{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:43:13Z","timestamp":1778884993990,"version":"3.51.4"},"reference-count":61,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T00:00:00Z","timestamp":1559692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009139","name":"Deutsches Zentrum f\u00fcr Infektionsforschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009139","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003107","name":"Bundesministerium f\u00fcr Gesundheit","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003107","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001350","name":"Ministry of Health -Singapore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001350","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001348","name":"Agency for Science, Technology and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.01097","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T04:43:50Z","timestamp":1559709830000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Identification and in vivo Efficacy Assessment of Approved Orally Bioavailable Human Host Protein-Targeting Drugs With Broad Anti-influenza A Activity"],"prefix":"10.3389","volume":"10","author":[{"given":"Theresa","family":"Enkirch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svenja","family":"Sauber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle E.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther S.","family":"Gan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitar","family":"Kenanov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Maurer-Stroh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronika","family":"von Messling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,6,5]]},"reference":[{"key":"B1","first-page":"9","article-title":"Influenza pandemics of the 20th century","volume-title":"Emerg Infect Dis.","author":"Kilbourne","year":"2006"},{"key":"B2","first-page":"7022","article-title":"Why should influenza be a public health priority","volume-title":"Vaccine.","author":"Osterhaus","year":"2015"},{"key":"B3","first-page":"1151","article-title":"Orthomyxoviridae","volume-title":"Fields Virology","author":"Shaw","year":"2013"},{"key":"B4","first-page":"3438","article-title":"Unusual influenza A viruses in bats","volume-title":"Viruses.","author":"Mehle","year":"2014"},{"key":"B5","first-page":"234","article-title":"Transmission of influenza A viruses","volume-title":"Virology.","author":"Neumann","year":"2015"},{"key":"B6","first-page":"237","article-title":"Highly pathogenic avian influenza as a zoonotic agent","volume-title":"Vet Microbiol.","author":"Kalthoff","year":"2010"},{"key":"B7","first-page":"317","article-title":"Public health risk from avian influenza viruses","volume-title":"Avian Dis.","author":"Perdue","year":"2005"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e0180763","DOI":"10.1371\/journal.pone.0180763","article-title":"Spatial characteristics and the epidemiology of human infections with avian influenza A(H7N9) virus in five waves from 2013 to 2017 in Zhejiang Province, China","volume":"12","author":"Wu","year":"2017","journal-title":"PLoS One"},{"key":"B9","first-page":"719","article-title":"Seasonal influenza vaccination and technologies","volume-title":"J Clin Pharmacol.","author":"Nafziger","year":"2014"},{"key":"B10","first-page":"342","article-title":"How amantadine and rimantadine inhibit proton transport in the M2 protein channel","volume-title":"J Mol Graph Model.","author":"Intharathep","year":"2008"},{"key":"B11","first-page":"187","article-title":"Influenza treatment and prophylaxis with neuraminidase inhibitors: a review","volume-title":"Infect Drug Resist.","author":"Kamali","year":"2013"},{"key":"B12","first-page":"249","article-title":"Surveillance of resistance to adamantanes among influenza A(H3N2) and A(H1N1) viruses isolated worldwide","volume-title":"J Infect Dis.","author":"Deyde","year":"2007"},{"key":"B13","first-page":"12","article-title":"Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2015\u20132016","volume-title":"Antiviral Res.","author":"Gubareva","year":"2017"},{"key":"B14","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1007\/s40265-018-0899-1","article-title":"Baloxavir: First global approval","volume":"78","author":"Heo","year":"2018","journal-title":"Drugs"},{"key":"B15","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1111\/irv.12446","article-title":"Influenza antivirals currently in late-phase clinical trial","volume":"11","author":"Koszalka","year":"2017","journal-title":"Influenza Other Respir Viruses"},{"key":"B16","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/s13073-014-0115-1","article-title":"Virus-host interactomics: new insights and opportunities for antiviral drug discovery","volume":"6","author":"de Chassey","year":"","journal-title":"Genome Med."