{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T08:47:49Z","timestamp":1778575669587,"version":"3.51.4"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T00:00:00Z","timestamp":1560297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004561","name":"Ministry of Education and Science of the Republic of Kazakhstan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004561","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006225","name":"Oak Ridge Associated Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2019.01353","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T14:28:53Z","timestamp":1560349733000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["CTHRC1: A New Candidate Biomarker for Improved Rheumatoid Arthritis Diagnosis"],"prefix":"10.3389","volume":"10","author":[{"given":"Askhat","family":"Myngbay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yergali","family":"Bexeitov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Altynai","family":"Adilbayeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenisbek","family":"Assylbekov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogdan P.","family":"Yevstratenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rysgul M.","family":"Aitzhanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bakhyt","family":"Matkarimov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vyacheslav A.","family":"Adarichev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeannette","family":"Kunz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,6,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"18001","DOI":"10.1038\/nrdp.2018.1","article-title":"Rheumatoid arthritis","volume":"4","author":"Smolen","year":"2018","journal-title":"Nat Rev Dis Primers."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1016\/S0140-6736(10)60826-4","article-title":"Rheumatoid arthritis","volume":"376","author":"Scott","year":"2010","journal-title":"Lancet."},{"key":"B3","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1136\/ard.2009.123919","article-title":"Treating rheumatoid arthritis to target: recommendations of an international task force","volume":"69","author":"Smolen","year":"2010","journal-title":"Ann Rheum Dis."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1038\/ng.2462","article-title":"High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis","volume":"44","author":"Eyre","year":"2012","journal-title":"Nat Genet."},{"key":"B5","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1038\/ng.3572","article-title":"A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases","volume":"48","author":"Han","year":"2016","journal-title":"Nat Genet."},{"key":"B6","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1086\/516736","article-title":"Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis","volume":"80","author":"Kallberg","year":"2007","journal-title":"Am J Hum Genet."},{"key":"B7","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1093\/rheumatology\/keu323","article-title":"The genetics of rheumatoid arthritis: risk and protection in different stages of the evolution of RA","volume":"55","author":"Yarwood","year":"2016","journal-title":"Rheumatology."},{"key":"B8","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1093\/rheumatology\/kei111","article-title":"Use and significance of anti-CCP autoantibodies in rheumatoid arthritis","volume":"45","author":"Zendman","year":"2006","journal-title":"Rheumatology."},{"key":"B9","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3109\/00365513.2010.493406","article-title":"Biomarkers for rheumatoid arthritis: making it personal","volume":"242","author":"Lindstrom","year":"2010","journal-title":"Scand J Clin Lab Invest Suppl."},{"key":"B10","doi-asserted-by":"publisher","first-page":"e1003394","DOI":"10.1371\/journal.pgen.1003394","article-title":"Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis","volume":"9","author":"Cui","year":"2013","journal-title":"PLoS Genet."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1136\/ard.2006.063412","article-title":"Rheumatoid arthritis subtypes identified by genomic profiling of peripheral blood cells: assignment of a type I interferon signature in a subpopulation of patients","volume":"66","author":"van der Pouw Kraan","year":"2007","journal-title":"Ann Rheum Dis."},{"key":"B12","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1002\/art.40428","article-title":"Identification of three rheumatoid arthritis disease subtypes by machine learning integration of synovial histologic features and RNA sequencing data","volume":"70","author":"Orange","year":"2018","journal-title":"Arthritis Rheumatol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/sj.gene.6363975","article-title":"Discovery of distinctive gene expression profiles in rheumatoid synovium using cDNA microarray technology: evidence for the existence of multiple pathways of tissue destruction and repair","volume":"4","author":"van der Pouw Kraan","year":"2003","journal-title":"Genes Immun."},{"key":"B14","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/qjmed\/hcp165","article-title":"Autoantibodies in rheumatoid arthritis: rheumatoid factors and anticitrullinated protein antibodies","volume":"103","author":"Song","year":"2010","journal-title":"QJM."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1136\/ard.2005.035691","article-title":"Autoantibody profiling as early diagnostic and prognostic tool for rheumatoid arthritis","volume":"64","author":"Nell","year":"2005","journal-title":"Ann Rheum Dis."},{"key":"B16","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1002\/1529-0131(200001)43:1<155::AID-ANR20>3.0.CO;2-3","article-title":"The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide","volume":"43","author":"Schellekens","year":"2000","journal-title":"Arthritis Rheum."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1002\/1529-0131(200008)43:8<1831::AID-ANR19>3.0.CO;2-6","article-title":"The prognostic value of anti-cyclic citrullinated peptide antibody in patients with recent-onset rheumatoid arthritis","volume":"43","author":"Kroot","year":"2000","journal-title":"Arthritis Rheum."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1794","DOI":"10.1002\/acr.21767","article-title":"Validation of a novel multibiomarker test to assess rheumatoid arthritis disease activity","volume":"64","author":"Curtis","year":"2012","journal-title":"Arthritis Care Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"2083","DOI":"10.1002\/art.39714","article-title":"Brief report: estimating disease activity using multi-biomarker disease activity scores in rheumatoid arthritis patients treated with abatacept or adalimumab","volume":"68","author":"Fleischmann","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1111\/j.0105-2896.2009.00859.x","article-title":"Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis","volume":"233","author":"Bartok","year":"2010","journal-title":"Immunol Rev."