{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:02:54Z","timestamp":1790355774147,"version":"4.1.0"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:00:00Z","timestamp":1560211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.01323","type":"journal-article","created":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:52:27Z","timestamp":1560214347000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":48,"title":["Airway M Cells Arise in the Lower Airway Due to RANKL Signaling and Reside in the Bronchiolar Epithelium Associated With iBALT in Murine Models of Respiratory Disease"],"prefix":"10.3389","volume":"10","author":[{"given":"Shunsuke","family":"Kimura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mami","family":"Mutoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meri","family":"Hisamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikaru","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Asakura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichiro","family":"Iida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Hase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Iwanaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,6,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1183\/09031936.00141514","article-title":"The innate immune function of airway epithelial cells in inflammatory lung disease","volume":"45","author":"Hiemstra","year":"2015","journal-title":"Eur Respir J."},{"key":"B2","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1111\/resp.12542","article-title":"Bronchial epithelial cells: the key effector cells in the pathogenesis of chronic obstructive pulmonary disease?","volume":"20","author":"Gao","year":"2015","journal-title":"Respirology."},{"key":"B3","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1183\/09031936.01.00228801","article-title":"Lung mucosal immunity: immunoglobulin-A revisited","volume":"18","author":"Pilette","year":"2001","journal-title":"Eur Respir J."},{"key":"B4","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/BF00215747","article-title":"Transport of membrane-bound macromolecules by M cells in follicle-associated epithelium of rabbit Peyer's patch","volume":"247","author":"Neutra","year":"1987","journal-title":"Cell Tissue Res."},{"key":"B5","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/aja.1001360406","article-title":"Pinocytosis by epithelium associated with lymphoid follicles in the bursa of Fabricius, appendix, and Peyer's patches. An electron microscopic study","volume":"136","author":"Bockman","year":"1973","journal-title":"Am J Anat."},{"key":"B6","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/S0016-5085(77)80254-0","article-title":"Sequential uptake of horseradish peroxidase by lymphoid follicle epithelium of Peyer's patches in the normal unobstructed mouse intestine: an ultrastructural study","volume":"72","author":"Owen","year":"1977","journal-title":"Gastroenterology."},{"key":"B7","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1038\/mi.2014.99","article-title":"Visualization of the entire differentiation process of murine M cells: suppression of their maturation in cecal patches","volume":"8","author":"Kimura","year":"2015","journal-title":"Mucosal Immunol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/nature08529","article-title":"Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response","volume":"462","author":"Hase","year":"2009","journal-title":"Nature"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1038\/ncb1990","article-title":"M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex","volume":"11","author":"Hase","year":"2009","journal-title":"Nat Cell Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1016\/j.yexcr.2012.05.013","article-title":"Tunneling nanotubes: emerging view of their molecular components and formation mechanisms","volume":"318","author":"Kimura","year":"2012","journal-title":"Exp Cell Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s00441-012-1518-1","article-title":"The molecular basis of induction and formation of tunneling nanotubes","volume":"352","author":"Kimura","year":"2013","journal-title":"Cell Tissue Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"33548","DOI":"10.1038\/srep33548","article-title":"Distinct roles for the N- and C-terminal regions of M-Sec in plasma membrane deformation during tunneling nanotube formation","volume":"6","author":"Kimura","year":"2016","journal-title":"Sci Rep."},{"key":"B13","doi-asserted-by":"publisher","first-page":"5738","DOI":"10.4049\/jimmunol.0901563","article-title":"RANKL is necessary and sufficient to initiate development of antigen-sampling M cells in the intestinal epithelium","volume":"183","author":"Knoop","year":"2009","journal-title":"J Immunol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"3639","DOI":"10.1128\/MCB.00434-12","article-title":"Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured \u201dminiguts\"","volume":"32","author":"de","year":"2012","journal-title":"Mol Cell Biol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1038\/mi.2012.122","article-title":"Transcription factor Spi-B-dependent and -independent pathways for the development of Peyer's patch M cells","volume":"6","author":"Sato","year":"2013","journal-title":"Mucosal Immunol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1038\/ni.2352","article-title":"The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells","volume":"13","author":"Kanaya","year":"2012","journal-title":"Nat Immunol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1084\/jem.20181604","article-title":"Sox8 is essential for M-cell maturation to accelerate IgA response at the early stage after weaning in mice","volume":"216","author":"Kimura","year":"2019","journal-title":"J Exp Med."},{"key":"B18","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/BF00318460","article-title":"Lymphoid and non-lymphoid cells in nasal-associated lymphoid tissue (NALT) in the rat. An immuno- and enzyme-histochemical study","volume":"259","author":"Kuper","year":"1990","journal-title":"Cell Tissue Res."},{"key":"B19","first-page":"219","article-title":"The role of nasopharyngeal lymphoid tissue. Immunol Today","volume":"13","author":"Kuper","year":"1992"},{"key":"B20","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s00441-015-2309-2","article-title":"RANKL regulates differentiation of microfold cells in mouse nasopharynx-associated lymphoid tissue (NALT)","volume":"364","author":"Mutoh","year":"2016","journal-title":"Cell Tissue Res."