{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:51:13Z","timestamp":1790859073780,"version":"4.1.0"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T00:00:00Z","timestamp":1559088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.01117","type":"journal-article","created":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T04:54:52Z","timestamp":1559105692000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Peri-Operative Anaphylaxis\u2014An Investigational Challenge"],"prefix":"10.3389","volume":"10","author":[{"given":"Siraj A.","family":"Misbah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamidipudi Thirumala","family":"Krishna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,5,29]]},"reference":[{"key":"B1","first-page":"172","article-title":"Anaesthesia, surgery and life-threatening allergic reactions: management and outcomes in the 6th National Audit Project (NAP6)","volume-title":"Br J Anaesth.","author":"Harper","year":"2018"},{"key":"B2","first-page":"545","article-title":"Serious intraoperative problems \u2013 a five year review of 83,444 anaesthetics","volume-title":"Can J Anaesth.","author":"Fasting","year":"2002"},{"key":"B3","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/S0750-7658(05)81016-0","article-title":"The incidence and clinical features of anaphylactic reactions during anaesthesia in Australia","volume":"12","author":"Fisher","year":"1993","journal-title":"Ann Fr Anesth Reanim"},{"key":"B4","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.jaci.2011.03.003","article-title":"Anaphylaxis during anaesthesia in France: an 8 year national survey","volume":"128","author":"Mertes","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"B5","first-page":"159","article-title":"Anaesthesia, surgery and life-threatening allergic reactions: epidemiology and clinical features in the 6th National Audit Project (NAP6)","volume-title":"Br J Anaesth.","author":"Harper","year":"2018"},{"key":"B6","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.jaip.2014.12.016","article-title":"Incidence of suspected perioperative anaphylaxis\u2014a multicentre snapshot study","volume":"3","author":"Savic","year":"2015","journal-title":"J Allergy Clin Immunol Pract"},{"key":"B7","first-page":"549","article-title":"Anaphylaxis during anaesthesis. Results of a two year survey in France","volume-title":"Br J Anaesth.","author":"Laxenaire","year":"2001"},{"key":"B8","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1111\/cei.12424","article-title":"Multicentre retrospective analysis of anaphylaxis during anaesthesia in the United Kingdom:aetiology and diagnostic performance of acute serum tryptase","volume":"178","author":"Krishna","year":"2014","journal-title":"Clin Exp Immunol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1016\/j.bja.2018.02.033","article-title":"Outcome of repeat anaesthesia after investigation for perioperative anaphylaxis","volume":"120","author":"Miller","year":"2018","journal-title":"Br J Anaesth"},{"key":"B10","first-page":"536","article-title":"Anaphylactic and anaphylactoid reactions during anaesthesia in France in 1999\u20132000","volume-title":"Anesthesiology.","author":"Mertes","year":"2003"},{"key":"B11","first-page":"301","article-title":"Anaphylactic and anaphylactoid reactions: clinical anaesthesiology","volume-title":"Bailliere's Clin Anaesthesiol.","author":"Whittington","year":"1998"},{"key":"B12","first-page":"846","article-title":"Specialist perioperative allergy clinic services in the UK 2018: results from the Royal College of Anaesthetists Sixth National Audit Project (NAP-6) investigation of perioperative anaphylaxis","volume-title":"Clin Exp Allergy.","author":"Egner","year":"2018"},{"key":"B13","first-page":"94","article-title":"Comprehensive allergy evaluation is useful in the subsequent care of patients with drug hypersensitivity reactions during anaesthesia","volume-title":"J Allergy Clin Immunol Pract.","author":"Guyer","year":"2015"},{"key":"B14","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.iac.2018.04.003","article-title":"Hereditary alpha tryptasaemia:genotyping and associated clinical features","volume":"38","author":"Lyons","year":"2018","journal-title":"Immunol Allergy Clin North Am"},{"key":"B15","first-page":"237","article-title":"Identification of a mast cell-specific receptor crucial for pseudo-allergic drug reactions","volume-title":"Nature.","author":"McNeil","year":"2015"},{"key":"B16","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.1111\/all.13456","article-title":"Neuromuscular blocking agent induced anaphylaxis: results and trends of a French pharmacovigilance survey from 2000 to 2012","volume":"73","author":"Petitpain","year":"2018","journal-title":"Allergy"},{"key":"B17","first-page":"1256","article-title":"Prevalence of IgE against neuromuscular blocking agents in hairdressers and bakers","volume-title":"Clin Exp Allergy.","author":"Dong","year":"2013"},{"key":"B18","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.iac.2009.04.002","article-title":"The pholcodine story","volume":"29","author":"Florvaag","year":"2009","journal-title":"Immunol Allergy Clin North Am"},{"key":"B19","first-page":"273","article-title":"Immediate allergic hypersensitivity to quinolones