","year":"2009","journal-title":"Cell Death Differ."},{"key":"B11","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1038\/nm.4027","article-title":"Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease","volume":"22","author":"Lood","year":"2016","journal-title":"Nat Med"},{"key":"B12","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1084\/jem.20151876","article-title":"Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus","volume":"213","author":"Caielli","year":"2016","journal-title":"J Exp Med"},{"key":"B13","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1038\/nm.1855","article-title":"Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense","volume":"14","author":"Yousefi","year":"2008","journal-title":"Nat Med"},{"key":"B14","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1182\/blood-2014-05-573543","article-title":"Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation","volume":"124","author":"Boudreau","year":"2014","journal-title":"Blood"},{"key":"B15","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1080\/09537104.2016.1218455","article-title":"Microparticle and mitochondrial release during extended storage of different types of platelet concentrates","volume":"28","author":"Marcoux","year":"2017","journal-title":"Platelets"},{"key":"B16","doi-asserted-by":"publisher","first-page":"e49767","DOI":"10.1371\/journal.pone.0049767","article-title":"Stimulated human mast cells secrete mitochondrial components that have autocrine and paracrine inflammatory actions","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS ONE."},{"key":"B17","doi-asserted-by":"publisher","first-page":"e1312","DOI":"10.1038\/cddis.2014.277","article-title":"Mitochondria released by cells undergoing TNF-\u03b1-induced necroptosis act as danger signals","volume":"5","author":"Maeda","year":"2014","journal-title":"Cell Death Dis."},{"key":"B18","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1172\/JCI83885","article-title":"Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9","volume":"126","author":"Garcia-Martinez","year":"2016","journal-title":"J Clin Invest"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1002\/hep.25801","article-title":"Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure","volume":"56","author":"Marques","year":"2012","journal-title":"Hepatology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/nature10992","article-title":"Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure","volume":"485","author":"Oka","year":"2012","journal-title":"Nature"},{"key":"B21","doi-asserted-by":"publisher","first-page":"2763","DOI":"10.1182\/blood-2015-12-688838","article-title":"Cardiolipin-mediated procoagulant activity of mitochondria contributes to traumatic brain injury-associated coagulopathy in mice","volume":"127","author":"Zhao","year":"2016","journal-title":"Blood"},{"key":"B22","doi-asserted-by":"publisher","first-page":"e1001577","DOI":"10.1371\/journal.pmed.1001577","article-title":"Circulating mitochondrial DNA in patients in the ICU as a marker of mortality: derivation and validation","volume":"10","author":"Nakahira","year":"2013","journal-title":"PLoS Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1097\/SLA.0b013e3182a4ea46","article-title":"Elevated levels of plasma mitochondrial DNA DAMPs are linked to clinical outcome in severely injured human subjects","volume":"258","author":"Simmons","year":"2013","journal-title":"Ann Surg"},{"key":"B24","doi-asserted-by":"publisher","first-page":"R234","DOI":"10.1186\/ar787","article-title":"Extracellular mitochondrial DNA and oxidatively damaged DNA in synovial fluid of patients with rheumatoid arthritis","volume":"5","author":"Hajizadeh","year":"2003","journal-title":"Arthritis Res Ther."},{"key":"B25","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.it.2011.01.005","article-title":"Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation","volume":"32","author":"Krysko","year":"2011","journal-title":"Trends Immunol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/464041a","article-title":"Clinical immunology: culprits with evolutionary ties","volume":"464","author":"Calfee","year":"2010","journal-title":"Nature"},{"key":"B27","doi-asserted-by":"publisher","first-page":"eaao6047","DOI":"10.1126\/science.aao6047","article-title":"BAK\/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis","volume":"359","author":"McArthur","year":"2018","journal-title":"Science."},{"key":"B28","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.immuni.2015.02.002","article-title":"Mitochondria in the regulation of innate and adaptive immunity","volume":"42","author":"Weinberg","year":"2015","journal-title":"Immunity"},{"key":"B29","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/nri2975","article-title":"Mitochondria in innate immune responses","volume":"11","author":"West","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1016\/j.bbadis.2016.10.020","article-title":"Mitochondria as a centrally positioned hub in the innate immune response","volume":"1863","author":"Sandhir","year":"2017","journal-title":"Biochim Biophys Acta"},{"key":"B31","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1038\/ni.3704","article-title":"Mitochondria are the powerhouses of immunity","volume":"18","author":"Mills","year":"2017","journal-title":"Nat Immunol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature."},{"key":"B33","doi-asserted-by":"publisher","first-page":"e72354","DOI":"10.1371\/journal.pone.0072354","article-title":"Mitochondrial transcription factor A, an endogenous danger signal, promotes TNFalpha release via RAGE- and TLR9-responsive plasmacytoid dendritic cells","volume":"8","author":"Julian","year":"2013","journal-title":"PLoS ONE."},{"key":"B34","doi-asserted-by":"publisher","first-page":"3190","DOI":"10.1002\/art.39296","article-title":"Neutrophil extracellular trap mitochondrial DNA and its autoantibody in systemic lupus erythematosus and a proof-of-concept trial of metformin","volume":"67","author":"Wang","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"B35","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.4049\/jimmunol.133.5.2532","article-title":"Anti-native DNA antibodies from autoimmune sera also bind to DNA in mitochondria","volume":"133","author":"Reimer","year":"1984","journal-title":"J Immunol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"4530","DOI":"10.1038\/s41598-019-40900-3","article-title":"Anti-mitochondrial autoantibodies in systemic lupus erythematosus and their association with disease manifestations","volume":"9","author":"Becker","year":"2019","journal-title":"Sci Rep"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3402\/jev.v3.24692","article-title":"Isolation and characterization of platelet-derived extracellular vesicles","author":"Aatonen","year":"","journal-title":"J Extracell Vesicles."},{"key":"B38","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1042\/BJ20112208","article-title":"The post-transcriptional life of mammalian mitochondrial RNA","volume":"444","author":"Rorbach","year":"2012","journal-title":"Biochem J"},{"key":"B39","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.cell.2011.06.051","article-title":"The human mitochondrial transcriptome","volume":"146","author":"Mercer","year":"2011","journal-title":"Cell"},{"key":"B40","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/35072063","article-title":"The genetics and pathology of oxidative phosphorylation","volume":"2","author":"Smeitink","year":"2001","journal-title":"Nat Rev Genet"},{"key":"B41","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1083\/jcb.201507125","article-title":"Mitochondrial RNA granules: compartmentalizing mitochondrial gene expression","volume":"212","author":"Jourdain","year":"2016","journal-title":"J Cell Biol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"10941","DOI":"10.1093\/nar\/gkx772","article-title":"The FASTK family of proteins: emerging regulators of mitochondrial RNA biology","volume":"45","author":"Jourdain","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"B43","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1038\/nprot.2006.478","article-title":"Organelle isolation: functional mitochondria from mouse liver, muscle and cultured fibroblasts","volume":"2","author":"Frezza","year":"2007","journal-title":"Nat Protoc"},{"key":"B44","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/art.1780251101","article-title":"The 1982 revised criteria for the classification of systemic lupus erythematosus","volume":"25","author":"Tan","year":"1982","journal-title":"Arthritis Rheum."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1002\/art.1780400928","article-title":"Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus","volume":"40","author":"Hochberg","year":"1997","journal-title":"Arthritis Rheum."},{"key":"B46","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1046\/j.1365-2249.2002.01816.x","article-title":"Analysis of mitochondrial antigens reveals inner membrane succinate dehydrogenase flavoprotein subunit as autoantigen to antibodies in anti-M7 sera","volume":"128","author":"Cicek","year":"2002","journal-title":"Clin Exp Immunol"},{"key":"B47","first-page":"68","article-title":"Characterization of a new mitochondrial antigen-antibody system (M9\/anti-M9) in patients with anti-M2 positive and anti-M2 negative primary biliary cirrhosis","volume":"74","author":"Klein","year":"1988","journal-title":"Clin Exp Immunol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1002\/hep.22906","article-title":"Primary biliary cirrhosis","volume":"50","author":"Lindor","year":"2009","journal-title":"Hepatology"},{"key":"B49","first-page":"373","article-title":"The Systemic Lupus International Collaborating Clinics\/American College of Rheumatology (SLICC\/ACR) damage index for systemic lupus erythematosus international comparison","volume":"27","author":"Gladman","year":"2000","journal-title":"J