{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:05:56Z","timestamp":1790791556690,"version":"4.1.0"},"reference-count":99,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T00:00:00Z","timestamp":1560297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1068065"],"award-info":[{"award-number":["APP1068065"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1105747"],"award-info":[{"award-number":["GNT1105747"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.01351","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T13:16:19Z","timestamp":1560345379000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":87,"title":["Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer"],"prefix":"10.3389","volume":"10","author":[{"given":"Abel H. Y.","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WenJuan","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"McCuaig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Hardy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomasina","family":"Donovan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofiya","family":"Tsimbalyuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jade K.","family":"Forwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudha","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,6,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1158\/1055-9965.EPI-15-0578","article-title":"Global cancer incidence and mortality rates and trends\u2013an update","volume":"25","author":"Torre","year":"2016","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"B2","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1007\/s11912-018-0726-6","article-title":"Triple-negative breast cancers: systematic review of the literature on molecular and clinical features with a focus on treatment with innovative drugs","volume":"20","author":"Diana","year":"2018","journal-title":"Curr Oncol Rep"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1056\/NEJMra1001389","article-title":"Triple-negative breast cancer","volume":"363","author":"Foulkes","year":"2010","journal-title":"N Engl J Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"4429","DOI":"10.1158\/1078-0432.CCR-06-3045","article-title":"Triple-negative breast cancer: clinical features and patterns of recurrence","volume":"13","author":"Dent","year":"2007","journal-title":"Clin Cancer Res"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1634\/theoncologist.2016-0067","article-title":"Biology and management of patients with triple-negative breast cancer","volume":"21","author":"Sharma","year":"2016","journal-title":"Oncologist"},{"key":"B6","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1002\/cncr.28914","article-title":"Subtyping of triple-negative breast cancer: implications for therapy","volume":"121","author":"Abramson","year":"2015","journal-title":"Cancer"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1634\/theoncologist.2011-S1-01","article-title":"Triple-negative breast cancer: an unmet medical need","volume":"16","author":"Hudis","year":"2011","journal-title":"Oncologist"},{"key":"B8","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1007\/s10549-015-3438-8","article-title":"Prognostic and predictive value of NanoString-based immune-related gene signatures in a neoadjuvant setting of triple-negative breast cancer: relationship to tumor-infiltrating lymphocytes","volume":"151","author":"Lee","year":"2015","journal-title":"Breast Cancer Res Treat"},{"key":"B9","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.tranon.2018.01.011","article-title":"A Comprehensive immunologic portrait of triple-negative breast cancer","volume":"11","author":"Liu","year":"2018","journal-title":"Transl Oncol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.3390\/cancers6031670","article-title":"Tumor-associated macrophages as major players in the tumor microenvironment","volume":"6","author":"Chanmee","year":"2014","journal-title":"Cancers"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1038\/bjc.2017.356","article-title":"TAMeless traitors: macrophages in cancer progression and metastasis","volume":"117","author":"Aras","year":"2017","journal-title":"Br J Cancer"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e0145342","DOI":"10.1371\/journal.pone.0145342","article-title":"Novel Markers to Delineate Murine M1 and M2 Macrophages","volume":"10","author":"Jablonski","year":"2015","journal-title":"PLoS ONE"},{"key":"B13","doi-asserted-by":"publisher","first-page":"7382","DOI":"10.3892\/mmr.2017.7511","article-title":"Microarray and bioinformatics analyses of gene expression profiles in BALB\/c murine macrophage polarization","volume":"16","author":"Jiang","year":"2017","journal-title":"Mol Med Rep"},{"key":"B14","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1172\/JCI59643","article-title":"Macrophage plasticity and polarization: in vivo veritas","volume":"122","author":"Sica","year":"2012","journal-title":"J Clin Invest"},{"key":"B15","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1093\/annonc\/mdy050","article-title":"Epigenetic modifiers as new immunomodulatory therapies in solid tumours","volume":"29","author":"Aspeslagh","year":"2018","journal-title":"Ann Oncol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"20908","DOI":"10.18632\/oncotarget.24556","article-title":"Epigenetic