associates with neuromuscular blocking agaent sensitisation","volume-title":"J Allergy Clin Immunol Pract.","author":"Rouzaire","year":"2013"},{"key":"B20","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.jaip.2013.07.017","article-title":"On the question of the association between immediate hypersensitivity to quinolones and neuromuscular blocking agent sensitisation","volume":"6","author":"Baldo","year":"2013","journal-title":"J Allergy Clin Immunol Pract"},{"key":"B21","unstructured":""},{"key":"B22","first-page":"813","article-title":"Six years without pholcodine:Norwegians are significantly less IgE-sensitised and clinically more tolerant to neuromuscular blocking agaents","volume-title":"Allergy.","author":"de Pater","year":"2017"},{"key":"B23","first-page":"1362","article-title":"Enhancing antibiotic stewardship by tackling \u201cspurious\u201d penicillin allergy","volume-title":"Clin Exp Allergy.","author":"Krishna","year":"2017"},{"key":"B24","article-title":"Penicillin allergy de-labelling ahead of elective surgery:feasibility and barriers","volume-title":"Br J Anaesth.","author":"Savic","year":"2018"},{"key":"B25","first-page":"595","article-title":"Teicoplanin allergy\u2014an emerging problem in the anaesthetic allergy clinic","volume-title":"Br J Anaesth.","author":"Savic","year":"2015"},{"key":"B26","first-page":"1038","article-title":"Teicoplanin anaphylaxis associated with surgical prophylaxis","volume-title":"Br J Clin Pharm.","author":"Azamgarhi","year":"2018"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1111\/all.12466","article-title":"Standardised testing with chlorhexidine in perioperative allergy\u2014a large single-centre evaluation","volume":"69","author":"Opstrup","year":"2014","journal-title":"Allergy"},{"key":"B28","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/j.jaip.2016.03.017","article-title":"Pitfalls and peculiarities in chlorhexidine allergy","volume":"4","author":"Spoerl","year":"2016","journal-title":"J Allergy Clin Parct"},{"key":"B29","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.anai.2016.10.013","article-title":"Anaphylaxis caused by immediate hypersensitivity to topical chlorhexidine in children","volume":"118","author":"Lasa","year":"2017","journal-title":"Ann Allergy Asthma Immunol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.anai.2015.02.002","article-title":"The utility of specific IgE testing to chlorhexidine in the investigation of peri-operative adverse reactions","volume":"114","author":"Anderson","year":"2015","journal-title":"Ann Allergy Asthma Immunol"},{"key":"B31","first-page":"409","article-title":"IgE-mediated allergy to chlorhexidine","volume-title":"J Allergy Clin Immunol.","author":"Garvey","year":"2007"},{"key":"B32","first-page":"348","article-title":"Anaphylaxis to dyes during the peri-operative period: reports of 14 clinical cases","volume-title":"J Allergy Clin Immunol.","author":"Mertes","year":"2008"},{"key":"B33","first-page":"77","article-title":"No evidence of contra-indications to the use of propofol in adults allergic to egg,soy or peanut","volume-title":"Br J Anaesth.","author":"Asserhoj","year":"2016"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1016\/j.jaip.2018.08.027","article-title":"Intraoperative anaphylaxis:remember the hidden allergens","volume":"6","author":"Opstrup","year":"2018","journal-title":"J Allergy Clin Immunol Pract"},{"key":"B35","unstructured":""},{"key":"B36","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1046\/j.1365-2222.1999.00453.x","article-title":"Prevalence of muscle relaxant sensitivity in a general population:implications for pre-operative screening","volume":"29","author":"Porri","year":"1999","journal-title":"Clin Exp Allergy"},{"key":"B37","first-page":"59","article-title":"Intradermal compared with prick testing in the diagnosis of anaesthetic allergy","volume-title":"Br J Anaesth.","author":"Fisher","year":"1997"},{"key":"B38","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/med\/9780199204854.003.0503","article-title":"BSACI guidelines for the investigation of suspected anaphylaxis during general anaesthesia","volume-title":"Clin Exp Allergy.","author":"Ewan","year":"2010"},{"key":"B39","first-page":"702","article-title":"Skin test concentrations for systemically administered drugs\u2014an ENDA\/EAACI drug allergy interest group position paper","volume-title":"Allergy.","author":"Brockow","year":"2013"},{"key":"B40","first-page":"543","article-title":"Australian and New Zealand anaesthetic allergy group perioperative anaphylaxis investigation guidelines","volume-title":"Anaesth Intensive Care.","author":"Scolaro","year":"2017"},{"key":"B41","first-page":"1069","article-title":"Predictive value of allergy tests for neuromuscular blocking agents:tackling an unmet need","volume-title":"Cin Exp Allergy.","author":"Leysen","year":"2014"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1111\/cea.12993","article-title":"Specialist perioperative allergy clinic services in the UK 2016: results from the royal college of anaesthetists sixth national audit project","volume":"47","author":"Egner","year":"2017","journal-title":"Clin Exp Allergy"},{"key":"B43","first-page":"770","article-title":"Failure to prevent an anaphylactic reaction