{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:43:05Z","timestamp":1790476985788,"version":"4.1.0"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:00:00Z","timestamp":1560211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB TR128"],"award-info":[{"award-number":["SFB TR128"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["ExC 1010 SyNergy"],"award-info":[{"award-number":["ExC 1010 SyNergy"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010571","name":"Bundesministerium f\u00fcr Bildung, Wissenschaft, Forschung und Technologie","doi-asserted-by":"publisher","award":["Clinical Competence Network for Multiple Sclerosis"],"award-info":[{"award-number":["Clinical Competence Network for Multiple Sclerosis"]}],"id":[{"id":"10.13039\/501100010571","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.01189","type":"journal-article","created":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:47:37Z","timestamp":1560214057000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["The Glycosylation Site of Myelin Oligodendrocyte Glycoprotein Affects Autoantibody Recognition in a Large Proportion of Patients"],"prefix":"10.3389","volume":"10","author":[{"given":"Iris","family":"Marti Fernandez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Macrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Krumbholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Hensbergen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes L.","family":"Hipgrave Ederveen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Winklmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atay","family":"Vural","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asli","family":"Kurne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Jenne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frits","family":"Kamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa Ann","family":"Gerdes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Hohlfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Wuhrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"K\u00fcmpfel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Meinl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,6,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/nm1488","article-title":"Wucherpfennig: Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein","volume":"13","author":"O'Connor","year":"2007","journal-title":"Nat Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1002\/ana.21916","article-title":"Antibodies to native myelin oligodendrocyte glycoprotein in children with inflammatory demyelinating central nervous system disease","volume":"66","author":"Brilot","year":"2009","journal-title":"Ann Neurol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1212\/WNL.0b013e318228c0b1","article-title":"Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis","volume":"77","author":"Pr\u00f6bstel","year":"2011","journal-title":"Neurology."},{"key":"B4","doi-asserted-by":"publisher","first-page":"529","DOI":"10.3389\/fimmu.2017.00529","article-title":"Myelin oligodendrocyte glycoprotein: deciphering a target in inflammatory demyelinating diseases","volume":"8","author":"Peschl","year":"2017","journal-title":"Front Immunol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1186\/s12974-016-0718-0","article-title":"MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 2: epidemiology, clinical presentation, radiological and laboratory features, treatment responses, and long-term outcome","volume":"13","author":"Jarius","year":"2016","journal-title":"J Neuroinflammation"},{"key":"B6","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.autrev.2015.12.004","article-title":"Anti-MOG antibody: the history, clinical phenotype, and pathogenicity of a serum biomarker for demyelination","volume":"15","author":"Ramanathan","year":"2016","journal-title":"Autoimmun Rev"},{"key":"B7","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/S1474-4422(15)00313-0","article-title":"The search for the target antigens of multiple sclerosis, part 2: CD8+ T cells, B cells, and antibodies in the focus of reverse-translational research","volume":"15","author":"Hohlfeld","year":"2016","journal-title":"Lancet Neurol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"3128","DOI":"10.1093\/brain\/awx276","article-title":"Clinical presentation and prognosis in MOG-antibody disease: a UK study","volume":"140","author":"Jurynczyk","year":"2017","journal-title":"Brain."},{"key":"B9","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1177\/1756285611433772","article-title":"Glycoproteins as targets of autoantibodies in CNS inflammation: MOG and more","volume":"5","author":"Mayer","year":"2012","journal-title":"Ther Adv Neurol Disord"},{"key":"B10","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/s41582-018-0112-x","article-title":"Myelin oligodendrocyte glycoprotein antibodies in neurological disease","volume":"15","author":"Reindl","year":"2018","journal-title":"Nat Rev Neurol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2753","DOI":"10.3389\/fimmu.2018.02753","article-title":"Myelin oligodendrocyte glycoprotein antibody-associated disorders: toward a new spectrum of inflammatory demyelinating CNS disorders?","volume":"9","author":"Di Pauli","year":"2018","journal-title":"Front Immunol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1186\/1742-2094-8-184","article-title":"Complement activating antibodies to myelin oligodendrocyte glycoprotein in neuromyelitis optica and related disorders","volume":"8","author":"Mader","year":"2011","journal-title":"J.Neuroinflammation."