Rheumatol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1002\/art.1780350606","article-title":"Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE","volume":"35","author":"Bombardier","year":"1992","journal-title":"Arthritis Rheum"},{"key":"B51","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1002\/art.1780400506","article-title":"The reliability of the Systemic Lupus International Collaborating Clinics\/American College of Rheumatology Damage Index in patients with systemic lupus erythematosus","volume":"40","author":"Gladman","year":"1997","journal-title":"Arthritis Rheum"},{"key":"B52","first-page":"1820","article-title":"Systemic lupus international collaborative clinics: development of a damage index in systemic lupus erythematosus","volume":"19","author":"Gladman","year":"1992","journal-title":"J Rheumatol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"2677","DOI":"10.1002\/art.34473","article-title":"Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus","volume":"64","author":"Petri","year":"2012","journal-title":"Arthritis Rheum"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1111\/j.1538-7836.2009.03555.x","article-title":"Update of the guidelines for lupus anticoagulant detection. Subcommittee on lupus anticoagulant\/antiphospholipid antibody of the scientific and standardisation committee of the international society on thrombosis and haemostasis","volume":"7","author":"Pengo","year":"2009","journal-title":"J Thromb Haemost"},{"key":"B55","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.autrev.2014.10.003","article-title":"A volcanic explosion of autoantibodies in systemic lupus erythematosus: a diversity of 180 different antibodies found in SLE patients","volume":"14","author":"Yaniv","year":"2015","journal-title":"Autoimmun Rev"},{"key":"B56","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.clim.2016.08.001","article-title":"Lupus nephritis biomarkers","volume":"185","author":"Soliman","year":"2017","journal-title":"Clin Immunol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1007\/BF01728613","article-title":"Mitochondrial antigens and autoantibodies: from anti-M1 to anti-M9","volume":"64","author":"Berg","year":"1986","journal-title":"Klin Wochenschr"},{"key":"B58","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1002\/hep.1840120116","article-title":"The demography of primary biliary cirrhosis in Ontario, Canada","volume":"12","author":"Witt-Sullivan","year":"1990","journal-title":"Hepatology"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1172\/JCI0214698","article-title":"Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis","volume":"109","author":"Kita","year":"2002","journal-title":"J Clin Invest"},{"key":"B60","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1172\/JCI200110716","article-title":"Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis","volume":"108","author":"Odin","year":"2001","journal-title":"J Clin Invest"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1016\/S0140-6736(88)91894-6","article-title":"Primary biliary cirrhosis: identification of two major M2 mitochondrial autoantigens","volume":"1","author":"Yeaman","year":"1988","journal-title":"Lancet"},{"key":"B62","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1002\/hep.1840050510","article-title":"Mitochondrial antibodies in primary biliary cirrhosis: species and nonspecies specific determinants of M2 antigen","volume":"5","author":"Lindenborn-Fotinos","year":"1985","journal-title":"Hepatology"},{"key":"B63","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1034\/j.1600-0528.2002.017402.x","article-title":"Primary biliary cirrhosis: an orchestrated immune response against epithelial cells","volume":"174","author":"Gershwin","year":"2000","journal-title":"Immunol Rev"},{"key":"B64","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.4049\/jimmunol.135.3.1739","article-title":"Reactivity of anti-mitochondrial autoantibodies in primary biliary cirrhosis: definition of two novel mitochondrial polypeptide autoantigens","volume":"135","author":"Frazer","year":"1985","journal-title":"J Immunol"},{"key":"B65","first-page":"445","article-title":"Anti-M4 antibodies in primary biliary cirrhosis react with sulphite oxidase, an enzyme of the mitochondrial inter-membrane space","volume":"84","author":"Klein","year":"1991","journal-title":"Clin Exp Immunol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1111\/j.1365-2249.1990.tb05292.x","article-title":"Anti-M9 antibodies in sera from patients with primary biliary cirrhosis recognize an epitope of glycogen phosphorylase","volume":"81","author":"Klein","year":"1990","journal-title":"Clin Exp Immunol"},{"key":"B67","doi-asserted-by":"publisher","first-page":"S36","DOI":"10.1016\/S0168-8278(87)80159-9","article-title":"Characterization of M9 by westernblot and relevance of anti-M9 as a marker antibody for early primary biliary cirrhosis (PBC)","volume":"5","author":"Klein","year":"1987","journal-title":"J