{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:57:59Z","timestamp":1791575879542,"version":"4.3.4"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.01137","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T04:29:55Z","timestamp":1558499395000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Complement System Inhibition Modulates the Pro-Inflammatory Effects of a Snake Venom Metalloproteinase"],"prefix":"10.3389","volume":"10","author":[{"given":"Lygia Samartin Gon\u00e7alves","family":"Luchini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giselle","family":"Pidde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Cristina","family":"Squaiella-Baptist\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise V.","family":"Tambourgi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,5,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s40409-017-0127-6","article-title":"Snakebite envenomation turns again into a neglected tropical disease!","volume":"23","author":"Chippaux","year":"2017","journal-title":"J Venom Anim Toxins Incl Trop Dis."},{"key":"B2","first-page":"515","article-title":"Snake-bites: appraisal of the global situation","volume":"76","author":"Chippaux","year":"1998","journal-title":"Bull World Health Organ."},{"key":"B3","doi-asserted-by":"publisher","first-page":"e218","DOI":"10.1371\/journal.pmed.0050218","article-title":"The global burden of snakebite: a literature analysis and modelling based on regional estimates of envenoming and deaths","volume":"5","author":"Kasturiratne","year":"2008","journal-title":"PLoS Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.molimm.2014.06.020","article-title":"Animal venoms\/toxins and the complement system","volume":"61","author":"Tambourgi","year":"2014","journal-title":"Mol Immunol."},{"key":"B5","unstructured":"WHO Guidelines for the Production, Control and Regulation of Snake Antivenom Immunoglobulins.2010"},{"key":"B6","doi-asserted-by":"publisher","first-page":"e2519","DOI":"10.1371\/journal.pntd.0002519","article-title":"P-I snake venom metalloproteinase is able to activate the complement system by direct cleavage of central components of the cascade","volume":"7","author":"Pidde-Queiroz","year":"2013","journal-title":"PLoS Negl Trop Dis."},{"key":"B7","doi-asserted-by":"publisher","first-page":"17063","DOI":"10.1038\/nrdp.2017.63","article-title":"Snakebite envenoming","volume":"3","author":"Guti\u00e9rrez","year":"2017","journal-title":"Nat Rev Dis Primers."},{"key":"B8","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/j.toxicon.2008.10.002","article-title":"Interspecific variation in venom composition and toxicity of Brazilian snakes from Bothrops genus","volume":"52","author":"Queiroz","year":"2008","journal-title":"Toxicon."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2537","DOI":"10.1016\/j.molimm.2010.07.003","article-title":"Human complement activation and anaphylatoxins generation induced by snake venom toxins from Bothrops genus","volume":"47","author":"Pidde-Queiroz","year":"2010","journal-title":"Mol Immunol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.jprot.2013.01.021","article-title":"Proteomic analysis of Bothrops pirajai snake venom and characterization of BpirMP, a new P-I metalloproteinase","volume":"80","author":"Bernardes","year":"2013","journal-title":"J Proteomics."},{"key":"B11","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.molimm.2015.09.023","article-title":"Evaluation of the local inflammatory events induced by BpirMP, a metalloproteinase from Bothrops pirajai venom","volume":"68","author":"Bernardes","year":"2015","journal-title":"Mol Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.intimp.2013.02.023","article-title":"Effects of two serine proteases from Bothrops pirajai snake venom on the complement system and the inflammatory response","volume":"15","author":"Menaldo","year":"2013","journal-title":"Int Immunopharmacol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s40409-015-0026-7","article-title":"Bothrops snake venoms and their isolated toxins, an L-amino acid oxidase and a serine protease, modulate human complement system pathways","volume":"21","author":"Ayres","year":"2015","journal-title":"J Venom Anim Toxins Incl Trop Dis."