},{"key":"B17","first-page":"455","article-title":"Systems virology: host-directed approaches to viral pathogenesis and drug targeting","volume-title":"Nat Rev Microbiol.","author":"Law","year":"2013"},{"key":"B18","first-page":"1243","article-title":"The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus","volume-title":"Cell.","author":"Brass","year":"2009"},{"key":"B19","first-page":"818","article-title":"Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication","volume-title":"Nature.","author":"Karlas","year":"2010"},{"key":"B20","first-page":"813","article-title":"Human host factors required for influenza virus replication","volume-title":"Nature.","author":"K\u00f6nig","year":"2010"},{"key":"B21","first-page":"1255","article-title":"A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection","volume-title":"Cell.","author":"Shapira","year":"2009"},{"key":"B22","first-page":"427","article-title":"Cellular networks involved in the influenza virus life cycle","volume-title":"Cell Host Microbe.","author":"Watanabe","year":"2010"},{"key":"B23","first-page":"53","article-title":"Severe seasonal influenza in ferrets correlates with reduced interferon and increased IL-6 induction","volume-title":"Virology.","author":"Svitek","year":"2008"},{"key":"B24","first-page":"1000","article-title":"Assessment of the efficacy of commercially available and candidate vaccines against a pandemic H1N1 2009 virus","volume-title":"J Infect Dis.","author":"Kobinger","year":"2010"},{"key":"B25","first-page":"D760","article-title":"NCBI GEO: mining tens of millions of expression profiles\u2013database and tools update","volume-title":"Nucleic Acids Res.","author":"Barrett","year":"2007"},{"key":"B26","first-page":"145","article-title":"Databases of protein-protein interactions and complexes","volume-title":"Methods Mol Biol.","author":"Ooi","year":"2010"},{"key":"B27","first-page":"D1035","article-title":"DrugBank 3.0: a comprehensive resource for \u201comics\u201d research on drugs","volume-title":"Nucleic Acids Res.","author":"Knox","year":"2011"},{"key":"B28","first-page":"2517","article-title":"In vitro antiviral activity of favipiravir (T-705) against drug-resistant influenza and 2009 A(H1N1) viruses","volume-title":"Antimicrobial Agents Chemother.","author":"Sleeman","year":"2010"},{"key":"B29","first-page":"240","article-title":"Effects of naltrexone on post-abstinence alcohol drinking in C57BL\/6NCRL and DBA\/2J mice","volume-title":"Prog Neuropsychopharmacol Biol Psychiatry.","author":"Tomie","year":"2013"},{"key":"B30","first-page":"327","article-title":"Therapeutic uses of gallium nitrate: past, present, and future","volume-title":"Am J Ther.","author":"Apseloff","year":"1999"},{"key":"B31","first-page":"5","article-title":"The effects of gallium nitrate on bone resorption","volume-title":"Semin Oncol.","author":"Bockman","year":"2003"},{"key":"B32","first-page":"e1002316","article-title":"Histone deacetylase 8 is required for centrosome cohesion and influenza A virus entry","volume-title":"PLoS Pathog.","author":"Yamauchi","year":"2011"},{"key":"B33","first-page":"262","article-title":"The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems","volume-title":"Trends Pharmacol Sci.","author":"Su","year":"2016"},{"key":"B34","first-page":"517","article-title":"The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog","volume-title":"J Pharmacol Exp Ther.","author":"Martin","year":"1976"},{"key":"B35","doi-asserted-by":"publisher","first-page":"e106533","DOI":"10.1371\/journal.pone.0106533","article-title":"Psychedelic N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine modulate innate and adaptive inflammatory responses through the sigma-1 receptor of human monocyte-derived dendritic cells","volume":"9","author":"Szabo","year":"2014","journal-title":"PLoS One"},{"key":"B36","first-page":"215","article-title":"Efficacy and tolerability of newer antihistamines in the treatment of allergic conjunctivitis","volume-title":"Drugs.","author":"Bielory","year":"2005"},{"key":"B37","first-page":"871","article-title":"Effects of some drugs on human erythrocyte glucose 6-phosphate dehydrogenase: an in vitro study","volume-title":"J Enzyme Inhib Med Chem.","author":"Akkemik","year":"2010"},{"key":"B38","first-page":"129","article-title":"Effect of influenza virus infection on key metabolic enzyme activities in MDCK cells","volume-title":"BMC Proc.","author":"Janke","year":"2011"},{"key":"B39","first-page":"3347","article-title":"Mast cell-induced lung injury in mice infected with H5N1 influenza virus","volume-title":"J Virol.","author":"Hu","year":"2012"},{"key":"B40","first-page":"161","article-title":"Dextromethorphan reduces oxidative stress and inhibits atherosclerosis and neointima formation in mice","volume-title":"Cardiovasc Res.","author":"Liu","year":"2009"},{"key":"B41","first-page":"2120","article-title":"Effects of double combinations of amantadine, oseltamivir, and ribavirin on influenza A (H5N1) virus infections in cell culture and in mice","volume-title":"Antimicrob Agents Chemother.","author":"Smee","year":"2009"},{"key":"B42","doi-asserted-by":"publisher","first-page":"e89985","DOI":"10.1371\/journal.pone.0089985","article-title":"Involvement of sigma-1 receptors in the antidepressant-like effects of dextromethorphan","volume":"9","author":"Nguyen","year":"","journal-title":"PLoS ONE."