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1002\/art.24453","article-title":"Cadherin 11 promotes invasive behavior of fibroblast-like synoviocytes","volume":"60","author":"Kiener","year":"2009","journal-title":"Arthritis Rheum."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1038\/nm.2050","article-title":"Synovial fibroblasts spread rheumatoid arthritis to unaffected joints","volume":"15","author":"Lefevre","year":"2009","journal-title":"Nat Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/nrrheum.2012.190","article-title":"Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors","volume":"9","author":"Bottini","year":"2013","journal-title":"Nat Rev Rheumatol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1002\/art.11016","article-title":"Sex effect on clinical and immunologic quantitative trait loci in a murine model of rheumatoid arthritis","volume":"48","author":"Adarichev","year":"2003","journal-title":"Arthritis Rheum."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1002\/art.33414","article-title":"Wnt signaling genes of murine chromosome 15 are involved in sex-affected pathways of inflammatory arthritis","volume":"64","author":"Kudryavtseva","year":"2012","journal-title":"Arthritis Rheum."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.4049\/jimmunol.181.2.1307","article-title":"Two loci on chromosome 15 control experimentally induced arthritis through the differential regulation of IL-6 and lymphocyte proliferation","volume":"181","author":"Glant","year":"2008","journal-title":"J Immunol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/gene.2008.54","article-title":"Congenic strains displaying similar clinical phenotype of arthritis represent different immunologic models of inflammation","volume":"9","author":"Adarichev","year":"2008","journal-title":"Genes Immun."},{"key":"B28","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1186\/s13075-016-1067-1","article-title":"Collagen triple helix repeat containing 1 is a new promigratory marker of arthritic pannus","volume":"18","author":"Shekhani","year":"2016","journal-title":"Arthritis Res Ther."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2635","DOI":"10.1210\/en.2007-0270","article-title":"Targeting the Wnt\/beta-catenin pathway to regulate bone formation in the adult skeleton","volume":"148","author":"Baron","year":"2007","journal-title":"Endocrinology."},{"key":"B30","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1002\/art.27584","article-title":"2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"62","author":"Aletaha","year":"2010","journal-title":"Arthritis Rheum."},{"key":"B31","doi-asserted-by":"publisher","first-page":"e100449","DOI":"10.1371\/journal.pone.0100449","article-title":"Elevated plasma levels of the pituitary hormone Cthrc1 in individuals with red hair but not in patients with solid tumors","volume":"9","author":"Duarte","year":"2014","journal-title":"PLoS ONE."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1093\/rheumatology\/keg323","article-title":"Inhibition of cytokine production by methotrexate. Studies in healthy volunteers and patients with rheumatoid arthritis","volume":"42","author":"Gerards","year":"2003","journal-title":"Rheumatology."},{"key":"B33","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1038\/nrrheum.2012.153","article-title":"Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment","volume":"8","author":"Schett","year":"2012","journal-title":"Nat Rev Rheumatol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/j.modgep.2006.03.008","article-title":"Expression analysis of the novel gene collagen triple helix repeat containing-1 (Cthrc1)","volume":"6","author":"Durmus","year":"2006","journal-title":"Gene Expr Patterns."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1161\/ATVBAHA.108.166579","article-title":"Intracellular localization of Cthrc1 characterizes differentiated smooth muscle","volume":"28","author":"Leclair","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1161\/01.RES.0000260806.99307.72","article-title":"Cthrc1 is a novel inhibitor of transforming growth factor-beta signaling and neointimal lesion formation","volume":"100","author":"LeClair","year":"2007","journal-title":"Circ Res."},{"key":"B37","doi-asserted-by":"publisher","first-page":"e47142","DOI":"10.1371\/journal.pone.0047142","article-title":"Cthrc1, a novel circulating hormone regulating metabolism","volume":"7","author":"Stohn","year":"2012","journal-title":"PLoS ONE."},{"key":"B38","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1038\/s41467-018-02892-y","article-title":"Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis","volume":"9","author":"Mizoguchi","year":"2018","journal-title":"Nat Commun."},{"key":"B39","doi-asserted-by":"publisher","first-page":"3914","DOI":"10.1172\/JCI69493","article-title":"Osteoclast-secreted CTHRC1 in the coupling of bone resorption to formation","volume":"123","author":"Takeshita","year":"2013","journal-title":"J Clin Invest."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1002\/jbmr.3436","article-title":"WAIF1 is a cell-surface CTHRC1 binding protein coupling bone resorption and formation","volume":"33","author":"Matsuoka","year":"2018","journal-title":"J Bone Miner Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.bone.2017.01.022","article-title":"Inhibition of osteoclast differentiation and collagen antibody-induced arthritis by CTHRC1","volume":"97","author":"Jin","year":"2017","journal-title":"Bone."},{"key":"B42","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.devcel.2008.05.007","article-title":"Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex","volume":"15","author":"Yamamoto","year":"2008","journal-title":"Dev Cell."},{"key":"B43","doi-asserted-by":"publisher","first-page":"e3174","DOI":"10.1371\/journal.pone.0003174","article-title":"Cthrc1 is a positive regulator of osteoblastic bone formation","volume":"3","author":"Kimura","year":"2008","journal-title":"PLoS ONE."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01353\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T14:28:55Z","timestamp":1560349735000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2019.01353\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,12]]},"references-count":43,"alternative-id":["10.3389\/fimmu.2019.01353"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2019.01353","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,12]]},"article-number":"1353"}}