control of macrophage polarization: implications for targeting tumor-associated macrophages","volume":"9","author":"de Groot","year":"2018","journal-title":"Oncotarget"},{"key":"B17","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s13072-018-0203-3","article-title":"KDM1A microenvironment, its oncogenic potential, and therapeutic significance","volume":"11","author":"Ismail","year":"2018","journal-title":"Epigenetics Chromatin"},{"key":"B18","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.it.2012.11.001","article-title":"Epigenetic regulation of macrophage polarization and function","volume":"34","author":"Ivashkiv","year":"2013","journal-title":"Trends Immunol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"e00633","DOI":"10.7554\/eLife.00633","article-title":"Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation","volume":"2","author":"Kerenyi","year":"2013","journal-title":"Elife"},{"key":"B20","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1038\/s41388-018-0451-5","article-title":"Inhibition of histone lysine-specific demethylase 1 elicits breast tumor immunity and enhances antitumor efficacy of immune checkpoint blockade","volume":"38","author":"Qin","year":"2018","journal-title":"Oncogene"},{"key":"B21","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1038\/nature05836","article-title":"Gene-specific control of inflammation by TLR-induced chromatin modifications","volume":"447","author":"Foster","year":"2007","journal-title":"Nature"},{"key":"B22","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/s41598-017-17913-x","article-title":"LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer","volume":"8","author":"Boulding","year":"2018","journal-title":"Sci Rep"},{"key":"B23","doi-asserted-by":"publisher","first-page":"Unit21.26","DOI":"10.1002\/0471142727.mb2126s102","article-title":"A detailed protocol for formaldehyde-assisted isolation of regulatory elements (FAIRE)","author":"Simon","year":"2013","journal-title":"Curr Protoc Mol Biol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1214\/aos\/1013699998","article-title":"The control of the false discovery rate in multiple testing under dependency","volume":"29","author":"Benjamini","year":"2001","journal-title":"Ann Stat"},{"key":"B25","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1107\/S0907444910048675","article-title":"iMOSFLM: a new graphical interface for diffraction-image processing with MOSFLM","volume":"67","author":"Battye","year":"2011","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1107\/S0907444913000061","article-title":"How good are my data and what is the resolution?","volume":"69","author":"Evans","year":"2013","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1110\/ps.0350503","article-title":"Matthews coefficient probabilities: Improved estimates for unit cell contents of proteins, DNA, and protein-nucleic acid complex crystals","volume":"12","author":"Kantardjieff","year":"2003","journal-title":"Protein Sci"},{"key":"B28","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/0022-2836(68)90205-2","article-title":"Solvent content of protein crystals","volume":"33","author":"Matthews","year":"1968","journal-title":"J Mol Biol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"B30","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1107\/S0907444911001314","article-title":"REFMAC5 for the refinement of macromolecular crystal structures","volume":"67","author":"Murshudov","year":"2011","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"B31","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.cell.2012.12.018","article-title":"Latent enhancers activated by stimulation in differentiated cells","volume":"152","author":"Ostuni","year":"2013","journal-title":"Cell"},{"key":"B32","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"B33","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat Methods"},{"key":"B34","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","article-title":"Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities","volume":"38","author":"Heinz","year":"2010","journal-title":"Mol Cell"},{"key":"B35","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"key":"B36","doi-asserted-by":"publisher","first-page":"3164","DOI":"10.1021\/ja909996p","article-title":"Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors","volume":"132","author":"Culhane","year":"2010","journal-title":"J Am Chem Soc"},{"key":"B37","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.ccell.2015.06.002","article-title":"A DNA hypomethylation signature predicts antitumor activity of LSD1 Inhibitors in SCLC","volume":"28","author":"Mohammad","year":"2015","journal-title":"Cancer Cell"},{"key":"B38","doi-asserted-by":"publisher","first-page":"6827","DOI":"10.1021\/ja101557k","article-title":"Biochemical, structural, and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2","volume":"132","author":"Binda","year":"2010","journal-title":"J Am Chem Soc"},{"key":"B39","doi-asserted-by":"publisher","first-page":"4408","DOI":"10.1021\/bi0618621","article-title":"trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1","volume":"46","author":"Schmidt","year":"2007","journal-title":"Biochemistry"},{"key":"B40","doi-asserted-by":"publisher","first-page":"5616","DOI":"10.1021\/bi8002814","article-title":"Structural