},{"key":"B43","first-page":"101","article-title":"Animal models for influenza virus transmission studies: a historical perspective","volume-title":"Curr Opin Virol.","author":"Bouvier","year":"2015"},{"key":"B44","first-page":"259","article-title":"Ferret models of viral pathogenesis","volume-title":"Virology.","author":"Enkirch","year":"2015"},{"key":"B45","first-page":"4027","article-title":"Systematic approaches towards the development of host-directed antiviral therapeutics","volume-title":"Int J Mol Sci.","author":"Prussia","year":"2011"},{"key":"B46","first-page":"124","article-title":"siRNA genome screening approaches to therapeutic drug repositioning","volume-title":"Pharmaceuticals.","author":"Perwitasari","year":"2013"},{"key":"B47","first-page":"153","article-title":"Drug repositioning: re-investigating existing drugs for new therapeutic indications","volume-title":"J Postgrad Med.","author":"Padhy","year":"2011"},{"key":"B48","first-page":"1307","article-title":"Target repurposing for neglected diseases","volume-title":"Future Med Chem.","author":"Pollastri","year":"2011"},{"key":"B49","first-page":"459","article-title":"Antiviral effects of inhibiting host gene expression","volume-title":"Curr Top Microbiol Immunol.","author":"Tripp","year":"2015"},{"key":"B50","first-page":"1052","article-title":"H1 -antihistamines for primary mast cell activation syndromes: a systematic review","volume-title":"Allergy.","author":"Nurmatov","year":"2015"},{"key":"B51","first-page":"S82","article-title":"Currently available cough suppressants for chronic cough","volume-title":"Lung.","author":"Chung","year":"2008"},{"key":"B52","first-page":"174","article-title":"Over-the-counter cough and cold medication use in young children","volume":"34","author":"Ryan","year":"2008","journal-title":"Pediatr Nurs"},{"key":"B53","doi-asserted-by":"publisher","first-page":"e76941","DOI":"10.1371\/journal.pone.0076941","article-title":"Sigma-1 receptor chaperone at the ER-mitochondrion interface mediates the mitochondrion-ER-nucleus signaling for cellular survival","volume":"8","author":"Mori","year":"","journal-title":"PLoS ONE."},{"key":"B54","first-page":"519","article-title":"Sigma-1Rs are upregulated via PERK\/eIF2\u03b1\/ATF4 pathway and execute protective function in ER stress","volume-title":"Biochem Biophys Res Commun.","author":"Mitsuda","year":"2011"},{"key":"B55","first-page":"12","article-title":"The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements","volume-title":"Eur J Pharmacol.","author":"Pal","year":"2012"},{"key":"B56","doi-asserted-by":"publisher","first-page":"e1290","DOI":"10.1038\/cddis.2014.243","article-title":"Loss of function of the ALS protein SigR1 leads to ER pathology associated with defective autophagy and lipid raft disturbances","volume":"5","author":"Vollrath","year":"","journal-title":"Cell Death Dis."},{"key":"B57","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.cell.2007.08.036","article-title":"Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival","volume":"131","author":"Hayashi","year":"2007","journal-title":"Cell"},{"key":"B58","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/0166-3542(91)90032-M","article-title":"Influence of trifluoperazine on the late stage of influenza virus infection in MDCK cells","volume":"15","author":"Ochiai","year":"1991","journal-title":"Antiviral Res"},{"key":"B59","doi-asserted-by":"publisher","first-page":"2763","DOI":"10.1038\/ncomms3763","article-title":"A Ca(2+)-dependent signalling circuit regulates influenza A virus internalization and infection","volume":"4","author":"Fujioka","year":"2013","journal-title":"Nat Commun"},{"key":"B60","first-page":"575","article-title":"The ferret as a model organism to study influenza A virus infection","volume-title":"Dis Model Mech.","author":"Belser","year":"2011"},{"key":"B61","doi-asserted-by":"publisher","first-page":"9361","DOI":"10.1128\/JVI.01214-12","article-title":"Characterization in vitro and in vivo of pandemic (H1N1) 2009 influenza viruses isolated from patients","volume":"86","author":"Watanabe","year":"2012"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01097\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T15:02:30Z","timestamp":1559833350000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01097\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,5]]},"references-count":61,"alternative-id":["10.3389\/fimmu.2019.01097"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.01097","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,5]]},"article-number":"1097"}}