},{"key":"B21","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/978-1-62703-125-7_9","article-title":"Culture and differentiation of mouse tracheal epithelial cells","volume":"945","author":"You","year":"2013","journal-title":"Methods Mol Biol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1038\/s41385-018-0077-5","article-title":"Sphingosine 1-phosphate receptor modulator ONO-4641 stimulates CD11b+Gr-1+ cell expansion and inhibits lymphocyte infiltration in the lungs to ameliorate murine pulmonary emphysema","volume":"11","author":"Asakura","year":"2018","journal-title":"Mucosal Immunol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1093\/infdis\/jiv527","article-title":"Pneumococcal infection aggravates elastase-induced emphysema via matrix metalloproteinase 12 overexpression","volume":"213","author":"Takahashi","year":"2016","journal-title":"J Infect Dis."},{"key":"B24","doi-asserted-by":"publisher","first-page":"L1039","DOI":"10.1152\/ajplung.00366.2014","article-title":"Evaluation of cigarette smoke-induced emphysema in mice using quantitative micro-computed tomography","volume":"308","author":"Sasaki","year":"2015","journal-title":"Am J Physiol Lung Cell Mol Physiol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/ni.2053","article-title":"The development of inducible bronchus-associated lymphoid tissue depends on IL-17","volume":"12","author":"Rangel-Moreno","year":"2011","journal-title":"Nat Immunol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods."},{"key":"B27","doi-asserted-by":"publisher","first-page":"351","DOI":"10.2220\/biomedres.37.351","article-title":"The broad distribution of GP2 in mucous glands and secretory products","volume":"37","author":"Kimura","year":"2016","journal-title":"Biomed Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s12565-017-0418-6","article-title":"Molecular insights into the mechanisms of M-cell differentiation and transcytosis in the mucosa-associated lymphoid tissues","volume":"93","author":"Kimura","year":"2018","journal-title":"Anat Sci Int."},{"key":"B29","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1084\/jem.20160659","article-title":"Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-\u03baB signaling","volume":"215","author":"Kanaya","year":"2018","journal-title":"J Exp Med."},{"key":"B30","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.jaut.2015.08.019","article-title":"The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes","volume":"66","author":"Pearson","year":"2016","journal-title":"J Autoimmun."},{"key":"B31","doi-asserted-by":"publisher","first-page":"C498","DOI":"10.1152\/ajpcell.00108.2016","article-title":"TNF-\u03b1 augments RANKL-dependent intestinal M cell differentiation in enteroid cultures","volume":"311","author":"Wood","year":"2016","journal-title":"Am J Physiol Cell Physiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"e0148216","DOI":"10.1371\/journal.pone.0148216","article-title":"Development of functional microfold (M) cells from intestinal stem cells in primary human enteroids","volume":"11","author":"Rouch","year":"2016","journal-title":"PLoS ONE."},{"key":"B33","doi-asserted-by":"publisher","first-page":"e00740","DOI":"10.1128\/IAI.00740-18","article-title":"Evaluating S. flexneri pathogenesis in the human enteroid model","volume":"87","author":"Ranganathan","year":"2019","journal-title":"Infect Immun."},{"key":"B34","doi-asserted-by":"publisher","first-page":"2532","DOI":"10.4049\/jimmunol.171.5.2532","article-title":"Membranous cells in nasal-associated lymphoid tissue: a portal of entry for the respiratory mucosal pathogen group A streptococcus","volume":"171","author":"Park","year":"2003","journal-title":"J Immunol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1016\/j.celrep.2016.06.080","article-title":"Microfold cells actively translocate Mycobacterium tuberculosis to initiate infection","volume":"16","author":"Nair","year":"2016","journal-title":"Cell Rep"},{"key":"B36","doi-asserted-by":"publisher","first-page":"258","DOI":"10.3389\/fimmu.2016.00258","article-title":"Inducible bronchus-associated lymphoid tissue: taming inflammation in the lung","volume":"7","author":"Hwang","year":"2016","journal-title":"Front Immunol."},{"key":"B37","first-page":"471","article-title":"The response of rat bronchus-associated lymphoid tissue to local antigenic challenge","volume":"60","author":"Gregson","year":"1979","journal-title":"Br J Exp Pathol."},{"key":"B38","first-page":"119","article-title":"Structure and function of bronchus-associated lymphoid tissue (BALT)","volume":"9","author":"Sminia","year":"1989","journal-title":"Crit Rev Immunol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1679\/aohc.63.81","article-title":"The presence of specialized epithelial cells on the bronchus-associated lymphoid tissue (BALT) in the mouse","volume":"63","author":"Tango","year":"2000","journal-title":"Arch Histol Cytol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/ncomms14509","article-title":"Allograft inflammatory factor 1 is a regulator of transcytosis in M cells","author":"Kishikawa","year":"2017","journal-title":"Nat Commun."},{"key":"B41","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/mi.2015.121","article-title":"Antigen sampling by intestinal M cells is the principal pathway initiating mucosal IgA production to commensal enteric bacteria","volume":"9","author":"Rios","year":"2016","journal-title":"Mucosal Immunol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"L231","DOI":"10.1152\/ajplung.90209.2008","article-title":"Ciliated epithelial cell lifespan in the mouse trachea and lung","volume":"295","author":"Rawlins","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol."},{"key":"B43","first-page":"539","article-title":"In vitro and in vivo growth and differentiation of clones of tracheal basal cells","volume":"134","author":"Inayama","year":"1989","journal-title":"Am J Pathol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"12771","DOI":"10.1073\/pnas.0906850106","article-title":"Basal cells as stem cells of the mouse trachea and human airway epithelium","volume":"106","author":"Rock","year":"2009","journal-title":"Proc Natl Acad Sci USA."},{"key":"B45","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.stem.2009.04.002","article-title":"The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium","volume":"4","author":"Rawlins","year":"2009","journal-title":"Cell Stem Cell."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01323\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T23:49:49Z","timestamp":1608248989000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01323\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,11]]},"references-count":45,"alternative-id":["10.3389\/fimmu.2019.01323"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.01323","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,11]]},"article-number":"1323"}}