and mechanistic studies of arylalkylhydrazine inhibition of human monoamine oxidases A and B","volume":"47","author":"Binda","year":"2008","journal-title":"Biochemistry"},{"key":"B41","doi-asserted-by":"publisher","first-page":"8058","DOI":"10.1021\/bi700664y","article-title":"Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine","volume":"46","author":"Yang","year":"2007","journal-title":"Biochemistry"},{"key":"B42","doi-asserted-by":"publisher","first-page":"52294","DOI":"10.18632\/oncotarget.10561","article-title":"TGF-beta induces M2-like macrophage polarization via SNAIL-mediated suppression of a pro-inflammatory phenotype","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"},{"key":"B43","doi-asserted-by":"publisher","first-page":"86","DOI":"10.3389\/fonc.2018.00086","article-title":"Anti-PD-1 and Anti-CTLA-4 therapies in cancer: mechanisms of action, efficacy, and limitations","volume":"8","author":"Seidel","year":"2018","journal-title":"Front Oncol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"328rv4","DOI":"10.1126\/scitranslmed.aad7118","article-title":"PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations","volume":"8","author":"Zou","year":"2016","journal-title":"Sci Transl Med"},{"key":"B45","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/nri.2017.28","article-title":"Monocyte differentiation and antigen-presenting functions","volume":"17","author":"Jakubzick","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/nri3818","article-title":"The ins and outs of MHC class II-mediated antigen processing and presentation","volume":"15","author":"Roche","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"12195","DOI":"10.1093\/nar\/gkx821","article-title":"Chromatin proteomics reveals novel combinatorial histone modification signatures that mark distinct subpopulations of macrophage enhancers","volume":"45","author":"Soldi","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1016\/j.cell.2016.05.075","article-title":"A Long noncoding RNA lincRNA-EPS acts as a transcriptional brake to restrain inflammation","volume":"165","author":"Atianand","year":"2016","journal-title":"Cell"},{"key":"B49","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/j.molcel.2005.08.027","article-title":"Regulation of LSD1 histone demethylase activity by its associated factors","volume":"19","author":"Shi","year":"2005","journal-title":"Mol Cell"},{"key":"B50","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1038\/nature04021","article-title":"An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation","volume":"437","author":"Lee","year":"2005","journal-title":"Nature"},{"key":"B51","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/nature04020","article-title":"LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription","volume":"437","author":"Metzger","year":"2005","journal-title":"Nature"},{"key":"B52","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/s41389-018-0042-x","article-title":"SNAIL1 action in tumor cells influences macrophage polarization and metastasis in breast cancer through altered GM-CSF secretion","volume":"7","author":"Brenot","year":"2018","journal-title":"Oncogenesis"},{"key":"B53","doi-asserted-by":"publisher","first-page":"2961","DOI":"10.1128\/MCB.01693-13","article-title":"Chromatinized protein kinase C-theta directly regulates inducible genes in epithelial to mesenchymal transition and breast cancer stem cells","volume":"34","author":"Zafar","year":"2014","journal-title":"Mol Cell Biol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"530","DOI":"10.3389\/fimmu.2015.00530","article-title":"PKC-theta in regulatory and effector T-cell functions","volume":"6","author":"Brezar","year":"2015","journal-title":"Front Immunol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s12964-016-0137-y","article-title":"Role of PKCtheta in macrophage-mediated immune response to Salmonella typhimurium infection in mice","volume":"14","author":"Pfeifhofer-Obermair","year":"2016","journal-title":"Cell Commun Signal"},{"key":"B56","doi-asserted-by":"publisher","first-page":"260","DOI":"10.3389\/fimmu.2012.00260","article-title":"Chromatinized protein kinase C-theta: can it escape the clutches of NF-kappaB?","volume":"3","author":"Sutcliffe","year":"2012","journal-title":"Front Immunol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"3244","DOI":"10.1182\/blood-2009-04-217620","article-title":"Epigenetic regulation of the alternatively activated macrophage phenotype","volume":"114","author":"Ishii","year":"2009","journal-title":"Blood"},{"key":"B58","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1038\/ni.1937","article-title":"Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm","volume":"11","author":"Biswas","year":"2010","journal-title":"Nat Immunol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.it.2004.09.015","article-title":"The chemokine system in diverse forms of macrophage activation and polarization","volume":"25","author":"Mantovani","year":"2004","journal-title":"Trends Immunol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"13","DOI":"10.12703\/P6-13","article-title":"The M1 and M2 paradigm of macrophage activation: time for reassessment","volume":"6","author":"Martinez","year":"2014","journal-title":"F1000Prime