},{"key":"B13","doi-asserted-by":"publisher","first-page":"e12","DOI":"10.1212\/NXI.0000000000000012","article-title":"Antibodies to MOG have a demyelination phenotype and affect oligodendrocyte cytoskeleton","volume":"1","author":"Dale","year":"2014","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"B14","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1186\/s12974-017-0984-5","article-title":"Human antibodies against the myelin oligodendrocyte glycoprotein can cause complement-dependent demyelination","volume":"14","author":"Peschl","year":"2017","journal-title":"J Neuroinflammation"},{"key":"B15","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s00401-016-1559-8","article-title":"Myelin-reactive antibodies initiate T cell-mediated CNS autoimmune disease by opsonization of endogenous antigen","volume":"132","author":"Kinzel","year":"2016","journal-title":"Acta Neuropathol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"19057","DOI":"10.1073\/pnas.0607242103","article-title":"Identification of a pathogenic antibody response to native myelin oligodendrocyte glycoprotein in multiple sclerosis","volume":"103","author":"Zhou","year":"2006","journal-title":"Proc Natl Acad Sci USA."},{"key":"B17","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/2051-5960-2-35","article-title":"Neuromyelitis optica MOG-IgG causes reversible lesions in mouse brain","volume":"2","author":"Saadoun","year":"2014","journal-title":"Acta Neuropathol Commun"},{"key":"B18","doi-asserted-by":"publisher","first-page":"3323","DOI":"10.1073\/pnas.1519608113","article-title":"Autoantibody-boosted T-cell reactivation in the target organ triggers manifestation of autoimmune CNS disease","volume":"113","author":"Flach","year":"2016","journal-title":"Proc Natl Acad Sci USA."},{"key":"B19","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.jaut.2017.09.002","article-title":"Myelin oligodendrocyte glycoprotein-specific antibodies from multiple sclerosis patients exacerbate disease in a humanized mouse model","volume":"86","author":"Khare","year":"2018","journal-title":"J Autoimmun"},{"key":"B20","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1002\/ana.25291","article-title":"Pathogenicity of human antibodies against myelin oligodendrocyte glycoprotein","volume":"84","author":"Spadaro","year":"2018","journal-title":"Ann Neurol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"11059","DOI":"10.1073\/pnas.1833158100","article-title":"The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosis","volume":"100","author":"Clements","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"B22","doi-asserted-by":"publisher","first-page":"9446","DOI":"10.1073\/pnas.1133443100","article-title":"Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein","volume":"100","author":"Breithaupt","year":"2003","journal-title":"Proc Natl Acad Sci USA."},{"key":"B23","doi-asserted-by":"publisher","first-page":"3594","DOI":"10.4049\/jimmunol.1301296","article-title":"Distinction and temporal stability of conformational epitopes on myelin oligodendrocyte glycoprotein recognized by patients with different inflammatory central nervous system diseases","volume":"191","author":"Mayer","year":"2013","journal-title":"J Immunol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.4049\/jimmunol.181.2.1255","article-title":"Demyelinating myelin oligodendrocyte glycoprotein-specific autoantibody response is focused on one dominant conformational epitope region in rodents","volume":"181","author":"Breithaupt","year":"2008","journal-title":"J Immunol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"7907","DOI":"10.1074\/jbc.M113.528489","article-title":"Specific contactin N-glycans are implicated in neurofascin binding and autoimmune targeting in peripheral neuropathies","volume":"289","author":"Labasque","year":"2014","journal-title":"J Biol Chem."},{"key":"B26","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/nm0698-679","article-title":"A role for carbohydrates in immune evasion in AIDS","volume":"4","author":"Reitter","year":"1998","journal-title":"Nat Med"},{"key":"B27","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/nature01470","article-title":"Antibody neutralization and escape by HIV-1","volume":"422","author":"Wei","year":"2003","journal-title":"Nature."},{"key":"B28","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.immuni.2014.04.009","article-title":"Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers","volume":"40","author":"Falkowska","year":"2014","journal-title":"Immunity."},{"key":"B29","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1002\/acn3.164","article-title":"Histopathology and clinical course of MOG-antibody associated encephalomyelitis","volume":"2","author":"Spadaro","year":"2015","journal-title":"Ann Clin Transl Neurol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"e89","DOI":"10.1212\/NXI.0000000000000089","article-title":"MOG cell-based assay detects non-MS patients with inflammatory neurologic disease","volume":"2","author":"Waters","year":"2015","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1001\/jamaneurol.2018.1814","article-title":"Association of MOG-IgG serostatus with relapse after acute disseminated encephalomyelitis and proposed diagnostic criteria for MOG-IgG-associated disorders","volume":"75","author":"Lopez-Chiriboga","year":"2018","journal-title":"JAMA Neurol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"e40","DOI":"10.1212\/NXI.0000000000000040","article-title":"Antibodies to myelin oligodendrocyte glycoprotein in bilateral and recurrent optic neuritis","volume":"1","author":"Ramanathan","year":"2014","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"B33","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1136\/jnnp-2018-317969","article-title":"CSF cytokine profile in MOG-IgG+ neurological disease is similar to AQP4-IgG+ NMOSD but distinct from MS: a cross-sectional study and potential therapeutic implications","volume":"89","author":"Kaneko","year":"2018","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"B34","doi-asserted-by":"publisher","first-page":"e257","DOI":"10.1212\/NXI.0000000000000257","article-title":"Autoantibodies to MOG in a distinct subgroup of adult multiple sclerosis","volume":"3","author":"Spadaro","year":"2016","journal-title":"Neurol Neuroimmunol Neuroinflamm."