},{"key":"B14","first-page":"1869","article-title":"Essential role of the C5a receptor in E. coli-induced oxidative burst and phagocytosis revealed by a novel lepirudin-based human whole blood model of inflammation","volume":"100","author":"Mollnes","year":"2002","journal-title":"Blood."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.3892\/mmr.2014.2025","article-title":"Direct thrombin inhibitors: patents 2002-2012 (Review)","volume":"9","author":"Kong","year":"2014","journal-title":"Mol Med Rep."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1189\/jlb.0806538","article-title":"The role of complement C3 opsonization, C5a receptor, and CD14 in E. coli-induced up-regulation of granulocyte and monocyte CD11b\/CD18 (CR3), phagocytosis, and oxidative burst in human whole blood","volume":"81","author":"Brekke","year":"2007","journal-title":"J Leukoc Biol."},{"key":"B17","doi-asserted-by":"crossref","first-page":"884","DOI":"10.4049\/jimmunol.157.2.884","article-title":"Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library","volume":"157","author":"Sahu","year":"1996","journal-title":"J Immunol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/978-0-387-78952-1_20","article-title":"Compstatin: a complement inhibitor on its way to clinical application","volume":"632","author":"Ricklin","year":"2008","journal-title":"Adv Exp Med Biol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/omi.12129","article-title":"Complement therapeutics in inflammatory diseases: promising drug candidates for C3-targeted intervention","volume":"31","author":"Mastellos","year":"2016","journal-title":"Mol Oral Microbiol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.molimm.2017.12.009","article-title":"Loxosceles venom Sphingomyelinase D activates human blood leukocytes: role of the complement system","volume":"94","author":"Manzoni-de-Almeida","year":"2018","journal-title":"Mol Immunol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.molimm.2017.05.013","article-title":"Complement in clinical medicine: clinical trials, case reports and therapy monitoring","volume":"89","author":"Ricklin","year":"2017","journal-title":"Mol Immunol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s00441-010-1034-0","article-title":"The complement system","volume":"343","author":"Sarma","year":"2011","journal-title":"Cell Tissue Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"402","DOI":"10.2353\/ajpath.2007.060984","article-title":"A protein toxin from the sea anemone Phyllodiscus semoni targets the kidney and causes a severe renal injury with predominant glomerular endothelial damage","volume":"171","author":"Mizuno","year":"2007","journal-title":"Am J Pathol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"e76558","DOI":"10.1371\/journal.pone.0076558","article-title":"Brown recluse spider bite mediated hemolysis: clinical features, a possible role for complement inhibitor therapy, and reduced RBC surface glycophorin A as a potential biomarker of venom exposure","volume":"8","author":"Gehrie","year":"2013","journal-title":"PLoS ONE."},{"key":"B25","doi-asserted-by":"publisher","first-page":"401","DOI":"10.2174\/1568010054022150","article-title":"Pro and anti-inflammatory properties of toxins from animal venoms","volume":"4","author":"Farsky","year":"2005","journal-title":"Curr Drug Targets Inflamm Allergy."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1016\/S0041-0101(98)00126-3","article-title":"Snake venoms and the hemostatic system","volume":"36","author":"Markland","year":"1998","journal-title":"Toxicon."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1016\/j.toxicon.2010.08.013","article-title":"Purification, cloning and characterization of a metalloproteinase from Naja atra venom","volume":"56","author":"Sun","year":"2010","journal-title":"Toxicon."},{"key":"B28","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.bcp.2008.05.033","article-title":"Recombinant fibrinogenase from Agkistrodon acutus venom protects against sepsis via direct degradation of fibrin and TNF-alpha","volume":"76","author":"Wang","year":"2008","journal-title":"Biochem Pharmacol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1016\/j.bcp.2012.11.012","article-title":"A novel recombinant fibrinogenase of Agkistrodon acutus venom protects against hyperacute rejection via degradation of complements","volume":"85","author":"Lin","year":"2013","journal-title":"Biochem Pharmacol."