Rep"},{"key":"B61","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1146\/annurev-physiol-022516-034339","article-title":"Macrophage polarization","volume":"79","author":"Murray","year":"2017","journal-title":"Annu Rev Physiol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"614","DOI":"10.3389\/fimmu.2014.00614","article-title":"Molecular mechanisms that influence the macrophage m1-m2 polarization balance","volume":"5","author":"Wang","year":"2014","journal-title":"Front Immunol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1038\/nri3088","article-title":"Transcriptional regulation of macrophage polarization: enabling diversity with identity","volume":"11","author":"Lawrence","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"4513","DOI":"10.1128\/IAI.00935-15","article-title":"STAT1 signaling within macrophages is required for antifungal activity against Cryptococcus neoformans","volume":"83","author":"Leopold Wager","year":"2015","journal-title":"Infect Immun"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1084\/jem.20080124","article-title":"An antiinflammatory role for IKKbeta through the inhibition of \u201cclassical\u201d macrophage activation","volume":"205","author":"Fong","year":"2008","journal-title":"J Exp Med"},{"key":"B66","doi-asserted-by":"publisher","first-page":"11432","DOI":"10.1158\/0008-5472.CAN-06-1867","article-title":"p50 nuclear factor-kappaB overexpression in tumor-associated macrophages inhibits M1 inflammatory responses and antitumor resistance","volume":"66","author":"Saccani","year":"2006","journal-title":"Cancer Res"},{"key":"B67","doi-asserted-by":"publisher","first-page":"e0188317","DOI":"10.1371\/journal.pone.0188317","article-title":"NF-kappaB pathways are involved in M1 polarization of RAW 264","volume":"12","author":"Liu","year":"2017","journal-title":"PLoS ONE"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1007\/s10753-016-0374-7","article-title":"Geraniin Inhibits LPS-Induced THP-1 macrophages switching to M1 Phenotype via SOCS1\/NF-kappaB pathway","volume":"39","author":"Liu","year":"2016","journal-title":"Inflammation"},{"key":"B69","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1007\/s10753-014-9816-2","article-title":"Punicalagin inhibits inflammation in LPS-induced RAW264","volume":"37","author":"Xu","year":"2014","journal-title":"Inflammation"},{"key":"B70","doi-asserted-by":"publisher","first-page":"2736","DOI":"10.1172\/JCI45444","article-title":"Kruppel-like factor 4 regulates macrophage polarization","volume":"121","author":"Liao","year":"2011","journal-title":"J Clin Invest"},{"key":"B71","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.celrep.2017.06.017","article-title":"RORalpha Induces KLF4-Mediated M2 polarization in the liver macrophages that protect against nonalcoholic steatohepatitis","volume":"20","author":"Han","year":"2017","journal-title":"Cell Rep"},{"key":"B72","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1038\/ni.1920","article-title":"The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection","volume":"11","author":"Satoh","year":"2010","journal-title":"Nat Immunol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"731023","DOI":"10.1155\/2013\/731023","article-title":"Interferon-regulatory factors determine macrophage phenotype polarization","volume":"2013","author":"Gunthner","year":"2013","journal-title":"Mediators Inflamm"},{"key":"B74","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/ni.1990","article-title":"IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses","volume":"12","author":"Krausgruber","year":"2011","journal-title":"Nat Immunol"},{"key":"B75","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/s41408-018-0136-x","article-title":"Effect of the BTK inhibitor ibrutinib on macrophage- and gammadelta T cell-mediated response against Mycobacterium tuberculosis","volume":"8","author":"Colado","year":"2018","journal-title":"Blood Cancer J"},{"key":"B76","doi-asserted-by":"publisher","first-page":"e85834","DOI":"10.1371\/journal.pone.0085834","article-title":"Btk regulates macrophage polarization in response to lipopolysaccharide","volume":"9","author":"Ni Gabhann","year":"2014","journal-title":"PLoS ONE"},{"key":"B77","first-page":"817","article-title":"Inhibition of angiogenesis by tissue inhibitor of metalloproteinase-3","volume":"38","author":"Anand-Apte","year":"1997","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B78","doi-asserted-by":"publisher","first-page":"3719","DOI":"10.1242\/jcs.00063","article-title":"Metalloproteinase inhibitors: biological actions and therapeutic opportunities","volume":"115","author":"Baker","year":"2002","journal-title":"J Cell Sci"},{"key":"B79","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/nm846","article-title":"A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2","volume":"9","author":"Qi","year":"2003","journal-title":"Nat Med"},{"key":"B80","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.immuni.2010.12.011","article-title":"CD169-positive macrophages dominate antitumor immunity by crosspresenting dead cell-associated antigens","volume":"34","author":"Asano","year":"2011","journal-title":"Immunity"},{"key":"B81","doi-asserted-by":"publisher","first-page":"263","DOI":"10.3389\/fimmu.2015.00263","article-title":"Much More than M1 and M2 Macrophages, there are also CD169(+) and