Hepatol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1016\/S0140-6736(80)92397-1","article-title":"Serological classification of chronic cholestatic liver disease by the use of two different types of antimitochondrial antibodies","volume":"2","author":"Berg","year":"1980","journal-title":"Lancet"},{"key":"B69","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/S0168-8278(88)80046-1","article-title":"The antimitochondrial antibody anti-M9. A marker for the diagnosis of early primary biliary cirrhosis","volume":"6","author":"Klein","year":"1988","journal-title":"J Hepatol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"3603","DOI":"10.4049\/jimmunol.170.7.3603","article-title":"Role of MHC class I in immune surveillance of mitochondrial DNA integrity","volume":"170","author":"Gu","year":"2003","journal-title":"J Immunol"},{"key":"B71","doi-asserted-by":"publisher","first-page":"7922","DOI":"10.1073\/pnas.0501190102","article-title":"Autophagy promotes MHC class II presentation of peptides from intracellular source proteins","volume":"102","author":"Dengjel","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B72","doi-asserted-by":"publisher","first-page":"5451","DOI":"10.4049\/jimmunol.165.10.5451","article-title":"Tumor cells present MHC class II-restricted nuclear and mitochondrial antigens and are the predominant antigen presenting cells in vivo","volume":"165","author":"Qi","year":"2000","journal-title":"J Immunol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1038\/cr.2016.104","article-title":"Presenting mitochondrial antigens: PINK1, Parkin and MDVs steal the show","volume":"26","author":"Roberts","year":"2016","journal-title":"Cell Res"},{"key":"B74","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.cell.2016.05.039","article-title":"Parkinson's disease-related proteins PINK1 and parkin repress mitochondrial antigen presentation","volume":"166","author":"Matheoud","year":"2016","journal-title":"Cell"},{"key":"B75","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.15252\/embr.201540861","article-title":"Human TLR8 senses UR\/URR motifs in bacterial and mitochondrial RNA","volume":"16","author":"Kr\u00fcger","year":"2015","journal-title":"EMBO Rep"},{"key":"B76","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1002\/art.1780340918","article-title":"Strategies for reducing excess morbidity and mortality in blacks with systemic lupus erythematosus","volume":"34","author":"Liang","year":"1991","journal-title":"Arthritis Rheum"},{"key":"B77","doi-asserted-by":"publisher","first-page":"e000144","DOI":"10.1136\/lupus-2015-000144","article-title":"I too, am America: a review of research on systemic lupus erythematosus in African-Americans","volume":"3","author":"Williams","year":"2016","journal-title":"Lupus Sci Med."},{"key":"B78","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/ar76","article-title":"Risk for rheumatic disease in relation to ethnicity and admixture","volume":"2","author":"Molokhia","year":"2000","journal-title":"Arthritis Res"},{"key":"B79","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1093\/rheumatology\/kex260","article-title":"The worldwide incidence and prevalence of systemic lupus erythematosus: a systematic review of epidemiological studies","volume":"56","author":"Rees","year":"2017","journal-title":"Rheumatol (Oxford)"},{"key":"B80","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.3899\/jrheum.080912","article-title":"The 1000 Canadian faces of lupus: determinants of disease outcome in a large multiethnic cohort","volume":"36","author":"Peschken","year":"2009","journal-title":"J Rheumatol"},{"key":"B81","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1177\/1759720X13485503","article-title":"Biomarkers in systemic lupus erythematosus: challenges and prospects for the future","volume":"5","author":"Liu","year":"2013","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"B82","doi-asserted-by":"publisher","first-page":"i32","DOI":"10.1093\/rheumatology\/kew407","article-title":"Systemic lupus erythematosus biomarkers: the challenging quest","volume":"56","author":"Arriens","year":"2017","journal-title":"Rheumatol (Oxford)."},{"key":"B83","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1111\/jcmm.13031","article-title":"Biomarkers of systemic lupus erythematosus identified using mass spectrometry-based proteomics: a systematic review","volume":"21","author":"Nicolaou","year":"2017","journal-title":"J Cell Mol Med"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01026\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T09:16:48Z","timestamp":1694855808000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01026\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,10]]},"references-count":83,"alternative-id":["10.3389\/fimmu.2019.01026"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.01026","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,10]]},"article-number":"1026"}}