},{"key":"B35","doi-asserted-by":"publisher","first-page":"e62","DOI":"10.1212\/NXI.0000000000000062","article-title":"Does MOG Ig-positive AQP4-seronegative opticospinal inflammatory disease justify a diagnosis of NMO spectrum disorder?","volume":"2","author":"Zamvil","year":"2015","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"B36","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1186\/s12974-018-1144-2","article-title":"MOG encephalomyelitis: international recommendations on diagnosis and antibody testing","volume":"15","author":"Jarius","year":"2018","journal-title":"J Neuroinflammation"},{"key":"B37","doi-asserted-by":"publisher","first-page":"7864","DOI":"10.1073\/pnas.1522730113","article-title":"Distinct oligoclonal band antibodies in multiple sclerosis recognize ubiquitous self-proteins","volume":"113","author":"Br\u00e4ndle","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"B38","doi-asserted-by":"publisher","first-page":"2700","DOI":"10.4049\/jimmunol.1301293","article-title":"NSP4 is stored in azurophil granules and released by activated neutrophils as active endoprotease with restricted specificity","volume":"191","author":"Perera","year":"2013","journal-title":"J Immunol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1385\/1-59745-167-3:125","article-title":"Detailed structural analysis of N-glycans released from glycoproteins in SDS-PAGE gel bands using HPLC combined with exoglycosidase array digestions","volume":"347","author":"Royle","year":"2006","journal-title":"Methods Mol Biol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"5784","DOI":"10.1021\/ac500335t","article-title":"High-throughput profiling of protein N-glycosylation by MALDI-TOF-MS employing linkage-specific sialic acid esterification","volume":"86","author":"Reiding","year":"2014","journal-title":"Anal Chem"},{"key":"B41","doi-asserted-by":"publisher","first-page":"6119","DOI":"10.1021\/ac800630x","article-title":"Hydrophilic interaction chromatography-based high-throughput sample preparation method for N-glycan analysis from total human plasma glycoproteins","volume":"80","author":"Ruhaak","year":"2008","journal-title":"Anal Chem"},{"key":"B42","doi-asserted-by":"publisher","first-page":"2492","DOI":"10.1021\/ac1027116","article-title":"Cotton HILIC SPE microtips for microscale purification and enrichment of glycans and glycopeptides","volume":"83","author":"Selman","year":"2011","journal-title":"Anal Chem"},{"key":"B43","doi-asserted-by":"publisher","first-page":"5088","DOI":"10.1021\/acs.jproteome.5b00658","article-title":"Massy tools: a high-throughput targeted data processing tool for relative quantitation and quality control developed for glycomic and glycoproteomic MALDI-MS","volume":"14","author":"Jansen","year":"2015","journal-title":"J Proteome Res"},{"key":"B44","doi-asserted-by":"publisher","first-page":"3613","DOI":"10.1073\/pnas.1616301114","article-title":"Common coding variant in SERPINA1 increases the risk for large artery stroke","volume":"114","author":"Malik","year":"2017","journal-title":"Proc Natl Acad Sci USA."},{"key":"B45","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1146\/annurev-immunol-051116-052433","article-title":"Signaling by antibodies: recent progress","volume":"35","author":"Bournazos","year":"2017","journal-title":"Annu Rev Immunol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"877","DOI":"10.3389\/fimmu.2017.00877","article-title":"Decoding the human immunoglobulin G-glycan repertoire reveals a spectrum of Fc-receptor- and complement-mediated-effector activities","volume":"8","author":"Dekkers","year":"2017","journal-title":"Front Immunol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/nrrheum.2017.146","article-title":"Differential antibody glycosylation in autoimmunity: sweet biomarker or modulator of disease activity?","volume":"13","author":"Seeling","year":"2017","journal-title":"Nat Rev Rheumatol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1186\/s12974-015-0450-1","article-title":"Pro-inflammatory pattern of IgG1 Fc glycosylation in multiple sclerosis cerebrospinal fluid","volume":"12","author":"Wuhrer","year":"2015","journal-title":"J Neuroinflammation"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.4049\/jimmunol.1502136","article-title":"The emerging importance of IgG fab glycosylation in immunity","volume":"196","author":"van de Bovenkamp","year":"2016","journal-title":"J Immunol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1084\/jem.20122192","article-title":"CNS myelin induces regulatory functions of DC-SIGN-expressing, antigen-presenting cells via cognate interaction with MOG","volume":"211","author":"Garcia-Vallejo","year":"2014","journal-title":"J Exp Med"},{"key":"B51","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/nri3737","article-title":"Siglec-mediated regulation of immune cell function in disease","volume":"14","author":"Macauley","year":"2014","journal-title":"Nat Rev Immunol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01189\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:47:40Z","timestamp":1560214060000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01189\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,11]]},"references-count":51,"alternative-id":["10.3389\/fimmu.2019.01189"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.01189","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,11]]},"article-number":"1189"}}