to a second neuromuscular blocking drug during anaesthesia","volume-title":"Br J Anaesth.","author":"Fisher","year":"1999"},{"key":"B44","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1177\/0310057X0503300620","article-title":"Anaphylaxis to cisatracurium following negative skin testing","volume":"33","author":"Fraser","year":"2005","journal-title":"Anaesth Intensive Care"},{"key":"B45","first-page":"442","article-title":"Reducing the risk of anaphylaxis during anesthesia:2011 updated guidelines for clinical practice","volume-title":"J Invest Allergol Clin Immunol.","author":"Mertes","year":"2011"},{"key":"B46","first-page":"216","article-title":"Practical guidelines for perioperative hypersensitivity reactions","volume-title":"J Invest Allergol Clin Immunol.","author":"Laguna","year":"2018"},{"key":"B47","unstructured":"MelchiorsBLB\n            KroigaardM\n            GarveyLH\n          Intravenous Provocation With Neuromuscular Blocking Agents in the Investigation of Perioperative Anaphylaxis\u2014Preliminary Findings From the Danish Anaesthesia Allergy Centre2018"},{"key":"B48","first-page":"47","article-title":"Relevance of the determination of serum-specific IgE antibodies in the diagnosis of immediate beta-lactam allergy","volume-title":"Allergy.","author":"Fontaine","year":"2007"},{"key":"B49","first-page":"1176","article-title":"In vitro diagnosis of immediate drug hypersensitivity during anaesthesia: a review of the literature","volume-title":"J Allergy Clin Immunol Pract.","author":"Ebo","year":"2018"},{"key":"B50","first-page":"1681","article-title":"Comparison of basophil activation test and skin testing performances in NMBA allergy","volume-title":"J Allergy Clin Immunol Pract.","author":"Dewachter","year":"2018"},{"key":"B51","first-page":"1690","article-title":"Hypersensitivity to neuromuscular blocking agents: can skin tests given the green light for re-exposure?","volume-title":"J Allergy Clin Immunol Pract.","author":"Sabato","year":"2018"},{"key":"B52","doi-asserted-by":"crossref","DOI":"10.1016\/j.bja.2019.02.024","article-title":"Integrating basophil activation tests into evaluation of perioperative anaphylaxis to neuromuscular blocking agents","volume-title":"Br J Anaesth.","author":"Li","year":"2019"},{"key":"B53","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1111\/j.1399-6576.2007.01313.x","article-title":"Scandinavian clinical practice guidelines on the diagnosis, management and follow-up of anaphylaxis during anaesthesia","volume":"51","author":"Kroigaard","year":"2007","journal-title":"Acta Anaesthesiol Scand"},{"key":"B54","first-page":"91","article-title":"Reducing the risk of anaphylaxis during anaesthesia: guidelines for clinical practice","volume":"15","author":"Mertes","year":"2005","journal-title":"J Invest Allergol Clin Immunol"},{"key":"B55","first-page":"820","article-title":"Early skin testing is effective for the diagnosis of hypersensitivity reactions occurring during anaesthesia","volume-title":"Allergy.","author":"Lafuente","year":"2013"},{"key":"B56","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1177\/0310057X1604400306","article-title":"Early skin and challenge testing after rocuronium anaphylaxis","volume":"44","author":"Schulberg","year":"2016","journal-title":"Anaesth Intensive Care"},{"key":"B57","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1177\/0310057X9902700212","article-title":"Subsequent general anaesthesia in patients with a history of previous anaphylactoid\/anaphylactic reactions to muscle relaxants","volume":"27","author":"Thacker","year":"1999","journal-title":"Anaesth Intensive Care"},{"key":"B58","doi-asserted-by":"publisher","first-page":"395","DOI":"10.2165\/00002018-200427060-00004","article-title":"Prevention of anaphylactic reactions to anaesthetic drugs","volume":"27","author":"Fisher","year":"2004","journal-title":"Drug Safety"},{"key":"B59","first-page":"99","article-title":"Follow up after anaesthetic anaphylaxis","volume-title":"Acta Anaesthesiol Scand.","author":"Fisher","year":"2011"},{"key":"B60","first-page":"1437","article-title":"Safety of subsequent general anaesthesia in patients allergic to neuromuscular blocking agents: value of allergy skin testing","volume-title":"Br J Anaesth.","author":"Chiriac","year":"2018"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1056\/NEJMc1510021","article-title":"Mast cells, mastocytosis and related disorders","volume":"373","author":"Miller","year":"2015","journal-title":"New Engl J Med"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1177\/0310057X1204000619","article-title":"Failure to investigate anaesthetic anaphylaxis resulting in a preventable second anaphylactic reaction","volume":"40","author":"Pedersen","year":"2012","journal-title":"Anaesth Intensive Care"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01117\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T04:55:02Z","timestamp":1559105702000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01117\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,29]]},"references-count":62,"alternative-id":["10.3389\/fimmu.2019.01117"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.01117","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,29]]},"article-number":"1117"}}