},{"key":"B30","doi-asserted-by":"crossref","first-page":"535","DOI":"10.4049\/jimmunol.104.3.535","article-title":"C5 chemotactic fragments produced by an enzyme in lysosomal granules of neutrophils","volume":"104","author":"Ward","year":"1970","journal-title":"J Immunol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/S0171-2985(00)80099-6","article-title":"Cleavage of the fifth component of complement and generation of a functionally active C5b6-like complex by human leukocyte elastase","volume":"201","author":"Vogt","year":"2000","journal-title":"Immunobiology."},{"key":"B32","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1038\/nri3761","article-title":"Complement\u2013tapping into new sites and effector systems","volume":"14","author":"Kolev","year":"2014","journal-title":"Nat Rev Immunol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1182\/blood-2015-03-637645","article-title":"Eculizumab treatment efficiently prevents C5 cleavage without C5a generation in vivo","volume":"126","author":"Volokhina","year":"2015","journal-title":"Blood."},{"key":"B34","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3389\/fmed.2018.00052","article-title":"CD11b activity modulates pathogenesis of lupus nephritis","volume":"5","author":"Khan","year":"2018","journal-title":"Front Med (Lausanne)."},{"key":"B35","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1111\/cei.12645","article-title":"The anti-inflammatory effect of combined complement and CD14 inhibition is preserved during escalating bacterial load","volume":"181","author":"Egge","year":"2015","journal-title":"Clin Exp Immunol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.molimm.2017.05.019","article-title":"Novel insights into the expression pattern of anaphylatoxin receptors in mice and men","volume":"89","author":"Laumonnier","year":"2017","journal-title":"Mol Immunol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.molimm.2017.05.015","article-title":"New concepts on the therapeutic control of complement anaphylatoxin receptors","volume":"89","author":"Hawksworth","year":"2017","journal-title":"Mol Immunol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1111\/imr.12467","article-title":"More than complementing Tolls: complement-Toll-like receptor synergy and crosstalk in innate immunity and inflammation","volume":"274","author":"Hajishengallis","year":"2016","journal-title":"Immunol Rev."},{"key":"B39","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/S1471-4906(02)02233-0","article-title":"Lipopolysaccharide recognition: CD14, TLRs and the LPS-activation cluster","volume":"23","author":"Triantafilou","year":"2002","journal-title":"Trends Immunol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"e88174","DOI":"10.1371\/journal.pone.0088174","article-title":"TLR2, TLR4 and CD14 recognize venom-associated molecular patterns from Tityus serrulatus to induce macrophage-derived inflammatory mediators","volume":"9","author":"Zoccal","year":"2014","journal-title":"PLoS ONE."},{"key":"B41","doi-asserted-by":"publisher","first-page":"E304","DOI":"10.3390\/toxins8100304","article-title":"A comprehensive view of the structural and functional alterations of extracellular matrix by snake venom metalloproteinases (SVMPs): novel perspectives on the pathophysiology of envenoming","volume":"8","author":"Guti\u00e9rrez","year":"2016","journal-title":"Toxins (Basel)"},{"key":"B42","doi-asserted-by":"publisher","first-page":"e235","DOI":"10.1016\/B978-0-323-47778-9.50127-6","article-title":"CXCL9 chemokine in ulcerative colitis","volume":"169","author":"Elia","year":"2018","journal-title":"Clin Ter."}],"updated-by":[{"DOI":"10.3389\/fimmu.2019.01539","type":"corrigendum","label":"Corrigendum","source":"publisher","updated":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T00:00:00Z","timestamp":1562112000000}}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01137\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T20:05:31Z","timestamp":1694894731000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01137\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,22]]},"references-count":42,"alternative-id":["10.3389\/fimmu.2019.01137"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.01137","relation":{"corrigendum":[{"id-type":"doi","id":"10.3389\/fimmu.2019.01539","asserted-by":"object"}]},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,22]]},"article-number":"1137"}}