TCR(+) Macrophages","volume":"6","author":"Chavez-Galan","year":"2015","journal-title":"Front Immunol"},{"key":"B82","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.it.2011.11.001","article-title":"CD169+ macrophages at the crossroads of antigen presentation","volume":"33","author":"Martinez-Pomares","year":"2012","journal-title":"Trends Immunol"},{"key":"B83","doi-asserted-by":"publisher","first-page":"e0166680","DOI":"10.1371\/journal.pone.0166680","article-title":"The clinical significance of CD169-positive lymph node macrophage in patients with breast cancer","volume":"11","author":"Shiota","year":"2016","journal-title":"PLoS ONE"},{"key":"B84","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1016\/j.celrep.2018.01.021","article-title":"Functional CD169 on macrophages mediates interaction with dendritic cells for CD8(+) T cell cross-priming","volume":"22","author":"van Dinther","year":"2018","journal-title":"Cell Rep"},{"key":"B85","doi-asserted-by":"publisher","first-page":"657","DOI":"10.2217\/epi.10.44","article-title":"Molecular coupling of DNA methylation and histone methylation","volume":"2","author":"Hashimoto","year":"2010","journal-title":"Epigenomics"},{"key":"B86","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.tcb.2015.05.002","article-title":"YAP and TAZ: a nexus for Hippo signaling and beyond","volume":"25","author":"Hansen","year":"2015","journal-title":"Trends Cell Biol"},{"key":"B87","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1038\/s41419-018-0818-0","article-title":"Crosstalk between hepatic tumor cells and macrophages via Wnt\/beta-catenin signaling promotes M2-like macrophage polarization and reinforces tumor malignant behaviors","volume":"9","author":"Yang","year":"2018","journal-title":"Cell Death Dis"},{"key":"B88","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/2045-824X-4-13","article-title":"Macrophages and angiogenesis: a role for Wnt signaling","volume":"4","author":"Newman","year":"2012","journal-title":"Vasc Cell"},{"key":"B89","doi-asserted-by":"publisher","first-page":"702","DOI":"10.4049\/jimmunol.0902360","article-title":"Gene expression analysis of macrophages that facilitate tumor invasion supports a role for Wnt-signaling in mediating their activity in primary mammary tumors","volume":"184","author":"Ojalvo","year":"2010","journal-title":"J Immunol"},{"key":"B90","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1038\/onc.2016.304","article-title":"Wnt signaling in cancer","volume":"36","author":"Zhan","year":"2017","journal-title":"Oncogene"},{"key":"B91","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrc969","article-title":"Targeting RAS signalling pathways in cancer therapy","volume":"3","author":"Downward","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"B92","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1038\/nrc2945","article-title":"The renin-angiotensin system and cancer: old dog, new tricks","volume":"10","author":"George","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"B93","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/j.cell.2017.11.013","article-title":"Myc cooperates with ras by programming inflammation and immune suppression","volume":"171","author":"Kortlever","year":"2017","journal-title":"Cell"},{"key":"B94","doi-asserted-by":"publisher","first-page":"117","DOI":"10.3389\/fonc.2018.00117","article-title":"Influence of the tumor microenvironment on cancer cells metabolic reprogramming","volume":"8","author":"Gouirand","year":"2018","journal-title":"Front Oncol"},{"key":"B95","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/j.tcb.2017.06.003","article-title":"Metabolic interactions in the tumor microenvironment","volume":"27","author":"Lyssiotis","year":"2017","journal-title":"Trends Cell Biol"},{"key":"B96","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1002\/med.21511","article-title":"Metabolism within the tumor microenvironment and its implication on cancer progression: an ongoing therapeutic target","volume":"39","author":"Ocana","year":"2019","journal-title":"Med Res Rev"},{"key":"B97","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/2052-8426-2-14","article-title":"Extracellular matrix macromolecules: potential tools and targets in cancer gene therapy","volume":"2","author":"Sainio","year":"2014","journal-title":"Mol Cell Ther"},{"key":"B98","doi-asserted-by":"publisher","first-page":"270","DOI":"10.3389\/fimmu.2018.00270","article-title":"Metabolic Modulation in Macrophage Effector Function","volume":"9","author":"Diskin","year":"2018","journal-title":"Front Immunol"},{"key":"B99","doi-asserted-by":"publisher","first-page":"eaav7759","DOI":"10.1126\/sciimmunol.aav7759","article-title":"A sweet alternative: maintaining M2 macrophage polarization","volume":"3","author":"Hamers","year":"2018","journal-title":"Sci Immunol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01351\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T13:16:22Z","timestamp":1560345382000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01351\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,12]]},"references-count":99,"alternative-id":["10.3389\/fimmu.2019.01351"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.01351","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,12]]},"article-number":"1351"}}